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O42152 (MT_AMBME) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothionein
Alternative name(s):
AnMT
Short name=MT
Gene names
Name:MT-A
OrganismAmbystoma mexicanum (Axolotl)
Taxonomic identifier8296 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaAmbystomatidaeAmbystoma

Protein attributes

Sequence length60 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
   LigandMetal-binding
Metal-thiolate cluster
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6060Metallothionein
PRO_0000197320

Regions

Region1 – 2828Beta
Region29 – 6032Alpha

Sites

Metal binding31Divalent metal cation; cluster B
Metal binding51Divalent metal cation; cluster B
Metal binding111Divalent metal cation; cluster B
Metal binding131Divalent metal cation; cluster B
Metal binding171Divalent metal cation; cluster B
Metal binding191Divalent metal cation; cluster B
Metal binding221Divalent metal cation; cluster B
Metal binding241Divalent metal cation; cluster B
Metal binding271Divalent metal cation; cluster B
Metal binding311Divalent metal cation; cluster A
Metal binding321Divalent metal cation; cluster A
Metal binding341Divalent metal cation; cluster A
Metal binding351Divalent metal cation; cluster A
Metal binding391Divalent metal cation; cluster A
Metal binding421Divalent metal cation; cluster A
Metal binding461Divalent metal cation; cluster A
Metal binding481Divalent metal cation; cluster A
Metal binding561Divalent metal cation; cluster A
Metal binding581Divalent metal cation; cluster A
Metal binding591Divalent metal cation; cluster A

Sequences

Sequence LengthMass (Da)Tools
O42152 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: AB05F49153953279

FASTA605,979
        10         20         30         40         50         60 
MDCACATGGS CSCAGSCKCE NCKCTSCKKS CCSCCPSECE KCGQGCVCKG GSSEKCSCCN 

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References

[1]"Cloning of a complementary DNA encoding an Ambystoma mexicanum metallothionein, AmMT, and expression of the gene during early development."
Saint-Jacques E., Guay J., Wirtanen L., Huard V., Stewart G., Seguin C.
DNA Cell Biol. 17:83-91(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF008583 mRNA. Translation: AAB71835.1.

3D structure databases

ProteinModelPortalO42152.
SMRO42152. Positions 29-60.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D4.10.10.10. 1 hit.
InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERPTHR23299. PTHR23299. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. SSF57868. 1 hit.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMT_AMBME
AccessionPrimary (citable) accession number: O42152
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: October 16, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Metallothioneins

Classification of metallothioneins and list of entries