Reviewed, UniProtKB/Swiss-Prot O42422 (EPHA7_CHICK)

Names and origin

Protein names

Recommended name:
    Ephrin type-A receptor 7
    EC=2.7.10.1
Alternative name(s):
    Tyrosine-protein kinase receptor CEPHA7
    Tyrosine-protein kinase receptor CEK11

Gene names

Name:	EPHA7
Synonyms:	CEK11

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	993 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for members of the ephrin-A family.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Within the nervous system, expression is restricted to prosomeres 1 and 2 in the diencephalon and all the rhombomeres in the hindbrain during segmentation stages. Later on, a superimposed pattern appears that correlates with the formation of several axonal tracts. In the somitic mesoderm, the expression correlates with segmentation and the guidance of both neural crest and motor axons through the sclerotomes.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Signal Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ephrin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 993	963	Ephrin type-A receptor 7		PRO_0000016821
Regions
	Topological domain	31 – 551	521	Extracellular Potential
	Transmembrane	552 – 572	21	Potential
	Topological domain	573 – 993	421	Cytoplasmic Potential
	Domain	331 – 433	103	Fibronectin type-III 1
	Domain	443 – 535	93	Fibronectin type-III 2
	Domain	628 – 889	262	Protein kinase
	Domain	918 – 982	65	SAM
	Nucleotide binding	634 – 642	9	ATP By similarity
	Motif	991 – 993	3	PDZ-binding Potential
	Compositional bias	192 – 328	137	Cys-rich
Sites
	Active site	753	1	Proton acceptor By similarity
	Binding site	660	1	ATP By similarity
Amino acid modifications
	Modified residue	603	1	Phosphotyrosine; by autocatalysis Potential
	Modified residue	609	1	Phosphotyrosine; by autocatalysis Potential
	Modified residue	786	1	Phosphotyrosine; by autocatalysis Potential
	Modified residue	935	1	Phosphotyrosine; by autocatalysis Potential
	Glycosylation	343	1	N-linked (GlcNAc...) Potential
	Glycosylation	410	1	N-linked (GlcNAc...) Potential
	Disulfide bond	74 ↔ 109		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O42422-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: EECF9603047606BD	FASTA	993	111,367
	10 20 30 40 50 60 MVLRSRLPPW IMLCSVWLLR FAHTGEAQAA KEVILLDSKA QQTELEWISS PPNGWEEISG 70 80 90 100 110 120 LDENYTPIRT YQVCQVMESN QNNWLRTNWI AKSNAQRIFV ELKFTLRDCN SLPGVLGTCK 130 140 150 160 170 180 ETFNLYYYET DYDTGRNIRE NQYVKIDTIA ADESFTQGDL GERKMKLNTE VREIGPLSKK 190 200 210 220 230 240 GFYLAFQDVG ACIALVSVKV YYKKCWSIIE NLAIFPDTVT GSEFSSLVEV RGTCVSSAEE 250 260 270 280 290 300 EAENSPKMHC SAEGEWLVPI GKCICKAGYQ QKGDTCEPCG RGFYKSSSQD LQCSRCPTHS 310 320 330 340 350 360 FSDKEGSSRC DCEDSYYRAP SDPPYVACTR PPSAPQNLIF NINQTTVSLE WSPPADNGGR 370 380 390 400 410 420 NDVTYRILCK RCSWEQGECV PCGSNIGYMP QQTGLVDNYV TVMDLLAHAN YTFEVEAVNG 430 440 450 460 470 480 VSDLSRSQRL FAAVSITTGQ AAPSQVSGVM KERVLQRSVE LSWQEPEHPN GVITEYEIKY 490 500 510 520 530 540 YEKDQRERTY STVKTKSTSA SINNLKPGTV YVFQIRAFTA AGYGNYSPRL DVATLEEATA 550 560 570 580 590 600 TAVSSEQNPV IIIAVVAVAG TIILVFMVFG FIIGRRHCGY SKADQEGDEE LYFHFKFPGT 610 620 630 640 650 660 KTYIDPETYE DPNRAVHQFA KELDASCIKI ERVIGAGEFG EVCSGRLKLP GKRDVAVAIK 670 680 690 700 710 720 TLKVGYTEKQ RRDFLCEASI MGQFDHPNVV HLEGVVTRGK PVMIVIEYME NGALDAFLRK 730 740 750 760 770 780 HDGQFTVIQL VGMLRGIAAG MRYLADMGYV HRDLAARNIL VNSNLVCKVS DFGLSRVIED 790 800 810 820 830 840 DPEAVYTTTG GKIPVRWTAP EAIQYRKFTS ASDVWSYGIV MWEVMSYGER PYWDMSNQDV 850 860 870 880 890 900 IKAIEEGYRL PAPMDCPAGL HQLMLDCWQK ERGERPKFEQ IVGILDKMIR NPNSLKTPLG 910 920 930 940 950 960 TCSRPISPLL DQNTPDFTTF CSVGEWLQAI KMERYKDNFT AAGYNSLESV ARMTIEDVMS 970 980 990 LGITLVGHQK KIMSSIQTMR AQMLHLHGTG IQV

References

[1]	"The expression of chick EphA7 during segmentation of the central and peripheral nervous system." Araujo M., Nieto M.A. Mech. Dev. 68:173-177(1997) [PubMed: 9431814] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y14271 mRNA. Translation: CAA74643.1.
IPI	IPI00577591.
RefSeq	NP_990414.1.
UniGene	Gga.4157
3D structure databases
HSSP	HSSP built from PDB template 1JPA based on UniProtKB P54763.
SMR	O42422. Positions 608-896.
ModBase	Search...
Genome annotation databases
Ensembl	ENSGALT00000025144; ENSGALP00000025098; ENSGALG00000015593; Gallus gallus. [Genome view]
GeneID	395967.
KEGG	gga:395967.
Organism-specific databases
CTD	395967.
Phylogenomic databases
HOGENOM	O42422.
HOVERGEN	O42422.
OMA	AGYQQKG.
Enzyme and pathway databases
BRENDA	2.7.10.1. 4.
Family and domain databases
InterPro	IPR013032. EGF-like_reg_CS. IPR001090. Ephrin_rcpt_lig-bd. IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR003962. FnIII_subd. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR001660. SAM. IPR013761. SAM_type. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. IPR016257. TyrPK_ephrin_receptor. IPR001426. YKase_receptorV_CS. [Graphical view]
Gene3D	G3DSA:2.60.40.30. FN_III-like. 2 hits. G3DSA:1.10.150.50. SAM_type. 1 hit.
Pfam	PF01404. Ephrin_lbd. 1 hit. PF00041. fn3. 2 hits. PF07714. Pkinase_Tyr. 1 hit. PF00536. SAM_1. 1 hit. [Graphical view]
PIRSF	PIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTS	PR00014. FNTYPEIII. PR00109. TYRKINASE.
ProDom	PD001495. Ephrin_receptor. 1 hit. PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00615. EPH_lbd. 1 hit. SM00060. FN3. 2 hits. SM00454. SAM. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS01186. EGF_2. 1 hit. Uncertain. PS50853. FN3. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit. PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit. PS50105. SAM_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EPHA7_CHICK

Accession

Primary (citable) accession number: O42422

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)