O42368 (HXB3A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-B3a
Short name=Hox-B3

Gene names

Name:	hoxb3a
Synonyms:	hoxb3
ORF Names:	zgc:111819

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus.
Developmental stage	First expressed at the 1- to 2-somite stages posterior to rhombomere 5 (r5) of the developing hindbrain. By the 3- to 4-somite stages, the anterior expression limit is at the r4/r5 boundary. At 5- to 10-somite stages, expressed at high levels in r5 and r6. From the 20- to 30-somite stages, expressed weakly in r4. Ref.4
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 417	417	Homeobox protein Hox-B3a		PRO_0000200120
Regions
	DNA binding	180 – 239	60	Homeobox
	Motif	140 – 145	6	Antp-type hexapeptide
Experimental info
	Sequence conflict	114	1	G → V in AAH95559. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O42368 [UniParc]. Last modified February 1, 2005. Version 3. Checksum: 33A68839BE3CC35A	FASTA	417	44,580
	10 20 30 40 50 60 MQKTTYYDNS TLFGGYSYQG ANGFGYDAPA PAFQNSAHLE GDYQRSACSL QSLGTSAPPQ 70 80 90 100 110 120 PQHAKTKELN GSCMRPSLPP EHHPPPQVSP PQNTVNVAAT NATQQPGGSG GGGGAGSGGT 130 140 150 160 170 180 SKSSSKSSSM ATNPTLTKQI FPWMKESRQN TKQKNSSPSA SSANAESSGG EKSPPGSAAS 190 200 210 220 230 240 KRARTAYTSA QLVELEKEFH FNRYLCRPRR VEMANLLNLS ERQIKIWFQN RRMKYKKDQK 250 260 270 280 290 300 SKGIGSSSGG PSPTGSPPLP MQSSAGFMNS MHSMGSYDAP SPPSFNKPHQ NAYAMSTAYQ 310 320 330 340 350 360 NPMKGCPPQQ KYGNTPPDYD PHGLQGNSGN YGTPNMQGSP VYVGGNYVDA MPATGPSMYG 370 380 390 400 410 LNHLPHHQSA SMDYNGATQM SANQHHGPCD PHPTYTDLSA HHPSQGRIQE APKLTHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ectopic expression of Hox paralog group 3 genes disrupts zebrafish hindbrain organization and craniofacial development in the absence of homeotic transformations." Hunter M.P., Prince V.E. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
[2]	The Danio rerio sequencing project at the Sanger Institute Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AB.
[3]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Larva.
[4]	"Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino." Prince V.E., Moens C.B., Kimmel C.B., Ho R.K. Development 125:393-406(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-417, DEVELOPMENTAL STAGE. Tissue: Embryo.
[5]	Prince V.E. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[6]	"Comparative genomic analysis of vertebrate Hox3 and Hox4 genes." Hadrys T., Prince V.E., Hunter M.P., Baker R., Rinkwitz S. J. Exp. Zool. B Mol. Dev. Evol. 302:147-164(2004) [PubMed] [Europe PMC] [Abstract] Cited for: GENE STRUCTURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ537509 mRNA. Translation: CAD61096.1. AL645782 Genomic DNA. Translation: CAD59116.1. BC095559 mRNA. Translation: AAH95559.1. Y13944 mRNA. Translation: CAA74282.2. BK005081 mRNA. Translation: DAA05213.1. BK005082 mRNA. Translation: DAA05214.1.
IPI	IPI00486662.
RefSeq	NP_571192.2. NM_131117.3.
UniGene	Dr.132502.
3D structure databases
ProteinModelPortal	O42368.
SMR	O42368. Positions 180-239.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000078466; ENSDARP00000072928; ENSDARG00000029263.
GeneID	30339.
KEGG	dre:30339.
Organism-specific databases
CTD	30339.
ZFIN	ZDB-GENE-990415-104. hoxb3a.
Phylogenomic databases
eggNOG	NOG284589.
GeneTree	ENSGT00700000104189.
HOGENOM	HOG000252944.
HOVERGEN	HBG107984.
InParanoid	O42368.
KO	K09303.
OMA	ATYYDNT.
OrthoDB	EOG4S4PH1.
Gene expression databases
ArrayExpress	O42368.
Bgee	O42368.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR025281. DUF4074. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF13293. DUF4074. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20806770.

Entry information

Entry name

HXB3A_DANRE

Accession

Primary (citable) accession number: O42368
Secondary accession number(s): Q4VBK5, Q8AWY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	February 1, 2005
Last modified:	April 3, 2013
This is version 101 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program