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O42400 (AXIN1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Axin-1
Alternative name(s):
Axis inhibition protein 1
Gene names
Name:AXIN1
Synonyms:AXIN, AXN
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length841 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Developmental stage

Expressed at stage 12 to 15.

Post-translational modification

Probably phosphorylated by GSK3B and dephosphorylated by PP2A By similarity.

Sequence similarities

Contains 1 DIX domain.

Contains 1 RGS domain.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentCytoplasm
   Molecular functionDevelopmental protein
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway involved in somitogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt-activated signaling pathway involved in forebrain neuron fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

activation of JUN kinase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

axial mesoderm formation

Inferred from Biological aspect of Ancestor. Source: RefGenome

canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell death

Inferred from Biological aspect of Ancestor. Source: RefGenome

cellular response to organic cyclic compound

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasmic microtubule organization

Inferred from Biological aspect of Ancestor. Source: RefGenome

determination of left/right symmetry

Inferred from Biological aspect of Ancestor. Source: RefGenome

dorsal/ventral axis specification

Inferred from Biological aspect of Ancestor. Source: RefGenome

embryonic eye morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

embryonic skeletal joint morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

forebrain anterior/posterior pattern specification

Inferred from Biological aspect of Ancestor. Source: RefGenome

muscle cell development

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of canonical Wnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of fat cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

olfactory placode formation

Inferred from Biological aspect of Ancestor. Source: RefGenome

optic placode formation

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of GTPase activity

Inferred from Biological aspect of Ancestor. Source: GOC

positive regulation of JNK cascade

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of catenin import into nucleus

Inferred from Biological aspect of Ancestor. Source: RefGenome

termination of G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcell cortex

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasm

Inferred from sequence or structural similarity. Source: AgBase

cytoplasmic membrane-bounded vesicle

Inferred from sequence or structural similarity. Source: AgBase

cytoplasmic microtubule

Inferred from Biological aspect of Ancestor. Source: RefGenome

plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

postsynaptic density

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionGTPase activator activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

armadillo repeat domain binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

beta-catenin binding

Inferred from sequence or structural similarity. Source: AgBase

protein homodimerization activity

Inferred from sequence or structural similarity. Source: UniProtKB

protein kinase binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

signal transducer activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 841841Axin-1
PRO_0000220891

Regions

Domain88 – 211124RGS
Domain759 – 84183DIX
Region348 – 43386Interaction with GSK3B By similarity
Region434 – 50875Interaction with beta-catenin By similarity

Sequences

Sequence LengthMass (Da)Tools
O42400 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 400D0C90E72506FE

FASTA84194,932
        10         20         30         40         50         60 
MNIQGKGFPL DLGRSFTEDA PRPPVPGEEG ELVSTDPRPV SHGFYSSKSD AVRNETSTAT 

        70         80         90        100        110        120 
PRRSDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIN LFRTFLKQED CADLLDFWFA 

       130        140        150        160        170        180 
CSGFRKLEPC VSNEEKRLKL AKAIYKKYIL DNNGIVSRQI KPATKSFIKD CVMKLQIDPD 

       190        200        210        220        230        240 
MFDQAQTEIQ CMIEDNTYPL FLKSDIYLEY TRTGGESPKI YSDPSSGSGT GKGLPGYLPT 

       250        260        270        280        290        300 
LNEDEEWKCD QDTEPEASRD SAPSSRLTQK LLLETATQRA TSTRRYSEGR EFRHGSWREP 

       310        320        330        340        350        360 
VNPYYVNTGY AMAPATSAND SEQQSMSSDA DTMSLTDSSI DGIPPYRLRK QHRREMQESA 

       370        380        390        400        410        420 
KANGRVPLPH IPRTYRMPKD IHVEPEKFAA ELINRLEEVQ KEREAEEKLE ERLKRVRAEE 

       430        440        450        460        470        480 
EGEDADISSG PSVISHKMPS AQPFHHFAPR YSEMGCAGMQ MRDAHEENPE SILDEHVQRV 

       490        500        510        520        530        540 
MKTPGCQSPG PGRHSPKPRS PESGHLGKLS GTLGTIPPGH GKHTTKSGMK LDAANLYHHK 

       550        560        570        580        590        600 
HVYHHIHHHS MMKPKEQIEA EATQRVQNSF AWNVDSHNYA TKSRNYSENL GMAPVPMDSL 

       610        620        630        640        650        660 
GYSGKASLLS KRNIKKTDSG KSDGANYEMP GSPEDVERNQ KILQWIIEGE KEISRHKKTN 

       670        680        690        700        710        720 
HGSSGVKKQL SHDMVRPLSI ERPVAVHPWV SAQLRNVVQP SHPFIQDPTM PPNPAPNPLT 

       730        740        750        760        770        780 
QLEEARRRLE EEEKRAGKLP LKQRLKPQKR PGSGASQPCE NIVVAYYFCG EPIPYRTLVK 

       790        800        810        820        830        840 
GRVVTLGQFK ELLTKKGNYR YYFKKVSDEF DCGVVFEEVR EDDTILPIFE EKIIGKVEKI 


D 

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References

[1]"The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation."
Zeng L., Fagotto F., Zhang T., Hsu W., Vasicek T.J., Perry W.L. III, Lee J.J., Tilghman S.M., Gumbiner B.M., Costantini F.
Cell 90:181-192(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF009012 mRNA. Translation: AAC60245.1.
RefSeqNP_990275.1. NM_204944.2.
UniGeneGga.464.

3D structure databases

ProteinModelPortalO42400.
SMRO42400. Positions 74-220, 758-841.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbO42400.
PRIDEO42400.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395786.
KEGGgga:395786.

Organism-specific databases

CTD8312.

Phylogenomic databases

eggNOGNOG238205.
HOVERGENHBG004324.
InParanoidO42400.
KOK02157.
PhylomeDBO42400.

Family and domain databases

Gene3D1.10.196.10. 2 hits.
InterProIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815854.
PROO42400.

Entry information

Entry nameAXIN1_CHICK
AccessionPrimary (citable) accession number: O42400
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families