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O42400

- AXIN1_CHICK

UniProt

O42400 - AXIN1_CHICK

Protein

Axin-1

Gene

AXIN1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.

    GO - Molecular functioni

    1. armadillo repeat domain binding Source: RefGenome
    2. beta-catenin binding Source: AgBase
    3. GTPase activator activity Source: RefGenome
    4. protein homodimerization activity Source: UniProtKB
    5. protein kinase binding Source: RefGenome
    6. signal transducer activity Source: InterPro

    GO - Biological processi

    1. activation of JUN kinase activity Source: RefGenome
    2. axial mesoderm formation Source: RefGenome
    3. canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation Source: RefGenome
    4. cell death Source: RefGenome
    5. cellular response to organic cyclic compound Source: RefGenome
    6. cytoplasmic microtubule organization Source: RefGenome
    7. determination of left/right symmetry Source: RefGenome
    8. dorsal/ventral axis specification Source: RefGenome
    9. embryonic eye morphogenesis Source: RefGenome
    10. embryonic skeletal joint morphogenesis Source: RefGenome
    11. forebrain anterior/posterior pattern specification Source: RefGenome
    12. muscle cell development Source: RefGenome
    13. negative regulation of canonical Wnt signaling pathway Source: RefGenome
    14. negative regulation of fat cell differentiation Source: RefGenome
    15. olfactory placode formation Source: RefGenome
    16. optic placode formation Source: RefGenome
    17. positive regulation of GTPase activity Source: GOC
    18. positive regulation of JNK cascade Source: UniProtKB
    19. regulation of catenin import into nucleus Source: RefGenome
    20. termination of G-protein coupled receptor signaling pathway Source: InterPro
    21. Wnt-activated signaling pathway involved in forebrain neuron fate commitment Source: RefGenome
    22. Wnt signaling pathway involved in somitogenesis Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Axin-1
    Alternative name(s):
    Axis inhibition protein 1
    Gene namesi
    Name:AXIN1
    Synonyms:AXIN, AXN
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cell cortex Source: RefGenome
    2. cytoplasm Source: AgBase
    3. cytoplasmic membrane-bounded vesicle Source: AgBase
    4. cytoplasmic microtubule Source: RefGenome
    5. plasma membrane Source: RefGenome
    6. postsynaptic density Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 841841Axin-1PRO_0000220891Add
    BLAST

    Post-translational modificationi

    Probably phosphorylated by GSK3B and dephosphorylated by PP2A.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO42400.
    PRIDEiO42400.

    Expressioni

    Developmental stagei

    Expressed at stage 12 to 15.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO42400.
    SMRiO42400. Positions 74-220, 758-841.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini88 – 211124RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini759 – 84183DIXPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni348 – 43386Interaction with GSK3BBy similarityAdd
    BLAST
    Regioni434 – 50875Interaction with beta-cateninBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG238205.
    HOVERGENiHBG004324.
    InParanoidiO42400.
    KOiK02157.
    PhylomeDBiO42400.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00021. DAX. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42400-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIQGKGFPL DLGRSFTEDA PRPPVPGEEG ELVSTDPRPV SHGFYSSKSD    50
    AVRNETSTAT PRRSDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIN 100
    LFRTFLKQED CADLLDFWFA CSGFRKLEPC VSNEEKRLKL AKAIYKKYIL 150
    DNNGIVSRQI KPATKSFIKD CVMKLQIDPD MFDQAQTEIQ CMIEDNTYPL 200
    FLKSDIYLEY TRTGGESPKI YSDPSSGSGT GKGLPGYLPT LNEDEEWKCD 250
    QDTEPEASRD SAPSSRLTQK LLLETATQRA TSTRRYSEGR EFRHGSWREP 300
    VNPYYVNTGY AMAPATSAND SEQQSMSSDA DTMSLTDSSI DGIPPYRLRK 350
    QHRREMQESA KANGRVPLPH IPRTYRMPKD IHVEPEKFAA ELINRLEEVQ 400
    KEREAEEKLE ERLKRVRAEE EGEDADISSG PSVISHKMPS AQPFHHFAPR 450
    YSEMGCAGMQ MRDAHEENPE SILDEHVQRV MKTPGCQSPG PGRHSPKPRS 500
    PESGHLGKLS GTLGTIPPGH GKHTTKSGMK LDAANLYHHK HVYHHIHHHS 550
    MMKPKEQIEA EATQRVQNSF AWNVDSHNYA TKSRNYSENL GMAPVPMDSL 600
    GYSGKASLLS KRNIKKTDSG KSDGANYEMP GSPEDVERNQ KILQWIIEGE 650
    KEISRHKKTN HGSSGVKKQL SHDMVRPLSI ERPVAVHPWV SAQLRNVVQP 700
    SHPFIQDPTM PPNPAPNPLT QLEEARRRLE EEEKRAGKLP LKQRLKPQKR 750
    PGSGASQPCE NIVVAYYFCG EPIPYRTLVK GRVVTLGQFK ELLTKKGNYR 800
    YYFKKVSDEF DCGVVFEEVR EDDTILPIFE EKIIGKVEKI D 841
    Length:841
    Mass (Da):94,932
    Last modified:January 1, 1998 - v1
    Checksum:i400D0C90E72506FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF009012 mRNA. Translation: AAC60245.1.
    RefSeqiNP_990275.1. NM_204944.2.
    UniGeneiGga.464.

    Genome annotation databases

    GeneIDi395786.
    KEGGigga:395786.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF009012 mRNA. Translation: AAC60245.1 .
    RefSeqi NP_990275.1. NM_204944.2.
    UniGenei Gga.464.

    3D structure databases

    ProteinModelPortali O42400.
    SMRi O42400. Positions 74-220, 758-841.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi O42400.
    PRIDEi O42400.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395786.
    KEGGi gga:395786.

    Organism-specific databases

    CTDi 8312.

    Phylogenomic databases

    eggNOGi NOG238205.
    HOVERGENi HBG004324.
    InParanoidi O42400.
    KOi K02157.
    PhylomeDBi O42400.

    Miscellaneous databases

    NextBioi 20815854.
    PROi O42400.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00021. DAX. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation."
      Zeng L., Fagotto F., Zhang T., Hsu W., Vasicek T.J., Perry W.L. III, Lee J.J., Tilghman S.M., Gumbiner B.M., Costantini F.
      Cell 90:181-192(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiAXIN1_CHICK
    AccessioniPrimary (citable) accession number: O42400
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3