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Protein

Retinal homeobox protein Rx-A

Gene

rax-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi130 – 189HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal homeobox protein Rx-A
Short name:
Rx1A
Short name:
Xrx1
Alternative name(s):
Retina and anterior neural fold homeobox protein A
Gene namesi
Name:rax-a
Synonyms:rx1, rx1a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252134. rax.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492781 – 322Retinal homeobox protein Rx-AAdd BLAST322

Expressioni

Tissue specificityi

Highly expressed in anterior neural plate followed by neural retina, pigmented epithelium, in pineal gland, diencephalon floor and epiphysis. At later stages, the neuroretina remains the primary site of expression. No expression in the developing lens and cornea.2 Publications

Developmental stagei

Expression begins in stage 11 (late-gastrula) embryos and then appears to be maintained at fairly stable levels up to stage 45 (late tadpole), when it declines.1 Publication

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 39Octapeptide motif8
Motifi302 – 315OARPROSITE-ProRule annotationAdd BLAST14
Motifi308 – 312Nuclear localization signalSequence analysis5

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG021349.
KOiK09332.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLHSPSLMA DGSFSLSGHL LRSPGGNPSR LHSIEAILGF VKEDSVLGSF
60 70 80 90 100
QSEISPRNAK EVDKRSSRHC LHKMTEEIHP QQEHLEDGQT DGYGDPYLGK
110 120 130 140 150
TSSECLSPGL STSNSDNKLS DDEQQPKKKH RRNRTTFTTY QLHELERAFE
160 170 180 190 200
KSHYPDVYSR EELAMKVNLP EVRVQVWFQN RRAKWRRQEK LEVTSMKLQD
210 220 230 240 250
SPMLSFNRSP QPSAMSALSS SLPLDSWLTP TLSNSTALQS LPGFVTTPPS
260 270 280 290 300
LPGSYTPPPF INPVSVGHAL QPLGAMGPPP PYQCGANFVD KYPLEETDPR
310 320
NNSIASLRMK AKEHIQFIGK PW
Length:322
Mass (Da):36,084
Last modified:March 23, 2010 - v2
Checksum:i06B9BA6B8FA8EC97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90T → A in AAB70267 (PubMed:9076688).Curated1
Sequence conflicti98L → S in AAB70267 (PubMed:9076688).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017273 mRNA. Translation: AAB70267.1.
AF001048 mRNA. Translation: AAB62322.1.
BC170331 mRNA. Translation: AAI70331.1.
BC170333 mRNA. Translation: AAI70333.1.
RefSeqiNP_001081687.1. NM_001088218.1.
UniGeneiXl.186.

Genome annotation databases

GeneIDi397998.
KEGGixla:397998.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017273 mRNA. Translation: AAB70267.1.
AF001048 mRNA. Translation: AAB62322.1.
BC170331 mRNA. Translation: AAI70331.1.
BC170333 mRNA. Translation: AAI70333.1.
RefSeqiNP_001081687.1. NM_001088218.1.
UniGeneiXl.186.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397998.
KEGGixla:397998.

Organism-specific databases

CTDi397998.
XenbaseiXB-GENE-6252134. rax.

Phylogenomic databases

HOVERGENiHBG021349.
KOiK09332.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRXA_XENLA
AccessioniPrimary (citable) accession number: O42201
Secondary accession number(s): B7ZRY4, O42566
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 23, 2010
Last modified: May 11, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.