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Protein

Fibroblast growth factor

Gene

FGF10

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorSAAS annotation

Enzyme and pathway databases

ReactomeiR-GGA-109704. PI3K Cascade.
R-GGA-1257604. PIP3 activates AKT signaling.
R-GGA-190370. FGFR1b ligand binding and activation.
R-GGA-190377. FGFR2b ligand binding and activation.
R-GGA-5654219. Phospholipase C-mediated cascade: FGFR1.
R-GGA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-GGA-5654687. Downstream signaling of activated FGFR1.
R-GGA-5654688. SHC-mediated cascade:FGFR1.
R-GGA-5654689. PI-3K cascade:FGFR1.
R-GGA-5654693. FRS-mediated FGFR1 signaling.
R-GGA-5654695. PI-3K cascade:FGFR2.
R-GGA-5654699. SHC-mediated cascade:FGFR2.
R-GGA-5654700. FRS-mediated FGFR2 signaling.
R-GGA-5654706. FRS-mediated FGFR3 signaling.
R-GGA-5654712. FRS-mediated FGFR4 signaling.
R-GGA-5654726. Negative regulation of FGFR1 signaling.
R-GGA-5654727. Negative regulation of FGFR2 signaling.
R-GGA-5658623. FGFRL1 modulation of FGFR1 signaling.
R-GGA-5673001. RAF/MAP kinase cascade.
R-GGA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factorUniRule annotation
Short name:
FGFUniRule annotation
Gene namesi
Name:FGF10Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome Z

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34UniRule annotationAdd BLAST34
ChainiPRO_501075450635 – 212Fibroblast growth factorUniRule annotationAdd BLAST178

Expressioni

Gene expression databases

BgeeiENSGALG00000014872.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023949.

Structurei

3D structure databases

SMRiO42407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heparin-binding growth factors family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOVERGENiHBG007580.
KOiK04358.
OMAiSSIPVTC.
OrthoDBiEOG091G0NAY.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiView protein in InterPro
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR008996. IL1/FGF.
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PfamiView protein in Pfam
PF00167. FGF. 1 hit.
PRINTSiPR00263. HBGFFGF.
SMARTiView protein in SMART
SM00442. FGF. 1 hit.
SUPFAMiSSF50353. SSF50353. 1 hit.

Sequencei

Sequence statusi: Complete.

O42407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCKWILTNGA SAFSHLPCCC LLLLFLVSSV PVTCHDLGQD MLSPEATNSS
60 70 80 90 100
SSSSSSFPSS FSSPSSAGRH VRSYNHLQGD VRKRKLYSYN KYFLKIEKNG
110 120 130 140 150
KVSGTKKENC PFSILEITSV EIGVVAVKSI KSNYYLAMNK KGKVYGSKEF
160 170 180 190 200
NSDCKLKERI EENGYNTYAS LNWKHNGRQM FVALNGRGAT KRGQKTRRKN
210
TSAHFLPMVV MS
Length:212
Mass (Da):23,631
Last modified:June 1, 1998 - v2
Checksum:iAB4C0B32C72A0D90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC187589 Genomic DNA. No translation available.
AC192779 Genomic DNA. No translation available.
D86333 mRNA. Translation: BAA24945.1.
RefSeqiNP_990027.1. NM_204696.1.
XP_015132721.1. XM_015277235.1.
UniGeneiGga.234.

Genome annotation databases

EnsembliENSGALT00000023995; ENSGALP00000023949; ENSGALG00000014872.
GeneIDi395432.
KEGGigga:395432.

Similar proteinsi

Entry informationi

Entry nameiO42407_CHICK
AccessioniPrimary (citable) accession number: O42407
Secondary accession number(s): F1N9L5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: June 1, 1998
Last modified: October 25, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported