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O42365

- HXA2B_DANRE

UniProt

O42365 - HXA2B_DANRE

Protein

Homeobox protein Hox-A2b

Gene

hoxa2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi133 – 19260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A2b
    Short name:
    Hox-A2
    Gene namesi
    Name:hoxa2b
    Synonyms:hoxa2
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-990415-98. hoxa2b.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Homeobox protein Hox-A2bPRO_0000200040Add
    BLAST

    Expressioni

    Developmental stagei

    First expressed at the 2-somite stage as a stripe in the region of the hindbrain that will give rise to rhombomeres 2 and 3. By the 10-somite stage, expression has expanded posteriorly to rhombomeres 4 and 5.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000023072.

    Structurei

    3D structure databases

    ProteinModelPortaliO42365.
    SMRiO42365. Positions 134-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi88 – 936Antp-type hexapeptide

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG321520.
    HOGENOMiHOG000063664.
    HOVERGENiHBG006088.
    InParanoidiO42365.
    KOiK09302.
    PhylomeDBiO42365.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42365-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNYEFERETG FINSQPSLAE CLTSFPPVGD AFQSSSIKSS TLSHSTLIPP    50
    PFEQTIPSLN PGSHPRHSRP KQNPNGSCPL PAASLPPEYP WMKEKKASKK 100
    NQTTSTAATT DPGPLYFSPQ GSPEISDGGS GATRRLRTAY TNTQLLELEK 150
    EFHFNKYLCR PRRVEIAALL DLTERQVKVW FQNRRMKHKR QTQCKENHHG 200
    DGKPPSLEEA GGRGDGKSFF EQVANNVSGA LLEREGYPFQ QNTLTSQQSQ 250
    NGHNSDSQSA TVSPLGSNDK HLKHFPNPSP TVPICTTTMA PDCASAQDNG 300
    SPSALDVSLQ DFNVFSNDSC LHLSDAVSPS LSESVDSPIG LTTEAFDFFS 350
    ETLTTIDLQH LSY 363
    Length:363
    Mass (Da):39,814
    Last modified:February 1, 2005 - v2
    Checksum:i2808F51BBD3A8B6E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti360 – 3601H → P in CAA74283. (PubMed:9425135)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF307010 mRNA. Translation: AAG30510.1.
    AL645795 Genomic DNA. Translation: CAD59108.1.
    DQ060536 mRNA. Translation: AAY67914.1.
    Y13945 mRNA. Translation: CAA74283.1.
    RefSeqiNP_571181.1. NM_131106.1.
    UniGeneiDr.82597.

    Genome annotation databases

    GeneIDi30325.
    KEGGidre:30325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF307010 mRNA. Translation: AAG30510.1 .
    AL645795 Genomic DNA. Translation: CAD59108.1 .
    DQ060536 mRNA. Translation: AAY67914.1 .
    Y13945 mRNA. Translation: CAA74283.1 .
    RefSeqi NP_571181.1. NM_131106.1.
    UniGenei Dr.82597.

    3D structure databases

    ProteinModelPortali O42365.
    SMRi O42365. Positions 134-191.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000023072.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 30325.
    KEGGi dre:30325.

    Organism-specific databases

    CTDi 30325.
    ZFINi ZDB-GENE-990415-98. hoxa2b.

    Phylogenomic databases

    eggNOGi NOG321520.
    HOGENOMi HOG000063664.
    HOVERGENi HBG006088.
    InParanoidi O42365.
    KOi K09302.
    PhylomeDBi O42365.

    Miscellaneous databases

    NextBioi 20806759.
    PROi O42365.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ectopic Hoxa2 induction after neural crest migration results in homeosis of jaw elements in Xenopus."
      Pasqualetti M., Ori M., Nardi I., Rijli F.M.
      Development 127:5367-5378(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    3. "Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a."
      Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K.
      Evol. Dev. 7:362-375(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-132.
      Strain: Tuebingen.
    4. "Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino."
      Prince V.E., Moens C.B., Kimmel C.B., Ho R.K.
      Development 125:393-406(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 165-363, DEVELOPMENTAL STAGE.
      Tissue: Embryo.

    Entry informationi

    Entry nameiHXA2B_DANRE
    AccessioniPrimary (citable) accession number: O42365
    Secondary accession number(s): Q4PRA7, Q9DEZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3