UniProtKB - O42388 (O42388_CHICK)
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Protein
Submitted name:
Ubiquitin-60S ribosomal protein L40
Gene
UBA52
Organism
Gallus gallus (Chicken)
Status
Functioni
GO - Molecular functioni
- structural constituent of ribosome Source: InterPro
GO - Biological processi
- translation Source: InterPro
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal proteinImported |
Enzyme and pathway databases
Reactomei | R-GGA-110312. Translesion synthesis by REV1. R-GGA-110314. Recognition of DNA damage by PCNA-containing replication complex. R-GGA-110320. Translesion Synthesis by POLH. R-GGA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha. R-GGA-1253288. Downregulation of ERBB4 signaling. R-GGA-1295596. Spry regulation of FGF signaling. R-GGA-1358803. Downregulation of ERBB2:ERBB3 signaling. R-GGA-168638. NOD1/2 Signaling Pathway. R-GGA-174048. APC/C:Cdc20 mediated degradation of Cyclin B. R-GGA-174084. Autodegradation of Cdh1 by Cdh1:APC/C. R-GGA-174154. APC/C:Cdc20 mediated degradation of Securin. R-GGA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1. R-GGA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. R-GGA-179409. APC-Cdc20 mediated degradation of Nek2A. R-GGA-1799339. SRP-dependent cotranslational protein targeting to membrane. R-GGA-182971. EGFR downregulation. R-GGA-187577. SCF(Skp2)-mediated degradation of p27/p21. R-GGA-195253. Degradation of beta-catenin by the destruction complex. R-GGA-201681. TCF dependent signaling in response to WNT. R-GGA-202424. Downstream TCR signaling. R-GGA-209543. p75NTR recruits signalling complexes. R-GGA-209560. NF-kB is activated and signals survival. R-GGA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus. R-GGA-2173788. Downregulation of TGF-beta receptor signaling. R-GGA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition). R-GGA-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity. R-GGA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription. R-GGA-2467813. Separation of Sister Chromatids. R-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP). R-GGA-2672351. Stimuli-sensing channels. R-GGA-2871837. FCERI mediated NF-kB activation. R-GGA-3134975. Regulation of innate immune responses to cytosolic DNA. R-GGA-3322077. Glycogen synthesis. R-GGA-349425. Autodegradation of the E3 ubiquitin ligase COP1. R-GGA-3769402. Deactivation of the beta-catenin transactivating complex. R-GGA-382556. ABC-family proteins mediated transport. R-GGA-450302. activated TAK1 mediates p38 MAPK activation. R-GGA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1. R-GGA-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA. R-GGA-4641257. Degradation of AXIN. R-GGA-4641258. Degradation of DVL. R-GGA-4641263. Regulation of FZD by ubiquitination. R-GGA-5205685. Pink/Parkin Mediated Mitophagy. R-GGA-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle. R-GGA-5357905. Regulation of TNFR1 signaling. R-GGA-5357956. TNFR1-induced NFkappaB signaling pathway. R-GGA-5358346. Hedgehog ligand biogenesis. R-GGA-5607764. CLEC7A (Dectin-1) signaling. R-GGA-5610780. Degradation of GLI1 by the proteasome. R-GGA-5610785. GLI3 is processed to GLI3R by the proteasome. R-GGA-5632684. Hedgehog 'on' state. R-GGA-5654726. Negative regulation of FGFR1 signaling. R-GGA-5654727. Negative regulation of FGFR2 signaling. R-GGA-5654732. Negative regulation of FGFR3 signaling. R-GGA-5654733. Negative regulation of FGFR4 signaling. R-GGA-5655862. Translesion synthesis by POLK. R-GGA-5656121. Translesion synthesis by POLI. R-GGA-5656169. Termination of translesion DNA synthesis. R-GGA-5668541. TNFR2 non-canonical NF-kB pathway. R-GGA-5675221. Negative regulation of MAPK pathway. R-GGA-5675482. Regulation of necroptotic cell death. R-GGA-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation. R-GGA-5685942. HDR through Homologous Recombination (HRR). R-GGA-5687128. MAPK6/MAPK4 signaling. R-GGA-5689603. UCH proteinases. R-GGA-5689877. Josephin domain DUBs. R-GGA-5689880. Ub-specific processing proteases. R-GGA-5689896. Ovarian tumor domain proteases. R-GGA-5689901. Metalloprotease DUBs. R-GGA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks. R-GGA-5696394. DNA Damage Recognition in GG-NER. R-GGA-5696395. Formation of Incision Complex in GG-NER. R-GGA-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER. R-GGA-5696400. Dual Incision in GG-NER. R-GGA-6781823. Formation of TC-NER Pre-Incision Complex. R-GGA-6782135. Dual incision in TC-NER. R-GGA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER. R-GGA-6783310. Fanconi Anemia Pathway. R-GGA-6804756. Regulation of TP53 Activity through Phosphorylation. R-GGA-6804757. Regulation of TP53 Degradation. R-GGA-6804760. Regulation of TP53 Activity through Methylation. R-GGA-6807004. Negative regulation of MET activity. R-GGA-68827. CDT1 association with the CDC6:ORC:origin complex. R-GGA-68949. Orc1 removal from chromatin. R-GGA-69017. CDK-mediated phosphorylation and removal of Cdc6. R-GGA-69229. Ubiquitin-dependent degradation of Cyclin D1. R-GGA-69231. Cyclin D associated events in G1. R-GGA-69298. Association of licensing factors with the pre-replicative complex. R-GGA-69541. Stabilization of p53. R-GGA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A. R-GGA-72689. Formation of a pool of free 40S subunits. R-GGA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit. R-GGA-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1. R-GGA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis. R-GGA-8856825. Cargo recognition for clathrin-mediated endocytosis. R-GGA-8856828. Clathrin-mediated endocytosis. R-GGA-8863795. Downregulation of ERBB2 signaling. R-GGA-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes. R-GGA-8866654. E3 ubiquitin ligases ubiquitinate target proteins. R-GGA-8939236. RUNX1 regulates transcription of genes involved in differentiation of HSCs. R-GGA-8939902. Regulation of RUNX2 expression and activity. R-GGA-8941858. Regulation of RUNX3 expression and activity. R-GGA-8948747. Regulation of PTEN localization. R-GGA-8948751. Regulation of PTEN stability and activity. R-GGA-8951664. Neddylation. R-GGA-901032. ER Quality Control Compartment (ERQC). R-GGA-9010553. Regulation of expression of SLITs and ROBOs. R-GGA-9020702. Interleukin-1 signaling. R-GGA-912631. Regulation of signaling by CBL. R-GGA-917729. Endosomal Sorting Complex Required For Transport (ESCRT). R-GGA-917937. Iron uptake and transport. R-GGA-936964. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon. R-GGA-937041. IKK complex recruitment mediated by RIP1. R-GGA-937042. IRAK2 mediated activation of TAK1 complex. R-GGA-937072. TRAF6-mediated induction of TAK1 complex within TLR4 complex. R-GGA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling. R-GGA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation. R-GGA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC). R-GGA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC). R-GGA-983168. Antigen processing: Ubiquitination & Proteasome degradation. |
Names & Taxonomyi
Protein namesi | Submitted name: Ubiquitin-60S ribosomal protein L40ImportedSubmitted name: Ubiquitin-ribosomal protein fusion proteinImported |
Gene namesi | Name:UBA52Imported |
Organismi | Gallus gallus (Chicken)Imported |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 76 | Ubiquitin-likeInterPro annotationAdd BLAST | 76 |
Phylogenomic databases
eggNOGi | KOG0001. Eukaryota. COG5272. LUCA. |
GeneTreei | ENSGT00910000144104. |
HOVERGENi | HBG052927. |
KOi | K02927. |
Family and domain databases
Gene3Di | 2.20.28.70. 1 hit. |
InterProi | View protein in InterPro IPR038587. L40e_sf. IPR001975. Ribosomal_L40e. IPR019956. Ubiquitin. IPR029071. Ubiquitin-like_domsf. IPR019954. Ubiquitin_CS. IPR000626. Ubiquitin_dom. |
Pfami | View protein in Pfam PF01020. Ribosomal_L40e. 1 hit. PF00240. ubiquitin. 1 hit. |
PRINTSi | PR00348. UBIQUITIN. |
SMARTi | View protein in SMART SM01377. Ribosomal_L40e. 1 hit. SM00213. UBQ. 1 hit. |
SUPFAMi | SSF54236. SSF54236. 1 hit. |
PROSITEi | View protein in PROSITE PS00299. UBIQUITIN_1. 1 hit. PS50053. UBIQUITIN_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
O42388-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQIFVKTLTG KTITLEVEPN DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL
60 70 80 90 100
EDGRTLADYN IQKESTLHLV LRLRGGIIEP SLRQLAQKYN CDKMICRKCY
110 120
ARLHPRAVNC RKKKCGHTNN LRPKKKVK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN04000369 Genomic DNA. No translation available. Z29958 mRNA. Translation: CAA82846.1. |
PIRi | S01884. |
RefSeqi | NP_990406.1. NM_205075.1. |
UniGenei | Gga.569. |
Genome annotation databases
Ensembli | ENSGALT00000046741; ENSGALP00000053207; ENSGALG00000037716. |
GeneIDi | 395958. |
KEGGi | gga:395958. |
Similar proteinsi
Entry informationi
Entry namei | O42388_CHICK | |
Accessioni | O42388Primary (citable) accession number: O42388 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 1, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | March 28, 2018 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |