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Protein

Cellular nucleic acid-binding protein

Gene

CNBP

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 2118CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri46 – 6318CCHC-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri67 – 8418CCHC-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri91 – 10818CCHC-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri112 – 12918CCHC-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri130 – 14718CCHC-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri151 – 16818CCHC-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular nucleic acid-binding protein
Short name:
CNBP
Alternative name(s):
Zinc finger protein 9
Gene namesi
Name:CNBP
Synonyms:ZNF9
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Cellular nucleic acid-binding proteinPRO_0000089964Add
BLAST

Proteomic databases

PaxDbiO42395.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000035496.

Structurei

3D structure databases

ProteinModelPortaliO42395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 7 CCHC-type zinc fingers.PROSITE-ProRule annotation
To S.pombe BYR3 and to retroviral nucleic acid binding proteins (NBP).Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 2118CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri46 – 6318CCHC-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri67 – 8418CCHC-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri91 – 10818CCHC-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri112 – 12918CCHC-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri130 – 14718CCHC-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri151 – 16818CCHC-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4400. Eukaryota.
COG5082. LUCA.
HOGENOMiHOG000186262.
HOVERGENiHBG000397.
InParanoidiO42395.
KOiK09250.
PhylomeDBiO42395.

Family and domain databases

Gene3Di4.10.60.10. 4 hits.
InterProiIPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 7 hits.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 7 hits.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 4 hits.
PROSITEiPS50158. ZF_CCHC. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42395-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNECFKCG RTGHWARECP TGIGRGRGMR SRGRAGFQFM SSSLPDICYR
60 70 80 90 100
CGESGHLAKD CDLQEDKACY NCGRGGHIAK DCKEPKRERE QCCYNCGKPG
110 120 130 140 150
HLARDCDHAD EQKCYSCGEF GHIQKDCTKV KCYRCGETGH VAINCSKTSE
160 170
VNCYRCGESG HLARECTIEA TA
Length:172
Mass (Da):19,043
Last modified:January 1, 1998 - v1
Checksum:i123F4E248A980390
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004942 mRNA. Translation: AAB62243.1.
RefSeqiNP_990238.1. NM_204907.1.
UniGeneiGga.3333.

Genome annotation databases

GeneIDi395731.
KEGGigga:395731.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004942 mRNA. Translation: AAB62243.1.
RefSeqiNP_990238.1. NM_204907.1.
UniGeneiGga.3333.

3D structure databases

ProteinModelPortaliO42395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000035496.

Proteomic databases

PaxDbiO42395.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395731.
KEGGigga:395731.

Organism-specific databases

CTDi7555.

Phylogenomic databases

eggNOGiKOG4400. Eukaryota.
COG5082. LUCA.
HOGENOMiHOG000186262.
HOVERGENiHBG000397.
InParanoidiO42395.
KOiK09250.
PhylomeDBiO42395.

Miscellaneous databases

PROiO42395.

Family and domain databases

Gene3Di4.10.60.10. 4 hits.
InterProiIPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 7 hits.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 7 hits.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 4 hits.
PROSITEiPS50158. ZF_CCHC. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence and tissue distribution of chicken cellular nucleic acid binding protein cDNA."
    van Heumen W.R.A., Claxton C., Pickles J.O.
    Comp. Biochem. Physiol. 118B:659-665(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCNBP_CHICK
AccessioniPrimary (citable) accession number: O42395
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.