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Protein

Fibroblast growth factor

Gene

FGF10

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factorSAAS annotation

Enzyme and pathway databases

ReactomeiR-GGA-109704. PI3K Cascade.
R-GGA-1257604. PIP3 activates AKT signaling.
R-GGA-190370. FGFR1b ligand binding and activation.
R-GGA-190377. FGFR2b ligand binding and activation.
R-GGA-5654219. Phospholipase C-mediated cascade: FGFR1.
R-GGA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-GGA-5654687. Downstream signaling of activated FGFR1.
R-GGA-5654688. SHC-mediated cascade:FGFR1.
R-GGA-5654689. PI-3K cascade:FGFR1.
R-GGA-5654693. FRS-mediated FGFR1 signaling.
R-GGA-5654695. PI-3K cascade:FGFR2.
R-GGA-5654699. SHC-mediated cascade:FGFR2.
R-GGA-5654700. FRS-mediated FGFR2 signaling.
R-GGA-5654726. Negative regulation of FGFR1 signaling.
R-GGA-5654727. Negative regulation of FGFR2 signaling.
R-GGA-5658623. FGFRL1 modulation of FGFR1 signaling.
R-GGA-5673001. RAF/MAP kinase cascade.
R-GGA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factorUniRule annotation
Short name:
FGFUniRule annotation
Gene namesi
Name:FGF10Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome Z

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34UniRule annotationAdd BLAST34
ChainiPRO_500845192535 – 212Fibroblast growth factorUniRule annotationAdd BLAST178

Expressioni

Gene expression databases

BgeeiENSGALG00000014872.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023949.

Family & Domainsi

Sequence similaritiesi

Belongs to the heparin-binding growth factors family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOVERGENiHBG007580.
KOiK04358.
OMAiSSIPVTC.
OrthoDBiEOG091G0NAY.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.

Sequencei

Sequence statusi: Complete.

O42407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCKWILTNGA SAFSHLPCCC LLLLFLVSSV PVTCHDLGQD MLSPEATNSS
60 70 80 90 100
SSSSSSFPSS FSSPSSAGRH VRSYNHLQGD VRKRKLYSYN KYFLKIEKNG
110 120 130 140 150
KVSGTKKENC PFSILEITSV EIGVVAVKSI KSNYYLAMNK KGKVYGSKEF
160 170 180 190 200
NSDCKLKERI EENGYNTYAS LNWKHNGRQM FVALNGRGAT KRGQKTRRKN
210
TSAHFLPMVV MS
Length:212
Mass (Da):23,631
Last modified:June 1, 1998 - v2
Checksum:iAB4C0B32C72A0D90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC187589 Genomic DNA. No translation available.
AC192779 Genomic DNA. No translation available.
D86333 mRNA. Translation: BAA24945.1.
RefSeqiNP_990027.1. NM_204696.1.
XP_015132721.1. XM_015277235.1.
UniGeneiGga.234.

Genome annotation databases

EnsembliENSGALT00000023995; ENSGALP00000023949; ENSGALG00000014872.
GeneIDi395432.
KEGGigga:395432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC187589 Genomic DNA. No translation available.
AC192779 Genomic DNA. No translation available.
D86333 mRNA. Translation: BAA24945.1.
RefSeqiNP_990027.1. NM_204696.1.
XP_015132721.1. XM_015277235.1.
UniGeneiGga.234.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000023995; ENSGALP00000023949; ENSGALG00000014872.
GeneIDi395432.
KEGGigga:395432.

Organism-specific databases

CTDi2255.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOVERGENiHBG007580.
KOiK04358.
OMAiSSIPVTC.
OrthoDBiEOG091G0NAY.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiR-GGA-109704. PI3K Cascade.
R-GGA-1257604. PIP3 activates AKT signaling.
R-GGA-190370. FGFR1b ligand binding and activation.
R-GGA-190377. FGFR2b ligand binding and activation.
R-GGA-5654219. Phospholipase C-mediated cascade: FGFR1.
R-GGA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-GGA-5654687. Downstream signaling of activated FGFR1.
R-GGA-5654688. SHC-mediated cascade:FGFR1.
R-GGA-5654689. PI-3K cascade:FGFR1.
R-GGA-5654693. FRS-mediated FGFR1 signaling.
R-GGA-5654695. PI-3K cascade:FGFR2.
R-GGA-5654699. SHC-mediated cascade:FGFR2.
R-GGA-5654700. FRS-mediated FGFR2 signaling.
R-GGA-5654726. Negative regulation of FGFR1 signaling.
R-GGA-5654727. Negative regulation of FGFR2 signaling.
R-GGA-5658623. FGFRL1 modulation of FGFR1 signaling.
R-GGA-5673001. RAF/MAP kinase cascade.
R-GGA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Gene expression databases

BgeeiENSGALG00000014872.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO42407_CHICK
AccessioniPrimary (citable) accession number: O42407
Secondary accession number(s): F1N9L5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.