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Protein

Intersectin-1

Gene

itsn1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi66 – 77121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi266 – 277122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Intersectin-1
Gene namesi
Name:itsn1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5904211. itsn1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12701270Intersectin-1PRO_0000080960Add
BLAST

Proteomic databases

PRIDEiO42287.

Interactioni

Subunit structurei

Binds EPN1 and EPN2.

Protein-protein interaction databases

BioGridi98902. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliO42287.
SMRiO42287. Positions 897-955, 989-1044, 1054-1198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 10989EH 1PROSITE-ProRule annotationAdd
BLAST
Domaini53 – 8836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini220 – 30990EH 2PROSITE-ProRule annotationAdd
BLAST
Domaini253 – 28836EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini732 – 79362SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini897 – 95559SH3 2PROSITE-ProRule annotationAdd
BLAST
Domaini986 – 104459SH3 3PROSITE-ProRule annotationAdd
BLAST
Domaini1058 – 112265SH3 4PROSITE-ProRule annotationAdd
BLAST
Domaini1139 – 119860SH3 5PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni325 – 697373KLERQAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili349 – 691343Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 2 EH domains.PROSITE-ProRule annotation
Contains 5 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

HOVERGENiHBG052159.
KOiK20045.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12763. EF-hand_4. 2 hits.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 3 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF50044. SSF50044. 5 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50002. SH3. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFGTPFGG NLDIWAITVE ERAKHDQQFH GLKPTAGYIT GDQARNFFLQ
60 70 80 90 100
SGLPQPVLAQ IWALADMNND GRMDQLEFSI AMKLIKLKLQ GYPLPSILPS
110 120 130 140 150
NMLKQPVAMP AAAVAGFGMS GIVGIPPLAA VAPVPMPSIP VVGMSPPLVS
160 170 180 190 200
SVPTVPPLSN GAPAVIQSHP AFAHSATLPK SSSFGRSVAG SQINTKLQKA
210 220 230 240 250
QSFDVPAPPL VVEWAVPSSS RLKYRQLFNS QDKTMSGNLT GPQARTILMQ
260 270 280 290 300
SSLPQSQLAT IWNLSDIDQD GKLTAEEFIL AMHLIDVAMS GQPLPPILPP
310 320 330 340 350
EYIPPSFRRV RSGSGLSIMS SVSVDQRLPE EPEEEEPQNA DKKLPVTFED
360 370 380 390 400
KKRENFERGN LELEKRRQAL LEQQRKEQER LAQLERAEQE RKERERQDQE
410 420 430 440 450
RKRQQDLEKQ LEKQRELERQ REEERRKEIE RREAAKRELE RQRQLEWERN
460 470 480 490 500
RRQELLNQRN REQEDIVVLK AKKKTLEFEL EALNDKKHQL EGKLQDIRCR
510 520 530 540 550
LTTQRHEIES TNKSRELRIA EITHLQQQLQ ESQQLLGKMI PEKQSLIDQL
560 570 580 590 600
KQVQQNSLHR DSLLTLKRAL ETKEIGRQQL RDQLDEVEKE TRAKLQEIDV
610 620 630 640 650
FNNQLKELRE LYNKQQFQKQ QDFETEKIKQ KELERKTSEL DKLKEEDKRR
660 670 680 690 700
MLEQDKLWQD RVKQEEERYK FQDEEKEKRE ESVQKCEVEK KPEIQEKPNK
710 720 730 740 750
PFHQPPEPGK LGGQIPWMNT EKAPLTINQG DVKVVYYRAL YPFDARSHDE
760 770 780 790 800
ITIEPGDIIM VDESQTGEPG WLGGELKGKT GWFPANYAER MPESEFPSTT
810 820 830 840 850
KPAAETTAKP TVHVAPSPVA PAAFTNTSTN SNNWADFSST WPTNNTDKVE
860 870 880 890 900
SDNWDTWAAQ PSLTVPSAGQ HRQRSAFTPA TVTGSSPSPV LGQGEKVEGL
910 920 930 940 950
QAQALYPWRA KKDNHLNFNK NDVITVLEQQ DMWWFGEVQG QKGWFPKSYV
960 970 980 990 1000
KLISGPLRKS TSIDSTSSES PASLKRVSSP AFKPAIQGEE YISMYTYESN
1010 1020 1030 1040 1050
EQGDLTFQQG DLIVVIKKDG DWWTGTVGEK TGVFPSNYVR PKDSEAAGSG
1060 1070 1080 1090 1100
GKTGSLGKKP EIAQVIASYA ATAPEQLTLA PGQLILIRKK NPGGWWEGEL
1110 1120 1130 1140 1150
QARGKKRQIG WFPANYVKLL SPGTNKSTPT EPPKPTSLPP TCQVIGMYDY
1160 1170 1180 1190 1200
IAQNDDELAF SKGQVINVLN KEDPDWWKGE LNGHVGLFPS NYVKLTTDMD
1210 1220 1230 1240 1250
PSQQFRLGVK PAGGIPATGD RPFILFPFRD GPSLLPNAFQ APPLSVVMIK
1260 1270
FRCFTAPRFC PDMNVKYINI
Length:1,270
Mass (Da):143,671
Last modified:January 1, 1998 - v1
Checksum:iEA940C1F6B6A6858
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032118 mRNA. Translation: AAC73068.1.
PIRiT09194.
RefSeqiNP_001080955.1. NM_001087486.1.
UniGeneiXl.54777.

Genome annotation databases

GeneIDi394300.
KEGGixla:394300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032118 mRNA. Translation: AAC73068.1.
PIRiT09194.
RefSeqiNP_001080955.1. NM_001087486.1.
UniGeneiXl.54777.

3D structure databases

ProteinModelPortaliO42287.
SMRiO42287. Positions 897-955, 989-1044, 1054-1198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi98902. 4 interactions.

Proteomic databases

PRIDEiO42287.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi394300.
KEGGixla:394300.

Organism-specific databases

CTDi6453.
XenbaseiXB-GENE-5904211. itsn1.

Phylogenomic databases

HOVERGENiHBG052159.
KOiK20045.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12763. EF-hand_4. 2 hits.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 3 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF50044. SSF50044. 5 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50002. SH3. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITSN1_XENLA
AccessioniPrimary (citable) accession number: O42287
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.