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O42265

- PSA1_CHICK

UniProt

O42265 - PSA1_CHICK

Protein

Proteasome subunit alpha type-1

Gene

PSMA1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Protein family/group databases

    MEROPSiT01.976.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-1 (EC:3.4.25.1)
    Alternative name(s):
    Macropain subunit C2
    Multicatalytic endopeptidase complex subunit C2
    Proteasome component C2
    Gene namesi
    Name:PSMA1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex Source: UniProtKB
    4. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Proteasome subunit alpha type-1PRO_0000124065Add
    BLAST

    Proteomic databases

    PaxDbiO42265.
    PRIDEiO42265.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000038830.

    Structurei

    3D structure databases

    ProteinModelPortaliO42265.
    SMRiO42265. Positions 7-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    HOGENOMiHOG000091080.
    HOVERGENiHBG105373.
    InParanoidiO42265.
    KOiK02725.
    PhylomeDBiO42265.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42265-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPVAGSDVT VWSPQGRIHQ IEYAMEAVKQ GSATVGLKSK THAVLVALKR    50
    AQSELAAHQK KILYVDNHIG ISIAGLTADA RLLCNFMRQE CLDSRFVFDR 100
    PLPVSRLVSL IGSKTQIPTQ RYGRRPYGVG LLIAGYDDMG PHIFQTCPSA 150
    NYFDCKAMSI GARSQSARNY LERHMTEFTD CNLNELVKHG LRALRETLPA 200
    EQDLTTKNVS IGIVGKDMEF TIYDDDDVAP FLEGLEERPQ RKPALPADEP 250
    AEKAEEPMEH 260
    Length:260
    Mass (Da):28,925
    Last modified:August 1, 1998 - v2
    Checksum:i86E89FD70EAB7938
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027978 mRNA. Translation: AAC16604.1.
    RefSeqiNP_990351.1. NM_205020.1.
    UniGeneiGga.3661.

    Genome annotation databases

    GeneIDi395874.
    KEGGigga:395874.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027978 mRNA. Translation: AAC16604.1 .
    RefSeqi NP_990351.1. NM_205020.1.
    UniGenei Gga.3661.

    3D structure databases

    ProteinModelPortali O42265.
    SMRi O42265. Positions 7-240.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000038830.

    Protein family/group databases

    MEROPSi T01.976.

    Proteomic databases

    PaxDbi O42265.
    PRIDEi O42265.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395874.
    KEGGi gga:395874.

    Organism-specific databases

    CTDi 5682.

    Phylogenomic databases

    eggNOGi COG0638.
    HOGENOMi HOG000091080.
    HOVERGENi HBG105373.
    InParanoidi O42265.
    KOi K02725.
    PhylomeDBi O42265.

    Miscellaneous databases

    NextBioi 20815941.
    PROi O42265.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a chick homologue of human proteasome subunit C2."
      Singh I., Wagner B.J.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPSA1_CHICK
    AccessioniPrimary (citable) accession number: O42265
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 8, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3