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O42237

- SEM3E_CHICK

UniProt

O42237 - SEM3E_CHICK

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Protein

Semaphorin-3E

Gene

SEMA3E

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Induces the collapse and paralysis of neuronal growth cones. Plays an important role in ensuring the specificity of synapse formation (By similarity).By similarity

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. nervous system development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3E
Alternative name(s):
Collapsin-5
Short name:
COLL-5
Gene namesi
Name:SEMA3E
Synonyms:COLL5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 785760Semaphorin-3EPRO_0000032319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi109 ↔ 119PROSITE-ProRule annotation
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi137 ↔ 146PROSITE-ProRule annotation
Disulfide bondi274 ↔ 386PROSITE-ProRule annotation
Disulfide bondi298 ↔ 346PROSITE-ProRule annotation
Disulfide bondi523 ↔ 541PROSITE-ProRule annotation
Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi658 ↔ 733PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO42237.

Expressioni

Tissue specificityi

Collapsin-1, -2, -3, and -5 bind to overlapping but distinct axon tracts.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013846.

Structurei

3D structure databases

ProteinModelPortaliO42237.
SMRiO42237. Positions 33-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 520485SemaPROSITE-ProRule annotationAdd
BLAST
Domaini651 – 74090Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi741 – 78040Arg/Lys-rich (basic)Add
BLAST

Domaini

Strong binding to neuropilin is mediated by the carboxy third of the protein.

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG324739.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiO42237.
KOiK06840.
PhylomeDBiO42237.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015513. Semaphorin_3E.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PTHR11036:SF22. PTHR11036:SF22. 1 hit.
PfamiPF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42237-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGRMASAQD LLILALCGLL LELPAGYHAT DTRQPRLRLS HKELWDLNRT
60 70 80 90 100
SVFHSPFGYL GLHIMLLDEY QERLFVGGRD LLYSLSLDRI SNNYREIHWP
110 120 130 140 150
STPLQAEECI IKGRDADECA NYVRVLHRYN RTHLLACGTG AFDPVCTFIR
160 170 180 190 200
VGHPSEDHLF QLESHKFERG RGRCPFDPTS SFTSILIGGE LFTGLYSDYW
210 220 230 240 250
GRDAAVFRTM NRMAHLRTEP DSEHLLKEPK FVGSYMIPDN EDHDDNKVYL
260 270 280 290 300
FFTEKALEAE TSTHAIYTRV GRVCVNDMGG QRIVVNKWST FLKTRLVCSV
310 320 330 340 350
PGRNGIDTHF DELEDVFLLQ TRDNKNPVIF GLFSTTSNIF RGYAICVYHM
360 370 380 390 400
AIVRAAFNGP YAHKEGPEYY WALYEGKVPY PRPGSCASKV NGGLYTTTKD
410 420 430 440 450
YPDEAVHFAR SHPLMYQPIK PVHKRPILVK TDGKYNLKQI AVDRVEAEDG
460 470 480 490 500
QYDVLFIGTD NGIVLKVITI YNQETESMEE VILEELQVFK VPIPILSMEI
510 520 530 540 550
SSKRQQLYIG TESVIAQVKF HQCDMYGTAC ADCCLARDPY CAWDGISCSR
560 570 580 590 600
YYPTGMQAKR RFRRQDVRHG NAAQQCFGQQ FIGEVLEKTE ERLVYGIEYN
610 620 630 640 650
STLLEYTPRT LQAKVNWFVQ RAHETKKEEV KTDERIIKMD LGLLFLKLHR
660 670 680 690 700
LDAGTYFCQT VEHSIVHTVR KITLEIVEEE RVDEMFSKDY EEEISHKMPC
710 720 730 740 750
PMQSNIPQVS KPWYKEFLQL IGYSNFQRVE EYCEKVWCTD KKRKKLKMSP
760 770 780
SKWKYANPQE KRQDQEKKAR IRPEHYRLPR NIADS
Length:785
Mass (Da):90,979
Last modified:January 1, 1998 - v1
Checksum:iE551EBF717630632
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti246 – 2461N → D(PubMed:7605628)Curated
Sequence conflicti248 – 2481V → I(PubMed:7605628)Curated
Sequence conflicti250 – 2501L → F(PubMed:7605628)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022947 mRNA. Translation: AAB80952.1.
U28243 mRNA. Translation: AAA86899.1.
RefSeqiNP_989573.1. NM_204242.1.
UniGeneiGga.136.

Genome annotation databases

GeneIDi374089.
KEGGigga:374089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022947 mRNA. Translation: AAB80952.1 .
U28243 mRNA. Translation: AAA86899.1 .
RefSeqi NP_989573.1. NM_204242.1.
UniGenei Gga.136.

3D structure databases

ProteinModelPortali O42237.
SMRi O42237. Positions 33-526.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000013846.

Proteomic databases

PaxDbi O42237.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 374089.
KEGGi gga:374089.

Organism-specific databases

CTDi 9723.

Phylogenomic databases

eggNOGi NOG324739.
HOGENOMi HOG000039964.
HOVERGENi HBG055071.
InParanoidi O42237.
KOi K06840.
PhylomeDBi O42237.

Miscellaneous databases

NextBioi 20813608.
PROi O42237.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015513. Semaphorin_3E.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
PTHR11036:SF22. PTHR11036:SF22. 1 hit.
Pfami PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Secreted chick semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neurons in situ."
    Feiner L., Koppel A.M., Kobayashi H., Raper J.A.
    Neuron 19:539-545(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "A family of molecules related to collapsin in the embryonic chick nervous system."
    Luo Y., Shepherd I., Li J., Renzi M.J., Chang S., Raper J.A.
    Neuron 14:1131-1140(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-543.

Entry informationi

Entry nameiSEM3E_CHICK
AccessioniPrimary (citable) accession number: O42237
Secondary accession number(s): Q90666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3