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O42280

- WNT9A_CHICK

UniProt

O42280 - WNT9A_CHICK

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Protein

Protein Wnt-9a

Gene

WNT9A

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Biological processi

  1. cornea development in camera-type eye Source: BHF-UCL
  2. embryonic skeletal joint development Source: BHF-UCL
  3. iris morphogenesis Source: BHF-UCL
  4. negative regulation of chondrocyte differentiation Source: BHF-UCL
  5. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-9a
Alternative name(s):
Wnt-14
Gene namesi
Name:WNT9A
Synonyms:WNT14
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 354339Protein Wnt-9aPRO_0000041457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi85 ↔ 96By similarity
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi133 ↔ 141By similarity
Disulfide bondi143 ↔ 160By similarity
Disulfide bondi207 ↔ 221By similarity
Disulfide bondi209 ↔ 216By similarity
Lipidationi213 – 2131O-palmitoyl serine; by PORCNBy similarity
Disulfide bondi302 ↔ 313By similarity
Disulfide bondi328 ↔ 343By similarity
Disulfide bondi330 ↔ 340By similarity
Disulfide bondi335 ↔ 336By similarity

Post-translational modificationi

Palmitoylation at Ser-213 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO42280.
PRIDEiO42280.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008661.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG291879.
HOVERGENiHBG001595.
InParanoidiO42280.
KOiK01064.
PhylomeDBiO42280.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013303. Wnt9a.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01894. WNT14PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42280-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALLRALLGL LACTPRPSAA YFGLTGNEAL TILPLTSEME EAAVKAHYKV
60 70 80 90 100
CDRLKLEKKQ RRMCRRDPGG AETLMEAISM SALECQYQFR FERWNCTLEG
110 120 130 140 150
RYRASLLKRG FKETAFLYAI SSAGLTHAMA KACSAGRMER CTCDEAPDLE
160 170 180 190 200
NREAWQWGGC GDNLKYSNKF VKEFLGRKPN KDLRARVDFH NNLVGMKVIK
210 220 230 240 250
AGVETTCKCH GVSGSCTVRT CWRQLSPFHE IGKQLKQKYE TSLKVGSTTN
260 270 280 290 300
EATGEGDISP PKKSIPGHSD QIPRTTDLVY IDDSPSFCLM SRYSPGTSGR
310 320 330 340 350
KCYKDKNCDS ICCGRGHNTQ SRVVTRPCQC QVRWCCYVEC KQCTQREEVY

TCKD
Length:354
Mass (Da):39,814
Last modified:January 1, 1998 - v1
Checksum:i044BB0539CFD8669
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031168 mRNA. Translation: AAC41248.1.
RefSeqiNP_990312.1. NM_204981.1.
UniGeneiGga.491.

Genome annotation databases

GeneIDi395829.
KEGGigga:395829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031168 mRNA. Translation: AAC41248.1 .
RefSeqi NP_990312.1. NM_204981.1.
UniGenei Gga.491.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000008661.

Proteomic databases

PaxDbi O42280.
PRIDEi O42280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395829.
KEGGi gga:395829.

Organism-specific databases

CTDi 7483.

Phylogenomic databases

eggNOGi NOG291879.
HOVERGENi HBG001595.
InParanoidi O42280.
KOi K01064.
PhylomeDBi O42280.

Miscellaneous databases

NextBioi 20815897.
PROi O42280.

Family and domain databases

InterProi IPR005817. Wnt.
IPR013303. Wnt9a.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01894. WNT14PROTEIN.
PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."
    Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C.
    Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiWNT9A_CHICK
AccessioniPrimary (citable) accession number: O42280
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3