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Protein

Glucose-6-phosphatase

Gene

g6pc

Organism
Haplochromis nubilus (Blue Victoria mouthbrooder) (Tilapia nubila)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79SubstrateSequence analysis1
Active sitei115Proton donorSequence analysis1
Binding sitei166SubstrateSequence analysis1
Active sitei172NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Gluconeogenesis

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase (EC:3.1.3.9)
Short name:
G-6-Pase
Short name:
G6Pase
Gene namesi
Name:g6pc
Synonyms:g6pt
OrganismiHaplochromis nubilus (Blue Victoria mouthbrooder) (Tilapia nubila)
Taxonomic identifieri51172 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeHaplochrominiHaplochromis

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27LumenalSequence analysisAdd BLAST27
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 113LumenalSequence analysisAdd BLAST36
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 141CytoplasmicSequence analysis7
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 166LumenalSequence analysis4
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 205CytoplasmicSequence analysisAdd BLAST18
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 256LumenalSequence analysisAdd BLAST30
Transmembranei257 – 276HelicalSequence analysisAdd BLAST20
Topological domaini277 – 289CytoplasmicSequence analysisAdd BLAST13
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 324LumenalSequence analysisAdd BLAST14
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 352CytoplasmicSequence analysis7

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874111 – 352Glucose-6-phosphataseAdd BLAST352

Structurei

3D structure databases

ProteinModelPortaliO42153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi349 – 352Prevents secretion from ERSequence analysis4

Sequence similaritiesi

Belongs to the glucose-6-phosphatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG003560.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

O42153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLHSWGVE LAVYLQTRYG KYEGLFDLAS TVADLHTTFF WLFPIWFHLR
60 70 80 90 100
RDTALRLIWV AVIGDWLNLV LKWVLFGERP YWWVHETKFY GAGPAPSLQQ
110 120 130 140 150
FPITCETGPG SPSGHAMGAA GVWYVMVTAL LSIAREKQCP PLLYRFLYIG
160 170 180 190 200
LWMLMGLVEL VVCISRVYMA AHFPHQVIAG IITGTLVAEV VSKEKWIYSA
210 220 230 240 250
SLKKYFLITL FLTSFAVGFY VLLKALDVDL LWTMEKAQKW CIRPEWVHLD
260 270 280 290 300
SAPFASLLRN MGSLFGLGLG LHSPFYKTTK MRIMSAPLRI GCIVISVSLL
310 320 330 340 350
HLLDGWTFSP ENHMTFYALS FGKSAVALLI PTTLVPWALS KIYPVKTEGK

NL
Length:352
Mass (Da):39,904
Last modified:January 1, 1998 - v1
Checksum:i7E9F1DF417298BAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008945 mRNA. Translation: AAB69285.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008945 mRNA. Translation: AAB69285.1.

3D structure databases

ProteinModelPortaliO42153.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG003560.

Enzyme and pathway databases

UniPathwayiUPA00138.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiG6PC_HAPNU
AccessioniPrimary (citable) accession number: O42153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.