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Protein

Axin-1

Gene

AXIN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.

GO - Molecular functioni

  1. armadillo repeat domain binding Source: GO_Central
  2. beta-catenin binding Source: AgBase
  3. GTPase activator activity Source: GO_Central
  4. protein homodimerization activity Source: UniProtKB
  5. protein kinase binding Source: GO_Central

GO - Biological processi

  1. activation of JUN kinase activity Source: GO_Central
  2. axial mesoderm formation Source: GO_Central
  3. canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation Source: GO_Central
  4. cell death Source: GO_Central
  5. cellular response to organic cyclic compound Source: GO_Central
  6. cytoplasmic microtubule organization Source: GO_Central
  7. determination of left/right symmetry Source: GO_Central
  8. dorsal/ventral axis specification Source: GO_Central
  9. embryonic eye morphogenesis Source: GO_Central
  10. embryonic skeletal joint morphogenesis Source: GO_Central
  11. forebrain anterior/posterior pattern specification Source: GO_Central
  12. muscle cell development Source: GO_Central
  13. negative regulation of canonical Wnt signaling pathway Source: GO_Central
  14. negative regulation of fat cell differentiation Source: GO_Central
  15. olfactory placode formation Source: GO_Central
  16. optic placode formation Source: GO_Central
  17. positive regulation of GTPase activity Source: GOC
  18. positive regulation of JNK cascade Source: UniProtKB
  19. regulation of catenin import into nucleus Source: GO_Central
  20. termination of G-protein coupled receptor signaling pathway Source: InterPro
  21. Wnt-activated signaling pathway involved in forebrain neuron fate commitment Source: GO_Central
  22. Wnt signaling pathway involved in somitogenesis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Axin-1
Alternative name(s):
Axis inhibition protein 1
Gene namesi
Name:AXIN1
Synonyms:AXIN, AXN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cell cortex Source: GO_Central
  2. cytoplasm Source: AgBase
  3. cytoplasmic membrane-bounded vesicle Source: AgBase
  4. cytoplasmic microtubule Source: GO_Central
  5. plasma membrane Source: GO_Central
  6. postsynaptic density Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 841841Axin-1PRO_0000220891Add
BLAST

Post-translational modificationi

Probably phosphorylated by GSK3B and dephosphorylated by PP2A.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO42400.
PRIDEiO42400.

Expressioni

Developmental stagei

Expressed at stage 12 to 15.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO42400.
SMRiO42400. Positions 74-220, 758-841.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 211124RGSPROSITE-ProRule annotationAdd
BLAST
Domaini759 – 84183DIXPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni348 – 43386Interaction with GSK3BBy similarityAdd
BLAST
Regioni434 – 50875Interaction with beta-cateninBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG238205.
HOVERGENiHBG004324.
InParanoidiO42400.
KOiK02157.
PhylomeDBiO42400.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR029797. AXIN1.
IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10845:SF11. PTHR10845:SF11. 1 hit.
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42400-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNIQGKGFPL DLGRSFTEDA PRPPVPGEEG ELVSTDPRPV SHGFYSSKSD
60 70 80 90 100
AVRNETSTAT PRRSDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIN
110 120 130 140 150
LFRTFLKQED CADLLDFWFA CSGFRKLEPC VSNEEKRLKL AKAIYKKYIL
160 170 180 190 200
DNNGIVSRQI KPATKSFIKD CVMKLQIDPD MFDQAQTEIQ CMIEDNTYPL
210 220 230 240 250
FLKSDIYLEY TRTGGESPKI YSDPSSGSGT GKGLPGYLPT LNEDEEWKCD
260 270 280 290 300
QDTEPEASRD SAPSSRLTQK LLLETATQRA TSTRRYSEGR EFRHGSWREP
310 320 330 340 350
VNPYYVNTGY AMAPATSAND SEQQSMSSDA DTMSLTDSSI DGIPPYRLRK
360 370 380 390 400
QHRREMQESA KANGRVPLPH IPRTYRMPKD IHVEPEKFAA ELINRLEEVQ
410 420 430 440 450
KEREAEEKLE ERLKRVRAEE EGEDADISSG PSVISHKMPS AQPFHHFAPR
460 470 480 490 500
YSEMGCAGMQ MRDAHEENPE SILDEHVQRV MKTPGCQSPG PGRHSPKPRS
510 520 530 540 550
PESGHLGKLS GTLGTIPPGH GKHTTKSGMK LDAANLYHHK HVYHHIHHHS
560 570 580 590 600
MMKPKEQIEA EATQRVQNSF AWNVDSHNYA TKSRNYSENL GMAPVPMDSL
610 620 630 640 650
GYSGKASLLS KRNIKKTDSG KSDGANYEMP GSPEDVERNQ KILQWIIEGE
660 670 680 690 700
KEISRHKKTN HGSSGVKKQL SHDMVRPLSI ERPVAVHPWV SAQLRNVVQP
710 720 730 740 750
SHPFIQDPTM PPNPAPNPLT QLEEARRRLE EEEKRAGKLP LKQRLKPQKR
760 770 780 790 800
PGSGASQPCE NIVVAYYFCG EPIPYRTLVK GRVVTLGQFK ELLTKKGNYR
810 820 830 840
YYFKKVSDEF DCGVVFEEVR EDDTILPIFE EKIIGKVEKI D
Length:841
Mass (Da):94,932
Last modified:January 1, 1998 - v1
Checksum:i400D0C90E72506FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009012 mRNA. Translation: AAC60245.1.
RefSeqiNP_990275.1. NM_204944.2.
UniGeneiGga.464.

Genome annotation databases

GeneIDi395786.
KEGGigga:395786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009012 mRNA. Translation: AAC60245.1.
RefSeqiNP_990275.1. NM_204944.2.
UniGeneiGga.464.

3D structure databases

ProteinModelPortaliO42400.
SMRiO42400. Positions 74-220, 758-841.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiO42400.
PRIDEiO42400.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395786.
KEGGigga:395786.

Organism-specific databases

CTDi8312.

Phylogenomic databases

eggNOGiNOG238205.
HOVERGENiHBG004324.
InParanoidiO42400.
KOiK02157.
PhylomeDBiO42400.

Miscellaneous databases

NextBioi20815854.
PROiO42400.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR029797. AXIN1.
IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10845:SF11. PTHR10845:SF11. 1 hit.
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation."
    Zeng L., Fagotto F., Zhang T., Hsu W., Vasicek T.J., Perry W.L. III, Lee J.J., Tilghman S.M., Gumbiner B.M., Costantini F.
    Cell 90:181-192(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiAXIN1_CHICK
AccessioniPrimary (citable) accession number: O42400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: February 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.