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Submitted name:

Ubiquitin-60S ribosomal protein L40



Gallus gallus (Chicken)
Unreviewed-Annotation score: -Experimental evidence at transcript leveli


GO - Molecular functioni

GO - Biological processi


Molecular functionRibonucleoprotein, Ribosomal proteinImported

Enzyme and pathway databases

ReactomeiR-GGA-110312. Translesion synthesis by REV1.
R-GGA-110314. Recognition of DNA damage by PCNA-containing replication complex.
R-GGA-110320. Translesion Synthesis by POLH.
R-GGA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-GGA-1253288. Downregulation of ERBB4 signaling.
R-GGA-1295596. Spry regulation of FGF signaling.
R-GGA-1358803. Downregulation of ERBB2:ERBB3 signaling.
R-GGA-168638. NOD1/2 Signaling Pathway.
R-GGA-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-GGA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-GGA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-GGA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-GGA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-GGA-179409. APC-Cdc20 mediated degradation of Nek2A.
R-GGA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-GGA-182971. EGFR downregulation.
R-GGA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-GGA-195253. Degradation of beta-catenin by the destruction complex.
R-GGA-201681. TCF dependent signaling in response to WNT.
R-GGA-202424. Downstream TCR signaling.
R-GGA-209543. p75NTR recruits signalling complexes.
R-GGA-209560. NF-kB is activated and signals survival.
R-GGA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-GGA-2173788. Downregulation of TGF-beta receptor signaling.
R-GGA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-GGA-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-GGA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-GGA-2467813. Separation of Sister Chromatids.
R-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-GGA-2672351. Stimuli-sensing channels.
R-GGA-2871837. FCERI mediated NF-kB activation.
R-GGA-3134975. Regulation of innate immune responses to cytosolic DNA.
R-GGA-3322077. Glycogen synthesis.
R-GGA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-GGA-3769402. Deactivation of the beta-catenin transactivating complex.
R-GGA-382556. ABC-family proteins mediated transport.
R-GGA-450302. activated TAK1 mediates p38 MAPK activation.
R-GGA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-GGA-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-GGA-4641257. Degradation of AXIN.
R-GGA-4641258. Degradation of DVL.
R-GGA-4641263. Regulation of FZD by ubiquitination.
R-GGA-5205685. Pink/Parkin Mediated Mitophagy.
R-GGA-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-GGA-5357905. Regulation of TNFR1 signaling.
R-GGA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-GGA-5358346. Hedgehog ligand biogenesis.
R-GGA-5607764. CLEC7A (Dectin-1) signaling.
R-GGA-5610780. Degradation of GLI1 by the proteasome.
R-GGA-5610785. GLI3 is processed to GLI3R by the proteasome.
R-GGA-5632684. Hedgehog 'on' state.
R-GGA-5654726. Negative regulation of FGFR1 signaling.
R-GGA-5654727. Negative regulation of FGFR2 signaling.
R-GGA-5654732. Negative regulation of FGFR3 signaling.
R-GGA-5654733. Negative regulation of FGFR4 signaling.
R-GGA-5655862. Translesion synthesis by POLK.
R-GGA-5656121. Translesion synthesis by POLI.
R-GGA-5656169. Termination of translesion DNA synthesis.
R-GGA-5668541. TNFR2 non-canonical NF-kB pathway.
R-GGA-5675221. Negative regulation of MAPK pathway.
R-GGA-5675482. Regulation of necroptotic cell death.
R-GGA-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-GGA-5685942. HDR through Homologous Recombination (HRR).
R-GGA-5687128. MAPK6/MAPK4 signaling.
R-GGA-5689603. UCH proteinases.
R-GGA-5689877. Josephin domain DUBs.
R-GGA-5689880. Ub-specific processing proteases.
R-GGA-5689896. Ovarian tumor domain proteases.
R-GGA-5689901. Metalloprotease DUBs.
R-GGA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-GGA-5696394. DNA Damage Recognition in GG-NER.
R-GGA-5696395. Formation of Incision Complex in GG-NER.
R-GGA-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER.
R-GGA-5696400. Dual Incision in GG-NER.
R-GGA-6781823. Formation of TC-NER Pre-Incision Complex.
R-GGA-6782135. Dual incision in TC-NER.
R-GGA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-GGA-6783310. Fanconi Anemia Pathway.
R-GGA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-GGA-6804757. Regulation of TP53 Degradation.
R-GGA-6804760. Regulation of TP53 Activity through Methylation.
R-GGA-6807004. Negative regulation of MET activity.
R-GGA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-GGA-68949. Orc1 removal from chromatin.
R-GGA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-GGA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-GGA-69231. Cyclin D associated events in G1.
R-GGA-69298. Association of licensing factors with the pre-replicative complex.
R-GGA-69541. Stabilization of p53.
R-GGA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-GGA-72689. Formation of a pool of free 40S subunits.
R-GGA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-GGA-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
R-GGA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-GGA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-GGA-8856828. Clathrin-mediated endocytosis.
R-GGA-8863795. Downregulation of ERBB2 signaling.
R-GGA-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
R-GGA-8866654. E3 ubiquitin ligases ubiquitinate target proteins.
R-GGA-8939236. RUNX1 regulates transcription of genes involved in differentiation of HSCs.
R-GGA-8939902. Regulation of RUNX2 expression and activity.
R-GGA-8941858. Regulation of RUNX3 expression and activity.
R-GGA-8948747. Regulation of PTEN localization.
R-GGA-8948751. Regulation of PTEN stability and activity.
R-GGA-8951664. Neddylation.
R-GGA-901032. ER Quality Control Compartment (ERQC).
R-GGA-9010553. Regulation of expression of SLITs and ROBOs.
R-GGA-9020702. Interleukin-1 signaling.
R-GGA-912631. Regulation of signaling by CBL.
R-GGA-917729. Endosomal Sorting Complex Required For Transport (ESCRT).
R-GGA-917937. Iron uptake and transport.
R-GGA-936964. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
R-GGA-937041. IKK complex recruitment mediated by RIP1.
R-GGA-937042. IRAK2 mediated activation of TAK1 complex.
R-GGA-937072. TRAF6-mediated induction of TAK1 complex within TLR4 complex.
R-GGA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-GGA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
R-GGA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-GGA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
R-GGA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin-60S ribosomal protein L40Imported
Submitted name:
Ubiquitin-ribosomal protein fusion proteinImported
Gene namesi
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
  • UP000000539 Componenti: Chromosome 28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases


Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76Ubiquitin-likeInterPro annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
COG5272. LUCA.

Family and domain databases

Gene3Di2.20.28.70. 1 hit.
InterProiView protein in InterPro
IPR038587. L40e_sf.
IPR001975. Ribosomal_L40e.
IPR019956. Ubiquitin.
IPR029071. Ubiquitin-like_domsf.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF01020. Ribosomal_L40e. 1 hit.
PF00240. ubiquitin. 1 hit.
SMARTiView protein in SMART
SM01377. Ribosomal_L40e. 1 hit.
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.


Sequence statusi: Complete.

O42388-1 [UniParc]FASTAAdd to basket

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60 70 80 90 100
110 120
Mass (Da):14,739
Last modified:January 1, 1998 - v1

Sequence databases

Select the link destinations:
Links Updated
AADN04000369 Genomic DNA. No translation available.
Z29958 mRNA. Translation: CAA82846.1.
RefSeqiNP_990406.1. NM_205075.1.

Genome annotation databases

EnsembliENSGALT00000046741; ENSGALP00000053207; ENSGALG00000037716.

Similar proteinsi

Entry informationi

Entry nameiO42388_CHICK
AccessioniPrimary (citable) accession number: O42388
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)


Keywords - Technical termi

Complete proteome, Reference proteomeImported