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Protein

Retinal homeobox protein Rx3

Gene

rx3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi106 – 165HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • adenohypophysis development Source: ZFIN
  • camera-type eye morphogenesis Source: ZFIN
  • cell fate specification Source: ZFIN
  • embryonic camera-type eye morphogenesis Source: ZFIN
  • eye development Source: ZFIN
  • eye field cell fate commitment involved in camera-type eye formation Source: ZFIN
  • forebrain development Source: ZFIN
  • hypothalamus development Source: ZFIN
  • neural crest cell migration Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • retina development in camera-type eye Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal homeobox protein Rx3
Gene namesi
Name:rx3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990415-238. rx3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492851 – 292Retinal homeobox protein Rx3Add BLAST292

Proteomic databases

PaxDbiO42358.

Expressioni

Developmental stagei

Expressed in the ventral forebrain.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000069319.

Structurei

3D structure databases

ProteinModelPortaliO42358.
SMRiO42358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 39Octapeptide motif8
Motifi272 – 285OARPROSITE-ProRule annotationAdd BLAST14
Motifi278 – 282Nuclear localization signalSequence analysis5

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiO42358.
KOiK09332.
PhylomeDBiO42358.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR003654. OAR_dom.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.

Sequencei

Sequence statusi: Complete.

O42358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLVGSQYKD MEDRLSPSAR LVRSPGSQTR IHSIESILGF KGETLFHPAF
60 70 80 90 100
PYGSGKTGKD TEHLSPKKDS NKHFDGVCRS TVMVSPDLPD ADGGKLSDDE
110 120 130 140 150
NPKKKHRRNR TTFTTFQLHE LERAFEKSHY PDVYSREELA LKVNLPEVRV
160 170 180 190 200
QVWFQNRRAK WRRQEKLEVS SIKLQESSML SIPRSGPLSL GSGLPLEPWL
210 220 230 240 250
TGPISTSSSP LQSLPSFITP QQAVPASYTP PQFLSSSTLN HSLPHIGAVC
260 270 280 290
PPYQCSGFMD KFSLQEADPR NTSIASLRMK AKEHIQSIGK TW
Length:292
Mass (Da):32,757
Last modified:January 1, 1998 - v1
Checksum:i391892B067AA7A96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001909 mRNA. Translation: AAB62327.1.
RefSeqiNP_571302.1. NM_131227.1.
UniGeneiDr.540.

Genome annotation databases

GeneIDi30474.
KEGGidre:30474.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRX3_DANRE
AccessioniPrimary (citable) accession number: O42358
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: May 10, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families