ID   CP1A1_LIZAU             Reviewed;         521 AA.
AC   O42231;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 54.
DE   RecName: Full=Cytochrome P450 1A1;
DE            EC=1.14.14.1;
DE   AltName: Full=CYPIA1;
GN   Name=cyp1a1;
OS   Liza aurata (Golden grey mullet).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;
OC   Acanthomorpha; Acanthopterygii; Percomorpha; Mugilomorpha; Mugilidae;
OC   Liza.
OX   NCBI_TaxID=48191;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RA   Cousinou M., Lopez-Barea J., Dorado G.;
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate
CC       monooxygenases. They oxidize a variety of structurally unrelated
CC       compounds, including steroids, fatty acids, and xenobiotics.
CC   -!- CATALYTIC ACTIVITY: RH + reduced flavoprotein + O(2) = ROH +
CC       oxidized flavoprotein + H(2)O.
CC   -!- COFACTOR: Heme group (By similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
CC       membrane protein. Microsome membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
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DR   EMBL; AF022433; AAB70307.1; -; mRNA.
DR   HSSP; P00179; 1DT6.
DR   HOVERGEN; O42231; -.
DR   BRENDA; 1.14.14.1; 292698.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017973; Cyt_P450_C.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR008066; Cyt_P450_E_grp-I_CYP1.
DR   Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1.
DR   PANTHER; PTHR19383; Cyt_P450; 1.
DR   PANTHER; PTHR19383:SF63; Cyt_P450_E_grp-I_CYP1; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR01683; EP450ICYP1A.
DR   PRINTS; PR00385; P450.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase.
FT   CHAIN         1    521       Cytochrome P450 1A1.
FT                                /FTId=PRO_0000051638.
FT   METAL       463    463       Iron (heme axial ligand) (By similarity).
SQ   SEQUENCE   521 AA;  59064 MW;  CD23195E40228DBE CRC64;
     MALMILPFIG ALSVSESLVA LVTVCLVYLI IKSFQANIPE GLSRLPGPKP LPIIGNVLEV
     GSRPYLSLTE MSKRYGNVFQ IQIGMRPVVV LSGNETVRQA LIKQGDEFAG RPDLYSFRFI
     SEGKSLAFST DQAGVWRARR KLAYSALRSF STLEGTTPEY SCVLEEHISK EAEYLIKQLD
     TVMKADGSFD PFRYIVVSVA NVICGMCFGR RYDHHDRELL SLVNLSDEFG QVVGSGNPAD
     FIPILQYLPN KTMKKFVNIN DRFISFVQKI VSEHYATFNK DNIRDITDSL IDHCEDRKLD
     ENANVQMSDE KVVGIVNDLF GAGLDTISTA LSWSVMYLVA YPEIQERLYQ ELKENVGLDR
     TPVLSDRNNL PLLEAFILEI FRHSSFLPFT IPHCTTKDTS LNGYYIPKDT CVFINQWQIN
     HDPELWKEPS SFNPDRFLSA DGTEVNKVDG EKVMVFGLGK RRCIGEVIAR NEVYMFLAIL
     IQKLHFYNLP GEPLDMTPEY GLTMKHKRCH LRATVRVRSD H
//