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Protein

Axin-1

Gene

AXIN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Axin-1
Alternative name(s):
Axis inhibition protein 1
Gene namesi
Name:AXIN1
Synonyms:AXIN, AXN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208911 – 841Axin-1Add BLAST841

Post-translational modificationi

Probably phosphorylated by GSK3B and dephosphorylated by PP2A.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO42400.

Expressioni

Developmental stagei

Expressed at stage 12 to 15.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

ELMiO42400.
STRINGi9031.ENSGALP00000012076.

Structurei

3D structure databases

ProteinModelPortaliO42400.
SMRiO42400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 211RGSPROSITE-ProRule annotationAdd BLAST124
Domaini759 – 841DIXPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni348 – 433Interaction with GSK3BBy similarityAdd BLAST86
Regioni434 – 508Interaction with beta-cateninBy similarityAdd BLAST75

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
HOVERGENiHBG004324.
InParanoidiO42400.
KOiK02157.
PhylomeDBiO42400.

Family and domain databases

CDDicd11582. Axin_TNKS_binding. 1 hit.
Gene3Di1.10.196.10. 2 hits.
InterProiView protein in InterPro
IPR029797. AXIN1.
IPR014936. Axin_b-cat-bd.
IPR032101. Axin_TNKS-bd.
IPR001158. DIX.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
PANTHERiPTHR10845:SF214. PTHR10845:SF214. 1 hit.
PfamiView protein in Pfam
PF16646. AXIN1_TNKS_BD. 1 hit.
PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
PRINTSiPR01301. RGSPROTEIN.
SMARTiView protein in SMART
SM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.

Sequencei

Sequence statusi: Complete.

O42400-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIQGKGFPL DLGRSFTEDA PRPPVPGEEG ELVSTDPRPV SHGFYSSKSD
60 70 80 90 100
AVRNETSTAT PRRSDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIN
110 120 130 140 150
LFRTFLKQED CADLLDFWFA CSGFRKLEPC VSNEEKRLKL AKAIYKKYIL
160 170 180 190 200
DNNGIVSRQI KPATKSFIKD CVMKLQIDPD MFDQAQTEIQ CMIEDNTYPL
210 220 230 240 250
FLKSDIYLEY TRTGGESPKI YSDPSSGSGT GKGLPGYLPT LNEDEEWKCD
260 270 280 290 300
QDTEPEASRD SAPSSRLTQK LLLETATQRA TSTRRYSEGR EFRHGSWREP
310 320 330 340 350
VNPYYVNTGY AMAPATSAND SEQQSMSSDA DTMSLTDSSI DGIPPYRLRK
360 370 380 390 400
QHRREMQESA KANGRVPLPH IPRTYRMPKD IHVEPEKFAA ELINRLEEVQ
410 420 430 440 450
KEREAEEKLE ERLKRVRAEE EGEDADISSG PSVISHKMPS AQPFHHFAPR
460 470 480 490 500
YSEMGCAGMQ MRDAHEENPE SILDEHVQRV MKTPGCQSPG PGRHSPKPRS
510 520 530 540 550
PESGHLGKLS GTLGTIPPGH GKHTTKSGMK LDAANLYHHK HVYHHIHHHS
560 570 580 590 600
MMKPKEQIEA EATQRVQNSF AWNVDSHNYA TKSRNYSENL GMAPVPMDSL
610 620 630 640 650
GYSGKASLLS KRNIKKTDSG KSDGANYEMP GSPEDVERNQ KILQWIIEGE
660 670 680 690 700
KEISRHKKTN HGSSGVKKQL SHDMVRPLSI ERPVAVHPWV SAQLRNVVQP
710 720 730 740 750
SHPFIQDPTM PPNPAPNPLT QLEEARRRLE EEEKRAGKLP LKQRLKPQKR
760 770 780 790 800
PGSGASQPCE NIVVAYYFCG EPIPYRTLVK GRVVTLGQFK ELLTKKGNYR
810 820 830 840
YYFKKVSDEF DCGVVFEEVR EDDTILPIFE EKIIGKVEKI D
Length:841
Mass (Da):94,932
Last modified:January 1, 1998 - v1
Checksum:i400D0C90E72506FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009012 mRNA. Translation: AAC60245.1.
RefSeqiNP_990275.1. NM_204944.2.
UniGeneiGga.37565.
Gga.464.

Genome annotation databases

GeneIDi395786.
KEGGigga:395786.

Similar proteinsi

Entry informationi

Entry nameiAXIN1_CHICK
AccessioniPrimary (citable) accession number: O42400
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome