SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O42368

- HXB3A_DANRE

UniProt

O42368 - HXB3A_DANRE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Homeobox protein Hox-B3a

Gene
hoxb3a, hoxb3, zgc:111819
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi180 – 23960HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B3a
Short name:
Hox-B3
Gene namesi
Name:hoxb3a
Synonyms:hoxb3
ORF Names:zgc:111819
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-990415-104. hoxb3a.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Homeobox protein Hox-B3aPRO_0000200120Add
BLAST

Expressioni

Developmental stagei

First expressed at the 1- to 2-somite stages posterior to rhombomere 5 (r5) of the developing hindbrain. By the 3- to 4-somite stages, the anterior expression limit is at the r4/r5 boundary. At 5- to 10-somite stages, expressed at high levels in r5 and r6. From the 20- to 30-somite stages, expressed weakly in r4.1 Publication

Gene expression databases

BgeeiO42368.

Structurei

3D structure databases

ProteinModelPortaliO42368.
SMRiO42368. Positions 180-239.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi140 – 1456Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG284589.
GeneTreeiENSGT00750000117486.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiO42368.
KOiK09303.
OMAiATYYDNT.
OrthoDBiEOG754HPS.
PhylomeDBiO42368.
TreeFamiTF315938.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42368-1 [UniParc]FASTAAdd to Basket

« Hide

MQKTTYYDNS TLFGGYSYQG ANGFGYDAPA PAFQNSAHLE GDYQRSACSL    50
QSLGTSAPPQ PQHAKTKELN GSCMRPSLPP EHHPPPQVSP PQNTVNVAAT 100
NATQQPGGSG GGGGAGSGGT SKSSSKSSSM ATNPTLTKQI FPWMKESRQN 150
TKQKNSSPSA SSANAESSGG EKSPPGSAAS KRARTAYTSA QLVELEKEFH 200
FNRYLCRPRR VEMANLLNLS ERQIKIWFQN RRMKYKKDQK SKGIGSSSGG 250
PSPTGSPPLP MQSSAGFMNS MHSMGSYDAP SPPSFNKPHQ NAYAMSTAYQ 300
NPMKGCPPQQ KYGNTPPDYD PHGLQGNSGN YGTPNMQGSP VYVGGNYVDA 350
MPATGPSMYG LNHLPHHQSA SMDYNGATQM SANQHHGPCD PHPTYTDLSA 400
HHPSQGRIQE APKLTHL 417
Length:417
Mass (Da):44,580
Last modified:February 1, 2005 - v3
Checksum:i33A68839BE3CC35A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141G → V in AAH95559. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ537509 mRNA. Translation: CAD61096.1.
AL645782 Genomic DNA. Translation: CAD59116.1.
BC095559 mRNA. Translation: AAH95559.1.
Y13944 mRNA. Translation: CAA74282.2.
BK005081 mRNA. Translation: DAA05213.1.
BK005082 mRNA. Translation: DAA05214.1.
RefSeqiNP_571192.2. NM_131117.3.
XP_005171611.1. XM_005171554.1.
XP_005171612.1. XM_005171555.1.
XP_005171613.1. XM_005171556.1.
XP_005171614.1. XM_005171557.1.
XP_005171615.1. XM_005171558.1.
XP_005171616.1. XM_005171559.1.
XP_005171617.1. XM_005171560.1.
XP_005171618.1. XM_005171561.1.
XP_005171619.1. XM_005171562.1.
UniGeneiDr.132502.

Genome annotation databases

EnsembliENSDART00000078466; ENSDARP00000072928; ENSDARG00000029263.
ENSDART00000153512; ENSDARP00000128207; ENSDARG00000029263.
GeneIDi30339.
KEGGidre:30339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ537509 mRNA. Translation: CAD61096.1 .
AL645782 Genomic DNA. Translation: CAD59116.1 .
BC095559 mRNA. Translation: AAH95559.1 .
Y13944 mRNA. Translation: CAA74282.2 .
BK005081 mRNA. Translation: DAA05213.1 .
BK005082 mRNA. Translation: DAA05214.1 .
RefSeqi NP_571192.2. NM_131117.3.
XP_005171611.1. XM_005171554.1.
XP_005171612.1. XM_005171555.1.
XP_005171613.1. XM_005171556.1.
XP_005171614.1. XM_005171557.1.
XP_005171615.1. XM_005171558.1.
XP_005171616.1. XM_005171559.1.
XP_005171617.1. XM_005171560.1.
XP_005171618.1. XM_005171561.1.
XP_005171619.1. XM_005171562.1.
UniGenei Dr.132502.

3D structure databases

ProteinModelPortali O42368.
SMRi O42368. Positions 180-239.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000078466 ; ENSDARP00000072928 ; ENSDARG00000029263 .
ENSDART00000153512 ; ENSDARP00000128207 ; ENSDARG00000029263 .
GeneIDi 30339.
KEGGi dre:30339.

Organism-specific databases

CTDi 30339.
ZFINi ZDB-GENE-990415-104. hoxb3a.

Phylogenomic databases

eggNOGi NOG284589.
GeneTreei ENSGT00750000117486.
HOGENOMi HOG000252944.
HOVERGENi HBG107984.
InParanoidi O42368.
KOi K09303.
OMAi ATYYDNT.
OrthoDBi EOG754HPS.
PhylomeDBi O42368.
TreeFami TF315938.

Miscellaneous databases

NextBioi 20806770.
PROi O42368.

Gene expression databases

Bgeei O42368.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ectopic expression of Hox paralog group 3 genes disrupts zebrafish hindbrain organization and craniofacial development in the absence of homeotic transformations."
    Hunter M.P., Prince V.E.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Larva.
  4. "Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino."
    Prince V.E., Moens C.B., Kimmel C.B., Ho R.K.
    Development 125:393-406(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-417, DEVELOPMENTAL STAGE.
    Tissue: Embryo.
  5. Prince V.E.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  6. "Comparative genomic analysis of vertebrate Hox3 and Hox4 genes."
    Hadrys T., Prince V.E., Hunter M.P., Baker R., Rinkwitz S.
    J. Exp. Zool. B Mol. Dev. Evol. 302:147-164(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE STRUCTURE.

Entry informationi

Entry nameiHXB3A_DANRE
AccessioniPrimary (citable) accession number: O42368
Secondary accession number(s): Q4VBK5, Q8AWY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi