Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein subunit beta-2-like 1

Gene

gnb2l1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation.By similarity1 Publication

GO - Biological processi

  • angiogenesis Source: ZFIN
  • convergent extension involved in gastrulation Source: ZFIN
  • negative regulation of Wnt signaling pathway Source: UniProtKB
  • positive regulation of gastrulation Source: UniProtKB
  • regulation of cell division Source: UniProtKB
  • regulation of establishment of cell polarity Source: UniProtKB
  • regulation of protein localization Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-5357905. Regulation of TNFR1 signaling.
R-DRE-5357956. TNFR1-induced NFkappaB signaling pathway.
R-DRE-5626978. TNFR1-mediated ceramide production.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-2-like 1
Alternative name(s):
Receptor of activated protein kinase C
Short name:
RACK
Gene namesi
Name:gnb2l1
Synonyms:rack1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-990415-89. gnb2l1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001277361 – 317Guanine nucleotide-binding protein subunit beta-2-like 1Add BLAST317

Proteomic databases

PaxDbiO42248.
PRIDEiO42248.

Expressioni

Gene expression databases

BgeeiENSDARG00000041619.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061000.

Structurei

3D structure databases

ProteinModelPortaliO42248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 44WD 1Add BLAST32
Repeati61 – 91WD 2Add BLAST31
Repeati103 – 133WD 3Add BLAST31
Repeati146 – 178WD 4Add BLAST33
Repeati190 – 220WD 5Add BLAST31
Repeati231 – 260WD 6Add BLAST30
Repeati281 – 311WD 7Add BLAST31

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0279. Eukaryota.
ENOG410XQGZ. LUCA.
GeneTreeiENSGT00840000129847.
HOGENOMiHOG000091643.
HOVERGENiHBG000277.
InParanoidiO42248.
KOiK14753.
OMAiATSMENP.
OrthoDBiEOG091G0KZQ.
PhylomeDBiO42248.
TreeFamiTF300600.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42248-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQMTVRGT LKGHSGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET
60 70 80 90 100
NYGIPQRALR GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR
110 120 130 140 150
FVGHTKDVLS VAFSADNRQI VSGSRDKTIK LWNTLGVCKY TIQDDSHTEW
160 170 180 190 200
VSCVRFSPNS SNPIIVSCGW DKMVKVWNLA NCKLKTNHIG HTGYLNTVTV
210 220 230 240 250
SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDTINALC FSPNRYWLCA
260 270 280 290 300
ATGPSIKIWD LEGKIIVDEL RQDIITTNSK AEPPQCTSLA WSADGQTLFA
310
GYTDNLIRVW QVTIGTR
Length:317
Mass (Da):35,123
Last modified:January 1, 1998 - v1
Checksum:iDEC80E241A22808B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025330 mRNA. Translation: AAB81617.1.
AY423038 mRNA. Translation: AAQ98014.1.
BC049459 mRNA. Translation: AAH49459.1.
RefSeqiNP_571519.1. NM_131444.1.
UniGeneiDr.75572.

Genome annotation databases

EnsembliENSDART00000061001; ENSDARP00000061000; ENSDARG00000041619.
GeneIDi30722.
KEGGidre:30722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025330 mRNA. Translation: AAB81617.1.
AY423038 mRNA. Translation: AAQ98014.1.
BC049459 mRNA. Translation: AAH49459.1.
RefSeqiNP_571519.1. NM_131444.1.
UniGeneiDr.75572.

3D structure databases

ProteinModelPortaliO42248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061000.

Proteomic databases

PaxDbiO42248.
PRIDEiO42248.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000061001; ENSDARP00000061000; ENSDARG00000041619.
GeneIDi30722.
KEGGidre:30722.

Organism-specific databases

CTDi30722.
ZFINiZDB-GENE-990415-89. gnb2l1.

Phylogenomic databases

eggNOGiKOG0279. Eukaryota.
ENOG410XQGZ. LUCA.
GeneTreeiENSGT00840000129847.
HOGENOMiHOG000091643.
HOVERGENiHBG000277.
InParanoidiO42248.
KOiK14753.
OMAiATSMENP.
OrthoDBiEOG091G0KZQ.
PhylomeDBiO42248.
TreeFamiTF300600.

Enzyme and pathway databases

ReactomeiR-DRE-5357905. Regulation of TNFR1 signaling.
R-DRE-5357956. TNFR1-induced NFkappaB signaling pathway.
R-DRE-5626978. TNFR1-mediated ceramide production.

Miscellaneous databases

PROiO42248.

Gene expression databases

BgeeiENSDARG00000041619.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBLP_DANRE
AccessioniPrimary (citable) accession number: O42248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.