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Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Limanda limanda (Common dab) (Pleuronectes limanda)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei229 – 2291SubstrateBy similarity
Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:cyp1a1
OrganismiLimanda limanda (Common dab) (Pleuronectes limanda)
Taxonomic identifieri27771 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataCarangariaPleuronectiformesPleuronectoideiPleuronectidaeLimanda

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Cytochrome P450 1A1PRO_0000051637Add
BLAST

Structurei

3D structure databases

SMRiO42430. Positions 38-513.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLMMLPFIG SVSVSESLVA MTTVCLVYLI LKFFQTEIPE GLRRLPGPKP
60 70 80 90 100
LPIIGNVLEM GSRPYLSLTA MSKRYGNVFQ IQIGMRPVVV LSGSETVRQA
110 120 130 140 150
LIKQGDDFAG RPDLYSFRFI NEGKSLAFST DKAGIWRARR KLAYSALRSF
160 170 180 190 200
ATLEGTTPEY SCVLEEHVCK EGEYLIKQLN TAMTADGSFD PFRHIVVSVA
210 220 230 240 250
NVICGMCFGR RYDHDDQELV GLVTLSDEFG RVVGSGNPAD FIPILQYLPS
260 270 280 290 300
ATMKNFLRIN GRFTEFVQKI VTEHYTTFDK DNIRDITDSL IDHCEDRKLD
310 320 330 340 350
ENSNVQMSDE KIVGIVNDLF GAGFDTVSTA LSWSVMYLVA HPEIQERLYQ
360 370 380 390 400
EIEDKVGLDR MPLLSDKPNL PFLEAFILEI LRHSSFLPFT IPHCTTKDTS
410 420 430 440 450
LNGYFIPKDT CVFINQWQIN HDPEMWKDPS SFNPDRFLSA DGSEVNKLDG
460 470 480 490 500
EKVMAFGMGK RRCIGEVIAR NEVYLFLAIL IQKLHFLPIP GEKLDMTPEY
510 520
GLTMKHKRCH LKATMRARNE H
Length:521
Mass (Da):59,063
Last modified:December 31, 1997 - v1
Checksum:i11DE326C8A7FBDF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001724 mRNA. Translation: CAA04953.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001724 mRNA. Translation: CAA04953.1.

3D structure databases

SMRiO42430. Positions 38-513.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Measurement of cytochrome P4501A induction in dab (Limanda limanda) and other teleosts with species-specific cDNA probes: isolation and characterisation of dab cDNA and its use in expression studies with beta-naphthoflavone-treated fish."
    Craft J.A., Robertson F.E., McPhail M.E., Brown E., Stagg R.M.
    Comp. Biochem. Physiol. 129C:115-127(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A1_LIMLI
AccessioniPrimary (citable) accession number: O42430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2000
Last sequence update: December 31, 1997
Last modified: March 31, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.