Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor

Gene

FGF10

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorSAAS annotation

Enzyme and pathway databases

ReactomeiR-GGA-109704 PI3K Cascade
R-GGA-1257604 PIP3 activates AKT signaling
R-GGA-190370 FGFR1b ligand binding and activation
R-GGA-190377 FGFR2b ligand binding and activation
R-GGA-5654219 Phospholipase C-mediated cascade: FGFR1
R-GGA-5654221 Phospholipase C-mediated cascade, FGFR2
R-GGA-5654687 Downstream signaling of activated FGFR1
R-GGA-5654688 SHC-mediated cascade:FGFR1
R-GGA-5654689 PI-3K cascade:FGFR1
R-GGA-5654693 FRS-mediated FGFR1 signaling
R-GGA-5654695 PI-3K cascade:FGFR2
R-GGA-5654699 SHC-mediated cascade:FGFR2
R-GGA-5654700 FRS-mediated FGFR2 signaling
R-GGA-5654706 FRS-mediated FGFR3 signaling
R-GGA-5654712 FRS-mediated FGFR4 signaling
R-GGA-5654726 Negative regulation of FGFR1 signaling
R-GGA-5654727 Negative regulation of FGFR2 signaling
R-GGA-5658623 FGFRL1 modulation of FGFR1 signaling
R-GGA-5673001 RAF/MAP kinase cascade
R-GGA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factorUniRule annotation
Short name:
FGFUniRule annotation
Gene namesi
Name:FGF10Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome Z

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34UniRule annotationAdd BLAST34
ChainiPRO_501448662935 – 212Fibroblast growth factorUniRule annotationAdd BLAST178

Expressioni

Gene expression databases

BgeeiENSGALG00000014872

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023949

Family & Domainsi

Sequence similaritiesi

Belongs to the heparin-binding growth factors family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOVERGENiHBG007580
KOiK04358
OMAiSSIPVTC
OrthoDBiEOG091G0NAY
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028252 FGF10
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF21 PTHR11486:SF21, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit

Sequencei

Sequence statusi: Complete.

O42407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCKWILTNGA SAFSHLPCCC LLLLFLVSSV PVTCHDLGQD MLSPEATNSS
60 70 80 90 100
SSSSSSFPSS FSSPSSAGRH VRSYNHLQGD VRKRKLYSYN KYFLKIEKNG
110 120 130 140 150
KVSGTKKENC PFSILEITSV EIGVVAVKSI KSNYYLAMNK KGKVYGSKEF
160 170 180 190 200
NSDCKLKERI EENGYNTYAS LNWKHNGRQM FVALNGRGAT KRGQKTRRKN
210
TSAHFLPMVV MS
Length:212
Mass (Da):23,631
Last modified:June 1, 1998 - v2
Checksum:iAB4C0B32C72A0D90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC187589 Genomic DNA No translation available.
AC192779 Genomic DNA No translation available.
KY747398 mRNA Translation: AVG44235.1
D86333 mRNA Translation: BAA24945.1
RefSeqiNP_990027.1, NM_204696.1
XP_015132721.1, XM_015277235.1
UniGeneiGga.234

Genome annotation databases

EnsembliENSGALT00000023995; ENSGALP00000023949; ENSGALG00000014872
GeneIDi395432
KEGGigga:395432

Similar proteinsi

Entry informationi

Entry nameiO42407_CHICK
AccessioniPrimary (citable) accession number: O42407
Secondary accession number(s): F1N9L5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health