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Protein

Matrilin-3

Gene

MATN3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-GGA-3000178. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Matrilin-3
Gene namesi
Name:MATN3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000765925 – 452Matrilin-3Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi239 ↔ 250By similarity
Disulfide bondi246 ↔ 259By similarity
Disulfide bondi261 ↔ 274By similarity
Disulfide bondi280 ↔ 291By similarity
Disulfide bondi287 ↔ 300By similarity
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi302 ↔ 315By similarity
Disulfide bondi321 ↔ 332By similarity
Disulfide bondi328 ↔ 341By similarity
Disulfide bondi343 ↔ 356By similarity
Disulfide bondi362 ↔ 373By similarity
Disulfide bondi369 ↔ 382By similarity
Disulfide bondi384 ↔ 397By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO42401.

Expressioni

Tissue specificityi

Expression is restricted to cartilaginous tissues.

Gene expression databases

BgeeiENSGALG00000016478.

Interactioni

Subunit structurei

Can form homooligomers (monomers, dimers, trimers and tetramers) and heterooligomers with matrilin-1.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026536.

Structurei

3D structure databases

ProteinModelPortaliO42401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 229VWFAPROSITE-ProRule annotationAdd BLAST176
Domaini235 – 275EGF-like 1Add BLAST41
Domaini276 – 316EGF-like 2Add BLAST41
Domaini317 – 357EGF-like 3Add BLAST41
Domaini358 – 398EGF-like 4Add BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili419 – 451Sequence analysisAdd BLAST33

Sequence similaritiesi

Contains 4 EGF-like domains.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00760000119000.
HOGENOMiHOG000263415.
HOVERGENiHBG056906.
InParanoidiO42401.
KOiK19467.
OMAiRFQETFC.
OrthoDBiEOG091G04O4.
PhylomeDBiO42401.

Family and domain databases

Gene3Di1.20.5.30. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR009030. Growth_fac_rcpt_.
IPR030765. Matrilin-3/4.
IPR019466. Matrilin_coiled-coil_trimer.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR11132:SF50. PTHR11132:SF50. 1 hit.
PfamiPF07645. EGF_CA. 3 hits.
PF10393. Matrilin_ccoil. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
SM01279. Matrilin_ccoil. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS01186. EGF_2. 4 hits.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRALGTLGC CLALLLPLLP AARGVPHRHR RQPLGSGLGR HGAADTACKN
60 70 80 90 100
RPLDLVFIID SSRSVRPEEF EKVKIFLSKM IDTLDVGERT TRVAVMNYAS
110 120 130 140 150
TVKVEFPLRT YFDKASMKEA VSRIQPLSAG TMTGLAIQAA MDEVFTEEMG
160 170 180 190 200
TRPANFNIPK VVIIVTDGRP QDQVENVAAN ARTAGIEIYA VGVGRADMQS
210 220 230 240 250
LRIMASEPLD EHVFYVETYG VIEKLTSKFR ETFCAANTCA LGTHDCEQVC
260 270 280 290 300
VSNDGSYLCD CYEGYTLNPD KRTCSAVDVC APGRHECDQI CVSNNGSYVC
310 320 330 340 350
ECFEGYTLNP DKKTCSAMDV CAPGRHDCAQ VCRRNGGSYS CDCFEGFTLN
360 370 380 390 400
PDKKTCSAVD VCAPGRHDCE QVCVRDDLFY TCDCYQGYVL NPDKKTCSRA
410 420 430 440 450
TTSSLVTDEE ACKCEAIAAL QDSVTSRLEA LSTKLDEVSQ KLQAYQDRQQ

VV
Length:452
Mass (Da):49,622
Last modified:January 1, 1998 - v1
Checksum:i2D65324CEAED4CFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000055 mRNA. Translation: CAA03885.1.
RefSeqiNP_990403.1. NM_205072.1.
UniGeneiGga.3587.

Genome annotation databases

EnsembliENSGALT00000036867; ENSGALP00000036079; ENSGALG00000016478.
GeneIDi395954.
KEGGigga:395954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000055 mRNA. Translation: CAA03885.1.
RefSeqiNP_990403.1. NM_205072.1.
UniGeneiGga.3587.

3D structure databases

ProteinModelPortaliO42401.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026536.

Proteomic databases

PaxDbiO42401.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000036867; ENSGALP00000036079; ENSGALG00000016478.
GeneIDi395954.
KEGGigga:395954.

Organism-specific databases

CTDi4148.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00760000119000.
HOGENOMiHOG000263415.
HOVERGENiHBG056906.
InParanoidiO42401.
KOiK19467.
OMAiRFQETFC.
OrthoDBiEOG091G04O4.
PhylomeDBiO42401.

Enzyme and pathway databases

ReactomeiR-GGA-3000178. ECM proteoglycans.

Miscellaneous databases

PROiO42401.

Gene expression databases

BgeeiENSGALG00000016478.

Family and domain databases

Gene3Di1.20.5.30. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR009030. Growth_fac_rcpt_.
IPR030765. Matrilin-3/4.
IPR019466. Matrilin_coiled-coil_trimer.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR11132:SF50. PTHR11132:SF50. 1 hit.
PfamiPF07645. EGF_CA. 3 hits.
PF10393. Matrilin_ccoil. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
SM01279. Matrilin_ccoil. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS01186. EGF_2. 4 hits.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMATN3_CHICK
AccessioniPrimary (citable) accession number: O42401
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.