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O42224

- SMO_CHICK

UniProt

O42224 - SMO_CHICK

Protein

Smoothened homolog

Gene

SMO

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. smoothened signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Smoothened homolog
    Short name:
    SMO
    Gene namesi
    Name:SMO
    Synonyms:SMOH
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei‹1 – 15›15Sequence AnalysisAdd
    BLAST
    Chaini16 – 794779Smoothened homologPRO_0000013018Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi40 ↔ 104PROSITE-ProRule annotation
    Disulfide bondi48 ↔ 97PROSITE-ProRule annotation
    Disulfide bondi88 ↔ 124PROSITE-ProRule annotation
    Disulfide bondi117 ↔ 139PROSITE-ProRule annotation
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi163 ↔ 183PROSITE-ProRule annotation
    Disulfide bondi187 ↔ 264PROSITE-ProRule annotation
    Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi283 ↔ 359PROSITE-ProRule annotation
    Disulfide bondi459 ↔ 476PROSITE-ProRule annotation
    Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO42224.
    PRIDEiO42224.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000012824.

    Structurei

    3D structure databases

    ProteinModelPortaliO42224.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini16 – 201186ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini223 – 2319CytoplasmicSequence Analysis
    Topological domaini253 – 28331ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini305 – 32723CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini349 – 37123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini393 – 42028CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini441 – 49353ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini515 – 794280CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei202 – 22221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei328 – 34821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei421 – 44020Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei494 – 51421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 151117FZPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG312505.
    HOGENOMiHOG000252964.
    HOVERGENiHBG000352.
    InParanoidiO42224.
    PhylomeDBiO42224.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR017981. GPCR_2-like.
    IPR026544. SMO.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF35. PTHR11309:SF35. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O42224-1 [UniParc]FASTAAdd to Basket

    « Hide

    GPCWLWALAL GLALGPRRCP AAPLNASAAP PERCRRPAAC ERLRFGSCLG    50
    SALPYAHTST LLAADSGSQE EAHGKLLLWS GLRNAPRCWD VIQPLLCAVY 100
    MPKCEDGQVE LPSQTLCQAT RAPCTIVERE RGWPDFLKCT PDRFPEGCPN 150
    EVQNIKFNSS GQCEAPLVRT YNPKSWYEDV EGCGIQCQNP LFTETEHREM 200
    HVYIAFSSVT ISCTFFTLAT FVADWRNSNR YPAVILFYVN ACFFVGSIGC 250
    VAQFMDGARD EIVCRADGTM RLGEPTSNET LSCVIIFVIV YYSLMSGVIW 300
    FVMLTYAWHT SFKALGTTYQ PLLGKTSYFH LITWSIPFVL TVAILAVAQV 350
    DGDSVSGICF VGYKNYRYRA GFVLAPIGLV LIVGGYFLIR GVMTLFSIKS 400
    NHPGLLSEKA ASKINETMLR LGIFGFLAFG FVFITFGCHF YDFFNQAEWE 450
    RSFREYVLCE ANVTIATQTN KPIPECEIKN RPSLLVEKIN LFAMFGTGIS 500
    MSTWVWTKAT LLIWKRTWCR LTGQSDDQPK RIKKSKMIAK AFSKRKELLR 550
    DPGRELSFSM HTVSHDGPVA GLAFDINEPS ADVSSAWAQH VTKMVARRGA 600
    ILPQDVSVTP VATPVPPEER SNLWVVEADV SPELQKRSRK KKRRKKKKEE 650
    VCPERRAGLS VAPLTPSSVP RLPRLPQQPC LVAIPRHRGD TFIPTVLPGL 700
    SNGAGGLWDG RRRAHVPHFI TNPFCPESGS PEDEENPGPS VGHRQHNGGR 750
    RWPPEPLPGG SGVTRTRGRR AGLAPIHSRT NLVNAELLDA DLDF 794
    Length:794
    Mass (Da):88,255
    Last modified:January 1, 1998 - v1
    Checksum:iCE71AE9864A6C0CB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF019977 mRNA. Translation: AAB84389.1.
    UniGeneiGga.4082.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF019977 mRNA. Translation: AAB84389.1 .
    UniGenei Gga.4082.

    3D structure databases

    ProteinModelPortali O42224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000012824.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi O42224.
    PRIDEi O42224.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG312505.
    HOGENOMi HOG000252964.
    HOVERGENi HBG000352.
    InParanoidi O42224.
    PhylomeDBi O42224.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR017981. GPCR_2-like.
    IPR026544. SMO.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF35. PTHR11309:SF35. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The smoothened gene and hedgehog signal transduction in Drosophila and vertebrate development."
      Quirk J., van den Heuvel M., Henrique D., Marigo V., Sheer D., Tabin C., Ingham P.W.
      Cold Spring Harb. Symp. Quant. Biol. 62:217-226(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiSMO_CHICK
    AccessioniPrimary (citable) accession number: O42224
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3