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Protein

Peripherin-2

Gene

PRPH2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Peripherin-2
Alternative name(s):
CRDS1
Photoreceptor outer segment membrane glycoprotein 1
Retinal degeneration slow protein
Gene namesi
Name:PRPH2
Synonyms:RDS
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 43HelicalSequence analysisAdd BLAST19
Topological domaini44 – 61LumenalSequence analysisAdd BLAST18
Transmembranei62 – 80HelicalSequence analysisAdd BLAST19
Topological domaini81 – 99CytoplasmicSequence analysisAdd BLAST19
Transmembranei100 – 123HelicalSequence analysisAdd BLAST24
Topological domaini124 – 264LumenalSequence analysisAdd BLAST141
Transmembranei265 – 290HelicalSequence analysisAdd BLAST26
Topological domaini291 – 354CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001681081 – 354Peripherin-2Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO42281.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016098.

Family & Domainsi

Sequence similaritiesi

Belongs to the PRPH2/ROM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00390000016192.
HOGENOMiHOG000026780.
HOVERGENiHBG004964.
InParanoidiO42281.
KOiK17343.
OMAiGKICYDS.
OrthoDBiEOG091G0956.
PhylomeDBiO42281.
TreeFamiTF331684.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiView protein in InterPro
IPR000830. Peripherin/rom-1.
IPR018498. Peripherin/rom-1_CS.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
PfamiView protein in Pfam
PF00335. Tetraspannin. 1 hit.
PRINTSiPR00218. PERIPHERNRDS.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiView protein in PROSITE
PS00930. RDS_ROM1. 1 hit.

Sequencei

Sequence statusi: Complete.

O42281-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLKVKFNQ KKRVKLAQGL WLMNWFSVFA GIIVFSMGLF LKIELRKRSE
60 70 80 90 100
VMDNSESHFV PNSLILMGIL SCAFNGFAGK ICYDSLDPAK FAKWKPLLKP
110 120 130 140 150
YLALCFFFNI LLFFVALICF LMRGSLESTL AQGLKNSMKF YRDTDTPGRC
160 170 180 190 200
FMKKTIDMLQ IEFKCCGNNG FKDWFEIQWI SNRYLDFSSK EVKDRIKSNV
210 220 230 240 250
DGRYLVDGVP FSCCNPSSPR PCIQYQVTNN SAHYSYDYQT EELNLWGRGC
260 270 280 290 300
REALLHYYSS MMSSMGAVVL LVWLFEMSVM VGLRLLHTSL ESIANPEDPE
310 320 330 340 350
CESEGWILEN SLKDTLKSAL ESLKKIGKFN QVEAGAEGAE GEEAGKTPAI

TTVS
Length:354
Mass (Da):40,208
Last modified:January 1, 1998 - v1
Checksum:i5100F0DF6A9C96C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031238 mRNA. Translation: AAC06274.1.
RefSeqiNP_990369.1. NM_205038.1.
UniGeneiGga.532.

Genome annotation databases

EnsembliENSGALT00000016117; ENSGALP00000016098; ENSGALG00000009909.
GeneIDi395899.
KEGGigga:395899.

Similar proteinsi

Entry informationi

Entry nameiPRPH2_CHICK
AccessioniPrimary (citable) accession number: O42281
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families