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Protein

Vitamin D3 receptor

Gene

VDR

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Plays a central role in calcium homeostasis.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei329 – 3291Vitamin D3By similarity
Binding sitei421 – 4211Vitamin D3By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi44 – 11269Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri47 – 6721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri83 – 10725NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin D3 receptor
Short name:
VDR
Alternative name(s):
1,25-dihydroxyvitamin D3 receptor
Nuclear receptor subfamily 1 group I member 1
Gene namesi
Name:VDR
Synonyms:NR1I1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2353.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451Vitamin D3 receptorPRO_0000019933Add
BLAST

Expressioni

Tissue specificityi

Expressed in kidney and intestine.

Interactioni

Protein-protein interaction databases

BioGridi676260. 1 interaction.

Chemistry

BindingDBiO42392.

Structurei

3D structure databases

ProteinModelPortaliO42392.
SMRiO42392. Positions 44-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni113 – 215103HingeAdd
BLAST
Regioni216 – 451236Ligand-bindingAdd
BLAST
Regioni251 – 26111Vitamin D3 bindingBy similarityAdd
BLAST
Regioni270 – 28819Interaction with coactivator LXXLL motifBy similarityAdd
BLAST
Regioni295 – 3028Vitamin D3 bindingBy similarity

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.By similarity

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri47 – 6721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri83 – 10725NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG108655.
InParanoidiO42392.
KOiK08539.
PhylomeDBiO42392.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000324. VitD_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00350. VITAMINDR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform A (identifier: O42392-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSELRGSWDE QQQSMAYLPD ADMDTVAAST SLPDPAGDFD RNVPRICGVC
60 70 80 90 100
GDRATGFHFN AMTCEGCKGF FRRSMKRKAM FTCPFNGDCK ITKDNRRHCQ
110 120 130 140 150
ACRLKRCVDI GMMKEFILTD EEVQRKREMI LKRKEEEALK ESLKPKLSEE
160 170 180 190 200
QQKVIDTLLE AHHKTFDTTY SDFNKFRPPV RSKFSSRMAT HSSSVVSQDF
210 220 230 240 250
SSEDSNDVFG SDAFAAFPEP MEPQMFSNLD LSEESDESPS MNIELPHLPM
260 270 280 290 300
LPHLADLVSY SIQKVIGFAK MIPGFRDLTA EDQIALLKSS AIEVIMLRSN
310 320 330 340 350
QSFTMEDMSW TCGSNDFKYK VSDVTQAGHS MDLLEPLVKF QVGLKKLNLH
360 370 380 390 400
EEEHVLLMAI CILSPDRPGV QDTSLVESIQ DRLSDILQTY IRCRHPPPGS
410 420 430 440 450
RLLYAKMIQK LADLRSLNEE HSKQYRCLSF QPEHSMQLTP LVLEVFGNEI

S
Length:451
Mass (Da):51,300
Last modified:January 1, 1998 - v1
Checksum:i2078B6A6C8D8E5FC
GO
Isoform B (identifier: O42392-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: Missing.

Show »
Length:450
Mass (Da):51,213
Checksum:iED1068B077F80EE6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei14 – 141Missing in isoform B. 1 PublicationVSP_018771

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011356 mRNA. Translation: AAB62579.1.
PIRiA60912.
RefSeqiNP_990429.1. NM_205098.1. [O42392-1]
UniGeneiGga.584.

Genome annotation databases

GeneIDi395988.
KEGGigga:395988.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011356 mRNA. Translation: AAB62579.1.
PIRiA60912.
RefSeqiNP_990429.1. NM_205098.1. [O42392-1]
UniGeneiGga.584.

3D structure databases

ProteinModelPortaliO42392.
SMRiO42392. Positions 44-447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676260. 1 interaction.

Chemistry

BindingDBiO42392.
ChEMBLiCHEMBL2353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395988.
KEGGigga:395988.

Organism-specific databases

CTDi7421.

Phylogenomic databases

HOVERGENiHBG108655.
InParanoidiO42392.
KOiK08539.
PhylomeDBiO42392.

Miscellaneous databases

PROiO42392.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000324. VitD_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00350. VITAMINDR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVDR_CHICK
AccessioniPrimary (citable) accession number: O42392
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.