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O42231

- CP1A1_LIZAU

UniProt

O42231 - CP1A1_LIZAU

Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Liza aurata (Golden grey mullet)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei229 – 2291SubstrateBy similarity
    Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:cyp1a1
    OrganismiLiza aurata (Golden grey mullet)
    Taxonomic identifieri48191 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaMugilomorphaeMugilidaeLiza

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Cytochrome P450 1A1PRO_0000051638Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO42231.
    SMRiO42231. Positions 38-511.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42231-1 [UniParc]FASTAAdd to Basket

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    MALMILPFIG ALSVSESLVA LVTVCLVYLI IKSFQANIPE GLSRLPGPKP    50
    LPIIGNVLEV GSRPYLSLTE MSKRYGNVFQ IQIGMRPVVV LSGNETVRQA 100
    LIKQGDEFAG RPDLYSFRFI SEGKSLAFST DQAGVWRARR KLAYSALRSF 150
    STLEGTTPEY SCVLEEHISK EAEYLIKQLD TVMKADGSFD PFRYIVVSVA 200
    NVICGMCFGR RYDHHDRELL SLVNLSDEFG QVVGSGNPAD FIPILQYLPN 250
    KTMKKFVNIN DRFISFVQKI VSEHYATFNK DNIRDITDSL IDHCEDRKLD 300
    ENANVQMSDE KVVGIVNDLF GAGLDTISTA LSWSVMYLVA YPEIQERLYQ 350
    ELKENVGLDR TPVLSDRNNL PLLEAFILEI FRHSSFLPFT IPHCTTKDTS 400
    LNGYYIPKDT CVFINQWQIN HDPELWKEPS SFNPDRFLSA DGTEVNKVDG 450
    EKVMVFGLGK RRCIGEVIAR NEVYMFLAIL IQKLHFYNLP GEPLDMTPEY 500
    GLTMKHKRCH LRATVRVRSD H 521
    Length:521
    Mass (Da):59,064
    Last modified:January 1, 1998 - v1
    Checksum:iCD23195E40228DBE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022433 mRNA. Translation: AAB70307.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022433 mRNA. Translation: AAB70307.1 .

    3D structure databases

    ProteinModelPortali O42231.
    SMRi O42231. Positions 38-511.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cousinou M., Lopez-Barea J., Dorado G.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_LIZAU
    AccessioniPrimary (citable) accession number: O42231
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3