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Submitted name:

Ubiquitin-60S ribosomal protein L40



Gallus gallus (Chicken)
Unreviewed-Annotation score: -Experimental evidence at transcript leveli


GO - Molecular functioni

GO - Biological processi


Molecular functionRibonucleoprotein, Ribosomal proteinImported

Enzyme and pathway databases

ReactomeiR-GGA-110312 Translesion synthesis by REV1
R-GGA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-GGA-110320 Translesion Synthesis by POLH
R-GGA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-GGA-1253288 Downregulation of ERBB4 signaling
R-GGA-1295596 Spry regulation of FGF signaling
R-GGA-1358803 Downregulation of ERBB2:ERBB3 signaling
R-GGA-168638 NOD1/2 Signaling Pathway
R-GGA-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-GGA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-GGA-174154 APC/C:Cdc20 mediated degradation of Securin
R-GGA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-GGA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-GGA-179409 APC-Cdc20 mediated degradation of Nek2A
R-GGA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-GGA-182971 EGFR downregulation
R-GGA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-GGA-195253 Degradation of beta-catenin by the destruction complex
R-GGA-201681 TCF dependent signaling in response to WNT
R-GGA-209543 p75NTR recruits signalling complexes
R-GGA-209560 NF-kB is activated and signals survival
R-GGA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-GGA-2173788 Downregulation of TGF-beta receptor signaling
R-GGA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-GGA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-GGA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-GGA-2467813 Separation of Sister Chromatids
R-GGA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-GGA-2672351 Stimuli-sensing channels
R-GGA-3134975 Regulation of innate immune responses to cytosolic DNA
R-GGA-3322077 Glycogen synthesis
R-GGA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-GGA-3769402 Deactivation of the beta-catenin transactivating complex
R-GGA-382556 ABC-family proteins mediated transport
R-GGA-450302 activated TAK1 mediates p38 MAPK activation
R-GGA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-GGA-4641257 Degradation of AXIN
R-GGA-4641258 Degradation of DVL
R-GGA-4641263 Regulation of FZD by ubiquitination
R-GGA-5205685 Pink/Parkin Mediated Mitophagy
R-GGA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-GGA-5357905 Regulation of TNFR1 signaling
R-GGA-5357956 TNFR1-induced NFkappaB signaling pathway
R-GGA-5358346 Hedgehog ligand biogenesis
R-GGA-5610780 Degradation of GLI1 by the proteasome
R-GGA-5610785 GLI3 is processed to GLI3R by the proteasome
R-GGA-5632684 Hedgehog 'on' state
R-GGA-5654726 Negative regulation of FGFR1 signaling
R-GGA-5654727 Negative regulation of FGFR2 signaling
R-GGA-5654732 Negative regulation of FGFR3 signaling
R-GGA-5654733 Negative regulation of FGFR4 signaling
R-GGA-5655862 Translesion synthesis by POLK
R-GGA-5656121 Translesion synthesis by POLI
R-GGA-5656169 Termination of translesion DNA synthesis
R-GGA-5668541 TNFR2 non-canonical NF-kB pathway
R-GGA-5675221 Negative regulation of MAPK pathway
R-GGA-5675482 Regulation of necroptotic cell death
R-GGA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-GGA-5685942 HDR through Homologous Recombination (HRR)
R-GGA-5687128 MAPK6/MAPK4 signaling
R-GGA-5689603 UCH proteinases
R-GGA-5689877 Josephin domain DUBs
R-GGA-5689880 Ub-specific processing proteases
R-GGA-5689896 Ovarian tumor domain proteases
R-GGA-5689901 Metalloprotease DUBs
R-GGA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-GGA-5696394 DNA Damage Recognition in GG-NER
R-GGA-5696395 Formation of Incision Complex in GG-NER
R-GGA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-GGA-5696400 Dual Incision in GG-NER
R-GGA-6781823 Formation of TC-NER Pre-Incision Complex
R-GGA-6782135 Dual incision in TC-NER
R-GGA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-GGA-6783310 Fanconi Anemia Pathway
R-GGA-6804756 Regulation of TP53 Activity through Phosphorylation
R-GGA-6804757 Regulation of TP53 Degradation
R-GGA-6804760 Regulation of TP53 Activity through Methylation
R-GGA-6807004 Negative regulation of MET activity
R-GGA-68827 CDT1 association with the CDC6:ORC:origin complex
R-GGA-68949 Orc1 removal from chromatin
R-GGA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-GGA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-GGA-69231 Cyclin D associated events in G1
R-GGA-69541 Stabilization of p53
R-GGA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-GGA-72689 Formation of a pool of free 40S subunits
R-GGA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-GGA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-GGA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-GGA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-GGA-8856828 Clathrin-mediated endocytosis
R-GGA-8863795 Downregulation of ERBB2 signaling
R-GGA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-GGA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-GGA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-GGA-8939902 Regulation of RUNX2 expression and activity
R-GGA-8941858 Regulation of RUNX3 expression and activity
R-GGA-8948747 Regulation of PTEN localization
R-GGA-8948751 Regulation of PTEN stability and activity
R-GGA-8951664 Neddylation
R-GGA-901032 ER Quality Control Compartment (ERQC)
R-GGA-9010553 Regulation of expression of SLITs and ROBOs
R-GGA-9020702 Interleukin-1 signaling
R-GGA-9033241 Peroxisomal protein import
R-GGA-912631 Regulation of signaling by CBL
R-GGA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
R-GGA-917937 Iron uptake and transport
R-GGA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-GGA-937041 IKK complex recruitment mediated by RIP1
R-GGA-937042 IRAK2 mediated activation of TAK1 complex
R-GGA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-GGA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-GGA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-GGA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-GGA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin-60S ribosomal protein L40Imported
Submitted name:
Ubiquitin-ribosomal protein fusion proteinImported
Gene namesi
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
  • UP000000539 Componenti: Chromosome 28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76Ubiquitin-likeInterPro annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG0001 Eukaryota

Family and domain databases

Gene3Di2.20.28.70, 1 hit
InterProiView protein in InterPro
IPR038587 L40e_sf
IPR001975 Ribosomal_L40e
IPR019956 Ubiquitin
IPR029071 Ubiquitin-like_domsf
IPR019954 Ubiquitin_CS
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF01020 Ribosomal_L40e, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM01377 Ribosomal_L40e, 1 hit
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00299 UBIQUITIN_1, 1 hit
PS50053 UBIQUITIN_2, 1 hit


Sequence statusi: Complete.

O42388-1 [UniParc]FASTAAdd to basket

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Mass (Da):14,739
Last modified:January 1, 1998 - v1

Sequence databases

Select the link destinations:
Links Updated
AADN04000369 Genomic DNA No translation available.
Z29958 mRNA Translation: CAA82846.1
RefSeqiNP_990406.1, NM_205075.1

Genome annotation databases

EnsembliENSGALT00000046741; ENSGALP00000053207; ENSGALG00000037716

Similar proteinsi

Entry informationi

Entry nameiO42388_CHICK
AccessioniPrimary (citable) accession number: O42388
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)


Keywords - Technical termi

Complete proteome, Reference proteomeImported

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