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Protein

Retinal homeobox protein Rx2

Gene

rx2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi135 – 19460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • camera-type eye photoreceptor cell differentiation Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal homeobox protein Rx2
Gene namesi
Name:rx2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990415-237. rx2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Retinal homeobox protein Rx2PRO_0000049284Add
BLAST

Proteomic databases

PaxDbiO42357.

Expressioni

Tissue specificityi

Expressed in the outer nuclear layer, in cone photoreceptor.

Developmental stagei

Expressed in the developing retina.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000059002.

Structurei

3D structure databases

ProteinModelPortaliO42357.
SMRiO42357. Positions 136-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 448Octapeptide motif
Motifi304 – 31714OARPROSITE-ProRule annotationAdd
BLAST
Motifi310 – 3145Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi86 – 916Poly-Gln
Compositional biasi279 – 2846Poly-Pro

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiO42357.
PhylomeDBiO42357.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLSPDTMNM VDDGCLSTES YHDLGKGGVS GISGRVHSID VILGFSKDQD
60 70 80 90 100
PLLEPSGRHK VDEDQLEEQE KQVNADPYSH LQIPDQTQQQ QSVYHDTGLF
110 120 130 140 150
STDKCDADLG DPRSNVESDS RSPDIPDEDQ PKKKHRRNRT TFTTYQLHEL
160 170 180 190 200
ERAFEKSHYP DVYSREELAM KVNLPEVRVQ VWFQNRRAKW RRQEKMDTGT
210 220 230 240 250
MKLHDSPIRS FNRPPMAPNV GPMSNSLPLD PWLSSPLSSA TPMHSIPGFM
260 270 280 290 300
GPGQSLQPTY TAHPGFLNTS PGMMQNIQPM PPPPYQCQPV FNDKYPLEDV
310 320
DRSSSIAALR MKAKEHIQSM DKTWQPM
Length:327
Mass (Da):37,153
Last modified:January 1, 1998 - v1
Checksum:iA55EFF31888297BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001908 mRNA. Translation: AAB62326.1.
UniGeneiDr.152552.
Dr.75762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001908 mRNA. Translation: AAB62326.1.
UniGeneiDr.152552.
Dr.75762.

3D structure databases

ProteinModelPortaliO42357.
SMRiO42357. Positions 136-196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000059002.

Proteomic databases

PaxDbiO42357.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-990415-237. rx2.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiO42357.
PhylomeDBiO42357.

Miscellaneous databases

NextBioi20806866.
PROiO42357.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Rx homeobox gene is essential for vertebrate eye development."
    Mathers P.H., Grinberg A., Mahon K.A., Jamrich M.
    Nature 387:603-607(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiRX2_DANRE
AccessioniPrimary (citable) accession number: O42357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: December 9, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.