ID   IOD1_CHICK              Reviewed;         245 AA.
AC   O42411;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 3.
DT   27-MAR-2024, entry version 123.
DE   RecName: Full=Type I iodothyronine deiodinase;
DE            EC=1.21.99.4;
DE   AltName: Full=5DI;
DE   AltName: Full=DIOI;
DE   AltName: Full=Type 1 DI;
DE   AltName: Full=Type-I 5'-deiodinase;
DE   Flags: Fragment;
GN   Name=DIO1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=HYBRO; TISSUE=Liver;
RX   PubMed=9389494; DOI=10.1210/endo.138.12.5599;
RA   van der Geyten S., Sanders J.P., Kaptein E., Darras V.M., Kuehn E.R.,
RA   Leonard J.L., Visser T.J.;
RT   "Expression of chicken hepatic type I and type III iodothyronine
RT   deiodinases during embryonic development.";
RL   Endocrinology 138:5144-5152(1997).
CC   -!- FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-
CC       tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2
CC       (3,3'-diiodothyronine). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3,3',5-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-
CC         thyroxine; Xref=Rhea:RHEA:19745, ChEBI:CHEBI:13193,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16382, ChEBI:CHEBI:17499,
CC         ChEBI:CHEBI:58448, ChEBI:CHEBI:533015; EC=1.21.99.4;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10107};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the iodothyronine deiodinase family.
CC       {ECO:0000305}.
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DR   EMBL; Y11110; CAA71996.1; -; mRNA.
DR   PIR; JC5825; JC5825.
DR   RefSeq; NP_001091083.1; NM_001097614.1.
DR   STRING; 9031.ENSGALP00000017451; -.
DR   PaxDb; 9031-ENSGALP00000017451; -.
DR   GeneID; 395940; -.
DR   KEGG; gga:395940; -.
DR   CTD; 1733; -.
DR   VEuPathDB; HostDB:geneid_395940; -.
DR   eggNOG; ENOG502QUGZ; Eukaryota.
DR   InParanoid; O42411; -.
DR   PhylomeDB; O42411; -.
DR   BRENDA; 1.21.99.4; 1306.
DR   SABIO-RK; O42411; -.
DR   PRO; PR:O42411; -.
DR   Proteomes; UP000000539; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004800; F:thyroxine 5'-deiodinase activity; IBA:GO_Central.
DR   GO; GO:0042446; P:hormone biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0042403; P:thyroid hormone metabolic process; IBA:GO_Central.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR000643; Iodothyronine_deiodinase.
DR   InterPro; IPR008261; Iodothyronine_deiodinase_AS.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11781; IODOTHYRONINE DEIODINASE; 1.
DR   PANTHER; PTHR11781:SF23; TYPE I IODOTHYRONINE DEIODINASE; 1.
DR   Pfam; PF00837; T4_deiodinase; 1.
DR   PIRSF; PIRSF001330; IOD; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS01205; T4_DEIODINASE; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Oxidoreductase; Reference proteome;
KW   Selenocysteine; Thyroid hormones biosynthesis; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           <1..245
FT                   /note="Type I iodothyronine deiodinase"
FT                   /id="PRO_0000154315"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        123
FT   NON_STD         123
FT                   /note="Selenocysteine"
FT   NON_TER         1
SQ   SEQUENCE   245 AA;  28386 MW;  B5ED3C480884C3C1 CRC64;
     LSIRVLLHKL LILLQVTLSV VVGKTMMILF PDTTKRYILK LGEKSRMNQN PKFSYENWGP
     TFFSFQYLLF VLKVKWRRLE DEAHEGRPAP NTPVVALNGE MQHLFSFMRD NRPLILNFGS
     CTUPSFMLKF DEFNKLVKDF SSIADFLIIY IEEAHAVDGW AFRNNVVIKN HRSLEDRKTA
     AQFLQQKNPL CPVVLDTMEN LSSSKYAALP ERLYILQAGN VIYKGGVGPW NYHPQEIRAV
     LEKLK
//