ID   C19AA_DANRE             Reviewed;         509 AA.
AC   O42145;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 64.
DE   RecName: Full=Cytochrome P450 19A1a;
DE            EC=1.14.14.1;
DE   AltName: Full=CYPXIX;
DE   AltName: Full=Aromatase;
DE   AltName: Full=Estrogen synthetase;
DE   AltName: Full=P-450AROM;
GN   Name=cyp19a1a; Synonyms=cyp19, cyp19a;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RA   Bauer M.P., Goetz F.W.;
RT   "Isolation and characterization of a zebrafish (Danio rerio) aromatase
RT   cDNA.";
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the formation of aromatic C18 estrogens from
CC       C19 androgens (By similarity).
CC   -!- CATALYTIC ACTIVITY: RH + reduced flavoprotein + O(2) = ROH +
CC       oxidized flavoprotein + H(2)O.
CC   -!- COFACTOR: Heme group (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF004521; AAB65788.1; -; mRNA.
DR   IPI; IPI00482226; -.
DR   RefSeq; NP_571229.2; -.
DR   UniGene; Dr.75765; -.
DR   Ensembl; ENSDARG00000041348; Danio rerio.
DR   GeneID; 30390; -.
DR   KEGG; dre:30390; -.
DR   ZFIN; ZDB-GENE-990415-43; cyp19a1a.
DR   HOVERGEN; O42145; -.
DR   BRENDA; 1.14.14.1; 96826.
DR   ArrayExpress; O42145; -.
DR   Bgee; O42145; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017973; Cyt_P450_C.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1.
DR   PANTHER; PTHR19383; Cyt_P450; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase.
FT   CHAIN         1    509       Cytochrome P450 19A1a.
FT                                /FTId=PRO_0000051967.
FT   METAL       456    456       Iron (heme axial ligand) (By similarity).
SQ   SEQUENCE   509 AA;  57354 MW;  F04532DEA8FDB628 CRC64;
     MAGDLLQPCG MKPVRLGEAV VDLLIQRAHN GTERAQDNAC GATATILLLL LCLLLAIRHH
     RPHKSHIPGP SFFFGLGPVV SYCRFIWSGI GTASNYYNSK YGDIVRVWIN GEETLILSRS
     SAVYHVLRKS LYTSRFGSKL GLQCIGMHEQ GIIFNSNVAL WKKVRAFYAK ALTGPGLQRT
     MEICTTSTNS HLDDLSQLTD AQGQLDILNL LRCIVVDVSN RLFLGVPLNE HDLLQKIHKY
     FDTWQTVLIK PDVYFRLDWL HRKHKRDAQE LQDAITALIE QKKVQLAHAE KLDHLDFTAE
     LIFAQSHGEL SAENVRQCVL EMVIAAPDTL SISLFFMLLL LKQNPDVELK ILQEMDSVLA
     GQSLQHSHLS KLQILESFIN ESLRFHPVVD FTMRRALDDD VIEGYNVKKG TNIILNVGRM
     HRSEFFSKPN QFSLDNFHKN VPSRFFQPFG SGPRSCVGKH IAMVMMKSIL VALLSRFSVC
     PMKACTVENI PQTNNLSQQP VEEPSSLSV
//