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Protein

Type I iodothyronine deiodinase

Gene

DIO1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).By similarity

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1231

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Thyroid hormones biosynthesis

Enzyme and pathway databases

BRENDAi1.97.1.10. 1306.
SABIO-RKO42411.

Names & Taxonomyi

Protein namesi
Recommended name:
Type I iodothyronine deiodinase (EC:1.21.99.4)
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene namesi
Name:DIO1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000154315‹1 – 245Type I iodothyronine deiodinaseAdd BLAST›245

Proteomic databases

PaxDbiO42411.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017451.

Structurei

3D structure databases

ProteinModelPortaliO42411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the iodothyronine deiodinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWHX. Eukaryota.
ENOG4112999. LUCA.
HOVERGENiHBG000099.
InParanoidiO42411.
KOiK01562.
PhylomeDBiO42411.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiPF00837. T4_deiodinase. 1 hit.
[Graphical view]
PIRSFiPIRSF001330. IOD. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O42411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LSIRVLLHKL LILLQVTLSV VVGKTMMILF PDTTKRYILK LGEKSRMNQN
60 70 80 90 100
PKFSYENWGP TFFSFQYLLF VLKVKWRRLE DEAHEGRPAP NTPVVALNGE
110 120 130 140 150
MQHLFSFMRD NRPLILNFGS CTUPSFMLKF DEFNKLVKDF SSIADFLIIY
160 170 180 190 200
IEEAHAVDGW AFRNNVVIKN HRSLEDRKTA AQFLQQKNPL CPVVLDTMEN
210 220 230 240
LSSSKYAALP ERLYILQAGN VIYKGGVGPW NYHPQEIRAV LEKLK
Length:245
Mass (Da):28,386
Last modified:February 26, 2008 - v3
Checksum:iB5ED3C480884C3C1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei123Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11110 mRNA. Translation: CAA71996.1.
PIRiJC5825.
RefSeqiNP_001091083.1. NM_001097614.1.
UniGeneiGga.553.

Genome annotation databases

GeneIDi395940.
KEGGigga:395940.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11110 mRNA. Translation: CAA71996.1.
PIRiJC5825.
RefSeqiNP_001091083.1. NM_001097614.1.
UniGeneiGga.553.

3D structure databases

ProteinModelPortaliO42411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017451.

Proteomic databases

PaxDbiO42411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395940.
KEGGigga:395940.

Organism-specific databases

CTDi1733.

Phylogenomic databases

eggNOGiENOG410IWHX. Eukaryota.
ENOG4112999. LUCA.
HOVERGENiHBG000099.
InParanoidiO42411.
KOiK01562.
PhylomeDBiO42411.

Enzyme and pathway databases

BRENDAi1.97.1.10. 1306.
SABIO-RKO42411.

Miscellaneous databases

PROiO42411.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiPF00837. T4_deiodinase. 1 hit.
[Graphical view]
PIRSFiPIRSF001330. IOD. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIOD1_CHICK
AccessioniPrimary (citable) accession number: O42411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 26, 2008
Last modified: June 8, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.