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O42368

- HXB3A_DANRE

UniProt

O42368 - HXB3A_DANRE

Protein

Homeobox protein Hox-B3a

Gene

hoxb3a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 3 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi180 – 23960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B3a
    Short name:
    Hox-B3
    Gene namesi
    Name:hoxb3a
    Synonyms:hoxb3
    ORF Names:zgc:111819
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 3

    Organism-specific databases

    ZFINiZDB-GENE-990415-104. hoxb3a.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 417417Homeobox protein Hox-B3aPRO_0000200120Add
    BLAST

    Expressioni

    Developmental stagei

    First expressed at the 1- to 2-somite stages posterior to rhombomere 5 (r5) of the developing hindbrain. By the 3- to 4-somite stages, the anterior expression limit is at the r4/r5 boundary. At 5- to 10-somite stages, expressed at high levels in r5 and r6. From the 20- to 30-somite stages, expressed weakly in r4.1 Publication

    Gene expression databases

    BgeeiO42368.

    Structurei

    3D structure databases

    ProteinModelPortaliO42368.
    SMRiO42368. Positions 180-239.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi140 – 1456Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG284589.
    GeneTreeiENSGT00750000117486.
    HOGENOMiHOG000252944.
    HOVERGENiHBG107984.
    InParanoidiO42368.
    KOiK09303.
    OMAiATYYDNT.
    OrthoDBiEOG754HPS.
    PhylomeDBiO42368.
    TreeFamiTF315938.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR025281. DUF4074.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF13293. DUF4074. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42368-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKTTYYDNS TLFGGYSYQG ANGFGYDAPA PAFQNSAHLE GDYQRSACSL    50
    QSLGTSAPPQ PQHAKTKELN GSCMRPSLPP EHHPPPQVSP PQNTVNVAAT 100
    NATQQPGGSG GGGGAGSGGT SKSSSKSSSM ATNPTLTKQI FPWMKESRQN 150
    TKQKNSSPSA SSANAESSGG EKSPPGSAAS KRARTAYTSA QLVELEKEFH 200
    FNRYLCRPRR VEMANLLNLS ERQIKIWFQN RRMKYKKDQK SKGIGSSSGG 250
    PSPTGSPPLP MQSSAGFMNS MHSMGSYDAP SPPSFNKPHQ NAYAMSTAYQ 300
    NPMKGCPPQQ KYGNTPPDYD PHGLQGNSGN YGTPNMQGSP VYVGGNYVDA 350
    MPATGPSMYG LNHLPHHQSA SMDYNGATQM SANQHHGPCD PHPTYTDLSA 400
    HHPSQGRIQE APKLTHL 417
    Length:417
    Mass (Da):44,580
    Last modified:February 1, 2005 - v3
    Checksum:i33A68839BE3CC35A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141G → V in AAH95559. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ537509 mRNA. Translation: CAD61096.1.
    AL645782 Genomic DNA. Translation: CAD59116.1.
    BC095559 mRNA. Translation: AAH95559.1.
    Y13944 mRNA. Translation: CAA74282.2.
    BK005081 mRNA. Translation: DAA05213.1.
    BK005082 mRNA. Translation: DAA05214.1.
    RefSeqiNP_571192.2. NM_131117.3.
    XP_005171611.1. XM_005171554.1.
    XP_005171612.1. XM_005171555.1.
    XP_005171613.1. XM_005171556.1.
    XP_005171614.1. XM_005171557.1.
    XP_005171615.1. XM_005171558.1.
    XP_005171616.1. XM_005171559.1.
    XP_005171617.1. XM_005171560.1.
    XP_005171618.1. XM_005171561.1.
    XP_005171619.1. XM_005171562.1.
    UniGeneiDr.132502.

    Genome annotation databases

    EnsembliENSDART00000078466; ENSDARP00000072928; ENSDARG00000029263.
    ENSDART00000153512; ENSDARP00000128207; ENSDARG00000029263.
    GeneIDi30339.
    KEGGidre:30339.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ537509 mRNA. Translation: CAD61096.1 .
    AL645782 Genomic DNA. Translation: CAD59116.1 .
    BC095559 mRNA. Translation: AAH95559.1 .
    Y13944 mRNA. Translation: CAA74282.2 .
    BK005081 mRNA. Translation: DAA05213.1 .
    BK005082 mRNA. Translation: DAA05214.1 .
    RefSeqi NP_571192.2. NM_131117.3.
    XP_005171611.1. XM_005171554.1.
    XP_005171612.1. XM_005171555.1.
    XP_005171613.1. XM_005171556.1.
    XP_005171614.1. XM_005171557.1.
    XP_005171615.1. XM_005171558.1.
    XP_005171616.1. XM_005171559.1.
    XP_005171617.1. XM_005171560.1.
    XP_005171618.1. XM_005171561.1.
    XP_005171619.1. XM_005171562.1.
    UniGenei Dr.132502.

    3D structure databases

    ProteinModelPortali O42368.
    SMRi O42368. Positions 180-239.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000078466 ; ENSDARP00000072928 ; ENSDARG00000029263 .
    ENSDART00000153512 ; ENSDARP00000128207 ; ENSDARG00000029263 .
    GeneIDi 30339.
    KEGGi dre:30339.

    Organism-specific databases

    CTDi 30339.
    ZFINi ZDB-GENE-990415-104. hoxb3a.

    Phylogenomic databases

    eggNOGi NOG284589.
    GeneTreei ENSGT00750000117486.
    HOGENOMi HOG000252944.
    HOVERGENi HBG107984.
    InParanoidi O42368.
    KOi K09303.
    OMAi ATYYDNT.
    OrthoDBi EOG754HPS.
    PhylomeDBi O42368.
    TreeFami TF315938.

    Miscellaneous databases

    NextBioi 20806770.
    PROi O42368.

    Gene expression databases

    Bgeei O42368.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR025281. DUF4074.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF13293. DUF4074. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ectopic expression of Hox paralog group 3 genes disrupts zebrafish hindbrain organization and craniofacial development in the absence of homeotic transformations."
      Hunter M.P., Prince V.E.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Larva.
    4. "Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino."
      Prince V.E., Moens C.B., Kimmel C.B., Ho R.K.
      Development 125:393-406(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-417, DEVELOPMENTAL STAGE.
      Tissue: Embryo.
    5. Prince V.E.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    6. "Comparative genomic analysis of vertebrate Hox3 and Hox4 genes."
      Hadrys T., Prince V.E., Hunter M.P., Baker R., Rinkwitz S.
      J. Exp. Zool. B Mol. Dev. Evol. 302:147-164(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE STRUCTURE.

    Entry informationi

    Entry nameiHXB3A_DANRE
    AccessioniPrimary (citable) accession number: O42368
    Secondary accession number(s): Q4VBK5, Q8AWY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3