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Protein

Metallothionein

Gene

MT-A

Organism
Ambystoma mexicanum (Axolotl)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi3Divalent metal cation; cluster B1
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi11Divalent metal cation; cluster B1
Metal bindingi13Divalent metal cation; cluster B1
Metal bindingi17Divalent metal cation; cluster B1
Metal bindingi19Divalent metal cation; cluster B1
Metal bindingi22Divalent metal cation; cluster B1
Metal bindingi24Divalent metal cation; cluster B1
Metal bindingi27Divalent metal cation; cluster B1
Metal bindingi31Divalent metal cation; cluster A1
Metal bindingi32Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi35Divalent metal cation; cluster A1
Metal bindingi39Divalent metal cation; cluster A1
Metal bindingi42Divalent metal cation; cluster A1
Metal bindingi46Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi56Divalent metal cation; cluster A1
Metal bindingi58Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein
Alternative name(s):
AnMT
Short name:
MT
Gene namesi
Name:MT-A
OrganismiAmbystoma mexicanum (Axolotl)
Taxonomic identifieri8296 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaAmbystomatidaeAmbystoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973201 – 60MetallothioneinAdd BLAST60

Structurei

3D structure databases

ProteinModelPortaliO42152.
SMRiO42152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28BetaAdd BLAST28
Regioni29 – 60AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiView protein in Pfam
PF00131. Metallothio. 1 hit.
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiView protein in PROSITE
PS00203. METALLOTHIONEIN_VRT. 1 hit.

Sequencei

Sequence statusi: Complete.

O42152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCACATGGS CSCAGSCKCE NCKCTSCKKS CCSCCPSECE KCGQGCVCKG
60
GSSEKCSCCN
Length:60
Mass (Da):5,979
Last modified:January 1, 1998 - v1
Checksum:iAB05F49153953279
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008583 mRNA. Translation: AAB71835.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMT_AMBME
AccessioniPrimary (citable) accession number: O42152
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: May 10, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families