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O42224

- SMO_CHICK

UniProt

O42224 - SMO_CHICK

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Protein

Smoothened homolog

Gene
SMO, SMOH
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. smoothened signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Smoothened homolog
Short name:
SMO
Gene namesi
Name:SMO
Synonyms:SMOH
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini16 – 201186Extracellular Reviewed predictionAdd
BLAST
Transmembranei202 – 22221Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini223 – 2319Cytoplasmic Reviewed prediction
Transmembranei232 – 25221Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini253 – 28331Extracellular Reviewed predictionAdd
BLAST
Transmembranei284 – 30421Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini305 – 32723Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei328 – 34821Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini349 – 37123Extracellular Reviewed predictionAdd
BLAST
Transmembranei372 – 39221Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini393 – 42028Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei421 – 44020Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini441 – 49353Extracellular Reviewed predictionAdd
BLAST
Transmembranei494 – 51421Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini515 – 794280Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 15›15 Reviewed predictionAdd
BLAST
Chaini16 – 794779Smoothened homologPRO_0000013018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi40 ↔ 104 By similarity
Disulfide bondi48 ↔ 97 By similarity
Disulfide bondi88 ↔ 124 By similarity
Disulfide bondi117 ↔ 139 By similarity
Glycosylationi158 – 1581N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi163 ↔ 183 By similarity
Disulfide bondi187 ↔ 264 By similarity
Glycosylationi278 – 2781N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi283 ↔ 359 By similarity
Disulfide bondi459 ↔ 476 By similarity
Glycosylationi462 – 4621N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO42224.
PRIDEiO42224.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012824.

Structurei

3D structure databases

ProteinModelPortaliO42224.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 151117FZAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG312505.
HOGENOMiHOG000252964.
HOVERGENiHBG000352.
InParanoidiO42224.
PhylomeDBiO42224.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR017981. GPCR_2-like.
IPR026544. SMO.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF35. PTHR11309:SF35. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42224-1 [UniParc]FASTAAdd to Basket

« Hide

GPCWLWALAL GLALGPRRCP AAPLNASAAP PERCRRPAAC ERLRFGSCLG    50
SALPYAHTST LLAADSGSQE EAHGKLLLWS GLRNAPRCWD VIQPLLCAVY 100
MPKCEDGQVE LPSQTLCQAT RAPCTIVERE RGWPDFLKCT PDRFPEGCPN 150
EVQNIKFNSS GQCEAPLVRT YNPKSWYEDV EGCGIQCQNP LFTETEHREM 200
HVYIAFSSVT ISCTFFTLAT FVADWRNSNR YPAVILFYVN ACFFVGSIGC 250
VAQFMDGARD EIVCRADGTM RLGEPTSNET LSCVIIFVIV YYSLMSGVIW 300
FVMLTYAWHT SFKALGTTYQ PLLGKTSYFH LITWSIPFVL TVAILAVAQV 350
DGDSVSGICF VGYKNYRYRA GFVLAPIGLV LIVGGYFLIR GVMTLFSIKS 400
NHPGLLSEKA ASKINETMLR LGIFGFLAFG FVFITFGCHF YDFFNQAEWE 450
RSFREYVLCE ANVTIATQTN KPIPECEIKN RPSLLVEKIN LFAMFGTGIS 500
MSTWVWTKAT LLIWKRTWCR LTGQSDDQPK RIKKSKMIAK AFSKRKELLR 550
DPGRELSFSM HTVSHDGPVA GLAFDINEPS ADVSSAWAQH VTKMVARRGA 600
ILPQDVSVTP VATPVPPEER SNLWVVEADV SPELQKRSRK KKRRKKKKEE 650
VCPERRAGLS VAPLTPSSVP RLPRLPQQPC LVAIPRHRGD TFIPTVLPGL 700
SNGAGGLWDG RRRAHVPHFI TNPFCPESGS PEDEENPGPS VGHRQHNGGR 750
RWPPEPLPGG SGVTRTRGRR AGLAPIHSRT NLVNAELLDA DLDF 794
Length:794
Mass (Da):88,255
Last modified:January 1, 1998 - v1
Checksum:iCE71AE9864A6C0CB
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019977 mRNA. Translation: AAB84389.1.
UniGeneiGga.4082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019977 mRNA. Translation: AAB84389.1 .
UniGenei Gga.4082.

3D structure databases

ProteinModelPortali O42224.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000012824.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi O42224.
PRIDEi O42224.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG312505.
HOGENOMi HOG000252964.
HOVERGENi HBG000352.
InParanoidi O42224.
PhylomeDBi O42224.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR017981. GPCR_2-like.
IPR026544. SMO.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF35. PTHR11309:SF35. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The smoothened gene and hedgehog signal transduction in Drosophila and vertebrate development."
    Quirk J., van den Heuvel M., Henrique D., Marigo V., Sheer D., Tabin C., Ingham P.W.
    Cold Spring Harb. Symp. Quant. Biol. 62:217-226(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSMO_CHICK
AccessioniPrimary (citable) accession number: O42224
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi