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O42280 (WNT9A_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-9a
Alternative name(s):
Wnt-14
Gene names
Name:WNT9A
Synonyms:WNT14
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Post-translational modification

Palmitoylation at Ser-213 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-85. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 354339Protein Wnt-9a
PRO_0000041457

Amino acid modifications

Lipidation851S-palmitoyl cysteine By similarity
Lipidation2131O-palmitoyl serine; by PORCN By similarity
Glycosylation951N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O42280 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 044BB0539CFD8669

FASTA35439,814
        10         20         30         40         50         60 
MALLRALLGL LACTPRPSAA YFGLTGNEAL TILPLTSEME EAAVKAHYKV CDRLKLEKKQ 

        70         80         90        100        110        120 
RRMCRRDPGG AETLMEAISM SALECQYQFR FERWNCTLEG RYRASLLKRG FKETAFLYAI 

       130        140        150        160        170        180 
SSAGLTHAMA KACSAGRMER CTCDEAPDLE NREAWQWGGC GDNLKYSNKF VKEFLGRKPN 

       190        200        210        220        230        240 
KDLRARVDFH NNLVGMKVIK AGVETTCKCH GVSGSCTVRT CWRQLSPFHE IGKQLKQKYE 

       250        260        270        280        290        300 
TSLKVGSTTN EATGEGDISP PKKSIPGHSD QIPRTTDLVY IDDSPSFCLM SRYSPGTSGR 

       310        320        330        340        350 
KCYKDKNCDS ICCGRGHNTQ SRVVTRPCQC QVRWCCYVEC KQCTQREEVY TCKD 

« Hide

References

[1]"Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."
Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C.
Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF031168 mRNA. Translation: AAC41248.1.
RefSeqNP_990312.1. NM_204981.1.
UniGeneGga.491.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000008661.

Proteomic databases

PaxDbO42280.
PRIDEO42280.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395829.
KEGGgga:395829.

Organism-specific databases

CTD7483.

Phylogenomic databases

eggNOGNOG291879.
HOVERGENHBG001595.
InParanoidO42280.
KOK01064.
PhylomeDBO42280.

Family and domain databases

InterProIPR005817. Wnt.
IPR013303. Wnt9a.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01894. WNT14PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815897.
PROO42280.

Entry information

Entry nameWNT9A_CHICK
AccessionPrimary (citable) accession number: O42280
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families