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Protein

Homeobox protein pv.1

Gene

pv.1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Acts in a ventral signaling pathway downstream of bmp4, which suppresses dorsal mesoderm formation and leads to both ventral mesoderm and ventral ectoderm formation. Acts in the ectoderm to simultaneously specify epidermal lineages and restrict neuralization. Represses transcription of dorsal-specific genes. Binds to DNA, with preference for the target sequences 5'-TAATGC-3' and 5'-TAATTG-3'. Acts in a pathway downstream of bmp4 and fgf to negatively regulate erythroid specification.6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi129 – 188HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • BMP signaling pathway Source: UniProtKB
  • determination of ventral identity Source: UniProtKB
  • mesoderm formation Source: UniProtKB
  • negative regulation of erythrocyte differentiation Source: UniProtKB
  • negative regulation of neurogenesis Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of epidermal cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein pv.1
Alternative name(s):
Posterior-ventral 1 transcription factor
Gene namesi
Name:pv.1Imported
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-920512. ventx1.1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002865881 – 282Homeobox protein pv.1Add BLAST282

Expressioni

Tissue specificityi

Expressed in the ventral marginal zone of blastulae. At early gastrulation, expression begins to spread to the animal pole (ectoderm), and at stage 11.5 is expressed in a gradient across the animal cap, with levels highest in the ventral region. At the end of gastrulation, predominantly localized to the ventral and lateral regions of the closing slit blastopore. Also expressed at a low level in ventral endoderm.2 Publications

Developmental stagei

Expression begins in the late blastula, peaks at stage 11 (early gastrula) and decreases thereafter.1 Publication

Inductioni

By bmp4 and its downstream effector smad1. Fgf enhances bmp4-induced expression.3 Publications

Structurei

3D structure databases

ProteinModelPortaliO42173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi197 – 269Pro-richSequence analysisAdd BLAST73

Domaini

The repressor activity is mostly localized to the C-terminal region.1 Publication

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG082072.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQGFSIDL ILARSREEAA DGKDSMSSRP HIPCAPQPLP PNKYAKEMPR
60 70 80 90 100
RKDGQDVQEH SSWSLGEQGK KLQYSSPSSA ALHRSWGSSD DFSSVGSEDD
110 120 130 140 150
STEGSPSPMR NSQETETDHR GESPKSDLQR HLRTAFTPQQ ISKLEQAFNK
160 170 180 190 200
QRYLGASERK KLATSLRLSE IQVKTWFQNR RMKLKRQIQD QQHNMVPPPV
210 220 230 240 250
CYPQTFPYYP GVLPVPLNSG SFYQPPAHPF QAPQNSYIPD PRFIPQPLPH
260 270 280
HIRMSVALQQ QYPPLGLPPG RYFTGLASKN DG
Length:282
Mass (Da):31,846
Last modified:January 1, 1998 - v1
Checksum:i507AAEE91E884E2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012925 mRNA. Translation: AAB71353.1.
RefSeqiNP_001081704.1. NM_001088235.1.
UniGeneiXl.1420.

Genome annotation databases

GeneIDi398007.
KEGGixla:398007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012925 mRNA. Translation: AAB71353.1.
RefSeqiNP_001081704.1. NM_001088235.1.
UniGeneiXl.1420.

3D structure databases

ProteinModelPortaliO42173.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398007.
KEGGixla:398007.

Organism-specific databases

CTDi398007.
XenbaseiXB-GENE-920512. ventx1.1.

Phylogenomic databases

HOVERGENiHBG082072.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPV1_XENLA
AccessioniPrimary (citable) accession number: O42173
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.