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Protein

Matrix Gla protein

Gene

MGP

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix Gla protein
Short name:
MGP
Gene namesi
Name:MGP
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 10384Matrix Gla proteinPRO_0000011117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 2114-carboxyglutamatePROSITE-ProRule annotation
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei28 – 281PhosphoserineBy similarity
Modified residuei57 – 5714-carboxyglutamatePROSITE-ProRule annotation
Modified residuei61 – 6114-carboxyglutamatePROSITE-ProRule annotation
Modified residuei68 – 6814-carboxyglutamatePROSITE-ProRule annotation
Modified residuei72 – 7214-carboxyglutamatePROSITE-ProRule annotation
Disulfide bondi74 ↔ 80PROSITE-ProRule annotation

Post-translational modificationi

Requires vitamin K-dependent gamma-carboxylation for its function.By similarity

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

Proteomic databases

PaxDbiO42413.

Expressioni

Tissue specificityi

In 16-day-old embryo, expressed at high level in the sternum and tibia, at low level in skeletal muscle, heart and gizzard. Not present in skin, liver and brain.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019149.

Structurei

3D structure databases

ProteinModelPortaliO42413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 9847GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZCH. Eukaryota.
ENOG410Y2RM. LUCA.
GeneTreeiENSGT00390000003753.
HOGENOMiHOG000113581.
HOVERGENiHBG006353.
InParanoidiO42413.
KOiK19481.
OMAiAALCYES.
OrthoDBiEOG718KFT.
PhylomeDBiO42413.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR027118. MGP.
[Graphical view]
PANTHERiPTHR10109. PTHR10109. 1 hit.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALIVLVLL AVLVMAATCY ESHESMESHE YLNPFLNRQR ANGFIRDDTG
60 70 80 90 100
LRAVLQERIR ERNKAPQERQ REICEDFHLC EQYALNHGYP AAYRHYFGRR

RNK
Length:103
Mass (Da):12,266
Last modified:January 1, 1998 - v1
Checksum:i2BD458980F85047C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13903 mRNA. Translation: CAA74201.1.
RefSeqiNP_990375.1. NM_205044.1.
UniGeneiGga.540.

Genome annotation databases

EnsembliENSGALT00000019173; ENSGALP00000019149; ENSGALG00000011740.
GeneIDi395912.
KEGGigga:395912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13903 mRNA. Translation: CAA74201.1.
RefSeqiNP_990375.1. NM_205044.1.
UniGeneiGga.540.

3D structure databases

ProteinModelPortaliO42413.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019149.

Proteomic databases

PaxDbiO42413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000019173; ENSGALP00000019149; ENSGALG00000011740.
GeneIDi395912.
KEGGigga:395912.

Organism-specific databases

CTDi4256.

Phylogenomic databases

eggNOGiENOG410IZCH. Eukaryota.
ENOG410Y2RM. LUCA.
GeneTreeiENSGT00390000003753.
HOGENOMiHOG000113581.
HOVERGENiHBG006353.
InParanoidiO42413.
KOiK19481.
OMAiAALCYES.
OrthoDBiEOG718KFT.
PhylomeDBiO42413.
TreeFamiTF330920.

Miscellaneous databases

PROiO42413.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR027118. MGP.
[Graphical view]
PANTHERiPTHR10109. PTHR10109. 1 hit.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cartilage.

Entry informationi

Entry nameiMGP_CHICK
AccessioniPrimary (citable) accession number: O42413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.