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Protein
Submitted name:

Huntingtin

Gene

htt

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • anterior neural plate formation Source: ZFIN
  • cartilage development Source: ZFIN
  • cellular iron ion homeostasis Source: ZFIN
  • central nervous system neuron development Source: ZFIN
  • embryonic viscerocranium morphogenesis Source: ZFIN
  • neural tube formation Source: ZFIN
  • neuromast development Source: ZFIN
  • olfactory placode development Source: ZFIN
  • positive regulation of brain-derived neurotrophic factor receptor signaling pathway Source: ZFIN
  • regulation of cell-cell adhesion mediated by cadherin Source: ZFIN
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
HuntingtinImported
Gene namesi
Name:httImported
Synonyms:HDImported, hdImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-990415-131. htt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO42269.
PRIDEiO42269.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000069263.

Structurei

3D structure databases

ProteinModelPortaliO42269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IDZV. Eukaryota.
ENOG410XSEC. LUCA.
HOVERGENiHBG005953.
KOiK04533.
PhylomeDBiO42269.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000091. Huntingtin.
IPR028426. Huntingtin_fam.
IPR024613. Huntingtin_middle-repeat.
[Graphical view]
PANTHERiPTHR10170. PTHR10170. 2 hits.
PfamiPF12372. DUF3652. 1 hit.
[Graphical view]
PRINTSiPR00375. HUNTINGTIN.
SUPFAMiSSF48371. SSF48371. 12 hits.

Sequencei

Sequence statusi: Complete.

O42269-1 [UniParc]FASTAAdd to basket

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        10         20         30         40         50
MATMEKLMKA FESLKSFQQQ QGPLSAEELV QKQKKDLATT KKDRVTHCLT
60 70 80 90 100
ICENIVAQSL RTSPEFQKLL GIAMEMFLLC SDDKESDVRM VADECLNKII
110 120 130 140 150
KALMDSNLPR LQLELYKEIK KNAASRSLRA ALWRFAELAH LVRPQKCRPY
160 170 180 190 200
LVNLLPCLTR ITKRQEETVQ ETLSSSIPKI MAALGHFAND GEIKMLLKAF
210 220 230 240 250
VANLKSSSPT IRRTAASSAV SVCQHSRRTH YFYTWLLNVL LGLVVPVDEE
260 270 280 290 300
HSSHLILGVL LTLRYLMPLI QQQTPSTSLK GSFGLVRKEA DVTPAPEQLI
310 320 330 340 350
QVYELTLHYT QHWDHNVVTA SLELLQQMFR TPPPELLNVL ITRGKITHTS
360 370 380 390 400
VFREEMESRA RSGSILELIA GGSTCSPLLL RKQKGKLLSG EEEGLEDDPE
410 420 430 440 450
RAEVTTGSFT ASVGGDSSSE APSSSGVSSL GTSDIITEQP RSSQHALQPG
460 470 480 490 500
DSVDLSASEQ GVGPDTPDEE DEEDMLSRSS SGGAGLVSTS GDLVTDANQM
510 520 530 540 550
SAGAVSSSPP SESSQTTTEG PDSAVTPSDC AELVLDGSES QYSGMQIGTL
560 570 580 590 600
QDEEEEGSAP PPDKPPEPFS QSALALSKPH LLEGKGHNRQ SSDSSVDRFI
610 620 630 640 650
PKEEVLEPAE LDNKPSRIKG DIGHYTDPKE EPLMHCVRLL AASFLLTGQR
660 670 680 690 700
NGLVPDNEVR VSVKALAVSC VGAAAALLPE AFFNLLYLQP LDGQQTEEQQ
710 720 730 740 750
YISDILQYIE HGDHQIRGAT AILCGALIQA IQLKTRYNTE TWLSQIQSVT
760 770 780 790 800
GSSVTLENFV PLLQRSLKDE SSVTCKMACA AVRHCIMALC NGSLSELGLQ
810 820 830 840 850
LLIDLLTLKN CSYWLVRTEL LETLAEIDFR LISFLERKTE KLHKGEHHYT
860 870 880 890 900
GLLRLQDRVL NDVVLYLLGD EDPRVRHVAA NTIGRLVPRL FFDCDQGQTD
910 920 930 940 950
PVVAIARDQS SVHLQLLMHE TQPPSQFTVS TITRTYRGFN LCQSAPDVTV
960 970 980 990 1000
ENNLSRVITA ISHALTSSTS RAMTFGCCEA LCLLSSTFPV CNWSTGWHCG
1010 1020 1030 1040 1050
FVSSSVFHLN RSSQYRSRGR SFSLSQSGSN EEVRRSLTVG VASMVLSLIS
1060 1070 1080 1090 1100
SAWFPLDLSA HQAALLLAGN LLAAVAPKCM KSPWAGEEES SPASSKVEEP
1110 1120 1130 1140 1150
WPALNDRSLV VMVEQLFSHL LKILNICAHV LDDTPPGPAV KASLPSLANT
1160 1170 1180 1190 1200
PSLSPIRRKG KEKDMMEAGT TPMSPKKGGE TNTGRAADST ATAAVNKSTT
1210 1220 1230 1240 1250
LGSFYHLPPY LKLYDALRAT HANYKVTLDL HNPNEKFGGF LRSALDVLSQ
1260 1270 1280 1290 1300
LLELATLHDI GKCVEEILGY LKSCFSREPT MATVCVQQLL KALFGTNLAS
1310 1320 1330 1340 1350
QYEGASSNPC RSQGKALRLG SSSVRPGLYH YCFMAPYTHF TQALADASLR
1360 1370 1380 1390 1400
NMVQAEQEQD ASGWFDVMQK VSNQLRSSIT NVTRHRGDKN AIHNHIRLFE
1410 1420 1430 1440 1450
PLVIKALKQY TTSTSVALQR QVLDLLAQLV QLRVNYCLLD SDQVFIGFVL
1460 1470 1480 1490 1500
KQFEYIEVGQ FRDSEEIVPN IFFFLVLLSY ERYHSKQIIS IPKIIQLCDG
1510 1520 1530 1540 1550
IMASGRKAVT HAIPALQPIV HDLFVLRGSN KADAGKELET QKEVVVSMLL
1560 1570 1580 1590 1600
RLIQHHQVLE MFILVLQQCH KENEDKWKRL SRQVADIILP MIGKQQMHLD
1610 1620 1630 1640 1650
SHEALGVLNT LFESVAPSSL RPVDMLLKSM FITPSTLASV GTVQLWVSGI
1660 1670 1680 1690 1700
LAILRVLISQ STEDIILSRI QELSLSPYLL SCPTIRRLCD DDVPAPPETL
1710 1720 1730 1740 1750
PVAMEDANGE TTRFPPEETF ARFLLQLVGV LLDDIANKQV KVDMSEQQHT
1760 1770 1780 1790 1800
FYCQQLGTLL MCLIHIFKSG MFRRITAAGS KLLKAEGGEG GDFYTLEGLN
1810 1820 1830 1840 1850
SLVLQLITTH PSLVLLWCQV LLIINYTNYT WWSEVHQTPR RHSLSSTKLL
1860 1870 1880 1890 1900
SPHSSGEEER PEGKLTMCNR EIVRRGALIL FCDYVCQNLH DSEHLTWLTV
1910 1920 1930 1940 1950
NHVSDLISLS HEPPVQDLIS AVHRNSAASG LFIQAIQSRC DNLCTPVMLK
1960 1970 1980 1990 2000
KTLQCLEGIH LSQSGALLML YVDKLLNTPF RVLARMVDTL ACRRVEMLLA
2010 2020 2030 2040 2050
ETLQNSIAQL PLEELDRIQQ YLQTSGLAQR HQRFFSLLDR FRATVAEDTT
2060 2070 2080 2090 2100
SPVAPITTHP LDGDPPPPPE NVEPNKEWYV TLVKSQCCLR GEGALYETTE
2110 2120 2130 2140 2150
LLTKLPQSDL NAIMTCKDFN LCLLASCLSV GVQRVCKDHG AVLFDTAQQV
2160 2170 2180 2190 2200
TFERLAGVIE LLPSPHQPLL PSSKVCPDYW QKLNQVYGEP GFYQTVLSLC
2210 2220 2230 2240 2250
GVLSQYLLSL SKLPSSMHIP KDRETLITTF STLAIEVVVW RLLQDQLPLS
2260 2270 2280 2290 2300
VDMQMSLSCL CLALQQPAVW THFTSHSYLT HTCSIIHCIQ LLIHAVAVGP
2310 2320 2330 2340 2350
GDQFLRPERK ISEQSEDQVD SSDNQREWHC CEIMAELVEG LQTVLTLGHH
2360 2370 2380 2390 2400
KNKNIPAFLT PTLRNVIISL ARLPLVNSYT RIPPLVWKLG WSPKLSGEFG
2410 2420 2430 2440 2450
TALPEIPVEF LQEKDVFREF LYRINTLGWS SRTQFEETWA TLLGVLVTQP
2460 2470 2480 2490 2500
ITMDQEEETQ QEEDLERTQI NVLAVQAITS LVLSAMTLPT AGNPAVSCPE
2510 2520 2530 2540 2550
QQPRNKILKA LDTRFGRKLS VIRGMVEREI QAMVSKRDNI ATHFPYQAWD
2560 2570 2580 2590 2600
PVPSLSSSTA GTLISHEKLL LQINTEREMG NMDYKLGQVS IHSVWLGNNI
2610 2620 2630 2640 2650
TPLREEEWGE DEEDEADAPA PASPQLSPIN SRKHRAGVDI HSCSQFLLEL
2660 2670 2680 2690 2700
YSQWILPGSP SSRKTPVVLI SEVVRSLLAV SDLFTERNQF DMMFSTLTEL
2710 2720 2730 2740 2750
QKVHPPEDEI LNQYLVPAIC KAAAVLGMDK AIAEPVCRLL ESTLRSTHLP
2760 2770 2780 2790 2800
SRIGALHGVL YVLECDLLDD TARQLIPTVS EYLLSNLRAI AHCVNLHNQQ
2810 2820 2830 2840 2850
HVLVMCAVAF YMMENYPLDV GSEFNAGIIQ LCCMILSASE EATPSIIYHC
2860 2870 2880 2890 2900
VLRGLERLLL SEQLSRMDAE TLVKLSVDRV NMPSPHRAMA ALGLMLTCMY
2910 2920 2930 2940 2950
TGVAGEEGKE KGSPGRPADA DPTAPDSESV IVAMERVSVL FDRIRKGFPS
2960 2970 2980 2990 3000
EARVVARILP QFLDDLFPLQ DVMNKVIGEF LSNQQPYPQF MATVVYKVFQ
3010 3020 3030 3040 3050
TLHATGQSSM VRDWVLLSLS NFTQRTPVAM AMWSLSCFFV SASTSQWISA
3060 3070 3080 3090 3100
LLPHVISRMG KSDTVDISLF CLVAMDFYRH QIDEELDRRA FQSVFEMVAS
3110 3120
PGSPYYQLLC CLQSIHQDTS L
Length:3,121
Mass (Da):346,669
Last modified:November 1, 1998 - v3
Checksum:i3CC884E199D324AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052602 mRNA. Translation: AAC63983.1.
RefSeqiNP_571093.1. NM_131018.1.
UniGeneiDr.75813.

Genome annotation databases

GeneIDi30214.
KEGGidre:30214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052602 mRNA. Translation: AAC63983.1.
RefSeqiNP_571093.1. NM_131018.1.
UniGeneiDr.75813.

3D structure databases

ProteinModelPortaliO42269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000069263.

Proteomic databases

PaxDbiO42269.
PRIDEiO42269.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30214.
KEGGidre:30214.

Organism-specific databases

CTDi3064.
ZFINiZDB-GENE-990415-131. htt.

Phylogenomic databases

eggNOGiENOG410IDZV. Eukaryota.
ENOG410XSEC. LUCA.
HOVERGENiHBG005953.
KOiK04533.
PhylomeDBiO42269.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000091. Huntingtin.
IPR028426. Huntingtin_fam.
IPR024613. Huntingtin_middle-repeat.
[Graphical view]
PANTHERiPTHR10170. PTHR10170. 2 hits.
PfamiPF12372. DUF3652. 1 hit.
[Graphical view]
PRINTSiPR00375. HUNTINGTIN.
SUPFAMiSSF48371. SSF48371. 12 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiO42269_DANRE
AccessioniPrimary (citable) accession number: O42269
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.