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Protein

Zinc finger protein Gfi-1b

Gene

GFI1B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri170 – 19324C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri283 – 30523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33424C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Gfi-1b
Alternative name(s):
Growth factor-independent protein 1B
Gene namesi
Name:GFI1B
Synonyms:GFI
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 17

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Zinc finger protein Gfi-1bPRO_0000306329Add
BLAST

Proteomic databases

PaxDbiO42409.
PRIDEiO42409.

Expressioni

Tissue specificityi

Expressed in erythroid cells of primitive and definitive lineage and bone marrow cells.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005496.

Structurei

3D structure databases

ProteinModelPortaliO42409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2020Mediates repression of transcriptionBy similarityAdd
BLAST
Regioni1 – 2020SNAG domainBy similarityAdd
BLAST

Domaini

The zinc finger domain is essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain.By similarity

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri170 – 19324C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri283 – 30523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33424C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000067832.
HOVERGENiHBG106655.
InParanoidiO42409.
KOiK09223.
OMAiYGHSYRQ.
OrthoDBiEOG72RN05.
PhylomeDBiO42409.
TreeFamiTF350784.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR029840. GFI1/1B.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR19303:SF239. PTHR19303:SF239. 1 hit.
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSFLVKSK KAHTYHQHRF VEDDLPIFTW DPITSAFTAA GDRDKTPEDG
60 70 80 90 100
KKQDLEWVVP KQEKDSFQPK EESVPVQYLS RMLPGPSAQD MSISGLQVKD
110 120 130 140 150
CTNPTSMPTF YKTGFSWDAF QLPYSYRQMS STMQSALLEH PVSLYGSHLL
160 170 180 190 200
PSAEPPLDYS MRYSSDMETY HCVKCNKVFS TPHGLEVHVR RSHSGTRPFA
210 220 230 240 250
CEVCGKTFGH AVSLEQHTNI HSQERSFECK MCGKTFKRSS TLSTHLLIHS
260 270 280 290 300
DTRPYPCQYC GKRFHQKSDM KKHTYIHTGE KPHKCQVCGK AFSQSSNLIT
310 320 330
HSRKHTGFKP FSCELCAKGF QRKVDLRRHR ETQHSLK
Length:337
Mass (Da):38,687
Last modified:January 1, 1998 - v1
Checksum:i55871DA1D1A4F4FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10898 mRNA. Translation: CAA71836.1.
RefSeqiNP_990422.1. NM_205091.1.
XP_015134821.1. XM_015279335.1.
UniGeneiGga.44109.

Genome annotation databases

EnsembliENSGALT00000005506; ENSGALP00000005496; ENSGALG00000003478.
GeneIDi395977.
KEGGigga:395977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10898 mRNA. Translation: CAA71836.1.
RefSeqiNP_990422.1. NM_205091.1.
XP_015134821.1. XM_015279335.1.
UniGeneiGga.44109.

3D structure databases

ProteinModelPortaliO42409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005496.

Proteomic databases

PaxDbiO42409.
PRIDEiO42409.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000005506; ENSGALP00000005496; ENSGALG00000003478.
GeneIDi395977.
KEGGigga:395977.

Organism-specific databases

CTDi8328.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000067832.
HOVERGENiHBG106655.
InParanoidiO42409.
KOiK09223.
OMAiYGHSYRQ.
OrthoDBiEOG72RN05.
PhylomeDBiO42409.
TreeFamiTF350784.

Miscellaneous databases

NextBioi20816042.
PROiO42409.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR029840. GFI1/1B.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR19303:SF239. PTHR19303:SF239. 1 hit.
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and erythroid cell-restricted expression of a chicken cDNA encoding a novel zinc finger protein of the Cys + His class."
    Fuchs B., Wagner T., Roessel N., Antoine M., Beug H., Niessing J.
    Gene 195:277-284(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGFI1B_CHICK
AccessioniPrimary (citable) accession number: O42409
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.