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O42457

- CP1A1_SPAAU

UniProt

O42457 - CP1A1_SPAAU

Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Sparus aurata (Gilthead sea bream)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei229 – 2291SubstrateBy similarity
    Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:cyp1a1
    OrganismiSparus aurata (Gilthead sea bream)
    Taxonomic identifieri8175 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaSpariformesSparidaeSparus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Cytochrome P450 1A1PRO_0000051647Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO42457.
    SMRiO42457. Positions 38-516.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42457-1 [UniParc]FASTAAdd to Basket

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    MVLMILPFVG PVSVSESLVA IITMCLVYMI LKFFRTEIPE GLCQLPGPKP    50
    LPIIGNVLEV GRNPYLSLTA MSKRYGDVFQ IQIGMRPVVV LSGSETVRQA 100
    LIKQGDDFAG RPDLYSFRFI NDGKSLAFST DQAGVWRARR KLAYSALRSF 150
    STLEGTTPEY SCALEEHVSK EAEYLVKQLN TVMETDGSFD PFRHIVVSVA 200
    NVICGMCFGR RYDHNNQELL NLVNLSDEFG QVVASGNPAD FIPILQYLPS 250
    TSMKKFVSIN DRFNAFVQKI VSEHYTTFDK DNIRDITDSL IDHCEDRKLD 300
    ENSNVQMSDE KVVGIVNDLF GAGFDTISTA LSWSVMYLVA YPEIQERLYQ 350
    EMKESVGLDR TPCLSDKPKL PFLEAFILEI FRHSSFLPFT IPHCSSKDTS 400
    LNGYFIPKDT CVFINQWQIN HDPELWKDPS SFNPDRFLNT DGTELNKLEG 450
    EKMMVFGLGK RRCIGEVIAR NEVFLFLAIL VQNLRFHAKP GEPLDMTPEY 500
    GLTMKHKRCH LRAAMRSRNE E 521
    Length:521
    Mass (Da):59,122
    Last modified:January 1, 1998 - v1
    Checksum:i8FE00D86460B303B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti175 – 1773LVK → GTR in AAB62887. 1 PublicationCurated
    Sequence conflicti209 – 2091G → A in AAB62887. 1 PublicationCurated
    Sequence conflicti212 – 2121Y → S in AAB62887. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF011223 mRNA. Translation: AAB64297.1.
    AF005719 mRNA. Translation: AAB62887.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF011223 mRNA. Translation: AAB64297.1 .
    AF005719 mRNA. Translation: AAB62887.1 .

    3D structure databases

    ProteinModelPortali O42457.
    SMRi O42457. Positions 38-516.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cousinou M., Lopez-Barea J., Dorado G.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. Tom M.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 175-521.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_SPAAU
    AccessioniPrimary (citable) accession number: O42457
    Secondary accession number(s): O42458
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3