UniProtKB - O42388 (O42388_CHICK)
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Protein
Submitted name:
Ubiquitin-60S ribosomal protein L40
Gene
UBA52
Organism
Gallus gallus (Chicken)
Status
Functioni
GO - Molecular functioni
- structural constituent of ribosome Source: InterPro
GO - Biological processi
- translation Source: InterPro
Keywordsi
| Molecular function | Ribonucleoprotein, Ribosomal proteinImported |
Enzyme and pathway databases
| Reactomei | R-GGA-110312 Translesion synthesis by REV1 R-GGA-110314 Recognition of DNA damage by PCNA-containing replication complex R-GGA-110320 Translesion Synthesis by POLH R-GGA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-GGA-1253288 Downregulation of ERBB4 signaling R-GGA-1295596 Spry regulation of FGF signaling R-GGA-1358803 Downregulation of ERBB2:ERBB3 signaling R-GGA-168638 NOD1/2 Signaling Pathway R-GGA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-GGA-174084 Autodegradation of Cdh1 by Cdh1:APC/C R-GGA-174154 APC/C:Cdc20 mediated degradation of Securin R-GGA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-GGA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-GGA-179409 APC-Cdc20 mediated degradation of Nek2A R-GGA-1799339 SRP-dependent cotranslational protein targeting to membrane R-GGA-182971 EGFR downregulation R-GGA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-GGA-195253 Degradation of beta-catenin by the destruction complex R-GGA-201681 TCF dependent signaling in response to WNT R-GGA-209543 p75NTR recruits signalling complexes R-GGA-209560 NF-kB is activated and signals survival R-GGA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus R-GGA-2173788 Downregulation of TGF-beta receptor signaling R-GGA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-GGA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-GGA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-GGA-2467813 Separation of Sister Chromatids R-GGA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-GGA-2672351 Stimuli-sensing channels R-GGA-3134975 Regulation of innate immune responses to cytosolic DNA R-GGA-3322077 Glycogen synthesis R-GGA-349425 Autodegradation of the E3 ubiquitin ligase COP1 R-GGA-3769402 Deactivation of the beta-catenin transactivating complex R-GGA-382556 ABC-family proteins mediated transport R-GGA-450302 activated TAK1 mediates p38 MAPK activation R-GGA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-GGA-4641257 Degradation of AXIN R-GGA-4641258 Degradation of DVL R-GGA-4641263 Regulation of FZD by ubiquitination R-GGA-5205685 Pink/Parkin Mediated Mitophagy R-GGA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-GGA-5357905 Regulation of TNFR1 signaling R-GGA-5357956 TNFR1-induced NFkappaB signaling pathway R-GGA-5358346 Hedgehog ligand biogenesis R-GGA-5610780 Degradation of GLI1 by the proteasome R-GGA-5610785 GLI3 is processed to GLI3R by the proteasome R-GGA-5632684 Hedgehog 'on' state R-GGA-5654726 Negative regulation of FGFR1 signaling R-GGA-5654727 Negative regulation of FGFR2 signaling R-GGA-5654732 Negative regulation of FGFR3 signaling R-GGA-5654733 Negative regulation of FGFR4 signaling R-GGA-5655862 Translesion synthesis by POLK R-GGA-5656121 Translesion synthesis by POLI R-GGA-5656169 Termination of translesion DNA synthesis R-GGA-5668541 TNFR2 non-canonical NF-kB pathway R-GGA-5675221 Negative regulation of MAPK pathway R-GGA-5675482 Regulation of necroptotic cell death R-GGA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation R-GGA-5685942 HDR through Homologous Recombination (HRR) R-GGA-5687128 MAPK6/MAPK4 signaling R-GGA-5689603 UCH proteinases R-GGA-5689877 Josephin domain DUBs R-GGA-5689880 Ub-specific processing proteases R-GGA-5689896 Ovarian tumor domain proteases R-GGA-5689901 Metalloprotease DUBs R-GGA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-GGA-5696394 DNA Damage Recognition in GG-NER R-GGA-5696395 Formation of Incision Complex in GG-NER R-GGA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER R-GGA-5696400 Dual Incision in GG-NER R-GGA-6781823 Formation of TC-NER Pre-Incision Complex R-GGA-6782135 Dual incision in TC-NER R-GGA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER R-GGA-6783310 Fanconi Anemia Pathway R-GGA-6804756 Regulation of TP53 Activity through Phosphorylation R-GGA-6804757 Regulation of TP53 Degradation R-GGA-6804760 Regulation of TP53 Activity through Methylation R-GGA-6807004 Negative regulation of MET activity R-GGA-68827 CDT1 association with the CDC6:ORC:origin complex R-GGA-68949 Orc1 removal from chromatin R-GGA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-GGA-69229 Ubiquitin-dependent degradation of Cyclin D1 R-GGA-69231 Cyclin D associated events in G1 R-GGA-69541 Stabilization of p53 R-GGA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-GGA-72689 Formation of a pool of free 40S subunits R-GGA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-GGA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-GGA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-GGA-8856825 Cargo recognition for clathrin-mediated endocytosis R-GGA-8856828 Clathrin-mediated endocytosis R-GGA-8863795 Downregulation of ERBB2 signaling R-GGA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-GGA-8866654 E3 ubiquitin ligases ubiquitinate target proteins R-GGA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-GGA-8939902 Regulation of RUNX2 expression and activity R-GGA-8941858 Regulation of RUNX3 expression and activity R-GGA-8948747 Regulation of PTEN localization R-GGA-8948751 Regulation of PTEN stability and activity R-GGA-8951664 Neddylation R-GGA-901032 ER Quality Control Compartment (ERQC) R-GGA-9010553 Regulation of expression of SLITs and ROBOs R-GGA-9020702 Interleukin-1 signaling R-GGA-9033241 Peroxisomal protein import R-GGA-912631 Regulation of signaling by CBL R-GGA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) R-GGA-917937 Iron uptake and transport R-GGA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-GGA-937041 IKK complex recruitment mediated by RIP1 R-GGA-937042 IRAK2 mediated activation of TAK1 complex R-GGA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex R-GGA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-GGA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-GGA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-GGA-983168 Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
| Protein namesi | Submitted name: Ubiquitin-60S ribosomal protein L40ImportedSubmitted name: Ubiquitin-ribosomal protein fusion proteinImported |
| Gene namesi | Name:UBA52Imported |
| Organismi | Gallus gallus (Chicken)Imported |
| Taxonomic identifieri | 9031 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
| Proteomesi |
|
Subcellular locationi
Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Domaini | 1 – 76 | Ubiquitin-likeInterPro annotationAdd BLAST | 76 |
Phylogenomic databases
| eggNOGi | KOG0001 Eukaryota COG5272 LUCA |
| GeneTreei | ENSGT00910000144104 |
| HOVERGENi | HBG052927 |
| KOi | K02927 |
Family and domain databases
| Gene3Di | 2.20.28.70, 1 hit |
| InterProi | View protein in InterPro IPR038587 L40e_sf IPR001975 Ribosomal_L40e IPR019956 Ubiquitin IPR029071 Ubiquitin-like_domsf IPR019954 Ubiquitin_CS IPR000626 Ubiquitin_dom |
| Pfami | View protein in Pfam PF01020 Ribosomal_L40e, 1 hit PF00240 ubiquitin, 1 hit |
| PRINTSi | PR00348 UBIQUITIN |
| SMARTi | View protein in SMART SM01377 Ribosomal_L40e, 1 hit SM00213 UBQ, 1 hit |
| SUPFAMi | SSF54236 SSF54236, 1 hit |
| PROSITEi | View protein in PROSITE PS00299 UBIQUITIN_1, 1 hit PS50053 UBIQUITIN_2, 1 hit |
Sequencei
Sequence statusi: Complete.
O42388-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQIFVKTLTG KTITLEVEPN DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL
60 70 80 90 100
EDGRTLADYN IQKESTLHLV LRLRGGIIEP SLRQLAQKYN CDKMICRKCY
110 120
ARLHPRAVNC RKKKCGHTNN LRPKKKVK
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN04000369 Genomic DNA No translation available. Z29958 mRNA Translation: CAA82846.1 |
| PIRi | S01884 |
| RefSeqi | NP_990406.1, NM_205075.1 |
| UniGenei | Gga.569 |
Genome annotation databases
| Ensembli | ENSGALT00000046741; ENSGALP00000053207; ENSGALG00000037716 |
| GeneIDi | 395958 |
| KEGGi | gga:395958 |
Similar proteinsi
Entry informationi
| Entry namei | O42388_CHICK | |
| Accessioni | O42388Primary (citable) accession number: O42388 | |
| Entry historyi | Integrated into UniProtKB/TrEMBL: | January 1, 1998 |
| Last sequence update: | January 1, 1998 | |
| Last modified: | May 23, 2018 | |
| This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
