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O42265 (PSA1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-1

EC=3.4.25.1
Alternative name(s):
Macropain subunit C2
Multicatalytic endopeptidase complex subunit C2
Proteasome component C2
Gene names
Name:PSMA1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Proteasome subunit alpha type-1
PRO_0000124065

Sequences

Sequence LengthMass (Da)Tools
O42265 [UniParc].

Last modified August 1, 1998. Version 2.
Checksum: 86E89FD70EAB7938

FASTA26028,925
        10         20         30         40         50         60 
MLPVAGSDVT VWSPQGRIHQ IEYAMEAVKQ GSATVGLKSK THAVLVALKR AQSELAAHQK 

        70         80         90        100        110        120 
KILYVDNHIG ISIAGLTADA RLLCNFMRQE CLDSRFVFDR PLPVSRLVSL IGSKTQIPTQ 

       130        140        150        160        170        180 
RYGRRPYGVG LLIAGYDDMG PHIFQTCPSA NYFDCKAMSI GARSQSARNY LERHMTEFTD 

       190        200        210        220        230        240 
CNLNELVKHG LRALRETLPA EQDLTTKNVS IGIVGKDMEF TIYDDDDVAP FLEGLEERPQ 

       250        260 
RKPALPADEP AEKAEEPMEH 

« Hide

References

[1]"Cloning of a chick homologue of human proteasome subunit C2."
Singh I., Wagner B.J.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF027978 mRNA. Translation: AAC16604.1.
RefSeqNP_990351.1. NM_205020.1.
UniGeneGga.3661.

3D structure databases

ProteinModelPortalO42265.
SMRO42265. Positions 7-240.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000038830.

Protein family/group databases

MEROPST01.976.

Proteomic databases

PaxDbO42265.
PRIDEO42265.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395874.
KEGGgga:395874.

Organism-specific databases

CTD5682.

Phylogenomic databases

eggNOGCOG0638.
HOGENOMHOG000091080.
HOVERGENHBG105373.
InParanoidO42265.
KOK02725.
PhylomeDBO42265.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815941.
PROO42265.

Entry information

Entry namePSA1_CHICK
AccessionPrimary (citable) accession number: O42265
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: August 1, 1998
Last modified: June 11, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries