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O42154

- G6PC_HAPXE

UniProt

O42154 - G6PC_HAPXE

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Protein

Glucose-6-phosphatase

Gene

g6pc

Organism
Haplochromis xenognathus (Lake Victoria cichlid) (Ptyochromis xenognathus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei4 – 41SubstrateSequence Analysis
Active sitei40 – 401Proton donorSequence Analysis
Binding sitei91 – 911SubstrateSequence Analysis
Active sitei97 – 971NucleophileBy similarity

GO - Molecular functioni

  1. glucose-6-phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Gluconeogenesis

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase (EC:3.1.3.9)
Short name:
G-6-Pase
Short name:
G6Pase
Gene namesi
Name:g6pc
Synonyms:g6pt
OrganismiHaplochromis xenognathus (Lake Victoria cichlid) (Ptyochromis xenognathus)
Taxonomic identifieri51185 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeHaplochrominiHaplochromis

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 277›277Glucose-6-phosphatasePRO_0000087412Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO42154.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence AnalysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence AnalysisAdd
BLAST
Transmembranei250 – 27021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi274 – 2774Prevents secretion from ERSequence Analysis

Sequence similaritiesi

Belongs to the glucose-6-phosphatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG003560.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Fragment.

O42154-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
FGERPYWWVH ETKFYGAGPA PSLQQFPITC ETGPGSPSGH AMGAAGVWYV
60 70 80 90 100
MVTALLSIAR EKQCPPLLYR FLYIGLWMLM GLVELVVCIS RVYMAAHFPH
110 120 130 140 150
QVIAGIITGT LVAEVVSKEK WIYSASLKKY FLITLFLTSF AVGFYVLLKA
160 170 180 190 200
LDVDLLWTME KAQKWCIRPE WVHLDSAPFA SLLRNMGSLF GLGLGLHSPF
210 220 230 240 250
YKTTKMRIMS APLRIGCIVI SVSLLHLLDG WTFSPENHMT FYALSFGKSA
260 270
VALLIPTTLV PWALSKIYPV KTEGKNL
Length:277
Mass (Da):30,971
Last modified:January 1, 1998 - v1
Checksum:i9A05E82DFE1DA4A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF008946 mRNA. Translation: AAB69286.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF008946 mRNA. Translation: AAB69286.1 .

3D structure databases

ProteinModelPortali O42154.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG003560.

Enzyme and pathway databases

UniPathwayi UPA00138 .

Family and domain databases

Gene3Di 1.20.144.10. 1 hit.
InterProi IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view ]
Pfami PF01569. PAP2. 1 hit.
[Graphical view ]
SMARTi SM00014. acidPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF48317. SSF48317. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Isolation and sequencing of cDNA clones coding for the catalytic unit of glucose-6-phosphatase from two haplochromine cichlid fishes."
    Nagl S., Mayer W.E., Klein J.
    DNA Seq. 10:25-29(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiG6PC_HAPXE
AccessioniPrimary (citable) accession number: O42154
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3