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O42163

- COCH_CHICK

UniProt

O42163 - COCH_CHICK

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Protein

Cochlin

Gene

COCH

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role in the control of cell shape and motility in the trabecular meshwork.By similarity

GO - Biological processi

  1. defense response to bacterium Source: Ensembl
  2. positive regulation of innate immune response Source: Ensembl
  3. regulation of cell shape Source: Ensembl
  4. sensory perception of sound Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cochlin
Alternative name(s):
COCH-5B2
Gene namesi
Name:COCH
Synonyms:COCH5B2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. proteinaceous extracellular matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 547528CochlinPRO_0000020967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 46PROSITE-ProRule annotation
Disulfide bondi50 ↔ 70PROSITE-ProRule annotation
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO42163.

Expressioni

Tissue specificityi

Expressed in inner ear structures; the spindle-shaped cells of the basilar papilla. Weaker expression found in the inferior and superior fibrocartilaginous plates and skeletal muscle.1 Publication

Developmental stagei

Specifically expressed at the late developmental stages in the cochlea.1 Publication

Gene expression databases

ExpressionAtlasiO42163. baseline.

Interactioni

Protein-protein interaction databases

BioGridi676053. 1 interaction.
IntActiO42163. 1 interaction.
STRINGi9031.ENSGALP00000037066.

Structurei

3D structure databases

ProteinModelPortaliO42163.
SMRiO42163. Positions 23-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 11794LCCLPROSITE-ProRule annotationAdd
BLAST
Domaini162 – 347186VWFA 1PROSITE-ProRule annotationAdd
BLAST
Domaini364 – 534171VWFA 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 LCCL domain.PROSITE-ProRule annotation
Contains 2 VWFA domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG277584.
HOGENOMiHOG000013195.
HOVERGENiHBG005372.
InParanoidiO42163.
OrthoDBiEOG71RXJM.
PhylomeDBiO42163.

Family and domain databases

Gene3Di2.170.130.20. 1 hit.
3.40.50.410. 2 hits.
InterProiIPR004043. LCCL.
IPR002035. VWF_A.
[Graphical view]
PfamiPF03815. LCCL. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00603. LCCL. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
SSF69848. SSF69848. 1 hit.
PROSITEiPS50820. LCCL. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42163-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQFAPLLLGV FLLCGSARGS DSSASNAITC FTRGLDLRKE TEDVLCPANC
60 70 80 90 100
PLWQFYVFGD GIYASLSSVC GAAIHRGVIT NAGGAVRVQT LPGQENYPAV
110 120 130 140 150
HANGIQSQVL SRWASSFSVT PGTNNLALEA VGRSVATARP ATGKRPKKTL
160 170 180 190 200
EKKAGNKDCK ADIAFLIDGS YNIGQRRFNL QKNFVGKVAV MLGIGTEGPH
210 220 230 240 250
VGVVQASEHP KIEFYLKNFT AAKEVLFAIK ELGFRGGNSN TGKALKHAAQ
260 270 280 290 300
KFFSMENGAR KGIPKIIVVF LDGWPSDDLE EAGIVAREFG VNVFIVSVAK
310 320 330 340 350
PTTEELGMVQ DIGFIDKAVC RNNGFFSYQM PSWFGTTKYV KPLVQKLCSH
360 370 380 390 400
EQMLCSKTCY NSVNIGFLID GSSSVGESNF RLMLEFISNV AKAFEISDIG
410 420 430 440 450
SKIATVQFTY DQRTEFSFTD YTTKEKVLSA IRNIRYMSGG TATGDAISFT
460 470 480 490 500
TRNVFGPVKD GANKNFLVIL TDGQSYDDVR GPAVAAQKAG ITVFSVGVAW
510 520 530 540
APLDDLKDMA SEPRESHTFF TREFTGLEQM VPDVIRGICK DFLDSKQ
Length:547
Mass (Da):59,427
Last modified:January 1, 1998 - v1
Checksum:i172724242641DF88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF012252 mRNA. Translation: AAC62253.1.
RefSeqiNP_990268.1. NM_204937.1.
UniGeneiGga.2805.

Genome annotation databases

GeneIDi395779.
KEGGigga:395779.

Cross-referencesi

Web resourcesi

Protein Spotlight

The Japanese Horseshoe Crab and Deafness - Issue 4 of November 2000

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF012252 mRNA. Translation: AAC62253.1 .
RefSeqi NP_990268.1. NM_204937.1.
UniGenei Gga.2805.

3D structure databases

ProteinModelPortali O42163.
SMRi O42163. Positions 23-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 676053. 1 interaction.
IntActi O42163. 1 interaction.
STRINGi 9031.ENSGALP00000037066.

Proteomic databases

PaxDbi O42163.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395779.
KEGGi gga:395779.

Organism-specific databases

CTDi 1690.

Phylogenomic databases

eggNOGi NOG277584.
HOGENOMi HOG000013195.
HOVERGENi HBG005372.
InParanoidi O42163.
OrthoDBi EOG71RXJM.
PhylomeDBi O42163.

Miscellaneous databases

NextBioi 20815847.
PROi O42163.

Gene expression databases

ExpressionAtlasi O42163. baseline.

Family and domain databases

Gene3Di 2.170.130.20. 1 hit.
3.40.50.410. 2 hits.
InterProi IPR004043. LCCL.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF03815. LCCL. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view ]
SMARTi SM00603. LCCL. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 2 hits.
SSF69848. SSF69848. 1 hit.
PROSITEi PS50820. LCCL. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular markers for cell types of the inner ear and candidate genes for hearing disorders."
    Heller S., Sheane C.A., Javed Z., Hudspeth A.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:11400-11405(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: White leghorn.
    Tissue: Basilar papilla.

Entry informationi

Entry nameiCOCH_CHICK
AccessioniPrimary (citable) accession number: O42163
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3