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O42152

- MT_AMBME

UniProt

O42152 - MT_AMBME

Protein

Metallothionein

Gene

MT-A

Organism
Ambystoma mexicanum (Axolotl)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi3 – 31Divalent metal cation; cluster B
    Metal bindingi5 – 51Divalent metal cation; cluster B
    Metal bindingi11 – 111Divalent metal cation; cluster B
    Metal bindingi13 – 131Divalent metal cation; cluster B
    Metal bindingi17 – 171Divalent metal cation; cluster B
    Metal bindingi19 – 191Divalent metal cation; cluster B
    Metal bindingi22 – 221Divalent metal cation; cluster B
    Metal bindingi24 – 241Divalent metal cation; cluster B
    Metal bindingi27 – 271Divalent metal cation; cluster B
    Metal bindingi31 – 311Divalent metal cation; cluster A
    Metal bindingi32 – 321Divalent metal cation; cluster A
    Metal bindingi34 – 341Divalent metal cation; cluster A
    Metal bindingi35 – 351Divalent metal cation; cluster A
    Metal bindingi39 – 391Divalent metal cation; cluster A
    Metal bindingi42 – 421Divalent metal cation; cluster A
    Metal bindingi46 – 461Divalent metal cation; cluster A
    Metal bindingi48 – 481Divalent metal cation; cluster A
    Metal bindingi56 – 561Divalent metal cation; cluster A
    Metal bindingi58 – 581Divalent metal cation; cluster A
    Metal bindingi59 – 591Divalent metal cation; cluster A

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein
    Alternative name(s):
    AnMT
    Short name:
    MT
    Gene namesi
    Name:MT-A
    OrganismiAmbystoma mexicanum (Axolotl)
    Taxonomic identifieri8296 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaAmbystomatidaeAmbystoma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6060MetallothioneinPRO_0000197320Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO42152.
    SMRiO42152. Positions 29-60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2828BetaAdd
    BLAST
    Regioni29 – 6032AlphaAdd
    BLAST

    Domaini

    Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

    Sequence similaritiesi

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42152-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDCACATGGS CSCAGSCKCE NCKCTSCKKS CCSCCPSECE KCGQGCVCKG   50
    GSSEKCSCCN 60
    Length:60
    Mass (Da):5,979
    Last modified:January 1, 1998 - v1
    Checksum:iAB05F49153953279
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF008583 mRNA. Translation: AAB71835.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF008583 mRNA. Translation: AAB71835.1 .

    3D structure databases

    ProteinModelPortali O42152.
    SMRi O42152. Positions 29-60.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a complementary DNA encoding an Ambystoma mexicanum metallothionein, AmMT, and expression of the gene during early development."
      Saint-Jacques E., Guay J., Wirtanen L., Huard V., Stewart G., Seguin C.
      DNA Cell Biol. 17:83-91(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiMT_AMBME
    AccessioniPrimary (citable) accession number: O42152
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3