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O42449

- IOD1_ORENI

UniProt

O42449 - IOD1_ORENI

Protein

Type I iodothyronine deiodinase

Gene

dio1

Organism
Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).

    Catalytic activityi

    3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei126 – 1261

    GO - Molecular functioni

    1. thyroxine 5'-deiodinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. hormone biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Thyroid hormones biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type I iodothyronine deiodinase (EC:1.97.1.10)
    Alternative name(s):
    5DI
    DIOI
    Type 1 DI
    Type-I 5'-deiodinase
    Gene namesi
    Name:dio1
    OrganismiOreochromis niloticus (Nile tilapia) (Tilapia nilotica)
    Taxonomic identifieri8128 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis
    ProteomesiUP000005207: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248Type I iodothyronine deiodinasePRO_0000154316Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO42449.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2923HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the iodothyronine deiodinase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG000099.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR000643. Iodothyronine_deiodinase.
    IPR008261. Iodothyronine_deiodinase_AS.
    IPR027252. Iodothyronine_deiodinase_I/III.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR11781. PTHR11781. 1 hit.
    PfamiPF00837. T4_deiodinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001330. IOD. 1 hit.
    PIRSF500144. IODI_III. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS01205. T4_DEIODINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42449-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLQKIVLYL STACMFCYML GKFLMLVILQ FFSPSLAKKF ILRMGEKITM    50
    TQNPRFNYED WGLTFMSLAF IKTASSHMWL SLGEEAFVGG EAPDSPVVTM 100
    DREKTSISKY LKGNRPLVLS FGSCTUPPFM YKLDEFKQLV KDFSDVADFL 150
    VIYIAEAHST DGWAFKNNYD INQHQSLEDR LSAAQVLVQS EPLCPVVVDE 200
    MTDVTTIKYG ALPERLFILQ AGKVLYKGGK GPWGYNPAEV RSFLEKIK 248
    Length:248
    Mass (Da):28,210
    Last modified:February 26, 2008 - v3
    Checksum:iEB42DE7138551F87
    GO

    Non-standard residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-standard residuei126 – 1261Selenocysteine

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11109 mRNA. Translation: CAA71995.1.
    RefSeqiNP_001266442.1. NM_001279513.1.
    UniGeneiOni.1839.

    Genome annotation databases

    GeneIDi100534571.

    Keywords - Coding sequence diversityi

    Selenocysteine

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11109 mRNA. Translation: CAA71995.1 .
    RefSeqi NP_001266442.1. NM_001279513.1.
    UniGenei Oni.1839.

    3D structure databases

    ProteinModelPortali O42449.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100534571.

    Organism-specific databases

    CTDi 1733.

    Phylogenomic databases

    HOVERGENi HBG000099.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR000643. Iodothyronine_deiodinase.
    IPR008261. Iodothyronine_deiodinase_AS.
    IPR027252. Iodothyronine_deiodinase_I/III.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR11781. PTHR11781. 1 hit.
    Pfami PF00837. T4_deiodinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001330. IOD. 1 hit.
    PIRSF500144. IODI_III. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS01205. T4_DEIODINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a propylthiouracil-insensitive type I iodothyronine deiodinase."
      Sanders J.P., van der Geyten S., Kaptein E., Darras V.M., Kuehn E.R., Leonard J.L., Visser T.J.
      Endocrinology 138:5153-5160(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiIOD1_ORENI
    AccessioniPrimary (citable) accession number: O42449
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3