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Protein

43 kDa receptor-associated protein of the synapse

Gene

RAPSN

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri363 – 40341RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
43 kDa receptor-associated protein of the synapse
Short name:
RAPsyn
Alternative name(s):
43 kDa postsynaptic protein
Acetylcholine receptor-associated 43 kDa protein
Gene namesi
Name:RAPSN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 41241143 kDa receptor-associated protein of the synapsePRO_0000167593Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei196 – 1961PhosphotyrosineSequence Analysis

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiO42393.

Expressioni

Tissue specificityi

Expressed in muscle fibers and in neurons.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013132.

Structurei

3D structure databases

ProteinModelPortaliO42393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 3934TPR 1Add
BLAST
Repeati83 – 11634TPR 2Add
BLAST
Repeati123 – 15634TPR 3Add
BLAST
Repeati163 – 19634TPR 4Add
BLAST
Repeati206 – 23934TPR 5Add
BLAST
Repeati246 – 27934TPR 6Add
BLAST
Repeati286 – 31934TPR 7Add
BLAST

Domaini

A cysteine-rich region homologous to part of the regulatory domain of protein kinase C may be important in interactions of this protein with the lipid bilayer.

Sequence similaritiesi

Belongs to the RAPsyn family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 7 TPR repeats.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri363 – 40341RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG310031.
HOGENOMiHOG000231395.
HOVERGENiHBG061484.
InParanoidiO42393.
PhylomeDBiO42393.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
3.30.40.10. 1 hit.
InterProiIPR001237. Postsynaptic.
IPR018293. Postsynaptic_CS.
IPR019568. Rapsyn_myristoylation/link_N.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10579. Rapsyn_N. 1 hit.
PF00515. TPR_1. 2 hits.
PF13181. TPR_8. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
PRINTSiPR00217. POSTSYNAPTIC.
SMARTiSM00184. RING. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
PROSITEiPS00405. 43_KD_POSTSYNAPTIC. 1 hit.
PS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQDQTKQQI EKGLHLYQSN QTEKALQVWM RVLEKSADPA GRFRVLGCLI
60 70 80 90 100
TAHAEMGRYK DMLKFAVVQI DTARELEDPN YLTEGYLNLA RSNEKLCEFQ
110 120 130 140 150
KTISYCKTCL NMQGTTVSLQ LNGQVSLSMG NAFLGLSIFQ KALECFEKAL
160 170 180 190 200
RYAHNNDDKM LECRVCCSLG NFYAQIKDYE KALFFPCKAA ELVNDYGAGW
210 220 230 240 250
SLKYRAMSQY HMAVAYRKLG RLADAMDCCE ESMKIALQHG DRPLQALCLL
260 270 280 290 300
CFADIHLSRR DVQTAFPRYD SAMSIMTEIG NRLGQIQVLL GVAKCWMIQK
310 320 330 340 350
ELDKALESIE KAQELAEGLG NKLGLLKLHC LCERIYRTKG LQQELRDHVV
360 370 380 390 400
KFHECVEEME LYCGMCGESI GEKNNQLQAL PCSHFFHLKC LQTNGTRGCP
410
NCRRLSVKPG YV
Length:412
Mass (Da):46,808
Last modified:January 23, 2007 - v3
Checksum:i0882BB9F924202EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000138 mRNA. Translation: AAB63149.1.
RefSeqiNP_990428.1. NM_205097.1.
UniGeneiGga.6394.

Genome annotation databases

GeneIDi395986.
KEGGigga:395986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000138 mRNA. Translation: AAB63149.1.
RefSeqiNP_990428.1. NM_205097.1.
UniGeneiGga.6394.

3D structure databases

ProteinModelPortaliO42393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013132.

Proteomic databases

PaxDbiO42393.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395986.
KEGGigga:395986.

Organism-specific databases

CTDi5913.

Phylogenomic databases

eggNOGiNOG310031.
HOGENOMiHOG000231395.
HOVERGENiHBG061484.
InParanoidiO42393.
PhylomeDBiO42393.

Miscellaneous databases

NextBioi20816050.
PROiO42393.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
3.30.40.10. 1 hit.
InterProiIPR001237. Postsynaptic.
IPR018293. Postsynaptic_CS.
IPR019568. Rapsyn_myristoylation/link_N.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10579. Rapsyn_N. 1 hit.
PF00515. TPR_1. 2 hits.
PF13181. TPR_8. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
PRINTSiPR00217. POSTSYNAPTIC.
SMARTiSM00184. RING. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
PROSITEiPS00405. 43_KD_POSTSYNAPTIC. 1 hit.
PS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Chick ciliary ganglion neurons contain transcripts coding for acetylcholine receptor-associated protein at synapses (rapsyn)."
    Burns A.L., Benson D., Howard M.J., Margiotta J.F.
    J. Neurosci. 17:5016-5026(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C.

Entry informationi

Entry nameiRAPSN_CHICK
AccessioniPrimary (citable) accession number: O42393
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.