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O42163 (COCH_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cochlin
Alternative name(s):
COCH-5B2
Gene names
Name:COCH
Synonyms:COCH5B2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length547 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in the control of cell shape and motility in the trabecular meshwork By similarity.

Subcellular location

Secreted Potential.

Tissue specificity

Expressed in inner ear structures; the spindle-shaped cells of the basilar papilla. Weaker expression found in the inferior and superior fibrocartilaginous plates and skeletal muscle. Ref.1

Developmental stage

Specifically expressed at the late developmental stages in the cochlea. Ref.1

Sequence similarities

Contains 1 LCCL domain.

Contains 2 VWFA domains.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of cell shape

Inferred from electronic annotation. Source: Ensembl

sensory perception of sound

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 547528Cochlin
PRO_0000020967

Regions

Domain24 – 11794LCCL
Domain162 – 347186VWFA 1
Domain364 – 534171VWFA 2

Amino acid modifications

Glycosylation2181N-linked (GlcNAc...) Potential
Disulfide bond30 ↔ 46 By similarity
Disulfide bond50 ↔ 70 By similarity

Sequences

Sequence LengthMass (Da)Tools
O42163 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 172724242641DF88

FASTA54759,427
        10         20         30         40         50         60 
MQFAPLLLGV FLLCGSARGS DSSASNAITC FTRGLDLRKE TEDVLCPANC PLWQFYVFGD 

        70         80         90        100        110        120 
GIYASLSSVC GAAIHRGVIT NAGGAVRVQT LPGQENYPAV HANGIQSQVL SRWASSFSVT 

       130        140        150        160        170        180 
PGTNNLALEA VGRSVATARP ATGKRPKKTL EKKAGNKDCK ADIAFLIDGS YNIGQRRFNL 

       190        200        210        220        230        240 
QKNFVGKVAV MLGIGTEGPH VGVVQASEHP KIEFYLKNFT AAKEVLFAIK ELGFRGGNSN 

       250        260        270        280        290        300 
TGKALKHAAQ KFFSMENGAR KGIPKIIVVF LDGWPSDDLE EAGIVAREFG VNVFIVSVAK 

       310        320        330        340        350        360 
PTTEELGMVQ DIGFIDKAVC RNNGFFSYQM PSWFGTTKYV KPLVQKLCSH EQMLCSKTCY 

       370        380        390        400        410        420 
NSVNIGFLID GSSSVGESNF RLMLEFISNV AKAFEISDIG SKIATVQFTY DQRTEFSFTD 

       430        440        450        460        470        480 
YTTKEKVLSA IRNIRYMSGG TATGDAISFT TRNVFGPVKD GANKNFLVIL TDGQSYDDVR 

       490        500        510        520        530        540 
GPAVAAQKAG ITVFSVGVAW APLDDLKDMA SEPRESHTFF TREFTGLEQM VPDVIRGICK 


DFLDSKQ 

« Hide

References

[1]"Molecular markers for cell types of the inner ear and candidate genes for hearing disorders."
Heller S., Sheane C.A., Javed Z., Hudspeth A.J.
Proc. Natl. Acad. Sci. U.S.A. 95:11400-11405(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: White leghorn.
Tissue: Basilar papilla.

Web resources

Protein Spotlight

The Japanese Horseshoe Crab and Deafness - Issue 4 of November 2000

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF012252 mRNA. Translation: AAC62253.1.
RefSeqNP_990268.1. NM_204937.1.
UniGeneGga.2805.

3D structure databases

ProteinModelPortalO42163.
SMRO42163. Positions 23-120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid676053. 1 interaction.
IntActO42163. 1 interaction.
STRING9031.ENSGALP00000037066.

Proteomic databases

PaxDbO42163.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395779.
KEGGgga:395779.

Organism-specific databases

CTD1690.

Phylogenomic databases

eggNOGNOG277584.
HOGENOMHOG000013195.
HOVERGENHBG005372.
OrthoDBEOG71RXJM.
PhylomeDBO42163.

Family and domain databases

Gene3D2.170.130.20. 1 hit.
3.40.50.410. 2 hits.
InterProIPR004043. LCCL.
IPR002035. VWF_A.
[Graphical view]
PfamPF03815. LCCL. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTSM00603. LCCL. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMSSF53300. SSF53300. 2 hits.
SSF69848. SSF69848. 1 hit.
PROSITEPS50820. LCCL. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815847.
PROO42163.

Entry information

Entry nameCOCH_CHICK
AccessionPrimary (citable) accession number: O42163
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries