O42164 (LEP_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leptin

Alternative name(s):
Obesity factor

Gene names

Name:	LEP
Synonyms:	OB

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass By similarity.
Subcellular location	Secreted Probable.
Tissue specificity	Not exclusively localized in adipose tissue but is also expressed in liver. Ref.1
Sequence similarities	Belongs to the leptin family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Obesity
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 163	145	Leptin		PRO_0000017692
Amino acid modifications
	Disulfide bond	113 ↔ 163		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O42164 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 9F578DB2528B18FC	FASTA	163	18,183
	10 20 30 40 50 60 MCWRPLCRLW SYLVYVQAVP CQIFQDDTKT LIKTIVTRIN DISHTSVSAK QRVTGLDFIP 70 80 90 100 110 120 GLHPILSLSK MDQTLAVYQQ VLTSLPSQNV LQIANDLENL RDLLHLLAFS KSCSLPQTSG 130 140 150 160 LQKPESLDGV LEASLYSTEV VALSRLQGSL QDILQQLDIS PEC

References

[1]	"Cloning the chicken leptin gene." Taouis M., Chen J.W., Daviaud C., Dupont J., Derouet M., Simon J. Gene 208:239-242(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: Broiler. Tissue: Liver.
[2]	"Chicken leptin (ob) mRNA, complete cds." Ashwell C.M., Czerwinski S.M., McMurtry J.P. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Shaver. Tissue: Adipose tissue and Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF012727 mRNA. Translation: AAC60368.1. AF082500 mRNA. Translation: AAC32380.1.
IPI	IPI00575666.
3D structure databases
ProteinModelPortal	O42164.
SMR	O42164. Positions 22-163.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG007860.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR000065. Leptin. [Graphical view]
PANTHER	PTHR11724. PTHR11724. 1 hit.
Pfam	PF02024. Leptin. 1 hit. [Graphical view]
PIRSF	PIRSF001837. Leptin. 1 hit.
PRINTS	PR00495. LEPTIN.
ProDom	PD005698. Leptin. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LEP_CHICK

Accession

Primary (citable) accession number: O42164

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program