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Protein

Vitamin D3 receptor

Gene

VDR

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Plays a central role in calcium homeostasis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei329Vitamin D3By similarity1
Binding sitei421Vitamin D3By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi44 – 112Nuclear receptorPROSITE-ProRule annotationAdd BLAST69
Zinc fingeri47 – 67NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri83 – 107NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • calcium ion transport Source: AgBase
  • response to vitamin D Source: AgBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin D3 receptor
Short name:
VDR
Alternative name(s):
1,25-dihydroxyvitamin D3 receptor
Nuclear receptor subfamily 1 group I member 1
Gene namesi
Name:VDR
Synonyms:NR1I1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • caveola Source: AgBase
  • nucleus Source: AgBase
  • plasma membrane Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2353.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000199331 – 451Vitamin D3 receptorAdd BLAST451

Expressioni

Tissue specificityi

Expressed in kidney and intestine.

Interactioni

Protein-protein interaction databases

BioGridi676260. 1 interactor.

Chemistry databases

BindingDBiO42392.

Structurei

3D structure databases

ProteinModelPortaliO42392.
SMRiO42392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 215HingeAdd BLAST103
Regioni216 – 451Ligand-bindingAdd BLAST236
Regioni251 – 261Vitamin D3 bindingBy similarityAdd BLAST11
Regioni270 – 288Interaction with coactivator LXXLL motifBy similarityAdd BLAST19
Regioni295 – 302Vitamin D3 bindingBy similarity8

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.By similarity

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri47 – 67NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri83 – 107NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG108655.
InParanoidiO42392.
KOiK08539.
PhylomeDBiO42392.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000324. VitD_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00350. VITAMINDR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform A (identifier: O42392-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSELRGSWDE QQQSMAYLPD ADMDTVAAST SLPDPAGDFD RNVPRICGVC
60 70 80 90 100
GDRATGFHFN AMTCEGCKGF FRRSMKRKAM FTCPFNGDCK ITKDNRRHCQ
110 120 130 140 150
ACRLKRCVDI GMMKEFILTD EEVQRKREMI LKRKEEEALK ESLKPKLSEE
160 170 180 190 200
QQKVIDTLLE AHHKTFDTTY SDFNKFRPPV RSKFSSRMAT HSSSVVSQDF
210 220 230 240 250
SSEDSNDVFG SDAFAAFPEP MEPQMFSNLD LSEESDESPS MNIELPHLPM
260 270 280 290 300
LPHLADLVSY SIQKVIGFAK MIPGFRDLTA EDQIALLKSS AIEVIMLRSN
310 320 330 340 350
QSFTMEDMSW TCGSNDFKYK VSDVTQAGHS MDLLEPLVKF QVGLKKLNLH
360 370 380 390 400
EEEHVLLMAI CILSPDRPGV QDTSLVESIQ DRLSDILQTY IRCRHPPPGS
410 420 430 440 450
RLLYAKMIQK LADLRSLNEE HSKQYRCLSF QPEHSMQLTP LVLEVFGNEI

S
Length:451
Mass (Da):51,300
Last modified:January 1, 1998 - v1
Checksum:i2078B6A6C8D8E5FC
GO
Isoform B (identifier: O42392-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: Missing.

Show »
Length:450
Mass (Da):51,213
Checksum:iED1068B077F80EE6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01877114Missing in isoform B. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011356 mRNA. Translation: AAB62579.1.
PIRiA60912.
RefSeqiNP_990429.1. NM_205098.1. [O42392-1]
UniGeneiGga.584.

Genome annotation databases

GeneIDi395988.
KEGGigga:395988.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011356 mRNA. Translation: AAB62579.1.
PIRiA60912.
RefSeqiNP_990429.1. NM_205098.1. [O42392-1]
UniGeneiGga.584.

3D structure databases

ProteinModelPortaliO42392.
SMRiO42392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676260. 1 interactor.

Chemistry databases

BindingDBiO42392.
ChEMBLiCHEMBL2353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395988.
KEGGigga:395988.

Organism-specific databases

CTDi7421.

Phylogenomic databases

HOVERGENiHBG108655.
InParanoidiO42392.
KOiK08539.
PhylomeDBiO42392.

Miscellaneous databases

PROiO42392.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000324. VitD_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00350. VITAMINDR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVDR_CHICK
AccessioniPrimary (citable) accession number: O42392
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.