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Protein

Smoothened homolog

Gene

SMO

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. smoothened signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Smoothened homolog
Short name:
SMO
Gene namesi
Name:SMO
Synonyms:SMOH
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini16 – 201186ExtracellularSequence AnalysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini223 – 2319CytoplasmicSequence Analysis
Transmembranei232 – 25221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini253 – 28331ExtracellularSequence AnalysisAdd
BLAST
Transmembranei284 – 30421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini305 – 32723CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei328 – 34821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini349 – 37123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei372 – 39221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini393 – 42028CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei421 – 44020Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini441 – 49353ExtracellularSequence AnalysisAdd
BLAST
Transmembranei494 – 51421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini515 – 794280CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 15›15Sequence AnalysisAdd
BLAST
Chaini16 – 794779Smoothened homologPRO_0000013018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi40 ↔ 104PROSITE-ProRule annotation
Disulfide bondi48 ↔ 97PROSITE-ProRule annotation
Disulfide bondi88 ↔ 124PROSITE-ProRule annotation
Disulfide bondi117 ↔ 139PROSITE-ProRule annotation
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi163 ↔ 183PROSITE-ProRule annotation
Disulfide bondi187 ↔ 264PROSITE-ProRule annotation
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi283 ↔ 359PROSITE-ProRule annotation
Disulfide bondi459 ↔ 476PROSITE-ProRule annotation
Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO42224.
PRIDEiO42224.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012824.

Structurei

3D structure databases

ProteinModelPortaliO42224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 151117FZPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG312505.
HOGENOMiHOG000252964.
HOVERGENiHBG000352.
InParanoidiO42224.
PhylomeDBiO42224.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR017981. GPCR_2-like.
IPR026544. SMO.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF35. PTHR11309:SF35. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GPCWLWALAL GLALGPRRCP AAPLNASAAP PERCRRPAAC ERLRFGSCLG
60 70 80 90 100
SALPYAHTST LLAADSGSQE EAHGKLLLWS GLRNAPRCWD VIQPLLCAVY
110 120 130 140 150
MPKCEDGQVE LPSQTLCQAT RAPCTIVERE RGWPDFLKCT PDRFPEGCPN
160 170 180 190 200
EVQNIKFNSS GQCEAPLVRT YNPKSWYEDV EGCGIQCQNP LFTETEHREM
210 220 230 240 250
HVYIAFSSVT ISCTFFTLAT FVADWRNSNR YPAVILFYVN ACFFVGSIGC
260 270 280 290 300
VAQFMDGARD EIVCRADGTM RLGEPTSNET LSCVIIFVIV YYSLMSGVIW
310 320 330 340 350
FVMLTYAWHT SFKALGTTYQ PLLGKTSYFH LITWSIPFVL TVAILAVAQV
360 370 380 390 400
DGDSVSGICF VGYKNYRYRA GFVLAPIGLV LIVGGYFLIR GVMTLFSIKS
410 420 430 440 450
NHPGLLSEKA ASKINETMLR LGIFGFLAFG FVFITFGCHF YDFFNQAEWE
460 470 480 490 500
RSFREYVLCE ANVTIATQTN KPIPECEIKN RPSLLVEKIN LFAMFGTGIS
510 520 530 540 550
MSTWVWTKAT LLIWKRTWCR LTGQSDDQPK RIKKSKMIAK AFSKRKELLR
560 570 580 590 600
DPGRELSFSM HTVSHDGPVA GLAFDINEPS ADVSSAWAQH VTKMVARRGA
610 620 630 640 650
ILPQDVSVTP VATPVPPEER SNLWVVEADV SPELQKRSRK KKRRKKKKEE
660 670 680 690 700
VCPERRAGLS VAPLTPSSVP RLPRLPQQPC LVAIPRHRGD TFIPTVLPGL
710 720 730 740 750
SNGAGGLWDG RRRAHVPHFI TNPFCPESGS PEDEENPGPS VGHRQHNGGR
760 770 780 790
RWPPEPLPGG SGVTRTRGRR AGLAPIHSRT NLVNAELLDA DLDF
Length:794
Mass (Da):88,255
Last modified:January 1, 1998 - v1
Checksum:iCE71AE9864A6C0CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019977 mRNA. Translation: AAB84389.1.
UniGeneiGga.4082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019977 mRNA. Translation: AAB84389.1.
UniGeneiGga.4082.

3D structure databases

ProteinModelPortaliO42224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012824.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO42224.
PRIDEiO42224.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG312505.
HOGENOMiHOG000252964.
HOVERGENiHBG000352.
InParanoidiO42224.
PhylomeDBiO42224.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR017981. GPCR_2-like.
IPR026544. SMO.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF35. PTHR11309:SF35. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The smoothened gene and hedgehog signal transduction in Drosophila and vertebrate development."
    Quirk J., van den Heuvel M., Henrique D., Marigo V., Sheer D., Tabin C., Ingham P.W.
    Cold Spring Harb. Symp. Quant. Biol. 62:217-226(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSMO_CHICK
AccessioniPrimary (citable) accession number: O42224
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: February 4, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.