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O42457

- CP1A1_SPAAU

UniProt

O42457 - CP1A1_SPAAU

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Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Sparus aurata (Gilthead sea bream)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei229 – 2291SubstrateBy similarity
Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:cyp1a1
OrganismiSparus aurata (Gilthead sea bream)
Taxonomic identifieri8175 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaSpariformesSparidaeSparus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Cytochrome P450 1A1PRO_0000051647Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO42457.
SMRiO42457. Positions 38-516.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42457-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLMILPFVG PVSVSESLVA IITMCLVYMI LKFFRTEIPE GLCQLPGPKP
60 70 80 90 100
LPIIGNVLEV GRNPYLSLTA MSKRYGDVFQ IQIGMRPVVV LSGSETVRQA
110 120 130 140 150
LIKQGDDFAG RPDLYSFRFI NDGKSLAFST DQAGVWRARR KLAYSALRSF
160 170 180 190 200
STLEGTTPEY SCALEEHVSK EAEYLVKQLN TVMETDGSFD PFRHIVVSVA
210 220 230 240 250
NVICGMCFGR RYDHNNQELL NLVNLSDEFG QVVASGNPAD FIPILQYLPS
260 270 280 290 300
TSMKKFVSIN DRFNAFVQKI VSEHYTTFDK DNIRDITDSL IDHCEDRKLD
310 320 330 340 350
ENSNVQMSDE KVVGIVNDLF GAGFDTISTA LSWSVMYLVA YPEIQERLYQ
360 370 380 390 400
EMKESVGLDR TPCLSDKPKL PFLEAFILEI FRHSSFLPFT IPHCSSKDTS
410 420 430 440 450
LNGYFIPKDT CVFINQWQIN HDPELWKDPS SFNPDRFLNT DGTELNKLEG
460 470 480 490 500
EKMMVFGLGK RRCIGEVIAR NEVFLFLAIL VQNLRFHAKP GEPLDMTPEY
510 520
GLTMKHKRCH LRAAMRSRNE E
Length:521
Mass (Da):59,122
Last modified:January 1, 1998 - v1
Checksum:i8FE00D86460B303B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1773LVK → GTR in AAB62887. 1 PublicationCurated
Sequence conflicti209 – 2091G → A in AAB62887. 1 PublicationCurated
Sequence conflicti212 – 2121Y → S in AAB62887. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF011223 mRNA. Translation: AAB64297.1.
AF005719 mRNA. Translation: AAB62887.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF011223 mRNA. Translation: AAB64297.1 .
AF005719 mRNA. Translation: AAB62887.1 .

3D structure databases

ProteinModelPortali O42457.
SMRi O42457. Positions 38-516.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cousinou M., Lopez-Barea J., Dorado G.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Tom M.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 175-521.
    Tissue: Liver.

Entry informationi

Entry nameiCP1A1_SPAAU
AccessioniPrimary (citable) accession number: O42457
Secondary accession number(s): O42458
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3