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Protein
Submitted name:

17-beta-hydroxysteroid dehydrogenase type IV

Gene

HSD17B4

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-GGA-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-GGA-2046106. alpha-linolenic acid (ALA) metabolism.
R-GGA-389887. Beta-oxidation of pristanoyl-CoA.
R-GGA-390247. Beta-oxidation of very long chain fatty acids.

Names & Taxonomyi

Protein namesi
Submitted name:
17-beta-hydroxysteroid dehydrogenase type IVImported
Gene namesi
Name:HSD17B4Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome Z

Subcellular locationi

GO - Cellular componenti

Expressioni

Gene expression databases

BgeeiENSGALG00000002187.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini482 – 598MaoC-likeInterPro annotationAdd BLAST117
Domaini627 – 730SCP2InterPro annotationAdd BLAST104

Phylogenomic databases

GeneTreeiENSGT00530000062928.
HOGENOMiHOG000170895.
HOVERGENiHBG002174.
KOiK12405.
OMAiTVMPEDL.
OrthoDBiEOG091G02S9.

Family and domain databases

Gene3Di3.10.129.10. 2 hits.
3.30.1050.10. 1 hit.
3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR029069. HotDog_dom.
IPR002539. MaoC_dom.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR003033. SCP2_sterol-bd_dom.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
PF02036. SCP2. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF54637. SSF54637. 2 hits.
SSF55718. SSF55718. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

O42484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGLRFDGR VVLVTGAGGG LGRAYALAFA ERGASVVVND LGGDFKGYGK
60 70 80 90 100
SSSAADKVVS EIRANGGKAV PNYDSVEDGE KLVKSALEAF GRIDIVINNA
110 120 130 140 150
GILRDRSFVR ISDEDWDIIH RIHLRGSFLV TRAAWNHMKN QKFGRIIMTS
160 170 180 190 200
SAAGIYGNFG QANYSAAKLG LLGLSNTIAI EGRKYNIHCN TIAPTAGSRL
210 220 230 240 250
TQTVMPQDLI DAFKPEYVAP LVLWLCHETC MENGSLFEVG AGWIGKLRWE
260 270 280 290 300
RSLGAIVRGK DQPMTPEAVR DKWEKVCDFN NASKPRSIQE SISVLNDALS
310 320 330 340 350
QIESQGSISM NSTNSRSVVS SAVDTTSLVG RELTTKVYKY THLEPILYAL
360 370 380 390 400
GVGMSTKDPD HLKFLFEGSE EFCCLPTFGV IPAQTSMFDG VPSIPGLDMD
410 420 430 440 450
LAKMLHGEQY LELYKPLPTS GELRSVSTIA DLLDKGSGAV LLIDVNTYCG
460 470 480 490 500
KDLVCYNQFS LFFVGAGGFG GKRTSEKAKV TVNPPKRPPD AILSDVTTSD
510 520 530 540 550
QAALYRLSGD WNPLHLDPSF AALGGFQKPI LHGLCTFGFA ARNVLKQFAN
560 570 580 590 600
NDVTRFKAIK VRFAKPVFPG QTLQTEMWKE GNRIHFQTKV KETGDLAIAG
610 620 630 640 650
GYVDIVSALD KPSALEPTAG LQSDLVFEEI GRRIKEVGHE LVRKVNAVFQ
660 670 680 690 700
WDITKDGKTA VQWTIDLKNG SGSVYQGPAR SSADTTFTLS DQDFMDVVQK
710 720 730
KTNPQKAFFS GKLKVKGNIM LSQKLEMILK DYAKL
Length:735
Mass (Da):80,149
Last modified:January 1, 1998 - v1
Checksum:i6D24AD4C7CC5179D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC192621 Genomic DNA. No translation available.
U77911 mRNA. Translation: AAC60249.1.
RefSeqiNP_990274.1. NM_204943.1.
UniGeneiGga.3546.

Genome annotation databases

EnsembliENSGALT00000003423; ENSGALP00000003418; ENSGALG00000002187.
GeneIDi395785.
KEGGigga:395785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC192621 Genomic DNA. No translation available.
U77911 mRNA. Translation: AAC60249.1.
RefSeqiNP_990274.1. NM_204943.1.
UniGeneiGga.3546.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000003423; ENSGALP00000003418; ENSGALG00000002187.
GeneIDi395785.
KEGGigga:395785.

Organism-specific databases

CTDi3295.

Phylogenomic databases

GeneTreeiENSGT00530000062928.
HOGENOMiHOG000170895.
HOVERGENiHBG002174.
KOiK12405.
OMAiTVMPEDL.
OrthoDBiEOG091G02S9.

Enzyme and pathway databases

ReactomeiR-GGA-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-GGA-2046106. alpha-linolenic acid (ALA) metabolism.
R-GGA-389887. Beta-oxidation of pristanoyl-CoA.
R-GGA-390247. Beta-oxidation of very long chain fatty acids.

Gene expression databases

BgeeiENSGALG00000002187.

Family and domain databases

Gene3Di3.10.129.10. 2 hits.
3.30.1050.10. 1 hit.
3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR029069. HotDog_dom.
IPR002539. MaoC_dom.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR003033. SCP2_sterol-bd_dom.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
PF02036. SCP2. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF54637. SSF54637. 2 hits.
SSF55718. SSF55718. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO42484_CHICK
AccessioniPrimary (citable) accession number: O42484
Secondary accession number(s): E1BW32
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: March 15, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.