O42265 (PSA1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proteasome subunit alpha type-1
EC=3.4.25.1

Alternative name(s):
Macropain subunit C2
Multicatalytic endopeptidase complex subunit C2
Proteasome component C2

Gene names

Name:

PSMA1

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Catalytic activity	Cleavage of peptide bonds with very broad specificity.
Subunit structure	The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the peptidase T1A family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus Proteasome
Molecular function	Hydrolase Protease Threonine protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell proteasome core complex, alpha-subunit complex Inferred from electronic annotation. Source: InterPro
Molecular function	threonine-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Proteasome subunit alpha type-1		PRO_0000124065

Sequences

	Sequence		Length	Mass (Da)
	O42265 [UniParc]. Last modified August 1, 1998. Version 2. Checksum: 86E89FD70EAB7938	FASTA	260	28,925
	10 20 30 40 50 60 MLPVAGSDVT VWSPQGRIHQ IEYAMEAVKQ GSATVGLKSK THAVLVALKR AQSELAAHQK 70 80 90 100 110 120 KILYVDNHIG ISIAGLTADA RLLCNFMRQE CLDSRFVFDR PLPVSRLVSL IGSKTQIPTQ 130 140 150 160 170 180 RYGRRPYGVG LLIAGYDDMG PHIFQTCPSA NYFDCKAMSI GARSQSARNY LERHMTEFTD 190 200 210 220 230 240 CNLNELVKHG LRALRETLPA EQDLTTKNVS IGIVGKDMEF TIYDDDDVAP FLEGLEERPQ 250 260 RKPALPADEP AEKAEEPMEH

References

[1]	"Cloning of a chick homologue of human proteasome subunit C2." Singh I., Wagner B.J. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF027978 mRNA. Translation: AAC16604.1.
IPI	IPI00602892.
RefSeq	NP_990351.1. NM_205020.1.
UniGene	Gga.3661.
3D structure databases
ProteinModelPortal	O42265.
SMR	O42265. Positions 7-240.
ModBase	Search...
Protein-protein interaction databases
STRING	O42265.
Protein family/group databases
MEROPS	T01.976.
Proteomic databases
PRIDE	O42265.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	395874.
KEGG	gga:395874.
Organism-specific databases
CTD	5682.
Phylogenomic databases
eggNOG	veNOG06455.
GeneTree	ENSGT00550000074855.
HOGENOM	HBG499923.
HOVERGEN	HBG105373.
InParanoid	O42265.
OrthoDB	EOG4S1T7S.
PhylomeDB	O42265.
Family and domain databases
InterPro	IPR000426. Proteasome_asu_N. IPR023332. Proteasome_suA-type. IPR001353. Proteasome_sua/b. [Graphical view]
KO	K02725.
Pfam	PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. [Graphical view]
SMART	SM00948. Proteasome_A_N. 1 hit. [Graphical view]
PROSITE	PS00388. PROTEASOME_A_1. 1 hit. PS51475. PROTEASOME_A_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PSA1_CHICK

Accession

Primary (citable) accession number: O42265

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 8, 2000
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program