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O42457

- CP1A1_SPAAU

UniProt

O42457 - CP1A1_SPAAU

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Protein
Cytochrome P450 1A1
Gene
cyp1a1
Organism
Sparus aurata (Gilthead sea bream)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei229 – 2291Substrate By similarity
Metal bindingi463 – 4631Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:cyp1a1
OrganismiSparus aurata (Gilthead sea bream)
Taxonomic identifieri8175 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaSpariformesSparidaeSparus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Cytochrome P450 1A1
PRO_0000051647Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO42457.
SMRiO42457. Positions 38-516.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42457-1 [UniParc]FASTAAdd to Basket

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MVLMILPFVG PVSVSESLVA IITMCLVYMI LKFFRTEIPE GLCQLPGPKP    50
LPIIGNVLEV GRNPYLSLTA MSKRYGDVFQ IQIGMRPVVV LSGSETVRQA 100
LIKQGDDFAG RPDLYSFRFI NDGKSLAFST DQAGVWRARR KLAYSALRSF 150
STLEGTTPEY SCALEEHVSK EAEYLVKQLN TVMETDGSFD PFRHIVVSVA 200
NVICGMCFGR RYDHNNQELL NLVNLSDEFG QVVASGNPAD FIPILQYLPS 250
TSMKKFVSIN DRFNAFVQKI VSEHYTTFDK DNIRDITDSL IDHCEDRKLD 300
ENSNVQMSDE KVVGIVNDLF GAGFDTISTA LSWSVMYLVA YPEIQERLYQ 350
EMKESVGLDR TPCLSDKPKL PFLEAFILEI FRHSSFLPFT IPHCSSKDTS 400
LNGYFIPKDT CVFINQWQIN HDPELWKDPS SFNPDRFLNT DGTELNKLEG 450
EKMMVFGLGK RRCIGEVIAR NEVFLFLAIL VQNLRFHAKP GEPLDMTPEY 500
GLTMKHKRCH LRAAMRSRNE E 521
Length:521
Mass (Da):59,122
Last modified:January 1, 1998 - v1
Checksum:i8FE00D86460B303B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1773LVK → GTR in AAB62887. 1 Publication
Sequence conflicti209 – 2091G → A in AAB62887. 1 Publication
Sequence conflicti212 – 2121Y → S in AAB62887. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF011223 mRNA. Translation: AAB64297.1.
AF005719 mRNA. Translation: AAB62887.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF011223 mRNA. Translation: AAB64297.1 .
AF005719 mRNA. Translation: AAB62887.1 .

3D structure databases

ProteinModelPortali O42457.
SMRi O42457. Positions 38-516.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cousinou M., Lopez-Barea J., Dorado G.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Tom M.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 175-521.
    Tissue: Liver.

Entry informationi

Entry nameiCP1A1_SPAAU
AccessioniPrimary (citable) accession number: O42457
Secondary accession number(s): O42458
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi