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Protein

Zinc finger protein Gfi-1b

Gene

GFI1B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 193C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Gfi-1b
Alternative name(s):
Growth factor-independent protein 1B
Gene namesi
Name:GFI1B
Synonyms:GFI
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003063291 – 337Zinc finger protein Gfi-1bAdd BLAST337

Proteomic databases

PaxDbiO42409

Expressioni

Tissue specificityi

Expressed in erythroid cells of primitive and definitive lineage and bone marrow cells.1 Publication

Gene expression databases

BgeeiENSGALG00000003478

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005496

Structurei

3D structure databases

ProteinModelPortaliO42409
SMRiO42409
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 20Mediates repression of transcriptionBy similarityAdd BLAST20
Regioni1 – 20SNAG domainBy similarityAdd BLAST20

Domaini

The zinc finger domain is essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 193C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00740000115096
HOGENOMiHOG000067832
HOVERGENiHBG106655
InParanoidiO42409
KOiK09223
OMAiKKAHTYH
OrthoDBiEOG091G0NDD
PhylomeDBiO42409
TreeFamiTF350784

Family and domain databases

InterProiView protein in InterPro
IPR037044 Gfi-1b
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44643 PTHR44643, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequencei

Sequence statusi: Complete.

O42409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSFLVKSK KAHTYHQHRF VEDDLPIFTW DPITSAFTAA GDRDKTPEDG
60 70 80 90 100
KKQDLEWVVP KQEKDSFQPK EESVPVQYLS RMLPGPSAQD MSISGLQVKD
110 120 130 140 150
CTNPTSMPTF YKTGFSWDAF QLPYSYRQMS STMQSALLEH PVSLYGSHLL
160 170 180 190 200
PSAEPPLDYS MRYSSDMETY HCVKCNKVFS TPHGLEVHVR RSHSGTRPFA
210 220 230 240 250
CEVCGKTFGH AVSLEQHTNI HSQERSFECK MCGKTFKRSS TLSTHLLIHS
260 270 280 290 300
DTRPYPCQYC GKRFHQKSDM KKHTYIHTGE KPHKCQVCGK AFSQSSNLIT
310 320 330
HSRKHTGFKP FSCELCAKGF QRKVDLRRHR ETQHSLK
Length:337
Mass (Da):38,687
Last modified:January 1, 1998 - v1
Checksum:i55871DA1D1A4F4FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10898 mRNA Translation: CAA71836.1
RefSeqiNP_990422.1, NM_205091.1
XP_015134821.1, XM_015279335.1
UniGeneiGga.44109

Genome annotation databases

EnsembliENSGALT00000005506; ENSGALP00000005496; ENSGALG00000003478
GeneIDi395977
KEGGigga:395977

Similar proteinsi

Entry informationi

Entry nameiGFI1B_CHICK
AccessioniPrimary (citable) accession number: O42409
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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