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O42224 (SMO_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Smoothened homolog

Short name=SMO
Gene names
Name:SMO
Synonyms:SMOH
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length794 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).

Subunit structure

Homodimer By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor Fz/Smo family.

Contains 1 FZ (frizzled) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide‹1 – 15›15 Potential
Chain16 – 794779Smoothened homolog
PRO_0000013018

Regions

Topological domain16 – 201186Extracellular Potential
Transmembrane202 – 22221Helical; Name=1; Potential
Topological domain223 – 2319Cytoplasmic Potential
Transmembrane232 – 25221Helical; Name=2; Potential
Topological domain253 – 28331Extracellular Potential
Transmembrane284 – 30421Helical; Name=3; Potential
Topological domain305 – 32723Cytoplasmic Potential
Transmembrane328 – 34821Helical; Name=4; Potential
Topological domain349 – 37123Extracellular Potential
Transmembrane372 – 39221Helical; Name=5; Potential
Topological domain393 – 42028Cytoplasmic Potential
Transmembrane421 – 44020Helical; Name=6; Potential
Topological domain441 – 49353Extracellular Potential
Transmembrane494 – 51421Helical; Name=7; Potential
Topological domain515 – 794280Cytoplasmic Potential
Domain35 – 151117FZ

Amino acid modifications

Glycosylation251N-linked (GlcNAc...) Potential
Glycosylation1581N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation4621N-linked (GlcNAc...) Potential
Disulfide bond40 ↔ 104 By similarity
Disulfide bond48 ↔ 97 By similarity
Disulfide bond88 ↔ 124 By similarity
Disulfide bond117 ↔ 139 By similarity
Disulfide bond163 ↔ 183 By similarity
Disulfide bond187 ↔ 264 By similarity
Disulfide bond283 ↔ 359 By similarity
Disulfide bond459 ↔ 476 By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
O42224 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: CE71AE9864A6C0CB

FASTA79488,255
        10         20         30         40         50         60 
GPCWLWALAL GLALGPRRCP AAPLNASAAP PERCRRPAAC ERLRFGSCLG SALPYAHTST 

        70         80         90        100        110        120 
LLAADSGSQE EAHGKLLLWS GLRNAPRCWD VIQPLLCAVY MPKCEDGQVE LPSQTLCQAT 

       130        140        150        160        170        180 
RAPCTIVERE RGWPDFLKCT PDRFPEGCPN EVQNIKFNSS GQCEAPLVRT YNPKSWYEDV 

       190        200        210        220        230        240 
EGCGIQCQNP LFTETEHREM HVYIAFSSVT ISCTFFTLAT FVADWRNSNR YPAVILFYVN 

       250        260        270        280        290        300 
ACFFVGSIGC VAQFMDGARD EIVCRADGTM RLGEPTSNET LSCVIIFVIV YYSLMSGVIW 

       310        320        330        340        350        360 
FVMLTYAWHT SFKALGTTYQ PLLGKTSYFH LITWSIPFVL TVAILAVAQV DGDSVSGICF 

       370        380        390        400        410        420 
VGYKNYRYRA GFVLAPIGLV LIVGGYFLIR GVMTLFSIKS NHPGLLSEKA ASKINETMLR 

       430        440        450        460        470        480 
LGIFGFLAFG FVFITFGCHF YDFFNQAEWE RSFREYVLCE ANVTIATQTN KPIPECEIKN 

       490        500        510        520        530        540 
RPSLLVEKIN LFAMFGTGIS MSTWVWTKAT LLIWKRTWCR LTGQSDDQPK RIKKSKMIAK 

       550        560        570        580        590        600 
AFSKRKELLR DPGRELSFSM HTVSHDGPVA GLAFDINEPS ADVSSAWAQH VTKMVARRGA 

       610        620        630        640        650        660 
ILPQDVSVTP VATPVPPEER SNLWVVEADV SPELQKRSRK KKRRKKKKEE VCPERRAGLS 

       670        680        690        700        710        720 
VAPLTPSSVP RLPRLPQQPC LVAIPRHRGD TFIPTVLPGL SNGAGGLWDG RRRAHVPHFI 

       730        740        750        760        770        780 
TNPFCPESGS PEDEENPGPS VGHRQHNGGR RWPPEPLPGG SGVTRTRGRR AGLAPIHSRT 

       790 
NLVNAELLDA DLDF 

« Hide

References

[1]"The smoothened gene and hedgehog signal transduction in Drosophila and vertebrate development."
Quirk J., van den Heuvel M., Henrique D., Marigo V., Sheer D., Tabin C., Ingham P.W.
Cold Spring Harb. Symp. Quant. Biol. 62:217-226(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF019977 mRNA. Translation: AAB84389.1.
UniGeneGga.4082.

3D structure databases

ProteinModelPortalO42224.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000012824.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbO42224.
PRIDEO42224.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG312505.
HOGENOMHOG000252964.
HOVERGENHBG000352.
InParanoidO42224.
PhylomeDBO42224.

Family and domain databases

Gene3D1.10.2000.10. 1 hit.
InterProIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR017981. GPCR_2-like.
IPR026544. SMO.
[Graphical view]
PANTHERPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF35. PTHR11309:SF35. 1 hit.
PfamPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSPR00489. FRIZZLED.
SMARTSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMSSF63501. SSF63501. 1 hit.
PROSITEPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSMO_CHICK
AccessionPrimary (citable) accession number: O42224
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries