UniProtKB - O42425 (HBA2_GADMO)
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Protein
Hemoglobin subunit alpha-2
Gene
hba2
Organism
Gadus morhua (Atlantic cod)
Status
Functioni
Involved in oxygen transport from gills to the various peripheral tissues.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 60 | Iron (heme distal ligand) | 1 | |
Metal bindingi | 89 | Iron (heme proximal ligand) | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- oxygen binding Source: InterPro
- oxygen carrier activity Source: UniProtKB-KW
Keywordsi
Biological process | Oxygen transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Hemoglobin subunit alpha-2Alternative name(s): Alpha-2-globin Hemoglobin alpha-2 chain |
Gene namesi | Name:hba2 Synonyms:hba |
Organismi | Gadus morhua (Atlantic cod) |
Taxonomic identifieri | 8049 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Neoteleostei › Acanthomorphata › Zeiogadaria › Gadariae › Gadiformes › Gadoidei › Gadidae › Gadus |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000052637 | 2 – 143 | Hemoglobin subunit alpha-2Add BLAST | 142 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserine1 Publication | 1 |
Keywords - PTMi
AcetylationPTM databases
iPTMneti | O42425 |
Expressioni
Tissue specificityi
Red blood cells.
Interactioni
Subunit structurei
Hb 2 is a heterotetramer of two alpha-2 and two beta-2 chains.1 Publication
Structurei
3D structure databases
ProteinModelPortali | O42425 |
SMRi | O42425 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the globin family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3378 Eukaryota COG1018 LUCA |
HOVERGENi | HBG009709 |
Family and domain databases
CDDi | cd08927 Hb-alpha_like, 1 hit |
Gene3Di | 1.10.490.101 hit |
InterProi | View protein in InterPro IPR000971 Globin IPR009050 Globin-like_sf IPR012292 Globin/Proto IPR002338 Haemoglobin_a-typ IPR002339 Haemoglobin_pi |
Pfami | View protein in Pfam PF00042 Globin, 1 hit |
PRINTSi | PR00612 ALPHAHAEM PR00815 PIHAEM |
SUPFAMi | SSF46458 SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033 GLOBIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O42425-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLSSKQKAT VKDFFSKMST RSDDIGAEAL SRLVAVYPQT KSYFSHWKDA
60 70 80 90 100
SPGSAPVRKH GITTMGGVYD AVGKIDDLKG GLLSLSELHA FMLRVDPVNF
110 120 130 140
KLLAHCMLVC MSMIFPEEFT PQVHVAVDKF LAQLALALAE KYR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X98195 mRNA Translation: CAA66866.1 |
Similar proteinsi
Entry informationi
Entry namei | HBA2_GADMO | |
Accessioni | O42425Primary (citable) accession number: O42425 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 2001 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 25, 2018 | |
This is version 78 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |