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Protein

Matrix Gla protein

Gene

MGP

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix Gla protein
Short name:
MGP
Gene namesi
Name:MGP
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 10384Matrix Gla proteinPRO_0000011117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 2114-carboxyglutamatePROSITE-ProRule annotation
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei28 – 281PhosphoserineBy similarity
Modified residuei57 – 5714-carboxyglutamatePROSITE-ProRule annotation
Modified residuei61 – 6114-carboxyglutamatePROSITE-ProRule annotation
Modified residuei68 – 6814-carboxyglutamatePROSITE-ProRule annotation
Modified residuei72 – 7214-carboxyglutamatePROSITE-ProRule annotation
Disulfide bondi74 ↔ 80PROSITE-ProRule annotation

Post-translational modificationi

Requires vitamin K-dependent gamma-carboxylation for its function.By similarity

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

Proteomic databases

PaxDbiO42413.

Expressioni

Tissue specificityi

In 16-day-old embryo, expressed at high level in the sternum and tibia, at low level in skeletal muscle, heart and gizzard. Not present in skin, liver and brain.

Gene expression databases

BgeeiENSGALG00000011740.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019149.

Structurei

3D structure databases

ProteinModelPortaliO42413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 9847GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZCH. Eukaryota.
ENOG410Y2RM. LUCA.
GeneTreeiENSGT00390000003753.
HOGENOMiHOG000113581.
HOVERGENiHBG006353.
InParanoidiO42413.
KOiK19481.
OMAiFLNRRNA.
OrthoDBiEOG091G0XPC.
PhylomeDBiO42413.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR027118. MGP.
[Graphical view]
PANTHERiPTHR10109. PTHR10109. 1 hit.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALIVLVLL AVLVMAATCY ESHESMESHE YLNPFLNRQR ANGFIRDDTG
60 70 80 90 100
LRAVLQERIR ERNKAPQERQ REICEDFHLC EQYALNHGYP AAYRHYFGRR

RNK
Length:103
Mass (Da):12,266
Last modified:January 1, 1998 - v1
Checksum:i2BD458980F85047C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13903 mRNA. Translation: CAA74201.1.
RefSeqiNP_990375.1. NM_205044.1.
UniGeneiGga.540.

Genome annotation databases

EnsembliENSGALT00000019173; ENSGALP00000019149; ENSGALG00000011740.
GeneIDi395912.
KEGGigga:395912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13903 mRNA. Translation: CAA74201.1.
RefSeqiNP_990375.1. NM_205044.1.
UniGeneiGga.540.

3D structure databases

ProteinModelPortaliO42413.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019149.

Proteomic databases

PaxDbiO42413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000019173; ENSGALP00000019149; ENSGALG00000011740.
GeneIDi395912.
KEGGigga:395912.

Organism-specific databases

CTDi4256.

Phylogenomic databases

eggNOGiENOG410IZCH. Eukaryota.
ENOG410Y2RM. LUCA.
GeneTreeiENSGT00390000003753.
HOGENOMiHOG000113581.
HOVERGENiHBG006353.
InParanoidiO42413.
KOiK19481.
OMAiFLNRRNA.
OrthoDBiEOG091G0XPC.
PhylomeDBiO42413.
TreeFamiTF330920.

Miscellaneous databases

PROiO42413.

Gene expression databases

BgeeiENSGALG00000011740.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR027118. MGP.
[Graphical view]
PANTHERiPTHR10109. PTHR10109. 1 hit.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMGP_CHICK
AccessioniPrimary (citable) accession number: O42413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.