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Protein

Guanylate cyclase

Gene
N/A
Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationImported

Keywords - Biological processi

cGMP biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

Nucleotide-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclaseUniRule annotationSAAS annotation (EC:4.6.1.2UniRule annotationSAAS annotation)
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)Imported
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 10551023Guanylate cyclaseSequence analysisPRO_5004158375Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000017201.

Structurei

3D structure databases

ProteinModelPortaliO42440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini522 – 795274Protein kinaseInterPro annotationAdd
BLAST
Domaini870 – 1000131Guanylate cyclaseInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili807 – 83428Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation
Contains guanylate cyclase domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiKOG1023. Eukaryota.
COG2114. LUCA.
HOGENOMiHOG000293307.
HOVERGENiHBG051862.
KOiK12324.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR001170. ANPR/GUC.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00255. NATPEPTIDER.
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPGQRMGC RGALGCCLFA ALCFCLLPGC RSNITAAVML PDNYHKYPWA
60 70 80 90 100
LPRVFPALLM AQEDLHTKHK LLLGHTITIL NYSTENPAAP GSCAESRAQV
110 120 130 140 150
VVVDAKLYSR PDVFFGPGCV YPLASVGRFV SHWKLPLITA GGPAYGFEKL
160 170 180 190 200
DEYRTIVRIG PSTTKLGAFV NVLHTQFNWT SRAVVIFYDL KQDDRPHYFL
210 220 230 240 250
SEGIFMNLKD EMNMTVSARP YTNEQDYKEL VSFIKENGRI IYICGPLETF
260 270 280 290 300
LSIMKLFQSE IQDPESYAIF YLDVFAESLT HRKPWQNAKF DWTNPIQVFK
310 320 330 340 350
SVFVITYHPP DNPEYKDFQR KLHARAQRDF GVNLEPSLMD YIAGSFYDGF
360 370 380 390 400
VLYAMALDET LAEGGAQNNG INITRRTQNR SFWGVTGLVS IDKRNARNID
410 420 430 440 450
VDLWAMTNQE TGEYGVVSYY NGSTKEIVWS QTEKIHWPSC GPPLDNPPCV
460 470 480 490 500
FSTDDPSCND GLPVLGIVAV GSGLALIIFG ISSFLIYRKL KLEKELAGML
510 520 530 540 550
WRVQWEDLQF ESPNKYHKRA GSRLTLSQRG SSYGSLITAQ GKYQLFAKTG
560 570 580 590 600
YFKGNLVAIK HVNKKRIELT RQVLMELKHM RDVQFNHLTR FIGACIDPPN
610 620 630 640 650
ICIVTEYCPR GSLQDILENE SINLDWMFRY SLINDIVKGM NFLHNSYFGC
660 670 680 690 700
HGNLKSSNCV VDSRFVLKIT DYGLASFRSS CKNDDSHALY AKKLWTAPEL
710 720 730 740 750
LIYDHHPPQG TQKGDVYSFG IILQEIALRN GPFYVESMDL SPKEIVQKVR
760 770 780 790 800
NGQRPYFRPT TDSRFHSEEL TILMEGCWAE DPAERPDFGH IKIYMAKLNK
810 820 830 840 850
EGSTSILNNL LSRMEQYANN LENLVEERTQ AYLEEKRKAE NLLYQILPHS
860 870 880 890 900
VAEQLKRGET VQAEAFDSVT IYFSDIVGFT SMSAESTPLQ VVTLLNDLYT
910 920 930 940 950
CFDAIIDNFD VYKVDTIADA YMVVSGLPVR NGKLHAREIA SMSLALLEQV
960 970 980 990 1000
KTFKIRHRPN DQLRLRIGIH TGPVCAGVVG LKMPRYCLFG DTVNTASRME
1010 1020 1030 1040 1050
SNGEALKNHV SSATKEVLDE FCYFNLELRG DVEMKGKGKM RTYWLLGEKT

DVYVI
Length:1,055
Mass (Da):119,661
Last modified:January 1, 1998 - v1
Checksum:iD89DDD2965005345
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004921 mRNA. Translation: BAA20563.1.
RefSeqiNP_001098128.1. NM_001104658.1.
UniGeneiOla.54.

Genome annotation databases

GeneIDi100049183.
KEGGiola:100049183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004921 mRNA. Translation: BAA20563.1.
RefSeqiNP_001098128.1. NM_001104658.1.
UniGeneiOla.54.

3D structure databases

ProteinModelPortaliO42440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8090.ENSORLP00000017201.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100049183.
KEGGiola:100049183.

Organism-specific databases

CTDi4882.

Phylogenomic databases

eggNOGiKOG1023. Eukaryota.
COG2114. LUCA.
HOGENOMiHOG000293307.
HOVERGENiHBG051862.
KOiK12324.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR001170. ANPR/GUC.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00255. NATPEPTIDER.
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO42440_ORYLA
AccessioniPrimary (citable) accession number: O42440
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.