Reviewed, UniProtKB/Swiss-Prot O42154 (G6PC_HAPXE)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphatase
      Short name=G-6-Pase
      Short name=G6Pase
    EC=3.1.3.9

Gene names

Name:	g6pc
Synonyms:	g6pt

Organism

Haplochromis xenognathus

Taxonomic identifier

51185 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Labroidei › Cichlidae › African cichlids › Pseudocrenilabrinae › Haplochromini › Ptyochromis

Protein attributes

Sequence length	277 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + H2O = D-glucose + phosphate.
Pathway	Carbohydrate biosynthesis; gluconeogenesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the glucose-6-phosphatase family.

Ontologies

Keywords
Biological process	Gluconeogenesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucose-6-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 277	›277	Glucose-6-phosphatase		PRO_0000087412
Regions
	Transmembrane	39 – 59	21	Potential
	Transmembrane	67 – 87	21	Potential
	Transmembrane	131 – 151	21	Potential
	Transmembrane	215 – 235	21	Potential
	Transmembrane	250 – 270	21	Potential
	Motif	274 – 277	4	Prevents secretion from ER Potential
Sites
	Active site	40	1	Proton donor Potential
	Active site	97	1	Nucleophile By similarity
	Binding site	4	1	Substrate Potential
	Binding site	91	1	Substrate Potential
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	O42154-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 9A05E82DFE1DA4A0	FASTA	277	30,971
	10 20 30 40 50 60 FGERPYWWVH ETKFYGAGPA PSLQQFPITC ETGPGSPSGH AMGAAGVWYV MVTALLSIAR 70 80 90 100 110 120 EKQCPPLLYR FLYIGLWMLM GLVELVVCIS RVYMAAHFPH QVIAGIITGT LVAEVVSKEK 130 140 150 160 170 180 WIYSASLKKY FLITLFLTSF AVGFYVLLKA LDVDLLWTME KAQKWCIRPE WVHLDSAPFA 190 200 210 220 230 240 SLLRNMGSLF GLGLGLHSPF YKTTKMRIMS APLRIGCIVI SVSLLHLLDG WTFSPENHMT 250 260 270 FYALSFGKSA VALLIPTTLV PWALSKIYPV KTEGKNL

References

[1]	"Isolation and sequencing of cDNA clones coding for the catalytic unit of glucose-6-phosphatase from two haplochromine cichlid fishes." Nagl S., Mayer W.E., Klein J. DNA Seq. 10:25-29(1999) [PubMed: 10565541] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF008946 mRNA. Translation: AAB69286.1.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	O42154.
Family and domain databases
InterPro	IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PC_HAPXE

Accession

Primary (citable) accession number: O42154

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	November 4, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)