Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O42163

- COCH_CHICK

UniProt

O42163 - COCH_CHICK

Protein

Cochlin

Gene

COCH

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays a role in the control of cell shape and motility in the trabecular meshwork.By similarity

    GO - Biological processi

    1. regulation of cell shape Source: Ensembl
    2. sensory perception of sound Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cochlin
    Alternative name(s):
    COCH-5B2
    Gene namesi
    Name:COCH
    Synonyms:COCH5B2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 547528CochlinPRO_0000020967Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 46PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 70PROSITE-ProRule annotation
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO42163.

    Expressioni

    Tissue specificityi

    Expressed in inner ear structures; the spindle-shaped cells of the basilar papilla. Weaker expression found in the inferior and superior fibrocartilaginous plates and skeletal muscle.1 Publication

    Developmental stagei

    Specifically expressed at the late developmental stages in the cochlea.1 Publication

    Interactioni

    Protein-protein interaction databases

    BioGridi676053. 1 interaction.
    IntActiO42163. 1 interaction.
    STRINGi9031.ENSGALP00000037066.

    Structurei

    3D structure databases

    ProteinModelPortaliO42163.
    SMRiO42163. Positions 23-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 11794LCCLPROSITE-ProRule annotationAdd
    BLAST
    Domaini162 – 347186VWFA 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini364 – 534171VWFA 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 LCCL domain.PROSITE-ProRule annotation
    Contains 2 VWFA domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG277584.
    HOGENOMiHOG000013195.
    HOVERGENiHBG005372.
    OrthoDBiEOG71RXJM.
    PhylomeDBiO42163.

    Family and domain databases

    Gene3Di2.170.130.20. 1 hit.
    3.40.50.410. 2 hits.
    InterProiIPR004043. LCCL.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF03815. LCCL. 1 hit.
    PF00092. VWA. 2 hits.
    [Graphical view]
    SMARTiSM00603. LCCL. 1 hit.
    SM00327. VWA. 2 hits.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 2 hits.
    SSF69848. SSF69848. 1 hit.
    PROSITEiPS50820. LCCL. 1 hit.
    PS50234. VWFA. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O42163-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQFAPLLLGV FLLCGSARGS DSSASNAITC FTRGLDLRKE TEDVLCPANC    50
    PLWQFYVFGD GIYASLSSVC GAAIHRGVIT NAGGAVRVQT LPGQENYPAV 100
    HANGIQSQVL SRWASSFSVT PGTNNLALEA VGRSVATARP ATGKRPKKTL 150
    EKKAGNKDCK ADIAFLIDGS YNIGQRRFNL QKNFVGKVAV MLGIGTEGPH 200
    VGVVQASEHP KIEFYLKNFT AAKEVLFAIK ELGFRGGNSN TGKALKHAAQ 250
    KFFSMENGAR KGIPKIIVVF LDGWPSDDLE EAGIVAREFG VNVFIVSVAK 300
    PTTEELGMVQ DIGFIDKAVC RNNGFFSYQM PSWFGTTKYV KPLVQKLCSH 350
    EQMLCSKTCY NSVNIGFLID GSSSVGESNF RLMLEFISNV AKAFEISDIG 400
    SKIATVQFTY DQRTEFSFTD YTTKEKVLSA IRNIRYMSGG TATGDAISFT 450
    TRNVFGPVKD GANKNFLVIL TDGQSYDDVR GPAVAAQKAG ITVFSVGVAW 500
    APLDDLKDMA SEPRESHTFF TREFTGLEQM VPDVIRGICK DFLDSKQ 547
    Length:547
    Mass (Da):59,427
    Last modified:January 1, 1998 - v1
    Checksum:i172724242641DF88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF012252 mRNA. Translation: AAC62253.1.
    RefSeqiNP_990268.1. NM_204937.1.
    UniGeneiGga.2805.

    Genome annotation databases

    GeneIDi395779.
    KEGGigga:395779.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    The Japanese Horseshoe Crab and Deafness - Issue 4 of November 2000

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF012252 mRNA. Translation: AAC62253.1 .
    RefSeqi NP_990268.1. NM_204937.1.
    UniGenei Gga.2805.

    3D structure databases

    ProteinModelPortali O42163.
    SMRi O42163. Positions 23-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 676053. 1 interaction.
    IntActi O42163. 1 interaction.
    STRINGi 9031.ENSGALP00000037066.

    Proteomic databases

    PaxDbi O42163.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395779.
    KEGGi gga:395779.

    Organism-specific databases

    CTDi 1690.

    Phylogenomic databases

    eggNOGi NOG277584.
    HOGENOMi HOG000013195.
    HOVERGENi HBG005372.
    OrthoDBi EOG71RXJM.
    PhylomeDBi O42163.

    Miscellaneous databases

    NextBioi 20815847.
    PROi O42163.

    Family and domain databases

    Gene3Di 2.170.130.20. 1 hit.
    3.40.50.410. 2 hits.
    InterProi IPR004043. LCCL.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF03815. LCCL. 1 hit.
    PF00092. VWA. 2 hits.
    [Graphical view ]
    SMARTi SM00603. LCCL. 1 hit.
    SM00327. VWA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 2 hits.
    SSF69848. SSF69848. 1 hit.
    PROSITEi PS50820. LCCL. 1 hit.
    PS50234. VWFA. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular markers for cell types of the inner ear and candidate genes for hearing disorders."
      Heller S., Sheane C.A., Javed Z., Hudspeth A.J.
      Proc. Natl. Acad. Sci. U.S.A. 95:11400-11405(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: White leghorn.
      Tissue: Basilar papilla.

    Entry informationi

    Entry nameiCOCH_CHICK
    AccessioniPrimary (citable) accession number: O42163
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3