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Protein

5-hydroxytryptamine receptor 1A-alpha

Gene

htr1aa

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity and behavior (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1A-alpha
Short name:
5-HT-1A-alpha
Short name:
5-HT1A-alpha
Alternative name(s):
F1A
Serotonin receptor 1A-alpha
Gene namesi
Name:htr1aa
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularBy similarityAdd
BLAST
Transmembranei46 – 7126Helical; Name=1By similarityAdd
BLAST
Topological domaini72 – 8211CytoplasmicBy similarityAdd
BLAST
Transmembranei83 – 10725Helical; Name=2By similarityAdd
BLAST
Topological domaini108 – 11912ExtracellularBy similarityAdd
BLAST
Transmembranei120 – 14122Helical; Name=3By similarityAdd
BLAST
Topological domaini142 – 16120CytoplasmicBy similarityAdd
BLAST
Transmembranei162 – 18625Helical; Name=4By similarityAdd
BLAST
Topological domaini187 – 20014ExtracellularBy similarityAdd
BLAST
Transmembranei201 – 22626Helical; Name=5By similarityAdd
BLAST
Topological domaini227 – 346120CytoplasmicBy similarityAdd
BLAST
Transmembranei347 – 36822Helical; Name=6By similarityAdd
BLAST
Topological domaini369 – 37911ExtracellularBy similarityAdd
BLAST
Transmembranei380 – 40425Helical; Name=7By similarityAdd
BLAST
Topological domaini405 – 42319CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4234235-hydroxytryptamine receptor 1A-alphaPRO_0000068909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence analysis
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence analysis
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence analysis
Disulfide bondi118 ↔ 196PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO42385.
SMRiO42385. Positions 130-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni121 – 13010Agonist bindingBy similarity
Regioni359 – 3635Agonist bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi142 – 1443DRY motif; important for ligand-induced conformation changesBy similarity
Motifi397 – 4015NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiO42385.

Family and domain databases

InterProiIPR000610. 5HT1A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF20. PTHR24247:SF20. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00512. 5HT1ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRATSSND SNATSGYSDT AAVDWDEGEN ATGSGSLPDP ELSYQIITSL
60 70 80 90 100
FLGALILCSI FGNSCVVAAI ALERSLQNVA NYLIGSLAVT DLMVSVLVLP
110 120 130 140 150
MAALYQVLNK WTLGQDICDL FIALDVLCCT SSILHLCAIA LDRYWAITDP
160 170 180 190 200
IDYVNKRTPR RAAVLISVTW LIGFSISIPP MLGWRSAEDR ANPDACIISQ
210 220 230 240 250
DPGYTIYSTF GAFYIPLILM LVLYGRIFKA ARFRIRKTVK KTEKAKASDM
260 270 280 290 300
CLTLSPAVFH KRANGDAVSA EWKRGYKFKP SSPCANGAVR HGEEMESLEI
310 320 330 340 350
IEVNSNSKTH LPLPNTPQSS SHENINEKTT GTRRKIALAR ERKTVKTLGI
360 370 380 390 400
IMGTFIFCWL PFFIVALVLP FCAENCYMPE WLGAVINWLG YSNSLLNPII
410 420
YAYFNKDFQS AFKKILRCKF HRH
Length:423
Mass (Da):47,001
Last modified:January 1, 1998 - v1
Checksum:i7B1308626B40190F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95936 Genomic DNA. Translation: CAA65175.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95936 Genomic DNA. Translation: CAA65175.1.

3D structure databases

ProteinModelPortaliO42385.
SMRiO42385. Positions 130-161.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

InParanoidiO42385.

Family and domain databases

InterProiIPR000610. 5HT1A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF20. PTHR24247:SF20. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00512. 5HT1ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of 5-hydroxytryptamine (5-HT) type 1 receptor genes from the Japanese puffer fish, Fugu rubripes."
    Yamaguchi F., Brenner S.
    Gene 191:219-223(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Testis.

Entry informationi

Entry namei5H1AA_TAKRU
AccessioniPrimary (citable) accession number: O42385
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.