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O42237

- SEM3E_CHICK

UniProt

O42237 - SEM3E_CHICK

Protein

Semaphorin-3E

Gene

SEMA3E

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Induces the collapse and paralysis of neuronal growth cones. Plays an important role in ensuring the specificity of synapse formation By similarity.By similarity

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. nervous system development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Angiogenesis, Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semaphorin-3E
    Alternative name(s):
    Collapsin-5
    Short name:
    COLL-5
    Gene namesi
    Name:SEMA3E
    Synonyms:COLL5
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 785760Semaphorin-3EPRO_0000032319Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi109 ↔ 119PROSITE-ProRule annotation
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi137 ↔ 146PROSITE-ProRule annotation
    Disulfide bondi274 ↔ 386PROSITE-ProRule annotation
    Disulfide bondi298 ↔ 346PROSITE-ProRule annotation
    Disulfide bondi523 ↔ 541PROSITE-ProRule annotation
    Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi658 ↔ 733PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO42237.

    Expressioni

    Tissue specificityi

    Collapsin-1, -2, -3, and -5 bind to overlapping but distinct axon tracts.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000013846.

    Structurei

    3D structure databases

    ProteinModelPortaliO42237.
    SMRiO42237. Positions 33-526.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 520485SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini651 – 74090Ig-like C2-typeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi741 – 78040Arg/Lys-rich (basic)Add
    BLAST

    Domaini

    Strong binding to neuropilin is mediated by the carboxy third of the protein.

    Sequence similaritiesi

    Belongs to the semaphorin family.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG324739.
    HOGENOMiHOG000039964.
    HOVERGENiHBG055071.
    InParanoidiO42237.
    KOiK06840.
    PhylomeDBiO42237.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR016201. Plexin-like_fold.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015513. Semaphorin_3E.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR11036. PTHR11036. 1 hit.
    PTHR11036:SF22. PTHR11036:SF22. 1 hit.
    PfamiPF01403. Sema. 1 hit.
    [Graphical view]
    SMARTiSM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEiPS51004. SEMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O42237-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGRMASAQD LLILALCGLL LELPAGYHAT DTRQPRLRLS HKELWDLNRT    50
    SVFHSPFGYL GLHIMLLDEY QERLFVGGRD LLYSLSLDRI SNNYREIHWP 100
    STPLQAEECI IKGRDADECA NYVRVLHRYN RTHLLACGTG AFDPVCTFIR 150
    VGHPSEDHLF QLESHKFERG RGRCPFDPTS SFTSILIGGE LFTGLYSDYW 200
    GRDAAVFRTM NRMAHLRTEP DSEHLLKEPK FVGSYMIPDN EDHDDNKVYL 250
    FFTEKALEAE TSTHAIYTRV GRVCVNDMGG QRIVVNKWST FLKTRLVCSV 300
    PGRNGIDTHF DELEDVFLLQ TRDNKNPVIF GLFSTTSNIF RGYAICVYHM 350
    AIVRAAFNGP YAHKEGPEYY WALYEGKVPY PRPGSCASKV NGGLYTTTKD 400
    YPDEAVHFAR SHPLMYQPIK PVHKRPILVK TDGKYNLKQI AVDRVEAEDG 450
    QYDVLFIGTD NGIVLKVITI YNQETESMEE VILEELQVFK VPIPILSMEI 500
    SSKRQQLYIG TESVIAQVKF HQCDMYGTAC ADCCLARDPY CAWDGISCSR 550
    YYPTGMQAKR RFRRQDVRHG NAAQQCFGQQ FIGEVLEKTE ERLVYGIEYN 600
    STLLEYTPRT LQAKVNWFVQ RAHETKKEEV KTDERIIKMD LGLLFLKLHR 650
    LDAGTYFCQT VEHSIVHTVR KITLEIVEEE RVDEMFSKDY EEEISHKMPC 700
    PMQSNIPQVS KPWYKEFLQL IGYSNFQRVE EYCEKVWCTD KKRKKLKMSP 750
    SKWKYANPQE KRQDQEKKAR IRPEHYRLPR NIADS 785
    Length:785
    Mass (Da):90,979
    Last modified:January 1, 1998 - v1
    Checksum:iE551EBF717630632
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti246 – 2461N → D(PubMed:7605628)Curated
    Sequence conflicti248 – 2481V → I(PubMed:7605628)Curated
    Sequence conflicti250 – 2501L → F(PubMed:7605628)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022947 mRNA. Translation: AAB80952.1.
    U28243 mRNA. Translation: AAA86899.1.
    RefSeqiNP_989573.1. NM_204242.1.
    UniGeneiGga.136.

    Genome annotation databases

    GeneIDi374089.
    KEGGigga:374089.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022947 mRNA. Translation: AAB80952.1 .
    U28243 mRNA. Translation: AAA86899.1 .
    RefSeqi NP_989573.1. NM_204242.1.
    UniGenei Gga.136.

    3D structure databases

    ProteinModelPortali O42237.
    SMRi O42237. Positions 33-526.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000013846.

    Proteomic databases

    PaxDbi O42237.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 374089.
    KEGGi gga:374089.

    Organism-specific databases

    CTDi 9723.

    Phylogenomic databases

    eggNOGi NOG324739.
    HOGENOMi HOG000039964.
    HOVERGENi HBG055071.
    InParanoidi O42237.
    KOi K06840.
    PhylomeDBi O42237.

    Miscellaneous databases

    NextBioi 20813608.
    PROi O42237.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR016201. Plexin-like_fold.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015513. Semaphorin_3E.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR11036. PTHR11036. 1 hit.
    PTHR11036:SF22. PTHR11036:SF22. 1 hit.
    Pfami PF01403. Sema. 1 hit.
    [Graphical view ]
    SMARTi SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEi PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Secreted chick semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neurons in situ."
      Feiner L., Koppel A.M., Kobayashi H., Raper J.A.
      Neuron 19:539-545(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. "A family of molecules related to collapsin in the embryonic chick nervous system."
      Luo Y., Shepherd I., Li J., Renzi M.J., Chang S., Raper J.A.
      Neuron 14:1131-1140(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-543.

    Entry informationi

    Entry nameiSEM3E_CHICK
    AccessioniPrimary (citable) accession number: O42237
    Secondary accession number(s): Q90666
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3