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O42365 (HXA2B_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A2b

Short name=Hox-A2
Gene names
Name:hoxa2b
Synonyms:hoxa2
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Developmental stage

First expressed at the 2-somite stage as a stripe in the region of the hindbrain that will give rise to rhombomeres 2 and 3. By the 10-somite stage, expression has expanded posteriorly to rhombomeres 4 and 5. Ref.4

Sequence similarities

Belongs to the Antp homeobox family. Proboscipedia subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Homeobox protein Hox-A2b
PRO_0000200040

Regions

DNA binding133 – 19260Homeobox
Motif88 – 936Antp-type hexapeptide

Experimental info

Sequence conflict3601H → P in CAA74283. Ref.4

Sequences

Sequence LengthMass (Da)Tools
O42365 [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: 2808F51BBD3A8B6E

FASTA36339,814
        10         20         30         40         50         60 
MNYEFERETG FINSQPSLAE CLTSFPPVGD AFQSSSIKSS TLSHSTLIPP PFEQTIPSLN 

        70         80         90        100        110        120 
PGSHPRHSRP KQNPNGSCPL PAASLPPEYP WMKEKKASKK NQTTSTAATT DPGPLYFSPQ 

       130        140        150        160        170        180 
GSPEISDGGS GATRRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL DLTERQVKVW 

       190        200        210        220        230        240 
FQNRRMKHKR QTQCKENHHG DGKPPSLEEA GGRGDGKSFF EQVANNVSGA LLEREGYPFQ 

       250        260        270        280        290        300 
QNTLTSQQSQ NGHNSDSQSA TVSPLGSNDK HLKHFPNPSP TVPICTTTMA PDCASAQDNG 

       310        320        330        340        350        360 
SPSALDVSLQ DFNVFSNDSC LHLSDAVSPS LSESVDSPIG LTTEAFDFFS ETLTTIDLQH 


LSY 

« Hide

References

« Hide 'large scale' references
[1]"Ectopic Hoxa2 induction after neural crest migration results in homeosis of jaw elements in Xenopus."
Pasqualetti M., Ori M., Nardi I., Rijli F.M.
Development 127:5367-5378(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[3]"Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a."
Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K.
Evol. Dev. 7:362-375(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-132.
Strain: Tuebingen.
[4]"Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino."
Prince V.E., Moens C.B., Kimmel C.B., Ho R.K.
Development 125:393-406(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 165-363, DEVELOPMENTAL STAGE.
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF307010 mRNA. Translation: AAG30510.1.
AL645795 Genomic DNA. Translation: CAD59108.1.
DQ060536 mRNA. Translation: AAY67914.1.
Y13945 mRNA. Translation: CAA74283.1.
RefSeqNP_571181.1. NM_131106.1.
UniGeneDr.82597.

3D structure databases

ProteinModelPortalO42365.
SMRO42365. Positions 134-191.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000023072.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID30325.
KEGGdre:30325.

Organism-specific databases

CTD30325.
ZFINZDB-GENE-990415-98. hoxa2b.

Phylogenomic databases

eggNOGNOG321520.
HOGENOMHOG000063664.
HOVERGENHBG006088.
InParanoidO42365.
KOK09302.
PhylomeDBO42365.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806759.
PROO42365.

Entry information

Entry nameHXA2B_DANRE
AccessionPrimary (citable) accession number: O42365
Secondary accession number(s): Q4PRA7, Q9DEZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 2005
Last modified: April 16, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries