Reviewed, UniProtKB/Swiss-Prot O42365 (HXA2B_DANRE)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A2b
      Short name=Hox-A2

Gene names

Name:	hoxa2b
Synonyms:	hoxa2

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Developmental stage	First expressed at the 2-somite stage as a stripe in the region of the hindbrain that will give rise to rhombomeres 2 and 3. By the 10-somite stage, expression has expanded posteriorly to rhombomeres 4 and 5. Ref.4
Sequence similarities	Belongs to the Antp homeobox family. Proboscipedia subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Homeobox protein Hox-A2b		PRO_0000200040
Regions
	DNA binding	133 – 192	60	Homeobox
	Motif	88 – 93	6	Antp-type hexapeptide
Experimental info
	Sequence conflict	360	1	H → P in CAA74283. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	O42365-1 [UniParc]. Last modified February 1, 2005. Version 2. Checksum: 2808F51BBD3A8B6E	FASTA	363	39,814
	10 20 30 40 50 60 MNYEFERETG FINSQPSLAE CLTSFPPVGD AFQSSSIKSS TLSHSTLIPP PFEQTIPSLN 70 80 90 100 110 120 PGSHPRHSRP KQNPNGSCPL PAASLPPEYP WMKEKKASKK NQTTSTAATT DPGPLYFSPQ 130 140 150 160 170 180 GSPEISDGGS GATRRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL DLTERQVKVW 190 200 210 220 230 240 FQNRRMKHKR QTQCKENHHG DGKPPSLEEA GGRGDGKSFF EQVANNVSGA LLEREGYPFQ 250 260 270 280 290 300 QNTLTSQQSQ NGHNSDSQSA TVSPLGSNDK HLKHFPNPSP TVPICTTTMA PDCASAQDNG 310 320 330 340 350 360 SPSALDVSLQ DFNVFSNDSC LHLSDAVSPS LSESVDSPIG LTTEAFDFFS ETLTTIDLQH LSY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ectopic Hoxa2 induction after neural crest migration results in homeosis of jaw elements in Xenopus." Pasqualetti M., Ori M., Nardi I., Rijli F.M. Development 127:5367-5378(2000) [PubMed: 11076758] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	The Danio rerio sequencing project at the Sanger Institute Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AB.
[3]	"Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a." Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K. Evol. Dev. 7:362-375(2005) [PubMed: 16174031] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-132. Strain: Tuebingen.
[4]	"Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino." Prince V.E., Moens C.B., Kimmel C.B., Ho R.K. Development 125:393-406(1998) [PubMed: 9425135] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 165-363, DEVELOPMENTAL STAGE. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF307010 mRNA. Translation: AAG30510.1. AL645795 Genomic DNA. Translation: CAD59108.1. DQ060536 mRNA. Translation: AAY67914.1. Y13945 mRNA. Translation: CAA74283.1.
IPI	IPI00486776.
RefSeq	NP_571181.1.
UniGene	Dr.82597
3D structure databases
SMR	O42365. Positions 135-191.
ModBase	Search...
Protein-protein interaction databases
STRING	O42365.
Genome annotation databases
Ensembl	ENSDART00000009827; ENSDARP00000023072; ENSDARG00000023031; Danio rerio. [Genome view]
GeneID	30325.
KEGG	dre:30325.
Organism-specific databases
CTD	30325.
ZFIN	ZDB-GENE-990415-98. hoxa2b.
Phylogenomic databases
HOGENOM	HBG282283.
HOVERGEN	O42365.
InParanoid	O42365.
Gene expression databases
ArrayExpress	O42365.
Bgee	O42365.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA2B_DANRE

Accession

Primary (citable) accession number: O42365
Secondary accession number(s): Q4PRA7, Q9DEZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	February 1, 2005
Last modified:	December 15, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project