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O42411 (IOD1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type I iodothyronine deiodinase

EC=1.97.1.10
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene names
Name:DIO1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length245 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine) By similarity.

Catalytic activity

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Ontologies

Keywords
   Biological processThyroid hormones biosynthesis
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversitySelenocysteine
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhormone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionthyroxine 5'-deiodinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 245›245Type I iodothyronine deiodinase
PRO_0000154315

Regions

Transmembrane10 – 3021Helical; Potential

Sites

Active site1231

Amino acid modifications

Non-standard residue1231Selenocysteine

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
O42411 [UniParc].

Last modified February 26, 2008. Version 3.
Checksum: B5ED3C480884C3C1

FASTA24528,386
        10         20         30         40         50         60 
LSIRVLLHKL LILLQVTLSV VVGKTMMILF PDTTKRYILK LGEKSRMNQN PKFSYENWGP 

        70         80         90        100        110        120 
TFFSFQYLLF VLKVKWRRLE DEAHEGRPAP NTPVVALNGE MQHLFSFMRD NRPLILNFGS 

       130        140        150        160        170        180 
CTUPSFMLKF DEFNKLVKDF SSIADFLIIY IEEAHAVDGW AFRNNVVIKN HRSLEDRKTA 

       190        200        210        220        230        240 
AQFLQQKNPL CPVVLDTMEN LSSSKYAALP ERLYILQAGN VIYKGGVGPW NYHPQEIRAV 


LEKLK 

« Hide

References

[1]"Expression of chicken hepatic type I and type III iodothyronine deiodinases during embryonic development."
van der Geyten S., Sanders J.P., Kaptein E., Darras V.M., Kuehn E.R., Leonard J.L., Visser T.J.
Endocrinology 138:5144-5152(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: HYBRO.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y11110 mRNA. Translation: CAA71996.1.
PIRJC5825.
RefSeqNP_001091083.1. NM_001097614.1.
UniGeneGga.553.

3D structure databases

ProteinModelPortalO42411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000017451.

Proteomic databases

PaxDbO42411.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395940.
KEGGgga:395940.

Organism-specific databases

CTD1733.

Phylogenomic databases

eggNOGNOG149534.
HOVERGENHBG000099.
KOK01562.
PhylomeDBO42411.

Enzyme and pathway databases

BRENDA1.97.1.10. 1306.
SABIO-RKO42411.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11781. PTHR11781. 1 hit.
PfamPF00837. T4_deiodinase. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816005.
PROO42411.

Entry information

Entry nameIOD1_CHICK
AccessionPrimary (citable) accession number: O42411
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 26, 2008
Last modified: April 16, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families