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Protein

Apolipoprotein A-I

Gene

apoa1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-1369062. ABC transporters in lipid homeostasis.
R-DRE-174800. Chylomicron-mediated lipid transport.
R-DRE-194223. HDL-mediated lipid transport.
R-DRE-3000471. Scavenging by Class B Receptors.
R-DRE-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-I
Short name:
Apo-AI
Short name:
ApoA-I
Alternative name(s):
Apolipoprotein A1
Cleaved into the following chain:
Proapolipoprotein A-I
Short name:
ProapoA-I
Gene namesi
Name:apoa1
Synonyms:apoa
ORF Names:zgc:103718
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-990415-14. apoa1a.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: ZFIN
  • high-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 262244Proapolipoprotein A-IPRO_0000425343Add
BLAST
Chaini24 – 262239Apolipoprotein A-IPRO_0000001964Add
BLAST

Proteomic databases

PaxDbiO42363.
PRIDEiO42363.

Expressioni

Developmental stagei

Highly expressed in the yolk syncytial layer during embryonic (starting at the gastrula stage) and early larval development, an extraembryonic structure implicated in embryonic and larval nutrition.1 Publication

Gene expression databases

BgeeiO42363.

Interactioni

Protein-protein interaction databases

BioGridi78555. 1 interaction.
STRINGi7955.ENSDARP00000025613.

Structurei

3D structure databases

ProteinModelPortaliO42363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 85221Add
BLAST
Repeati87 – 107212Add
BLAST
Repeati108 – 118113; half-lengthAdd
BLAST
Repeati119 – 140224Add
BLAST
Repeati141 – 162225Add
BLAST
Repeati163 – 184226Add
BLAST
Repeati185 – 206227Add
BLAST
Repeati207 – 228228Add
BLAST
Repeati229 – 239119; half-lengthAdd
BLAST
Repeati240 – 2622310Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni32 – 63323 X approximate tandem repeatsAdd
BLAST
Regioni64 – 26219910 X approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IWKR. Eukaryota.
ENOG410YGQ6. LUCA.
GeneTreeiENSGT00530000063081.
HOGENOMiHOG000232142.
HOVERGENiHBG106969.
InParanoidiO42363.
KOiK08757.
OMAiPYVEEYK.
OrthoDBiEOG7F24V5.
PhylomeDBiO42363.
TreeFamiTF334458.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFVALALTL LLALGSQANL FQADAPTQLE HYKAAALVYL NQVKDQAEKA
60 70 80 90 100
LDNLDGTDYE QYKLQLSESL TKLQEYAQTT SQALTPYAET ISTQLMENTK
110 120 130 140 150
QLRERVMTDV EDLRSKLEPH RAELYTALQK HIDEYREKLE PVFQEYSALN
160 170 180 190 200
RQNAEQLRAK LEPLMDDIRK AFESNIEETK SKVVPMVEAV RTKLTERLED
210 220 230 240 250
LRTMAAPYAE EYKEQLVKAV EEAREKIAPH TQDLQTRMEP YMENVRTTFA
260
QMYETIAKAI QA
Length:262
Mass (Da):30,256
Last modified:January 1, 1998 - v1
Checksum:iBB839A0A815365B9
GO

Sequence cautioni

The sequence AAH83473.1 differs from that shown. Reason: Frameshift at position 24. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651Q → L in AAH83473 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13653 mRNA. Translation: CAA74004.1.
BC083473 mRNA. Translation: AAH83473.1. Frameshift.
RefSeqiNP_571203.1. NM_131128.1.
UniGeneiDr.75775.

Genome annotation databases

EnsembliENSDART00000012050; ENSDARP00000025613; ENSDARG00000012076.
GeneIDi30355.
KEGGidre:30355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13653 mRNA. Translation: CAA74004.1.
BC083473 mRNA. Translation: AAH83473.1. Frameshift.
RefSeqiNP_571203.1. NM_131128.1.
UniGeneiDr.75775.

3D structure databases

ProteinModelPortaliO42363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi78555. 1 interaction.
STRINGi7955.ENSDARP00000025613.

Proteomic databases

PaxDbiO42363.
PRIDEiO42363.

Protocols and materials databases

DNASUi30355.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000012050; ENSDARP00000025613; ENSDARG00000012076.
GeneIDi30355.
KEGGidre:30355.

Organism-specific databases

CTDi30355.
ZFINiZDB-GENE-990415-14. apoa1a.

Phylogenomic databases

eggNOGiENOG410IWKR. Eukaryota.
ENOG410YGQ6. LUCA.
GeneTreeiENSGT00530000063081.
HOGENOMiHOG000232142.
HOVERGENiHBG106969.
InParanoidiO42363.
KOiK08757.
OMAiPYVEEYK.
OrthoDBiEOG7F24V5.
PhylomeDBiO42363.
TreeFamiTF334458.

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-1369062. ABC transporters in lipid homeostasis.
R-DRE-174800. Chylomicron-mediated lipid transport.
R-DRE-194223. HDL-mediated lipid transport.
R-DRE-3000471. Scavenging by Class B Receptors.
R-DRE-975634. Retinoid metabolism and transport.

Miscellaneous databases

NextBioi20806780.
PROiO42363.

Gene expression databases

BgeeiO42363.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development."
    Babin P.J., Thisse C., Durliat M., Andre M., Akimenko M.-A., Thisse B.
    Proc. Natl. Acad. Sci. U.S.A. 94:8622-8627(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Embryo.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiAPOA1_DANRE
AccessioniPrimary (citable) accession number: O42363
Secondary accession number(s): Q5XJ38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.