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Protein

Hemoglobin subunit alpha-2

Gene

hba2

Organism
Gadus morhua (Atlantic cod)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from gills to the various peripheral tissues.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron (heme distal ligand)
Metal bindingi89 – 891Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-2
Alternative name(s):
Alpha-2-globin
Hemoglobin alpha-2 chain
Gene namesi
Name:hba2
Synonyms:hba
OrganismiGadus morhua (Atlantic cod)
Taxonomic identifieri8049 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 143142Hemoglobin subunit alpha-2PRO_0000052637Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Hb 2 is a heterotetramer of two alpha-2 and two beta-2 chains.1 Publication

Protein-protein interaction databases

STRINGi8049.ENSGMOP00000006057.

Structurei

3D structure databases

ProteinModelPortaliO42425.
SMRiO42425. Positions 2-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOVERGENiHBG009709.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSSKQKAT VKDFFSKMST RSDDIGAEAL SRLVAVYPQT KSYFSHWKDA
60 70 80 90 100
SPGSAPVRKH GITTMGGVYD AVGKIDDLKG GLLSLSELHA FMLRVDPVNF
110 120 130 140
KLLAHCMLVC MSMIFPEEFT PQVHVAVDKF LAQLALALAE KYR
Length:143
Mass (Da):15,784
Last modified:January 23, 2007 - v3
Checksum:iFFFBD93E07E0F09F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98195 mRNA. Translation: CAA66866.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98195 mRNA. Translation: CAA66866.1.

3D structure databases

ProteinModelPortaliO42425.
SMRiO42425. Positions 2-143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8049.ENSGMOP00000006057.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOVERGENiHBG009709.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular genetic indicators of selection in haemoglobin encoding loci of the Atlantic cod, Gadus morhua."
    Tipping D.R., Birley A.J.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  2. "The oxygen transport system in three species of the boreal fish family Gadidae. Molecular phylogeny of hemoglobin."
    Verde C., Balestrieri M., de Pascale D., Pagnozzi D., Lecointre G., di Prisco G.
    J. Biol. Chem. 281:22073-22084(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-143, FUNCTION, SUBUNIT, ACETYLATION AT SER-2.
    Tissue: Blood.

Entry informationi

Entry nameiHBA2_GADMO
AccessioniPrimary (citable) accession number: O42425
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 23, 2007
Last modified: November 11, 2015
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.