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O42280

- WNT9A_CHICK

UniProt

O42280 - WNT9A_CHICK

Protein

Protein Wnt-9a

Gene

WNT9A

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Biological processi

    1. cornea development in camera-type eye Source: BHF-UCL
    2. embryonic skeletal joint development Source: BHF-UCL
    3. iris morphogenesis Source: BHF-UCL
    4. negative regulation of chondrocyte differentiation Source: BHF-UCL
    5. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-9a
    Alternative name(s):
    Wnt-14
    Gene namesi
    Name:WNT9A
    Synonyms:WNT14
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 354339Protein Wnt-9aPRO_0000041457Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi85 ↔ 96By similarity
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi133 ↔ 141By similarity
    Disulfide bondi143 ↔ 160By similarity
    Disulfide bondi207 ↔ 221By similarity
    Disulfide bondi209 ↔ 216By similarity
    Lipidationi213 – 2131O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi302 ↔ 313By similarity
    Disulfide bondi328 ↔ 343By similarity
    Disulfide bondi330 ↔ 340By similarity
    Disulfide bondi335 ↔ 336By similarity

    Post-translational modificationi

    Palmitoylation at Ser-213 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiO42280.
    PRIDEiO42280.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000008661.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG291879.
    HOVERGENiHBG001595.
    InParanoidiO42280.
    KOiK01064.
    PhylomeDBiO42280.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR013303. Wnt9a.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01894. WNT14PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O42280-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLRALLGL LACTPRPSAA YFGLTGNEAL TILPLTSEME EAAVKAHYKV    50
    CDRLKLEKKQ RRMCRRDPGG AETLMEAISM SALECQYQFR FERWNCTLEG 100
    RYRASLLKRG FKETAFLYAI SSAGLTHAMA KACSAGRMER CTCDEAPDLE 150
    NREAWQWGGC GDNLKYSNKF VKEFLGRKPN KDLRARVDFH NNLVGMKVIK 200
    AGVETTCKCH GVSGSCTVRT CWRQLSPFHE IGKQLKQKYE TSLKVGSTTN 250
    EATGEGDISP PKKSIPGHSD QIPRTTDLVY IDDSPSFCLM SRYSPGTSGR 300
    KCYKDKNCDS ICCGRGHNTQ SRVVTRPCQC QVRWCCYVEC KQCTQREEVY 350
    TCKD 354
    Length:354
    Mass (Da):39,814
    Last modified:January 1, 1998 - v1
    Checksum:i044BB0539CFD8669
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031168 mRNA. Translation: AAC41248.1.
    RefSeqiNP_990312.1. NM_204981.1.
    UniGeneiGga.491.

    Genome annotation databases

    GeneIDi395829.
    KEGGigga:395829.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031168 mRNA. Translation: AAC41248.1 .
    RefSeqi NP_990312.1. NM_204981.1.
    UniGenei Gga.491.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000008661.

    Proteomic databases

    PaxDbi O42280.
    PRIDEi O42280.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395829.
    KEGGi gga:395829.

    Organism-specific databases

    CTDi 7483.

    Phylogenomic databases

    eggNOGi NOG291879.
    HOVERGENi HBG001595.
    InParanoidi O42280.
    KOi K01064.
    PhylomeDBi O42280.

    Miscellaneous databases

    NextBioi 20815897.
    PROi O42280.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR013303. Wnt9a.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01894. WNT14PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."
      Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C.
      Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiWNT9A_CHICK
    AccessioniPrimary (citable) accession number: O42280
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3