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Protein

Retinal homeobox protein Rx3

Gene

rx3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi106 – 16560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • adenohypophysis development Source: ZFIN
  • camera-type eye morphogenesis Source: ZFIN
  • cell fate specification Source: ZFIN
  • embryonic camera-type eye morphogenesis Source: ZFIN
  • eye development Source: ZFIN
  • eye field cell fate commitment involved in camera-type eye formation Source: ZFIN
  • forebrain development Source: ZFIN
  • neural crest cell migration Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • retina development in camera-type eye Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal homeobox protein Rx3
Gene namesi
Name:rx3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990415-238. rx3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Retinal homeobox protein Rx3PRO_0000049285Add
BLAST

Proteomic databases

PaxDbiO42358.

Expressioni

Developmental stagei

Expressed in the ventral forebrain.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000069319.

Structurei

3D structure databases

ProteinModelPortaliO42358.
SMRiO42358. Positions 107-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 398Octapeptide motif
Motifi272 – 28514OARPROSITE-ProRule annotationAdd
BLAST
Motifi278 – 2825Nuclear localization signalSequence analysis

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiO42358.
KOiK09332.
PhylomeDBiO42358.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLVGSQYKD MEDRLSPSAR LVRSPGSQTR IHSIESILGF KGETLFHPAF
60 70 80 90 100
PYGSGKTGKD TEHLSPKKDS NKHFDGVCRS TVMVSPDLPD ADGGKLSDDE
110 120 130 140 150
NPKKKHRRNR TTFTTFQLHE LERAFEKSHY PDVYSREELA LKVNLPEVRV
160 170 180 190 200
QVWFQNRRAK WRRQEKLEVS SIKLQESSML SIPRSGPLSL GSGLPLEPWL
210 220 230 240 250
TGPISTSSSP LQSLPSFITP QQAVPASYTP PQFLSSSTLN HSLPHIGAVC
260 270 280 290
PPYQCSGFMD KFSLQEADPR NTSIASLRMK AKEHIQSIGK TW
Length:292
Mass (Da):32,757
Last modified:January 1, 1998 - v1
Checksum:i391892B067AA7A96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001909 mRNA. Translation: AAB62327.1.
RefSeqiNP_571302.1. NM_131227.1.
UniGeneiDr.540.

Genome annotation databases

GeneIDi30474.
KEGGidre:30474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001909 mRNA. Translation: AAB62327.1.
RefSeqiNP_571302.1. NM_131227.1.
UniGeneiDr.540.

3D structure databases

ProteinModelPortaliO42358.
SMRiO42358. Positions 107-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000069319.

Proteomic databases

PaxDbiO42358.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30474.
KEGGidre:30474.

Organism-specific databases

CTDi30474.
ZFINiZDB-GENE-990415-238. rx3.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiO42358.
KOiK09332.
PhylomeDBiO42358.

Miscellaneous databases

PROiO42358.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRX3_DANRE
AccessioniPrimary (citable) accession number: O42358
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.