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O42430

- CP1A1_LIMLI

UniProt

O42430 - CP1A1_LIMLI

Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Limanda limanda (Common dab) (Pleuronectes limanda)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei229 – 2291SubstrateBy similarity
    Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:cyp1a1
    OrganismiLimanda limanda (Common dab) (Pleuronectes limanda)
    Taxonomic identifieri27771 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataCarangimorphariaePleuronectiformesPleuronectoideiPleuronectidaePleuronectinaeLimanda

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Cytochrome P450 1A1PRO_0000051637Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO42430.
    SMRiO42430. Positions 38-513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42430-1 [UniParc]FASTAAdd to Basket

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    MMLMMLPFIG SVSVSESLVA MTTVCLVYLI LKFFQTEIPE GLRRLPGPKP    50
    LPIIGNVLEM GSRPYLSLTA MSKRYGNVFQ IQIGMRPVVV LSGSETVRQA 100
    LIKQGDDFAG RPDLYSFRFI NEGKSLAFST DKAGIWRARR KLAYSALRSF 150
    ATLEGTTPEY SCVLEEHVCK EGEYLIKQLN TAMTADGSFD PFRHIVVSVA 200
    NVICGMCFGR RYDHDDQELV GLVTLSDEFG RVVGSGNPAD FIPILQYLPS 250
    ATMKNFLRIN GRFTEFVQKI VTEHYTTFDK DNIRDITDSL IDHCEDRKLD 300
    ENSNVQMSDE KIVGIVNDLF GAGFDTVSTA LSWSVMYLVA HPEIQERLYQ 350
    EIEDKVGLDR MPLLSDKPNL PFLEAFILEI LRHSSFLPFT IPHCTTKDTS 400
    LNGYFIPKDT CVFINQWQIN HDPEMWKDPS SFNPDRFLSA DGSEVNKLDG 450
    EKVMAFGMGK RRCIGEVIAR NEVYLFLAIL IQKLHFLPIP GEKLDMTPEY 500
    GLTMKHKRCH LKATMRARNE H 521
    Length:521
    Mass (Da):59,063
    Last modified:January 1, 1998 - v1
    Checksum:i11DE326C8A7FBDF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001724 mRNA. Translation: CAA04953.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001724 mRNA. Translation: CAA04953.1 .

    3D structure databases

    ProteinModelPortali O42430.
    SMRi O42430. Positions 38-513.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Measurement of cytochrome P4501A induction in dab (Limanda limanda) and other teleosts with species-specific cDNA probes: isolation and characterisation of dab cDNA and its use in expression studies with beta-naphthoflavone-treated fish."
      Craft J.A., Robertson F.E., McPhail M.E., Brown E., Stagg R.M.
      Comp. Biochem. Physiol. 129C:115-127(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_LIMLI
    AccessioniPrimary (citable) accession number: O42430
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3