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O42393

- RAPSN_CHICK

UniProt

O42393 - RAPSN_CHICK

Protein

43 kDa receptor-associated protein of the synapse

Gene

RAPSN

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri363 – 40341RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. synaptic transmission Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    43 kDa receptor-associated protein of the synapse
    Short name:
    RAPsyn
    Alternative name(s):
    43 kDa postsynaptic protein
    Acetylcholine receptor-associated 43 kDa protein
    Gene namesi
    Name:RAPSN
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasm Source: UniProtKB-KW
    3. cytoskeleton Source: UniProtKB-SubCell
    4. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 41241143 kDa receptor-associated protein of the synapsePRO_0000167593Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity
    Modified residuei196 – 1961PhosphotyrosineSequence Analysis

    Keywords - PTMi

    Lipoprotein, Myristate, Phosphoprotein

    Proteomic databases

    PaxDbiO42393.

    Expressioni

    Tissue specificityi

    Expressed in muscle fibers and in neurons.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000013132.

    Structurei

    3D structure databases

    ProteinModelPortaliO42393.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati6 – 3934TPR 1Add
    BLAST
    Repeati83 – 11634TPR 2Add
    BLAST
    Repeati123 – 15634TPR 3Add
    BLAST
    Repeati163 – 19634TPR 4Add
    BLAST
    Repeati206 – 23934TPR 5Add
    BLAST
    Repeati246 – 27934TPR 6Add
    BLAST
    Repeati286 – 31934TPR 7Add
    BLAST

    Domaini

    A cysteine-rich region homologous to part of the regulatory domain of protein kinase C may be important in interactions of this protein with the lipid bilayer.

    Sequence similaritiesi

    Belongs to the RAPsyn family.Curated
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
    Contains 7 TPR repeats.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri363 – 40341RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, TPR repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG310031.
    HOGENOMiHOG000231395.
    HOVERGENiHBG061484.
    InParanoidiO42393.
    PhylomeDBiO42393.

    Family and domain databases

    Gene3Di1.25.40.10. 3 hits.
    3.30.40.10. 1 hit.
    InterProiIPR001237. Postsynaptic.
    IPR018293. Postsynaptic_CS.
    IPR019568. Rapsyn_myristoylation/link_N.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF10579. Rapsyn_N. 1 hit.
    PF00515. TPR_1. 2 hits.
    PF13181. TPR_8. 1 hit.
    PF13639. zf-RING_2. 1 hit.
    [Graphical view]
    PRINTSiPR00217. POSTSYNAPTIC.
    SMARTiSM00184. RING. 1 hit.
    SM00028. TPR. 6 hits.
    [Graphical view]
    PROSITEiPS00405. 43_KD_POSTSYNAPTIC. 1 hit.
    PS50005. TPR. 5 hits.
    PS50293. TPR_REGION. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O42393-1 [UniParc]FASTAAdd to Basket

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    MGQDQTKQQI EKGLHLYQSN QTEKALQVWM RVLEKSADPA GRFRVLGCLI    50
    TAHAEMGRYK DMLKFAVVQI DTARELEDPN YLTEGYLNLA RSNEKLCEFQ 100
    KTISYCKTCL NMQGTTVSLQ LNGQVSLSMG NAFLGLSIFQ KALECFEKAL 150
    RYAHNNDDKM LECRVCCSLG NFYAQIKDYE KALFFPCKAA ELVNDYGAGW 200
    SLKYRAMSQY HMAVAYRKLG RLADAMDCCE ESMKIALQHG DRPLQALCLL 250
    CFADIHLSRR DVQTAFPRYD SAMSIMTEIG NRLGQIQVLL GVAKCWMIQK 300
    ELDKALESIE KAQELAEGLG NKLGLLKLHC LCERIYRTKG LQQELRDHVV 350
    KFHECVEEME LYCGMCGESI GEKNNQLQAL PCSHFFHLKC LQTNGTRGCP 400
    NCRRLSVKPG YV 412
    Length:412
    Mass (Da):46,808
    Last modified:January 23, 2007 - v3
    Checksum:i0882BB9F924202EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000138 mRNA. Translation: AAB63149.1.
    RefSeqiNP_990428.1. NM_205097.1.
    UniGeneiGga.6394.

    Genome annotation databases

    GeneIDi395986.
    KEGGigga:395986.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000138 mRNA. Translation: AAB63149.1 .
    RefSeqi NP_990428.1. NM_205097.1.
    UniGenei Gga.6394.

    3D structure databases

    ProteinModelPortali O42393.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000013132.

    Proteomic databases

    PaxDbi O42393.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395986.
    KEGGi gga:395986.

    Organism-specific databases

    CTDi 5913.

    Phylogenomic databases

    eggNOGi NOG310031.
    HOGENOMi HOG000231395.
    HOVERGENi HBG061484.
    InParanoidi O42393.
    PhylomeDBi O42393.

    Miscellaneous databases

    NextBioi 20816050.
    PROi O42393.

    Family and domain databases

    Gene3Di 1.25.40.10. 3 hits.
    3.30.40.10. 1 hit.
    InterProi IPR001237. Postsynaptic.
    IPR018293. Postsynaptic_CS.
    IPR019568. Rapsyn_myristoylation/link_N.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF10579. Rapsyn_N. 1 hit.
    PF00515. TPR_1. 2 hits.
    PF13181. TPR_8. 1 hit.
    PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00217. POSTSYNAPTIC.
    SMARTi SM00184. RING. 1 hit.
    SM00028. TPR. 6 hits.
    [Graphical view ]
    PROSITEi PS00405. 43_KD_POSTSYNAPTIC. 1 hit.
    PS50005. TPR. 5 hits.
    PS50293. TPR_REGION. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chick ciliary ganglion neurons contain transcripts coding for acetylcholine receptor-associated protein at synapses (rapsyn)."
      Burns A.L., Benson D., Howard M.J., Margiotta J.F.
      J. Neurosci. 17:5016-5026(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C.

    Entry informationi

    Entry nameiRAPSN_CHICK
    AccessioniPrimary (citable) accession number: O42393
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 109 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3