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O42411

- IOD1_CHICK

UniProt

O42411 - IOD1_CHICK

Protein

Type I iodothyronine deiodinase

Gene

DIO1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 3 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).By similarity

    Catalytic activityi

    3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei123 – 1231

    GO - Molecular functioni

    1. thyroxine 5'-deiodinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. hormone biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Thyroid hormones biosynthesis

    Enzyme and pathway databases

    BRENDAi1.97.1.10. 1306.
    SABIO-RKO42411.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type I iodothyronine deiodinase (EC:1.97.1.10)
    Alternative name(s):
    5DI
    DIOI
    Type 1 DI
    Type-I 5'-deiodinase
    Gene namesi
    Name:DIO1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 245›245Type I iodothyronine deiodinasePRO_0000154315Add
    BLAST

    Proteomic databases

    PaxDbiO42411.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000017451.

    Structurei

    3D structure databases

    ProteinModelPortaliO42411.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the iodothyronine deiodinase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149534.
    HOVERGENiHBG000099.
    KOiK01562.
    PhylomeDBiO42411.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR000643. Iodothyronine_deiodinase.
    IPR008261. Iodothyronine_deiodinase_AS.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR11781. PTHR11781. 1 hit.
    PfamiPF00837. T4_deiodinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS01205. T4_DEIODINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    O42411-1 [UniParc]FASTAAdd to Basket

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    LSIRVLLHKL LILLQVTLSV VVGKTMMILF PDTTKRYILK LGEKSRMNQN    50
    PKFSYENWGP TFFSFQYLLF VLKVKWRRLE DEAHEGRPAP NTPVVALNGE 100
    MQHLFSFMRD NRPLILNFGS CTUPSFMLKF DEFNKLVKDF SSIADFLIIY 150
    IEEAHAVDGW AFRNNVVIKN HRSLEDRKTA AQFLQQKNPL CPVVLDTMEN 200
    LSSSKYAALP ERLYILQAGN VIYKGGVGPW NYHPQEIRAV LEKLK 245
    Length:245
    Mass (Da):28,386
    Last modified:February 26, 2008 - v3
    Checksum:iB5ED3C480884C3C1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Non-standard residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-standard residuei123 – 1231Selenocysteine

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11110 mRNA. Translation: CAA71996.1.
    PIRiJC5825.
    RefSeqiNP_001091083.1. NM_001097614.1.
    UniGeneiGga.553.

    Genome annotation databases

    GeneIDi395940.
    KEGGigga:395940.

    Keywords - Coding sequence diversityi

    Selenocysteine

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11110 mRNA. Translation: CAA71996.1 .
    PIRi JC5825.
    RefSeqi NP_001091083.1. NM_001097614.1.
    UniGenei Gga.553.

    3D structure databases

    ProteinModelPortali O42411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000017451.

    Proteomic databases

    PaxDbi O42411.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395940.
    KEGGi gga:395940.

    Organism-specific databases

    CTDi 1733.

    Phylogenomic databases

    eggNOGi NOG149534.
    HOVERGENi HBG000099.
    KOi K01562.
    PhylomeDBi O42411.

    Enzyme and pathway databases

    BRENDAi 1.97.1.10. 1306.
    SABIO-RK O42411.

    Miscellaneous databases

    NextBioi 20816005.
    PROi O42411.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR000643. Iodothyronine_deiodinase.
    IPR008261. Iodothyronine_deiodinase_AS.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR11781. PTHR11781. 1 hit.
    Pfami PF00837. T4_deiodinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS01205. T4_DEIODINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of chicken hepatic type I and type III iodothyronine deiodinases during embryonic development."
      van der Geyten S., Sanders J.P., Kaptein E., Darras V.M., Kuehn E.R., Leonard J.L., Visser T.J.
      Endocrinology 138:5144-5152(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: HYBRO.
      Tissue: Liver.

    Entry informationi

    Entry nameiIOD1_CHICK
    AccessioniPrimary (citable) accession number: O42411
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 94 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3