O42365 (HXA2B_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A2b
Short name=Hox-A2

Gene names

Name:	hoxa2b
Synonyms:	hoxa2

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Developmental stage	First expressed at the 2-somite stage as a stripe in the region of the hindbrain that will give rise to rhombomeres 2 and 3. By the 10-somite stage, expression has expanded posteriorly to rhombomeres 4 and 5. Ref.4
Sequence similarities	Belongs to the Antp homeobox family. Proboscipedia subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Homeobox protein Hox-A2b		PRO_0000200040
Regions
	DNA binding	133 – 192	60	Homeobox
	Motif	88 – 93	6	Antp-type hexapeptide
Experimental info
	Sequence conflict	360	1	H → P in CAA74283. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	O42365 [UniParc]. Last modified February 1, 2005. Version 2. Checksum: 2808F51BBD3A8B6E	FASTA	363	39,814
	10 20 30 40 50 60 MNYEFERETG FINSQPSLAE CLTSFPPVGD AFQSSSIKSS TLSHSTLIPP PFEQTIPSLN 70 80 90 100 110 120 PGSHPRHSRP KQNPNGSCPL PAASLPPEYP WMKEKKASKK NQTTSTAATT DPGPLYFSPQ 130 140 150 160 170 180 GSPEISDGGS GATRRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL DLTERQVKVW 190 200 210 220 230 240 FQNRRMKHKR QTQCKENHHG DGKPPSLEEA GGRGDGKSFF EQVANNVSGA LLEREGYPFQ 250 260 270 280 290 300 QNTLTSQQSQ NGHNSDSQSA TVSPLGSNDK HLKHFPNPSP TVPICTTTMA PDCASAQDNG 310 320 330 340 350 360 SPSALDVSLQ DFNVFSNDSC LHLSDAVSPS LSESVDSPIG LTTEAFDFFS ETLTTIDLQH LSY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ectopic Hoxa2 induction after neural crest migration results in homeosis of jaw elements in Xenopus." Pasqualetti M., Ori M., Nardi I., Rijli F.M. Development 127:5367-5378(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	The Danio rerio sequencing project at the Sanger Institute Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AB.
[3]	"Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a." Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K. Evol. Dev. 7:362-375(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-132. Strain: Tuebingen.
[4]	"Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino." Prince V.E., Moens C.B., Kimmel C.B., Ho R.K. Development 125:393-406(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 165-363, DEVELOPMENTAL STAGE. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF307010 mRNA. Translation: AAG30510.1. AL645795 Genomic DNA. Translation: CAD59108.1. DQ060536 mRNA. Translation: AAY67914.1. Y13945 mRNA. Translation: CAA74283.1.
IPI	IPI00486776.
RefSeq	NP_571181.1. NM_131106.1.
UniGene	Dr.82597.
3D structure databases
ProteinModelPortal	O42365.
SMR	O42365. Positions 134-191.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000023072.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	30325.
KEGG	dre:30325.
Organism-specific databases
CTD	30325.
ZFIN	ZDB-GENE-990415-98. hoxa2b.
Phylogenomic databases
eggNOG	NOG321520.
HOGENOM	HOG000063664.
HOVERGEN	HBG006088.
InParanoid	O42365.
KO	K09302.
OrthoDB	EOG43TZVT.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20806759.

Entry information

Entry name

HXA2B_DANRE

Accession

Primary (citable) accession number: O42365
Secondary accession number(s): Q4PRA7, Q9DEZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	February 1, 2005
Last modified:	April 3, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program