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O42265

- PSA1_CHICK

UniProt

O42265 - PSA1_CHICK

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Protein

Proteasome subunit alpha type-1

Gene
PSMA1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Protein family/group databases

MEROPSiT01.976.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-1 (EC:3.4.25.1)
Alternative name(s):
Macropain subunit C2
Multicatalytic endopeptidase complex subunit C2
Proteasome component C2
Gene namesi
Name:PSMA1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. proteasome core complex Source: UniProtKB
  4. proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Proteasome subunit alpha type-1PRO_0000124065Add
BLAST

Proteomic databases

PaxDbiO42265.
PRIDEiO42265.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038830.

Structurei

3D structure databases

ProteinModelPortaliO42265.
SMRiO42265. Positions 7-240.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.

Phylogenomic databases

eggNOGiCOG0638.
HOGENOMiHOG000091080.
HOVERGENiHBG105373.
InParanoidiO42265.
KOiK02725.
PhylomeDBiO42265.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42265-1 [UniParc]FASTAAdd to Basket

« Hide

MLPVAGSDVT VWSPQGRIHQ IEYAMEAVKQ GSATVGLKSK THAVLVALKR    50
AQSELAAHQK KILYVDNHIG ISIAGLTADA RLLCNFMRQE CLDSRFVFDR 100
PLPVSRLVSL IGSKTQIPTQ RYGRRPYGVG LLIAGYDDMG PHIFQTCPSA 150
NYFDCKAMSI GARSQSARNY LERHMTEFTD CNLNELVKHG LRALRETLPA 200
EQDLTTKNVS IGIVGKDMEF TIYDDDDVAP FLEGLEERPQ RKPALPADEP 250
AEKAEEPMEH 260
Length:260
Mass (Da):28,925
Last modified:August 1, 1998 - v2
Checksum:i86E89FD70EAB7938
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027978 mRNA. Translation: AAC16604.1.
RefSeqiNP_990351.1. NM_205020.1.
UniGeneiGga.3661.

Genome annotation databases

GeneIDi395874.
KEGGigga:395874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027978 mRNA. Translation: AAC16604.1 .
RefSeqi NP_990351.1. NM_205020.1.
UniGenei Gga.3661.

3D structure databases

ProteinModelPortali O42265.
SMRi O42265. Positions 7-240.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000038830.

Protein family/group databases

MEROPSi T01.976.

Proteomic databases

PaxDbi O42265.
PRIDEi O42265.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395874.
KEGGi gga:395874.

Organism-specific databases

CTDi 5682.

Phylogenomic databases

eggNOGi COG0638.
HOGENOMi HOG000091080.
HOVERGENi HBG105373.
InParanoidi O42265.
KOi K02725.
PhylomeDBi O42265.

Miscellaneous databases

NextBioi 20815941.
PROi O42265.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view ]
SMARTi SM00948. Proteasome_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of a chick homologue of human proteasome subunit C2."
    Singh I., Wagner B.J.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPSA1_CHICK
AccessioniPrimary (citable) accession number: O42265
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: August 1, 1998
Last modified: June 11, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi