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O42449 (IOD1_ORENI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type I iodothyronine deiodinase

EC=1.97.1.10
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene names
Name:dio1
OrganismOreochromis niloticus (Nile tilapia) (Tilapia nilotica) [Reference proteome]
Taxonomic identifier8128 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).

Catalytic activity

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Ontologies

Keywords
   Biological processThyroid hormones biosynthesis
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversitySelenocysteine
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhormone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionthyroxine 5'-deiodinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Type I iodothyronine deiodinase
PRO_0000154316

Regions

Transmembrane7 – 2923Helical; Potential

Sites

Active site1261

Amino acid modifications

Non-standard residue1261Selenocysteine

Sequences

Sequence LengthMass (Da)Tools
O42449 [UniParc].

Last modified February 26, 2008. Version 3.
Checksum: EB42DE7138551F87

FASTA24828,210
        10         20         30         40         50         60 
MFLQKIVLYL STACMFCYML GKFLMLVILQ FFSPSLAKKF ILRMGEKITM TQNPRFNYED 

        70         80         90        100        110        120 
WGLTFMSLAF IKTASSHMWL SLGEEAFVGG EAPDSPVVTM DREKTSISKY LKGNRPLVLS 

       130        140        150        160        170        180 
FGSCTUPPFM YKLDEFKQLV KDFSDVADFL VIYIAEAHST DGWAFKNNYD INQHQSLEDR 

       190        200        210        220        230        240 
LSAAQVLVQS EPLCPVVVDE MTDVTTIKYG ALPERLFILQ AGKVLYKGGK GPWGYNPAEV 


RSFLEKIK 

« Hide

References

[1]"Characterization of a propylthiouracil-insensitive type I iodothyronine deiodinase."
Sanders J.P., van der Geyten S., Kaptein E., Darras V.M., Kuehn E.R., Leonard J.L., Visser T.J.
Endocrinology 138:5153-5160(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y11109 mRNA. Translation: CAA71995.1.
RefSeqNP_001266442.1. NM_001279513.1.
UniGeneOni.1839.

3D structure databases

ProteinModelPortalO42449.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100534571.

Organism-specific databases

CTD1733.

Phylogenomic databases

HOVERGENHBG000099.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR027252. Iodothyronine_deiodinase_I/III.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11781. PTHR11781. 1 hit.
PfamPF00837. T4_deiodinase. 1 hit.
[Graphical view]
PIRSFPIRSF001330. IOD. 1 hit.
PIRSF500144. IODI_III. 1 hit.
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOD1_ORENI
AccessionPrimary (citable) accession number: O42449
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 26, 2008
Last modified: June 11, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families