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Protein
Submitted name:

Putative uncharacterized protein PKD1

Gene

PKD1

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized protein PKD1Imported
Gene namesi
Name:PKD1Imported
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)Imported
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3206 – 3226HelicalSequence analysisAdd BLAST21
Transmembranei3412 – 3433HelicalSequence analysisAdd BLAST22
Transmembranei3453 – 3475HelicalSequence analysisAdd BLAST23
Transmembranei3722 – 3742HelicalSequence analysisAdd BLAST21
Transmembranei3809 – 3828HelicalSequence analysisAdd BLAST20
Transmembranei4026 – 4047HelicalSequence analysisAdd BLAST22
Transmembranei4059 – 4078HelicalSequence analysisAdd BLAST20
Transmembranei4109 – 4127HelicalSequence analysisAdd BLAST19
Transmembranei4148 – 4168HelicalSequence analysisAdd BLAST21
Transmembranei4217 – 4239HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000020126.

Structurei

3D structure databases

ProteinModelPortaliO42181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini198 – 296WSCInterPro annotationAdd BLAST99
Domaini297 – 347PKDInterPro annotationAdd BLAST51
Domaini425 – 540C-type lectinInterPro annotationAdd BLAST116
Domaini1100 – 1178PKDInterPro annotationAdd BLAST79
Domaini1189 – 1248PKDInterPro annotationAdd BLAST60
Domaini1283 – 1329PKDInterPro annotationAdd BLAST47
Domaini1358 – 1424PKDInterPro annotationAdd BLAST67
Domaini1428 – 1516PKDInterPro annotationAdd BLAST89
Domaini1536 – 1600PKDInterPro annotationAdd BLAST65
Domaini1624 – 1684PKDInterPro annotationAdd BLAST61
Domaini2157 – 2206PKDInterPro annotationAdd BLAST50
Domaini2209 – 2950REJInterPro annotationAdd BLAST742
Domaini3143 – 3192GPSInterPro annotationAdd BLAST50
Domaini3249 – 3364PLATInterPro annotationAdd BLAST116

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQ5D. Eukaryota.
ENOG411005C. LUCA.
HOGENOMiHOG000168445.

Family and domain databases

Gene3Di2.60.40.670. 11 hits.
2.60.60.20. 1 hit.
3.10.100.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000483. Cys-rich_flank_reg_C.
IPR000203. GPS.
IPR007110. Ig-like_dom.
IPR032675. L_dom-like.
IPR000434. PC1.
IPR022409. PKD/Chitinase_dom.
IPR002859. PKD/REJ-like.
IPR013122. PKD1_2_channel.
IPR000601. PKD_dom.
IPR001024. PLAT/LH2_dom.
IPR006228. Polycystin_cat.
IPR014010. REJ_dom.
IPR002889. WSC_carb-bd.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00801. PKD. 9 hits.
PF08016. PKD_channel. 1 hit.
PF01477. PLAT. 1 hit.
PF02010. REJ. 1 hit.
PF01822. WSC. 1 hit.
[Graphical view]
PRINTSiPR00500. POLYCYSTIN1.
SMARTiSM00034. CLECT. 1 hit.
SM00303. GPS. 1 hit.
SM00308. LH2. 1 hit.
SM00082. LRRCT. 1 hit.
SM00089. PKD. 14 hits.
SM00321. WSC. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49299. SSF49299. 10 hits.
SSF49723. SSF49723. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF56436. SSF56436. 1 hit.
TIGRFAMsiTIGR00864. PCC. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS50221. GPS. 1 hit.
PS50093. PKD. 9 hits.
PS50095. PLAT. 1 hit.
PS51111. REJ. 1 hit.
PS51212. WSC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRLYPSENM ASASRGLASA PFCLWRSGAW RRGAPGRRGT AAGAAARVPR
60 70 80 90 100
TAAACWRRRP NTPASSTAPT SAWRGPQQPP TSRWLLLCCK ISLEIFPRIT
110 120 130 140 150
SPPLISAFWS ESWDFVSCDD LSNNQISTIE EGTCNRQCNL TQIDLSSNPF
160 170 180 190 200
ECHCKLFRLV SWLREKGVKV RRPEATLCDN PPALRHRPLL NVSLLTCDLN
210 220 230 240 250
YVACLKESSS GGGAERSELV IFSSSTPGNF TREQCNSVCF TASHRYGGLG
260 270 280 290 300
GRHECLCSTN SEPNFISESQ CSAACTNPQV MEVIGALPLP IQNVHSSISF
310 320 330 340 350
SAASSVAPVT MSWDFGDLSS RVNTSGAGGT TTTSHKYGHP GRYLVSLMGW
360 370 380 390 400
SGNNKVSAHG EVVVTLPPKL ELHCPTLVVA NQSLQLTLVS WGSVDVDVDW
410 420 430 440 450
KITKHGVQVA KASPHCPKDG VLHEESSRCF QIVPGELSWT DARKQCLDRG
460 470 480 490 500
GDLAIVRNDA LRNLLARKVT HSMERGVWLG LSDVNSAGKL HWVNGSEAQE
510 520 530 540 550
GEEGLAPWSS VARGNLCVSL DQRSQTSSHS CNARRAYVCQ YNPQVRVPDS
560 570 580 590 600
GVFAMGLAVF PSHHLLQATA AMITTPPPPH GGVEVLLFPA LSFVRAGRLS
610 620 630 640 650
SLEFVTRELS SQTHILFQIY RPRCRYPGCG GPACSPMALC VPSESRSADP
660 670 680 690 700
PSCPKLEQWC PFQHRCLPLS SPCQPSSCLN CSQGHQLPSE ARMPLYTLQY
710 720 730 740 750
EVLFSLTAGP AAHVLLQDQL EDLLVSRGDV IALQHDAGPA SLIHCQSSPH
760 770 780 790 800
SLWRQPVFAL NLSEWFGINN TPVPPDNLAG DGADPLPDPE LDLKALVEGT
810 820 830 840 850
RGSWLENAVC PIRVLYVGQS ETRLRGAELS AGLPQPGLYN LLVTSAKQSD
860 870 880 890 900
LVSASCSLQV LPPLDLTVLH PSPQNGTLFL ESNRTRLLLR VQSRYETKAF
910 920 930 940 950
YRTSNSSATF HPYCPQEFSS RLCHPSTSEG SGAEVAEPSM YAVLDLNLKI
960 970 980 990 1000
KEHTGPVQVE LMAHNNVTEA SLTVLVQLEE SLRGLVVQPH PARRVLMESV
1010 1020 1030 1040 1050
VSYTASVLEG SNPTFKWTVD DKPFFTYYNT VLNVIYQHAD VYKLTVTAMN
1060 1070 1080 1090 1100
HVSTLTEDFN VTVDRLQPMT NLTVKGVPDV VPQGSTQTLT TSVLIDMAVP
1110 1120 1130 1140 1150
ATVRWSFGDG GYEQFEHKPP YPSSLTCPES PYQVLLSSNV TYIYSQPGIY
1160 1170 1180 1190 1200
TAVVSVSNRY ENISRSINMS VYSILTRVDI QTEPSLLLAG KTADFEAHPL
1210 1220 1230 1240 1250
PSPYGIHYEW NFGDGSALLQ GRRVAHTFEK SGPFNVCVSV NNTISSTAVC
1260 1270 1280 1290 1300
TEMFAYEEIE SLTAESSSPT ELHSATTVRA HLSSGNNITW TFSMGDGKSY
1310 1320 1330 1340 1350
TLSEPTVSHK YAKDGRFTVN ITAMNAVSSG WTIIPVEVFV FQVAGIEPSG
1360 1370 1380 1390 1400
CVGEHALVNF RARVSGNASS YLYEWSFGDG SPNETHHGNP GISHTYRGNG
1410 1420 1430 1440 1450
THPLSLTITS GVSKANFVTQ VCVQPVLTKI SVTAEKSHFA VGEKIQFQAR
1460 1470 1480 1490 1500
AEPEFNYTYE WDFGGEEDLV LPHAPANVVK TYNNPGCYVV TVAASNNVSN
1510 1520 1530 1540 1550
TTGSISIEVL TPVGAVVFQH NGTHYNNLTL GVPYYFSAFS SASNVSYLWN
1560 1570 1580 1590 1600
FGHGNLLKGQ NILHTFNTPG HHNITLTAAN RVGKNHTTVP VAVLASVSGL
1610 1620 1630 1640 1650
TINSSLVNVP LNTSVHFEAH MDEGDSVRFS WILCDHCTPI FRNNTMFYTF
1660 1670 1680 1690 1700
RSVGTFNIIV TAENDVGAAQ ASIYLFVQRE LEGLQILVET AEGGGGGVQE
1710 1720 1730 1740 1750
LDWCYFETNR VVRFHAGFKE GTNLTFTWNV ILKNEPDNSI FNLTGKTAKV
1760 1770 1780 1790 1800
NPSKPGPCDI FLQAANLLGQ VTVNRTIYFL EPARNVQLQI SDNPVAVNAL
1810 1820 1830 1840 1850
INMTVLNMEG SNLQYRWFVN GDDLQWSKSW MSHTFTSAGQ KQVTVKVFNE
1860 1870 1880 1890 1900
VSSEVRSEIV SVQEVISGLK ITSADATEQN YFPTDVSVCL QGELSTGTNV
1910 1920 1930 1940 1950
TWSWLIDGMS KMQKKACVTF PKPKTVAVTL NATNDVSGKV VSREFFVQER
1960 1970 1980 1990 2000
IFSLELKASK KIAAINEKVE FSISLVAGTN VNLSLSISRD ATVVLQPNQT
2010 2020 2030 2040 2050
YVHTFSRVDT YMVNLTAYNE VSCKRRNLHI EVMEPVRGLS IQDSCAAIAV
2060 2070 2080 2090 2100
GEKKVFVANV QTGKPVHFLW TFDLHHLHKE THMGKEVSYT AEEEGLLTIY
2110 2120 2130 2140 2150
LGAINALHAQ NITRQMLAQN VLMDAVLYAL PQDTFVNKMV TMNVLVTPKS
2160 2170 2180 2190 2200
NFMDCLWIFG DVSAPRHTNN TTVGHEYTHP GHYRVQVNCS NLVSWVSAHA
2210 2220 2230 2240 2250
EINVSVLECE EPEVQVVQAP RLAIWRSQPT LVEASVDLKG CLRYGAQYLW
2260 2270 2280 2290 2300
QILSAPSCDN DPHFASGRVN GATRSFPVIP LPAEVDVQRL QLSLPKMVLA
2310 2320 2330 2340 2350
AGNYTLVFSL SYENVPLKKA ACLQLGVMAA RLMPIIEGGT YRVWSRTQDL
2360 2370 2380 2390 2400
QLSAEQSYDP NMDPDNQSLL HYHWECQSTS KGPEHCSTLS FGLGSKGPVL
2410 2420 2430 2440 2450
GISGSELEAG IEYTFKLSIG KEGMPPESTT QTVLVQSGHI PMVYLECVSC
2460 2470 2480 2490 2500
KAQSLYEVSQ NSYVYLRGTC SNCQGFHRGR WSAVTLQNDT LVLDSSSTTT
2510 2520 2530 2540 2550
GSGGMNLVLR QGVLHLGESY NFTLHVTDDS LDGEGAASIT LHHNMPPDGG
2560 2570 2580 2590 2600
ECHLRRGGET GQEHGDKEDE VWRIETLLDR VQFSCSGYSD LGVSETPLLY
2610 2620 2630 2640 2650
SLLVNRCRDD YCEEFYVYRG SSPEHSAFLP PGFSSAQHRV SVFITVEDHQ
2660 2670 2680 2690 2700
GAAIRALNKT IKVVLPDPPP EYSSLPHWLS DLIDSKLKKL LDQGDFQRVR
2710 2720 2730 2740 2750
ELSLVLITVL NEYEQTRESV RVSRVERGYR GRVRNNITRA LTALDLTTVN
2760 2770 2780 2790 2800
DIQQTSAALA QCTAVSREFI CEECQNSTLN KLESMLEILQ TDTKQGIVTP
2810 2820 2830 2840 2850
TEIADNILNI MGDLIHQVSQ STSQSYNQPP YVDSPSPSFI QKDMGGLDPS
2860 2870 2880 2890 2900
PPSLEPHPLR VAAKAYSLSS VLMLILMHAR VLNEEPLVLK GAEIAATGKL
2910 2920 2930 2940 2950
ADPQSLLCYH GNNSPGGFTL HETLKANILF LSSRSLRALL FSFHQVESNP
2960 2970 2980 2990 3000
FPFNYVANYT VSTEVASMEF RTENGTHIPI SGLDDSLAIT VAVNNGSNGA
3010 3020 3030 3040 3050
ETGPEGAGTG GVPTAGAVNI SSCDSVIVRV SMGNTNRRAG LFVQLNFTSL
3060 3070 3080 3090 3100
QDVGLQDKRE EAEELSITAY LHSHEKPNEF NCTDRKRITL GMTRGHDLDH
3110 3120 3130 3140 3150
RKYTFFLSPE LYDTTLDYFI NVSTACGSGS GAAGVRLEVG VFASLCQYFS
3160 3170 3180 3190 3200
ESEKQWRTDG MVPLAETNAS RAVCRTRHLT AFAAGLFVPA NAISFTVPER
3210 3220 3230 3240 3250
SGTPSLVVLL VCVLGLMSYV VAAAILHKLD QLDLRRAAVV PLCGCDGLFK
3260 3270 3280 3290 3300
YEIQVKTGWS RGAGTTAHVG ISLYGRESRS GHRHLDSRGS FARNALDIFH
3310 3320 3330 3340 3350
IATDTSLGNV WKMRIWHDNK GLSPAWMLQY VLVKDLQTGS SSYFLVEEWL
3360 3370 3380 3390 3400
SVDNEKTDGH VEIEVEASEE AMLLQLPRLL RYELQRALCE SHLWLSLFQR
3410 3420 3430 3440 3450
PPRSPFTRLQ RATCCALLLQ LLLLANTLWY SIVVDVRYSP RPVSRFASLS
3460 3470 3480 3490 3500
GETVAVGVVT CLVAYPLYLL VFTLLRMSRS KCVSVEQVPP QVDQESVEID
3510 3520 3530 3540 3550
DFLDNSMGGT SFLFYNGEVE SSPCVCLDRF IFCFRPTRRK PIVESWDMTE
3560 3570 3580 3590 3600
GEMEVRDWPD LLSDAPAMGG VGCGAGLPRL KRGQGSRHLG VDMAFNADNE
3610 3620 3630 3640 3650
DGANQRHKHF TSSDEDLIKH ILTDGHRFFS QPDESEMADL SSIFEDQTEV
3660 3670 3680 3690 3700
ILLQKHHEPL PLESVRRDPP RTAFTSNTVV TDVCRPRRFP SSCGRAALWG
3710 3720 3730 3740 3750
SWTGIALASG VSMWAGRGFT QNVAMLWLLS CFASFLCSCL LLEPIKVACE
3760 3770 3780 3790 3800
AVYYAVYVRR LRPEDQDVLV EFPRVERVVQ RVSKVRPPQG FALSQARQQA
3810 3820 3830 3840 3850
RKVHMLHTML KNFLVYTFFL LVVLLLNYSD SDKDAHSLRL RTQLQRALRT
3860 3870 3880 3890 3900
PEYRGVSSVL LWLNQSLFPR LLDDSALLRD TGSVLLGTLR LRQIFDKQTF
3910 3920 3930 3940 3950
HILPADDVVP EVGGDGTAEN ITDYRNISAV NSVPRAWRSG RLKANDSRDV
3960 3970 3980 3990 4000
LQLRSLGEAF SSLQQHHWLD QRTRAVVVEF SLYNINTNLL AVFSFLIEFP
4010 4020 4030 4040 4050
VSDRALSSMD LHVITLWPFT GLDLQLLLTI ILLALVLYFL VPGVTGFLRE
4060 4070 4080 4090 4100
GYTYLLSTWR ALGICKLALA ASVCGLHLSR CTMATQLWTQ YVKHPHDDFT
4110 4120 4130 4140 4150
DFYPLARQTQ LYTVASALLL FVFVLKVSHQ LRFLREWAVF GRALRHSVRE
4160 4170 4180 4190 4200
LLAVAFALLL LLLAYSHAGH LLLHSVIDGY NSVTSTCLSL VGTSGRTLLS
4210 4220 4230 4240 4250
WRASWTTTGP SNTISSLVFH TTFAILRLAF LWLVISVLLR NYQRARAELY
4260 4270 4280 4290 4300
RPAVDLQDYE MVELFLRRLK MWMGLSRAKE FRHKVRFEGM ELPPSRSSST
4310 4320 4330 4340 4350
GDCKSLCLPP LDAPESPPTP DSIDAGSEAS WRPASSSPCS LTEAPGVSLG
4360 4370 4380 4390 4400
LGLGLGLNLS PGVLMGNINW RERAETEASL RRLLPTLDAL LQQLDRVTVA
4410 4420 4430 4440 4450
TEDLYHVECR LERAQSKRRH AGSEKGGAAQ GSSGDRVETA GGWRERKRGK
4460 4470 4480 4490 4500
EKHGVGKKVE KSELPKDGSA SANLKKTPAA ASSPFSKPRS APDSHLPRTN
4510 4520 4530 4540 4550
TPTVPPTTPA PTPPPLLAPN AQNWDPPVER DMPPSSSLFN HPAHTTTIPT
4560 4570
RKRKRKTPPL KNKVHPNLDK HSPGHPKP
Length:4,578
Mass (Da):504,595
Last modified:January 1, 1998 - v1
Checksum:i62AA07B61C4CFC7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013614 Genomic DNA. Translation: AAB86683.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013614 Genomic DNA. Translation: AAB86683.1.

3D structure databases

ProteinModelPortaliO42181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000020126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IQ5D. Eukaryota.
ENOG411005C. LUCA.
HOGENOMiHOG000168445.

Family and domain databases

Gene3Di2.60.40.670. 11 hits.
2.60.60.20. 1 hit.
3.10.100.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000483. Cys-rich_flank_reg_C.
IPR000203. GPS.
IPR007110. Ig-like_dom.
IPR032675. L_dom-like.
IPR000434. PC1.
IPR022409. PKD/Chitinase_dom.
IPR002859. PKD/REJ-like.
IPR013122. PKD1_2_channel.
IPR000601. PKD_dom.
IPR001024. PLAT/LH2_dom.
IPR006228. Polycystin_cat.
IPR014010. REJ_dom.
IPR002889. WSC_carb-bd.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00801. PKD. 9 hits.
PF08016. PKD_channel. 1 hit.
PF01477. PLAT. 1 hit.
PF02010. REJ. 1 hit.
PF01822. WSC. 1 hit.
[Graphical view]
PRINTSiPR00500. POLYCYSTIN1.
SMARTiSM00034. CLECT. 1 hit.
SM00303. GPS. 1 hit.
SM00308. LH2. 1 hit.
SM00082. LRRCT. 1 hit.
SM00089. PKD. 14 hits.
SM00321. WSC. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49299. SSF49299. 10 hits.
SSF49723. SSF49723. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF56436. SSF56436. 1 hit.
TIGRFAMsiTIGR00864. PCC. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS50221. GPS. 1 hit.
PS50093. PKD. 9 hits.
PS50095. PLAT. 1 hit.
PS51111. REJ. 1 hit.
PS51212. WSC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO42181_TAKRU
AccessioniPrimary (citable) accession number: O42181
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.