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Protein

Neurogenic differentiation factor 1

Gene

neurod1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1.1 Publication

GO - Molecular functioni

GO - Biological processi

  • compound eye photoreceptor development Source: ZFIN
  • endocrine pancreas development Source: ZFIN
  • inner ear receptor cell development Source: ZFIN
  • negative regulation of Notch signaling pathway Source: ZFIN
  • posterior lateral line neuromast hair cell differentiation Source: ZFIN
  • regeneration Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DRE-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenic differentiation factor 1
Short name:
NeuroD
Short name:
NeuroD1
Gene namesi
Name:neurod1By similarity
Synonyms:neurodImported, nrdImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-990415-172 neurod1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi107N → S: Reduction in ability to induce ectopic expression of isl1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002748171 – 350Neurogenic differentiation factor 1Add BLAST350

Proteomic databases

PaxDbiO42202
PRIDEiO42202

Expressioni

Tissue specificityi

In the embryo, expressed broadly in a subset of primary neurons in the brain and spinal cord. At 28 hours post-fertilization (hpf), regions of expression include telencephalon, olfactory placode, epiphysis, cranial ganglia, acoustic ganglia, Rohon-Beard mechano-sensory neurons and motoneurons. In 2 day postembryonic brain, expressed in many brain regions but absent from subpallium, the ventral preoptic region, ventral thalamus and hypothalamus; sites of expression extend laterally from the ventricular proliferative regions and correspond to freshly determined cell populations. In adult, expressed in all tissues examined with highest levels in brain.4 Publications

Developmental stagei

First detected at 10 hpf (1-somite stage), with increased levels during subsequent embryonic development. Also expressed in adult.3 Publications

Gene expression databases

BgeeiENSDARG00000019566
ExpressionAtlasiO42202 baseline

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000026490

Structurei

3D structure databases

ProteinModelPortaliO42202
SMRiO42202
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 148bHLHPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi82 – 88Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 50Poly-AspSequence analysis4
Compositional biasi62 – 69Poly-GluSequence analysis8
Compositional biasi82 – 85Poly-LysSequence analysis4

Phylogenomic databases

eggNOGiENOG410IQ4I Eukaryota
ENOG410Z6FG LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000049256
HOVERGENiHBG000250
InParanoidiO42202
KOiK08033
OMAiEEHETDK
OrthoDBiEOG091G15AI
PhylomeDBiO42202
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032652 Neurod1
IPR022575 Neurogenic_DUF
IPR016637 TF_bHLH_NeuroD
PANTHERiPTHR19290:SF88 PTHR19290:SF88, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF12533 Neuro_bHLH, 1 hit
PIRSFiPIRSF015618 bHLH_NeuroD, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

O42202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSYSEESM MLESQSSSNW TDKCHSSSQD ERDVDKTSEP MLNDMEDDDD
60 70 80 90 100
AGLNRLEDED DEEEEEEEED GDDTKPKRRG PKKKKMTKAR MQRFKMRRMK
110 120 130 140 150
ANARERNRMH GLNDALESLR KVVPCYSKTQ KLSKIETLRL AKNYIWALSE
160 170 180 190 200
ILRSGKSPDL MSFVQALCKG LSQPTTNLVA GCLQLNPRTF LPEQSQEMPP
210 220 230 240 250
HMQTASASFS ALPYSYQTPG LPSPPYGTMD SSHIFHVKPH AYGSALEPFF
260 270 280 290 300
DTTLTDCTSP SFDGPLSPPL SVNGNFSFKH EPSSEFEKNY AFTMHYQAAG
310 320 330 340 350
LAGAQGHAAS LYAGSTQRCD IPMENIMSYD GHSHHERVMN AQLNAIFHDS
Length:350
Mass (Da):39,415
Last modified:January 1, 1998 - v1
Checksum:i90A3812107858433
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017302 Genomic DNA Translation: AAB70529.1
AF036148 mRNA Translation: AAB88820.1
BC056603 mRNA Translation: AAH56603.1
RefSeqiNP_571053.1, NM_130978.2
UniGeneiDr.75801

Genome annotation databases

EnsembliENSDART00000011837; ENSDARP00000026490; ENSDARG00000019566
GeneIDi30169
KEGGidre:30169

Similar proteinsi

Entry informationi

Entry nameiNDF1_DANRE
AccessioniPrimary (citable) accession number: O42202
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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