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Protein

Matrilin-3

Gene

MATN3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-GGA-3000178 ECM proteoglycans
R-GGA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-GGA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Matrilin-3
Gene namesi
Name:MATN3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000765925 – 452Matrilin-3Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi239 ↔ 250By similarity
Disulfide bondi246 ↔ 259By similarity
Disulfide bondi261 ↔ 274By similarity
Disulfide bondi280 ↔ 291By similarity
Disulfide bondi287 ↔ 300By similarity
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi302 ↔ 315By similarity
Disulfide bondi321 ↔ 332By similarity
Disulfide bondi328 ↔ 341By similarity
Disulfide bondi343 ↔ 356By similarity
Disulfide bondi362 ↔ 373By similarity
Disulfide bondi369 ↔ 382By similarity
Disulfide bondi384 ↔ 397By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO42401
PRIDEiO42401

Expressioni

Tissue specificityi

Expression is restricted to cartilaginous tissues.

Gene expression databases

BgeeiENSGALG00000016478

Interactioni

Subunit structurei

Can form homooligomers (monomers, dimers, trimers and tetramers) and heterooligomers with matrilin-1.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026536

Structurei

3D structure databases

ProteinModelPortaliO42401
SMRiO42401
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 229VWFAPROSITE-ProRule annotationAdd BLAST176
Domaini235 – 275EGF-like 1Add BLAST41
Domaini276 – 316EGF-like 2Add BLAST41
Domaini317 – 357EGF-like 3Add BLAST41
Domaini358 – 398EGF-like 4Add BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili419 – 451Sequence analysisAdd BLAST33

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
GeneTreeiENSGT00910000144060
HOGENOMiHOG000263415
HOVERGENiHBG056906
InParanoidiO42401
KOiK19467
OMAiRFQETFC
OrthoDBiEOG091G04O4
PhylomeDBiO42401

Family and domain databases

Gene3Di1.20.5.30, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR030765 Matrilin_3
IPR036337 Matrilin_cc_sf
IPR019466 Matrilin_coiled-coil_trimer
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR45117 PTHR45117, 1 hit
PfamiView protein in Pfam
PF07645 EGF_CA, 3 hits
PF10393 Matrilin_ccoil, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 4 hits
SM01279 Matrilin_ccoil, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF57184 SSF57184, 1 hit
SSF58002 SSF58002, 1 hit
PROSITEiView protein in PROSITE
PS01186 EGF_2, 4 hits
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRALGTLGC CLALLLPLLP AARGVPHRHR RQPLGSGLGR HGAADTACKN
60 70 80 90 100
RPLDLVFIID SSRSVRPEEF EKVKIFLSKM IDTLDVGERT TRVAVMNYAS
110 120 130 140 150
TVKVEFPLRT YFDKASMKEA VSRIQPLSAG TMTGLAIQAA MDEVFTEEMG
160 170 180 190 200
TRPANFNIPK VVIIVTDGRP QDQVENVAAN ARTAGIEIYA VGVGRADMQS
210 220 230 240 250
LRIMASEPLD EHVFYVETYG VIEKLTSKFR ETFCAANTCA LGTHDCEQVC
260 270 280 290 300
VSNDGSYLCD CYEGYTLNPD KRTCSAVDVC APGRHECDQI CVSNNGSYVC
310 320 330 340 350
ECFEGYTLNP DKKTCSAMDV CAPGRHDCAQ VCRRNGGSYS CDCFEGFTLN
360 370 380 390 400
PDKKTCSAVD VCAPGRHDCE QVCVRDDLFY TCDCYQGYVL NPDKKTCSRA
410 420 430 440 450
TTSSLVTDEE ACKCEAIAAL QDSVTSRLEA LSTKLDEVSQ KLQAYQDRQQ

VV
Length:452
Mass (Da):49,622
Last modified:January 1, 1998 - v1
Checksum:i2D65324CEAED4CFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000055 mRNA Translation: CAA03885.1
RefSeqiNP_990403.1, NM_205072.1
UniGeneiGga.3587

Genome annotation databases

EnsembliENSGALT00000036867; ENSGALP00000036079; ENSGALG00000016478
GeneIDi395954
KEGGigga:395954

Similar proteinsi

Entry informationi

Entry nameiMATN3_CHICK
AccessioniPrimary (citable) accession number: O42401
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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