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O42393 (RAPSN_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
43 kDa receptor-associated protein of the synapse
Short name=RAPsyn
Alternative name(s):
43 kDa postsynaptic protein
Acetylcholine receptor-associated 43 kDa protein
Gene names
Name:RAPSN
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Thought to play some role in anchoring or stabilizing the nicotinic acetylcholine receptor at synaptic sites. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin.

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction › synapse › postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm › cytoskeleton. Note: Cytoplasmic surface of postsynaptic membranes.

Tissue specificity

Expressed in muscle fibers and in neurons.

Domain

A cysteine-rich region homologous to part of the regulatory domain of protein kinase C may be important in interactions of this protein with the lipid bilayer.

Sequence similarities

Belongs to the RAPsyn family.

Contains 1 RING-type zinc finger.

Contains 7 TPR repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 41241143 kDa receptor-associated protein of the synapse
PRO_0000167593

Regions

Repeat6 – 3934TPR 1
Repeat83 – 11634TPR 2
Repeat123 – 15634TPR 3
Repeat163 – 19634TPR 4
Repeat206 – 23934TPR 5
Repeat246 – 27934TPR 6
Repeat286 – 31934TPR 7
Zinc finger363 – 40341RING-type

Amino acid modifications

Modified residue1961Phosphotyrosine Potential
Lipidation21N-myristoyl glycine By similarity

Sequences

Sequence LengthMass (Da)Tools
O42393 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 0882BB9F924202EE

FASTA41246,808
        10         20         30         40         50         60 
MGQDQTKQQI EKGLHLYQSN QTEKALQVWM RVLEKSADPA GRFRVLGCLI TAHAEMGRYK 

        70         80         90        100        110        120 
DMLKFAVVQI DTARELEDPN YLTEGYLNLA RSNEKLCEFQ KTISYCKTCL NMQGTTVSLQ 

       130        140        150        160        170        180 
LNGQVSLSMG NAFLGLSIFQ KALECFEKAL RYAHNNDDKM LECRVCCSLG NFYAQIKDYE 

       190        200        210        220        230        240 
KALFFPCKAA ELVNDYGAGW SLKYRAMSQY HMAVAYRKLG RLADAMDCCE ESMKIALQHG 

       250        260        270        280        290        300 
DRPLQALCLL CFADIHLSRR DVQTAFPRYD SAMSIMTEIG NRLGQIQVLL GVAKCWMIQK 

       310        320        330        340        350        360 
ELDKALESIE KAQELAEGLG NKLGLLKLHC LCERIYRTKG LQQELRDHVV KFHECVEEME 

       370        380        390        400        410 
LYCGMCGESI GEKNNQLQAL PCSHFFHLKC LQTNGTRGCP NCRRLSVKPG YV

« Hide

References

[1]"Chick ciliary ganglion neurons contain transcripts coding for acetylcholine receptor-associated protein at synapses (rapsyn)."
Burns A.L., Benson D., Howard M.J., Margiotta J.F.
J. Neurosci. 17:5016-5026(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF000138 mRNA. Translation: AAB63149.1.
IPIIPI00598926.
RefSeqNP_990428.1. NM_205097.1.
UniGeneGga.6394.

3D structure databases

ProteinModelPortalO42393.
ModBaseSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000013132.

Proteomic databases

PaxDbO42393.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395986.
KEGGgga:395986.

Organism-specific databases

CTD5913.

Phylogenomic databases

eggNOGNOG310031.
HOGENOMHOG000231395.
HOVERGENHBG061484.
InParanoidO42393.
OrthoDBEOG405S12.

Family and domain databases

Gene3D1.25.40.10. 3 hits.
3.30.40.10. 1 hit.
InterProIPR001237. Postsynaptic.
IPR018293. Postsynaptic_CS.
IPR019568. Rapsyn_myristoylation/link_N.
IPR001440. TPR-1.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF10579. Rapsyn_N. 1 hit.
PF00515. TPR_1. 2 hits.
PF13181. TPR_8. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
PRINTSPR00217. POSTSYNAPTIC.
SMARTSM00184. RING. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
PROSITEPS00405. 43_KD_POSTSYNAPTIC. 1 hit.
PS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
PS00518. ZF_RING_1. False negative.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816050.

Entry information

Entry nameRAPSN_CHICK
AccessionPrimary (citable) accession number: O42393
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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