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Protein

Guanine nucleotide-binding protein subunit beta-2-like 1

Gene

gnb2l1

Organism
Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-2-like 1
Alternative name(s):
Receptor of activated protein kinase C
Short name:
RACK
Gene namesi
Name:gnb2l1
Synonyms:rack1
OrganismiOreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Taxonomic identifieri8128 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis
Proteomesi
  • UP000005207 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Guanine nucleotide-binding protein subunit beta-2-like 1PRO_0000127737Add
BLAST

Proteomic databases

PRIDEiO42249.

Interactioni

Protein-protein interaction databases

STRINGi8128.ENSONIP00000016329.

Structurei

3D structure databases

ProteinModelPortaliO42249.
SMRiO42249. Positions 4-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati13 – 4432WD 1Add
BLAST
Repeati61 – 9131WD 2Add
BLAST
Repeati103 – 13331WD 3Add
BLAST
Repeati146 – 17833WD 4Add
BLAST
Repeati190 – 22031WD 5Add
BLAST
Repeati231 – 26030WD 6Add
BLAST
Repeati281 – 31131WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0279. Eukaryota.
ENOG410XQGZ. LUCA.
HOVERGENiHBG000277.
InParanoidiO42249.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQMTVRGT LKGHSGWVTQ IATTPKYPDM ILSASRDKSI IMWKLTRDET
60 70 80 90 100
NYGIPQRSLK GHSHFVSDVV ISSDGQFALS GAWDGTLRLW DLTTGLTTRR
110 120 130 140 150
FVGHTKDVLS VAFSADNRQI VSGSRDKTIK LWNTLGVCKY TIQDEGHTEW
160 170 180 190 200
VSCVRFSPNS SNPIIVSCGW DKMVKVWNLA NCKLKTNHIG HTGYLNTVTV
210 220 230 240 250
SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DSGDVINALC FSPNRYWLCA
260 270 280 290 300
ATGPSIKIWD LEGKIIVDEL RQEVISTNSK AEPPQCTSLA WSADGQTLFA
310
GYTDNLIRVW QVTIGTR
Length:317
Mass (Da):35,107
Last modified:January 1, 1998 - v1
Checksum:i4DA8360358D9BD99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025331 mRNA. Translation: AAB81618.1.
RefSeqiNP_001266445.1. NM_001279516.1.
UniGeneiOni.25.

Genome annotation databases

GeneIDi100534572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025331 mRNA. Translation: AAB81618.1.
RefSeqiNP_001266445.1. NM_001279516.1.
UniGeneiOni.25.

3D structure databases

ProteinModelPortaliO42249.
SMRiO42249. Positions 4-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8128.ENSONIP00000016329.

Proteomic databases

PRIDEiO42249.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100534572.

Organism-specific databases

CTDi30722.

Phylogenomic databases

eggNOGiKOG0279. Eukaryota.
ENOG410XQGZ. LUCA.
HOVERGENiHBG000277.
InParanoidiO42249.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of complementary DNAs coding for a receptor for activated C kinase (RACK) from zebrafish (Danio rerio) and Tilapia (Oreochromis niloticus): constitutive developmental and tissue expression."
    Hamilton L.C., Wright J.M.
    Mar. Biotechnol. 1:279-285(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGBLP_ORENI
AccessioniPrimary (citable) accession number: O42249
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.