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O42237

- SEM3E_CHICK

UniProt

O42237 - SEM3E_CHICK

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Protein

Semaphorin-3E

Gene
SEMA3E, COLL5
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Induces the collapse and paralysis of neuronal growth cones. Plays an important role in ensuring the specificity of synapse formation By similarity.

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. nervous system development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3E
Alternative name(s):
Collapsin-5
Short name:
COLL-5
Gene namesi
Name:SEMA3E
Synonyms:COLL5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 785760Semaphorin-3EPRO_0000032319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi109 ↔ 119 By similarity
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi137 ↔ 146 By similarity
Disulfide bondi274 ↔ 386 By similarity
Disulfide bondi298 ↔ 346 By similarity
Disulfide bondi523 ↔ 541 By similarity
Glycosylationi600 – 6001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi658 ↔ 733 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO42237.

Expressioni

Tissue specificityi

Collapsin-1, -2, -3, and -5 bind to overlapping but distinct axon tracts.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013846.

Structurei

3D structure databases

ProteinModelPortaliO42237.
SMRiO42237. Positions 33-526.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 520485SemaAdd
BLAST
Domaini651 – 74090Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi741 – 78040Arg/Lys-rich (basic)Add
BLAST

Domaini

Strong binding to neuropilin is mediated by the carboxy third of the protein.

Sequence similaritiesi

Belongs to the semaphorin family.
Contains 1 Sema domain.

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG324739.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiO42237.
KOiK06840.
PhylomeDBiO42237.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015513. Semaphorin_3E.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PTHR11036:SF22. PTHR11036:SF22. 1 hit.
PfamiPF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42237-1 [UniParc]FASTAAdd to Basket

« Hide

MLGRMASAQD LLILALCGLL LELPAGYHAT DTRQPRLRLS HKELWDLNRT    50
SVFHSPFGYL GLHIMLLDEY QERLFVGGRD LLYSLSLDRI SNNYREIHWP 100
STPLQAEECI IKGRDADECA NYVRVLHRYN RTHLLACGTG AFDPVCTFIR 150
VGHPSEDHLF QLESHKFERG RGRCPFDPTS SFTSILIGGE LFTGLYSDYW 200
GRDAAVFRTM NRMAHLRTEP DSEHLLKEPK FVGSYMIPDN EDHDDNKVYL 250
FFTEKALEAE TSTHAIYTRV GRVCVNDMGG QRIVVNKWST FLKTRLVCSV 300
PGRNGIDTHF DELEDVFLLQ TRDNKNPVIF GLFSTTSNIF RGYAICVYHM 350
AIVRAAFNGP YAHKEGPEYY WALYEGKVPY PRPGSCASKV NGGLYTTTKD 400
YPDEAVHFAR SHPLMYQPIK PVHKRPILVK TDGKYNLKQI AVDRVEAEDG 450
QYDVLFIGTD NGIVLKVITI YNQETESMEE VILEELQVFK VPIPILSMEI 500
SSKRQQLYIG TESVIAQVKF HQCDMYGTAC ADCCLARDPY CAWDGISCSR 550
YYPTGMQAKR RFRRQDVRHG NAAQQCFGQQ FIGEVLEKTE ERLVYGIEYN 600
STLLEYTPRT LQAKVNWFVQ RAHETKKEEV KTDERIIKMD LGLLFLKLHR 650
LDAGTYFCQT VEHSIVHTVR KITLEIVEEE RVDEMFSKDY EEEISHKMPC 700
PMQSNIPQVS KPWYKEFLQL IGYSNFQRVE EYCEKVWCTD KKRKKLKMSP 750
SKWKYANPQE KRQDQEKKAR IRPEHYRLPR NIADS 785
Length:785
Mass (Da):90,979
Last modified:January 1, 1998 - v1
Checksum:iE551EBF717630632
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti246 – 2461N → D1 Publication
Sequence conflicti248 – 2481V → I1 Publication
Sequence conflicti250 – 2501L → F1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022947 mRNA. Translation: AAB80952.1.
U28243 mRNA. Translation: AAA86899.1.
RefSeqiNP_989573.1. NM_204242.1.
UniGeneiGga.136.

Genome annotation databases

GeneIDi374089.
KEGGigga:374089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022947 mRNA. Translation: AAB80952.1 .
U28243 mRNA. Translation: AAA86899.1 .
RefSeqi NP_989573.1. NM_204242.1.
UniGenei Gga.136.

3D structure databases

ProteinModelPortali O42237.
SMRi O42237. Positions 33-526.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000013846.

Proteomic databases

PaxDbi O42237.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 374089.
KEGGi gga:374089.

Organism-specific databases

CTDi 9723.

Phylogenomic databases

eggNOGi NOG324739.
HOGENOMi HOG000039964.
HOVERGENi HBG055071.
InParanoidi O42237.
KOi K06840.
PhylomeDBi O42237.

Miscellaneous databases

NextBioi 20813608.
PROi O42237.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015513. Semaphorin_3E.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
PTHR11036:SF22. PTHR11036:SF22. 1 hit.
Pfami PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Secreted chick semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neurons in situ."
    Feiner L., Koppel A.M., Kobayashi H., Raper J.A.
    Neuron 19:539-545(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "A family of molecules related to collapsin in the embryonic chick nervous system."
    Luo Y., Shepherd I., Li J., Renzi M.J., Chang S., Raper J.A.
    Neuron 14:1131-1140(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-543.

Entry informationi

Entry nameiSEM3E_CHICK
AccessioniPrimary (citable) accession number: O42237
Secondary accession number(s): Q90666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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