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O42411

- IOD1_CHICK

UniProt

O42411 - IOD1_CHICK

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Protein

Type I iodothyronine deiodinase

Gene

DIO1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).By similarity

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei123 – 1231

GO - Molecular functioni

  1. thyroxine 5'-deiodinase activity Source: UniProtKB-EC

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Thyroid hormones biosynthesis

Enzyme and pathway databases

BRENDAi1.97.1.10. 1306.
SABIO-RKO42411.

Names & Taxonomyi

Protein namesi
Recommended name:
Type I iodothyronine deiodinase (EC:1.97.1.10)
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene namesi
Name:DIO1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 245›245Type I iodothyronine deiodinasePRO_0000154315Add
BLAST

Proteomic databases

PaxDbiO42411.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017451.

Structurei

3D structure databases

ProteinModelPortaliO42411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the iodothyronine deiodinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149534.
HOVERGENiHBG000099.
InParanoidiO42411.
KOiK01562.
PhylomeDBiO42411.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiPF00837. T4_deiodinase. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O42411-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LSIRVLLHKL LILLQVTLSV VVGKTMMILF PDTTKRYILK LGEKSRMNQN
60 70 80 90 100
PKFSYENWGP TFFSFQYLLF VLKVKWRRLE DEAHEGRPAP NTPVVALNGE
110 120 130 140 150
MQHLFSFMRD NRPLILNFGS CTUPSFMLKF DEFNKLVKDF SSIADFLIIY
160 170 180 190 200
IEEAHAVDGW AFRNNVVIKN HRSLEDRKTA AQFLQQKNPL CPVVLDTMEN
210 220 230 240
LSSSKYAALP ERLYILQAGN VIYKGGVGPW NYHPQEIRAV LEKLK
Length:245
Mass (Da):28,386
Last modified:February 26, 2008 - v3
Checksum:iB5ED3C480884C3C1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei123 – 1231Selenocysteine

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11110 mRNA. Translation: CAA71996.1.
PIRiJC5825.
RefSeqiNP_001091083.1. NM_001097614.1.
UniGeneiGga.553.

Genome annotation databases

GeneIDi395940.
KEGGigga:395940.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11110 mRNA. Translation: CAA71996.1 .
PIRi JC5825.
RefSeqi NP_001091083.1. NM_001097614.1.
UniGenei Gga.553.

3D structure databases

ProteinModelPortali O42411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000017451.

Proteomic databases

PaxDbi O42411.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395940.
KEGGi gga:395940.

Organism-specific databases

CTDi 1733.

Phylogenomic databases

eggNOGi NOG149534.
HOVERGENi HBG000099.
InParanoidi O42411.
KOi K01562.
PhylomeDBi O42411.

Enzyme and pathway databases

BRENDAi 1.97.1.10. 1306.
SABIO-RK O42411.

Miscellaneous databases

NextBioi 20816005.
PROi O42411.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11781. PTHR11781. 1 hit.
Pfami PF00837. T4_deiodinase. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS01205. T4_DEIODINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of chicken hepatic type I and type III iodothyronine deiodinases during embryonic development."
    van der Geyten S., Sanders J.P., Kaptein E., Darras V.M., Kuehn E.R., Leonard J.L., Visser T.J.
    Endocrinology 138:5144-5152(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: HYBRO.
    Tissue: Liver.

Entry informationi

Entry nameiIOD1_CHICK
AccessioniPrimary (citable) accession number: O42411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 26, 2008
Last modified: November 26, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3