UBA52

Functionⁱ

GO - Molecular functionⁱ

structural constituent of ribosome Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

translation Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal proteinImported

Molecular function

Ribonucleoprotein, Ribosomal proteinImported

Enzyme and pathway databases

Reactomeⁱ	R-GGA-110312. Translesion synthesis by REV1. R-GGA-110320. Translesion Synthesis by POLH. R-GGA-1169091. Activation of NF-kappaB in B cells. R-GGA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha. R-GGA-1253288. Downregulation of ERBB4 signaling. R-GGA-1295596. Spry regulation of FGF signaling. R-GGA-1358803. Downregulation of ERBB2:ERBB3 signaling. R-GGA-168638. NOD1/2 Signaling Pathway. R-GGA-174048. APC/C:Cdc20 mediated degradation of Cyclin B. R-GGA-174084. Autodegradation of Cdh1 by Cdh1:APC/C. R-GGA-174113. SCF-beta-TrCP mediated degradation of Emi1. R-GGA-174154. APC/C:Cdc20 mediated degradation of Securin. R-GGA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1. R-GGA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. R-GGA-179409. APC-Cdc20 mediated degradation of Nek2A. R-GGA-1799339. SRP-dependent cotranslational protein targeting to membrane. R-GGA-182971. EGFR downregulation. R-GGA-187577. SCF(Skp2)-mediated degradation of p27/p21. R-GGA-195253. Degradation of beta-catenin by the destruction complex. R-GGA-201681. TCF dependent signaling in response to WNT. R-GGA-202424. Downstream TCR signaling. R-GGA-209543. p75NTR recruits signalling complexes. R-GGA-209560. NF-kB is activated and signals survival. R-GGA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus. R-GGA-2173788. Downregulation of TGF-beta receptor signaling. R-GGA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition). R-GGA-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity. R-GGA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription. R-GGA-2467813. Separation of Sister Chromatids. R-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP). R-GGA-2565942. Regulation of PLK1 Activity at G2/M Transition. R-GGA-2672351. Stimuli-sensing channels. R-GGA-2871837. FCERI mediated NF-kB activation. R-GGA-3134975. Regulation of innate immune responses to cytosolic DNA. R-GGA-3322077. Glycogen synthesis. R-GGA-349425. Autodegradation of the E3 ubiquitin ligase COP1. R-GGA-3769402. Deactivation of the beta-catenin transactivating complex. R-GGA-382556. ABC-family proteins mediated transport. R-GGA-446652. Interleukin-1 signaling. R-GGA-450302. activated TAK1 mediates p38 MAPK activation. R-GGA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1. R-GGA-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA. R-GGA-4641257. Degradation of AXIN. R-GGA-4641258. Degradation of DVL. R-GGA-4641263. Regulation of FZD by ubiquitination. R-GGA-5205685. Pink/Parkin Mediated Mitophagy. R-GGA-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle. R-GGA-5357905. Regulation of TNFR1 signaling. R-GGA-5357956. TNFR1-induced NFkappaB signaling pathway. R-GGA-5358346. Hedgehog ligand biogenesis. R-GGA-5607764. CLEC7A (Dectin-1) signaling. R-GGA-5610780. Degradation of GLI1 by the proteasome. R-GGA-5610785. GLI3 is processed to GLI3R by the proteasome. R-GGA-5632684. Hedgehog 'on' state. R-GGA-5654726. Negative regulation of FGFR1 signaling. R-GGA-5654727. Negative regulation of FGFR2 signaling. R-GGA-5654732. Negative regulation of FGFR3 signaling. R-GGA-5654733. Negative regulation of FGFR4 signaling. R-GGA-5655862. Translesion synthesis by POLK. R-GGA-5656121. Translesion synthesis by POLI. R-GGA-5656169. Termination of translesion DNA synthesis. R-GGA-5668541. TNFR2 non-canonical NF-kB pathway. R-GGA-5675221. Negative regulation of MAPK pathway. R-GGA-5675482. Regulation of necroptotic cell death. R-GGA-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation. R-GGA-5685942. HDR through Homologous Recombination (HRR). R-GGA-5687128. MAPK6/MAPK4 signaling. R-GGA-5689603. UCH proteinases. R-GGA-5689877. Josephin domain DUBs. R-GGA-5689880. Ub-specific processing proteases. R-GGA-5689896. Ovarian tumor domain proteases. R-GGA-5689901. Metalloprotease DUBs. R-GGA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks. R-GGA-5693607. Processing of DNA double-strand break ends. R-GGA-5696394. DNA Damage Recognition in GG-NER. R-GGA-5696395. Formation of Incision Complex in GG-NER. R-GGA-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER. R-GGA-5696400. Dual Incision in GG-NER. R-GGA-6781823. Formation of TC-NER Pre-Incision Complex. R-GGA-6782135. Dual incision in TC-NER. R-GGA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER. R-GGA-6783310. Fanconi Anemia Pathway. R-GGA-6804756. Regulation of TP53 Activity through Phosphorylation. R-GGA-6804757. Regulation of TP53 Degradation. R-GGA-6804760. Regulation of TP53 Activity through Methylation. R-GGA-6807004. Negative regulation of MET activity. R-GGA-68827. CDT1 association with the CDC6:ORC:origin complex. R-GGA-68949. Orc1 removal from chromatin. R-GGA-69017. CDK-mediated phosphorylation and removal of Cdc6. R-GGA-69229. Ubiquitin-dependent degradation of Cyclin D1. R-GGA-69231. Cyclin D associated events in G1. R-GGA-69298. Association of licensing factors with the pre-replicative complex. R-GGA-69541. Stabilization of p53. R-GGA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A. R-GGA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit. R-GGA-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1. R-GGA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis. R-GGA-8856825. Cargo recognition for clathrin-mediated endocytosis. R-GGA-8856828. Clathrin-mediated endocytosis. R-GGA-8863795. Downregulation of ERBB2 signaling. R-GGA-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes. R-GGA-8866654. E3 ubiquitin ligases ubiquitinate target proteins. R-GGA-8941858. Regulation of RUNX3 expression and activity. R-GGA-8951664. Neddylation. R-GGA-901032. ER Quality Control Compartment (ERQC). R-GGA-912631. Regulation of signaling by CBL. R-GGA-917729. Endosomal Sorting Complex Required For Transport (ESCRT). R-GGA-917937. Iron uptake and transport. R-GGA-937042. IRAK2 mediated activation of TAK1 complex. R-GGA-937072. TRAF6 mediated induction of TAK1 complex. R-GGA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling. R-GGA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation. R-GGA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC). R-GGA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC). R-GGA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Reactomeⁱ

R-GGA-110312. Translesion synthesis by REV1.
R-GGA-110320. Translesion Synthesis by POLH.
R-GGA-1169091. Activation of NF-kappaB in B cells.
R-GGA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-GGA-1253288. Downregulation of ERBB4 signaling.
R-GGA-1295596. Spry regulation of FGF signaling.
R-GGA-1358803. Downregulation of ERBB2:ERBB3 signaling.
R-GGA-168638. NOD1/2 Signaling Pathway.
R-GGA-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-GGA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-GGA-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-GGA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-GGA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-GGA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-GGA-179409. APC-Cdc20 mediated degradation of Nek2A.
R-GGA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-GGA-182971. EGFR downregulation.
R-GGA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-GGA-195253. Degradation of beta-catenin by the destruction complex.
R-GGA-201681. TCF dependent signaling in response to WNT.
R-GGA-202424. Downstream TCR signaling.
R-GGA-209543. p75NTR recruits signalling complexes.
R-GGA-209560. NF-kB is activated and signals survival.
R-GGA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-GGA-2173788. Downregulation of TGF-beta receptor signaling.
R-GGA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-GGA-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-GGA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-GGA-2467813. Separation of Sister Chromatids.
R-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-GGA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-GGA-2672351. Stimuli-sensing channels.
R-GGA-2871837. FCERI mediated NF-kB activation.
R-GGA-3134975. Regulation of innate immune responses to cytosolic DNA.
R-GGA-3322077. Glycogen synthesis.
R-GGA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-GGA-3769402. Deactivation of the beta-catenin transactivating complex.
R-GGA-382556. ABC-family proteins mediated transport.
R-GGA-446652. Interleukin-1 signaling.
R-GGA-450302. activated TAK1 mediates p38 MAPK activation.
R-GGA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-GGA-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-GGA-4641257. Degradation of AXIN.
R-GGA-4641258. Degradation of DVL.
R-GGA-4641263. Regulation of FZD by ubiquitination.
R-GGA-5205685. Pink/Parkin Mediated Mitophagy.
R-GGA-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-GGA-5357905. Regulation of TNFR1 signaling.
R-GGA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-GGA-5358346. Hedgehog ligand biogenesis.
R-GGA-5607764. CLEC7A (Dectin-1) signaling.
R-GGA-5610780. Degradation of GLI1 by the proteasome.
R-GGA-5610785. GLI3 is processed to GLI3R by the proteasome.
R-GGA-5632684. Hedgehog 'on' state.
R-GGA-5654726. Negative regulation of FGFR1 signaling.
R-GGA-5654727. Negative regulation of FGFR2 signaling.
R-GGA-5654732. Negative regulation of FGFR3 signaling.
R-GGA-5654733. Negative regulation of FGFR4 signaling.
R-GGA-5655862. Translesion synthesis by POLK.
R-GGA-5656121. Translesion synthesis by POLI.
R-GGA-5656169. Termination of translesion DNA synthesis.
R-GGA-5668541. TNFR2 non-canonical NF-kB pathway.
R-GGA-5675221. Negative regulation of MAPK pathway.
R-GGA-5675482. Regulation of necroptotic cell death.
R-GGA-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-GGA-5685942. HDR through Homologous Recombination (HRR).
R-GGA-5687128. MAPK6/MAPK4 signaling.
R-GGA-5689603. UCH proteinases.
R-GGA-5689877. Josephin domain DUBs.
R-GGA-5689880. Ub-specific processing proteases.
R-GGA-5689896. Ovarian tumor domain proteases.
R-GGA-5689901. Metalloprotease DUBs.
R-GGA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-GGA-5693607. Processing of DNA double-strand break ends.
R-GGA-5696394. DNA Damage Recognition in GG-NER.
R-GGA-5696395. Formation of Incision Complex in GG-NER.
R-GGA-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER.
R-GGA-5696400. Dual Incision in GG-NER.
R-GGA-6781823. Formation of TC-NER Pre-Incision Complex.
R-GGA-6782135. Dual incision in TC-NER.
R-GGA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-GGA-6783310. Fanconi Anemia Pathway.
R-GGA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-GGA-6804757. Regulation of TP53 Degradation.
R-GGA-6804760. Regulation of TP53 Activity through Methylation.
R-GGA-6807004. Negative regulation of MET activity.
R-GGA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-GGA-68949. Orc1 removal from chromatin.
R-GGA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-GGA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-GGA-69231. Cyclin D associated events in G1.
R-GGA-69298. Association of licensing factors with the pre-replicative complex.
R-GGA-69541. Stabilization of p53.
R-GGA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-GGA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-GGA-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
R-GGA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-GGA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-GGA-8856828. Clathrin-mediated endocytosis.
R-GGA-8863795. Downregulation of ERBB2 signaling.
R-GGA-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
R-GGA-8866654. E3 ubiquitin ligases ubiquitinate target proteins.
R-GGA-8941858. Regulation of RUNX3 expression and activity.
R-GGA-8951664. Neddylation.
R-GGA-901032. ER Quality Control Compartment (ERQC).
R-GGA-912631. Regulation of signaling by CBL.
R-GGA-917729. Endosomal Sorting Complex Required For Transport (ESCRT).
R-GGA-917937. Iron uptake and transport.
R-GGA-937042. IRAK2 mediated activation of TAK1 complex.
R-GGA-937072. TRAF6 mediated induction of TAK1 complex.
R-GGA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-GGA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
R-GGA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-GGA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
R-GGA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Ubiquitin-60S ribosomal protein L40Imported Submitted name: Ubiquitin-ribosomal protein fusion proteinImported
Gene namesⁱ	Name:UBA52Imported
Organismⁱ	Gallus gallus (Chicken)Imported
Taxonomic identifierⁱ	9031 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Sauropsida › Sauria › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus
Proteomesⁱ	UP000000539 Componentⁱ: Chromosome 28

Subcellular locationⁱ

GO - Cellular componentⁱ

cytosol Source: Ensembl
endoplasmic reticulum Source: Ensembl
extracellular exosome Source: Ensembl
extracellular space Source: Ensembl
lysosomal membrane Source: Ensembl
myelin sheath Source: Ensembl
nucleoplasm Source: Ensembl
plasma membrane Source: Ensembl
ribosome Source: UniProtKB-KW

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	O42388.
PRIDEⁱ	O42388.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 76	Ubiquitin-likeInterPro annotationAdd BLAST		76

Phylogenomic databases

eggNOGⁱ	KOG0001. Eukaryota. COG5272. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136502.
HOVERGENⁱ	HBG052927.
KEGG Orthology (KO) More...KOⁱ	K02927.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001975. Ribosomal_L40e. IPR019956. Ubiquitin. IPR029071. Ubiquitin-rel_dom. IPR019954. Ubiquitin_CS. IPR000626. Ubiquitin_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01020. Ribosomal_L40e. 1 hit. PF00240. ubiquitin. 1 hit.
PRINTSⁱ	PR00348. UBIQUITIN.
SMARTⁱ	View protein in SMART SM01377. Ribosomal_L40e. 1 hit. SM00213. UBQ. 1 hit.
SUPFAMⁱ	SSF54236. SSF54236. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00299. UBIQUITIN_1. 1 hit. PS50053. UBIQUITIN_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

O42388-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQIFVKTLTG KTITLEVEPN DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL 
        60         70         80         90        100
EDGRTLADYN IQKESTLHLV LRLRGGIIEP SLRQLAQKYN CDKMICRKCY 
       110        120 
ARLHPRAVNC RKKKCGHTNN LRPKKKVK

Length:128

Mass (Da):14,739

Last modified:January 1, 1998 - v1

Checksum:ⁱ0C7CD4AF4F6B72B8

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AADN04000369 Genomic DNA. No translation available. Z29958 mRNA. Translation: CAA82846.1.
PIRⁱ	S01884.
NCBI Reference Sequences More...RefSeqⁱ	NP_990406.1. NM_205075.1.
UniGeneⁱ	Gga.569.

Genome annotation databases

Ensemblⁱ	ENSGALT00000046741; ENSGALP00000053207; ENSGALG00000037716.
GeneIDⁱ	395958.
KEGGⁱ	gga:395958.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AADN04000369 Genomic DNA. No translation available. Z29958 mRNA. Translation: CAA82846.1.
PIRⁱ	S01884.
NCBI Reference Sequences More...RefSeqⁱ	NP_990406.1. NM_205075.1.
UniGeneⁱ	Gga.569.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	O42388.
PRIDEⁱ	O42388.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSGALT00000046741; ENSGALP00000053207; ENSGALG00000037716.
GeneIDⁱ	395958.
KEGGⁱ	gga:395958.

Organism-specific databases

CTDⁱ	7311.

CTDⁱ

7311.

Phylogenomic databases

eggNOGⁱ	KOG0001. Eukaryota. COG5272. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136502.
HOVERGENⁱ	HBG052927.
KEGG Orthology (KO) More...KOⁱ	K02927.

Enzyme and pathway databases

Reactomeⁱ	R-GGA-110312. Translesion synthesis by REV1. R-GGA-110320. Translesion Synthesis by POLH. R-GGA-1169091. Activation of NF-kappaB in B cells. R-GGA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha. R-GGA-1253288. Downregulation of ERBB4 signaling. R-GGA-1295596. Spry regulation of FGF signaling. R-GGA-1358803. Downregulation of ERBB2:ERBB3 signaling. R-GGA-168638. NOD1/2 Signaling Pathway. R-GGA-174048. APC/C:Cdc20 mediated degradation of Cyclin B. R-GGA-174084. Autodegradation of Cdh1 by Cdh1:APC/C. R-GGA-174113. SCF-beta-TrCP mediated degradation of Emi1. R-GGA-174154. APC/C:Cdc20 mediated degradation of Securin. R-GGA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1. R-GGA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. R-GGA-179409. APC-Cdc20 mediated degradation of Nek2A. R-GGA-1799339. SRP-dependent cotranslational protein targeting to membrane. R-GGA-182971. EGFR downregulation. R-GGA-187577. SCF(Skp2)-mediated degradation of p27/p21. R-GGA-195253. Degradation of beta-catenin by the destruction complex. R-GGA-201681. TCF dependent signaling in response to WNT. R-GGA-202424. Downstream TCR signaling. R-GGA-209543. p75NTR recruits signalling complexes. R-GGA-209560. NF-kB is activated and signals survival. R-GGA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus. R-GGA-2173788. Downregulation of TGF-beta receptor signaling. R-GGA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition). R-GGA-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity. R-GGA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription. R-GGA-2467813. Separation of Sister Chromatids. R-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP). R-GGA-2565942. Regulation of PLK1 Activity at G2/M Transition. R-GGA-2672351. Stimuli-sensing channels. R-GGA-2871837. FCERI mediated NF-kB activation. R-GGA-3134975. Regulation of innate immune responses to cytosolic DNA. R-GGA-3322077. Glycogen synthesis. R-GGA-349425. Autodegradation of the E3 ubiquitin ligase COP1. R-GGA-3769402. Deactivation of the beta-catenin transactivating complex. R-GGA-382556. ABC-family proteins mediated transport. R-GGA-446652. Interleukin-1 signaling. R-GGA-450302. activated TAK1 mediates p38 MAPK activation. R-GGA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1. R-GGA-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA. R-GGA-4641257. Degradation of AXIN. R-GGA-4641258. Degradation of DVL. R-GGA-4641263. Regulation of FZD by ubiquitination. R-GGA-5205685. Pink/Parkin Mediated Mitophagy. R-GGA-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle. R-GGA-5357905. Regulation of TNFR1 signaling. R-GGA-5357956. TNFR1-induced NFkappaB signaling pathway. R-GGA-5358346. Hedgehog ligand biogenesis. R-GGA-5607764. CLEC7A (Dectin-1) signaling. R-GGA-5610780. Degradation of GLI1 by the proteasome. R-GGA-5610785. GLI3 is processed to GLI3R by the proteasome. R-GGA-5632684. Hedgehog 'on' state. R-GGA-5654726. Negative regulation of FGFR1 signaling. R-GGA-5654727. Negative regulation of FGFR2 signaling. R-GGA-5654732. Negative regulation of FGFR3 signaling. R-GGA-5654733. Negative regulation of FGFR4 signaling. R-GGA-5655862. Translesion synthesis by POLK. R-GGA-5656121. Translesion synthesis by POLI. R-GGA-5656169. Termination of translesion DNA synthesis. R-GGA-5668541. TNFR2 non-canonical NF-kB pathway. R-GGA-5675221. Negative regulation of MAPK pathway. R-GGA-5675482. Regulation of necroptotic cell death. R-GGA-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation. R-GGA-5685942. HDR through Homologous Recombination (HRR). R-GGA-5687128. MAPK6/MAPK4 signaling. R-GGA-5689603. UCH proteinases. R-GGA-5689877. Josephin domain DUBs. R-GGA-5689880. Ub-specific processing proteases. R-GGA-5689896. Ovarian tumor domain proteases. R-GGA-5689901. Metalloprotease DUBs. R-GGA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks. R-GGA-5693607. Processing of DNA double-strand break ends. R-GGA-5696394. DNA Damage Recognition in GG-NER. R-GGA-5696395. Formation of Incision Complex in GG-NER. R-GGA-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER. R-GGA-5696400. Dual Incision in GG-NER. R-GGA-6781823. Formation of TC-NER Pre-Incision Complex. R-GGA-6782135. Dual incision in TC-NER. R-GGA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER. R-GGA-6783310. Fanconi Anemia Pathway. R-GGA-6804756. Regulation of TP53 Activity through Phosphorylation. R-GGA-6804757. Regulation of TP53 Degradation. R-GGA-6804760. Regulation of TP53 Activity through Methylation. R-GGA-6807004. Negative regulation of MET activity. R-GGA-68827. CDT1 association with the CDC6:ORC:origin complex. R-GGA-68949. Orc1 removal from chromatin. R-GGA-69017. CDK-mediated phosphorylation and removal of Cdc6. R-GGA-69229. Ubiquitin-dependent degradation of Cyclin D1. R-GGA-69231. Cyclin D associated events in G1. R-GGA-69298. Association of licensing factors with the pre-replicative complex. R-GGA-69541. Stabilization of p53. R-GGA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A. R-GGA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit. R-GGA-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1. R-GGA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis. R-GGA-8856825. Cargo recognition for clathrin-mediated endocytosis. R-GGA-8856828. Clathrin-mediated endocytosis. R-GGA-8863795. Downregulation of ERBB2 signaling. R-GGA-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes. R-GGA-8866654. E3 ubiquitin ligases ubiquitinate target proteins. R-GGA-8941858. Regulation of RUNX3 expression and activity. R-GGA-8951664. Neddylation. R-GGA-901032. ER Quality Control Compartment (ERQC). R-GGA-912631. Regulation of signaling by CBL. R-GGA-917729. Endosomal Sorting Complex Required For Transport (ESCRT). R-GGA-917937. Iron uptake and transport. R-GGA-937042. IRAK2 mediated activation of TAK1 complex. R-GGA-937072. TRAF6 mediated induction of TAK1 complex. R-GGA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling. R-GGA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation. R-GGA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC). R-GGA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC). R-GGA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Reactomeⁱ

R-GGA-110312. Translesion synthesis by REV1.
R-GGA-110320. Translesion Synthesis by POLH.
R-GGA-1169091. Activation of NF-kappaB in B cells.
R-GGA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-GGA-1253288. Downregulation of ERBB4 signaling.
R-GGA-1295596. Spry regulation of FGF signaling.
R-GGA-1358803. Downregulation of ERBB2:ERBB3 signaling.
R-GGA-168638. NOD1/2 Signaling Pathway.
R-GGA-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-GGA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-GGA-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-GGA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-GGA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-GGA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-GGA-179409. APC-Cdc20 mediated degradation of Nek2A.
R-GGA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-GGA-182971. EGFR downregulation.
R-GGA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-GGA-195253. Degradation of beta-catenin by the destruction complex.
R-GGA-201681. TCF dependent signaling in response to WNT.
R-GGA-202424. Downstream TCR signaling.
R-GGA-209543. p75NTR recruits signalling complexes.
R-GGA-209560. NF-kB is activated and signals survival.
R-GGA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-GGA-2173788. Downregulation of TGF-beta receptor signaling.
R-GGA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-GGA-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-GGA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-GGA-2467813. Separation of Sister Chromatids.
R-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-GGA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-GGA-2672351. Stimuli-sensing channels.
R-GGA-2871837. FCERI mediated NF-kB activation.
R-GGA-3134975. Regulation of innate immune responses to cytosolic DNA.
R-GGA-3322077. Glycogen synthesis.
R-GGA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-GGA-3769402. Deactivation of the beta-catenin transactivating complex.
R-GGA-382556. ABC-family proteins mediated transport.
R-GGA-446652. Interleukin-1 signaling.
R-GGA-450302. activated TAK1 mediates p38 MAPK activation.
R-GGA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-GGA-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-GGA-4641257. Degradation of AXIN.
R-GGA-4641258. Degradation of DVL.
R-GGA-4641263. Regulation of FZD by ubiquitination.
R-GGA-5205685. Pink/Parkin Mediated Mitophagy.
R-GGA-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-GGA-5357905. Regulation of TNFR1 signaling.
R-GGA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-GGA-5358346. Hedgehog ligand biogenesis.
R-GGA-5607764. CLEC7A (Dectin-1) signaling.
R-GGA-5610780. Degradation of GLI1 by the proteasome.
R-GGA-5610785. GLI3 is processed to GLI3R by the proteasome.
R-GGA-5632684. Hedgehog 'on' state.
R-GGA-5654726. Negative regulation of FGFR1 signaling.
R-GGA-5654727. Negative regulation of FGFR2 signaling.
R-GGA-5654732. Negative regulation of FGFR3 signaling.
R-GGA-5654733. Negative regulation of FGFR4 signaling.
R-GGA-5655862. Translesion synthesis by POLK.
R-GGA-5656121. Translesion synthesis by POLI.
R-GGA-5656169. Termination of translesion DNA synthesis.
R-GGA-5668541. TNFR2 non-canonical NF-kB pathway.
R-GGA-5675221. Negative regulation of MAPK pathway.
R-GGA-5675482. Regulation of necroptotic cell death.
R-GGA-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-GGA-5685942. HDR through Homologous Recombination (HRR).
R-GGA-5687128. MAPK6/MAPK4 signaling.
R-GGA-5689603. UCH proteinases.
R-GGA-5689877. Josephin domain DUBs.
R-GGA-5689880. Ub-specific processing proteases.
R-GGA-5689896. Ovarian tumor domain proteases.
R-GGA-5689901. Metalloprotease DUBs.
R-GGA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-GGA-5693607. Processing of DNA double-strand break ends.
R-GGA-5696394. DNA Damage Recognition in GG-NER.
R-GGA-5696395. Formation of Incision Complex in GG-NER.
R-GGA-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER.
R-GGA-5696400. Dual Incision in GG-NER.
R-GGA-6781823. Formation of TC-NER Pre-Incision Complex.
R-GGA-6782135. Dual incision in TC-NER.
R-GGA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-GGA-6783310. Fanconi Anemia Pathway.
R-GGA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-GGA-6804757. Regulation of TP53 Degradation.
R-GGA-6804760. Regulation of TP53 Activity through Methylation.
R-GGA-6807004. Negative regulation of MET activity.
R-GGA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-GGA-68949. Orc1 removal from chromatin.
R-GGA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-GGA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-GGA-69231. Cyclin D associated events in G1.
R-GGA-69298. Association of licensing factors with the pre-replicative complex.
R-GGA-69541. Stabilization of p53.
R-GGA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-GGA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-GGA-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
R-GGA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-GGA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-GGA-8856828. Clathrin-mediated endocytosis.
R-GGA-8863795. Downregulation of ERBB2 signaling.
R-GGA-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
R-GGA-8866654. E3 ubiquitin ligases ubiquitinate target proteins.
R-GGA-8941858. Regulation of RUNX3 expression and activity.
R-GGA-8951664. Neddylation.
R-GGA-901032. ER Quality Control Compartment (ERQC).
R-GGA-912631. Regulation of signaling by CBL.
R-GGA-917729. Endosomal Sorting Complex Required For Transport (ESCRT).
R-GGA-917937. Iron uptake and transport.
R-GGA-937042. IRAK2 mediated activation of TAK1 complex.
R-GGA-937072. TRAF6 mediated induction of TAK1 complex.
R-GGA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-GGA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
R-GGA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-GGA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
R-GGA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001975. Ribosomal_L40e. IPR019956. Ubiquitin. IPR029071. Ubiquitin-rel_dom. IPR019954. Ubiquitin_CS. IPR000626. Ubiquitin_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01020. Ribosomal_L40e. 1 hit. PF00240. ubiquitin. 1 hit.
PRINTSⁱ	PR00348. UBIQUITIN.
SMARTⁱ	View protein in SMART SM01377. Ribosomal_L40e. 1 hit. SM00213. UBQ. 1 hit.
SUPFAMⁱ	SSF54236. SSF54236. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00299. UBIQUITIN_1. 1 hit. PS50053. UBIQUITIN_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O42388_CHICK
Accessionⁱ	O42388Primary (citable) accession number: O42388
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	January 1, 1998
	Last sequence update:	January 1, 1998
	Last modified:	July 5, 2017
	This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - O42388 (O42388_CHICK)

Your basket is currently empty.

Ubiquitin-60S ribosomal protein L40

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O42388 (O42388_CHICK)

Your basket is currently empty.

Ubiquitin-60S ribosomal protein L40

UBA52

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ