O42358 (RX3_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinal homeobox protein Rx3

Gene names

Name:

rx3

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation By similarity.
Subcellular location	Nucleus By similarity.
Developmental stage	Expressed in the ventral forebrain.
Sequence similarities	Belongs to the paired homeobox family. Bicoid subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenohypophysis development Inferred from mutant phenotype PubMed 17373855. Source: ZFIN cell fate specification Inferred from mutant phenotype PubMed 16300752. Source: ZFIN embryonic camera-type eye morphogenesis Inferred from mutant phenotype PubMed 16300752PubMed 16818451. Source: ZFIN neural crest cell migration Inferred from mutant phenotype PubMed 18498099. Source: ZFIN retina development in camera-type eye Inferred from mutant phenotype PubMed 12947416. Source: ZFIN transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Retinal homeobox protein Rx3		PRO_0000049285
Regions
	DNA binding	106 – 165	60	Homeobox
	Motif	32 – 39	8	Octapeptide motif
	Motif	272 – 285	14	OAR
	Motif	278 – 282	5	Nuclear localization signal Potential

Sequences

	Sequence		Length	Mass (Da)
	O42358 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 391892B067AA7A96	FASTA	292	32,757
	10 20 30 40 50 60 MRLVGSQYKD MEDRLSPSAR LVRSPGSQTR IHSIESILGF KGETLFHPAF PYGSGKTGKD 70 80 90 100 110 120 TEHLSPKKDS NKHFDGVCRS TVMVSPDLPD ADGGKLSDDE NPKKKHRRNR TTFTTFQLHE 130 140 150 160 170 180 LERAFEKSHY PDVYSREELA LKVNLPEVRV QVWFQNRRAK WRRQEKLEVS SIKLQESSML 190 200 210 220 230 240 SIPRSGPLSL GSGLPLEPWL TGPISTSSSP LQSLPSFITP QQAVPASYTP PQFLSSSTLN 250 260 270 280 290 HSLPHIGAVC PPYQCSGFMD KFSLQEADPR NTSIASLRMK AKEHIQSIGK TW

References

[1]	"The Rx homeobox gene is essential for vertebrate eye development." Mathers P.H., Grinberg A., Mahon K.A., Jamrich M. Nature 387:603-607(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF001909 mRNA. Translation: AAB62327.1.
IPI	IPI00493738.
RefSeq	NP_571302.1. NM_131227.1.
UniGene	Dr.540.
3D structure databases
ProteinModelPortal	O42358.
SMR	O42358. Positions 107-167.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	30474.
KEGG	dre:30474.
Organism-specific databases
CTD	30474.
ZFIN	ZDB-GENE-990415-238. rx3.
Phylogenomic databases
eggNOG	NOG261733.
HOGENOM	HOG000231518.
HOVERGEN	HBG021349.
InParanoid	O42358.
KO	K09332.
OrthoDB	EOG4V4387.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR003654. OAR_dom. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. PF03826. OAR. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS50803. OAR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20806867.

Entry information

Entry name

RX3_DANRE

Accession

Primary (citable) accession number: O42358

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program