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O42145

- C19AA_DANRE

UniProt

O42145 - C19AA_DANRE

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Protein

Aromatase

Gene

cyp19a1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.By similarity

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi456 – 4561Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1a
Estrogen synthase
Gene namesi
Name:cyp19a1a
Synonyms:cyp19, cyp19a
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990415-43. cyp19a1a.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509AromatasePRO_0000051967Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO42145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiO42145.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42145-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGDLLQPCG MKPVRLGEAV VDLLIQRAHN GTERAQDNAC GATATILLLL
60 70 80 90 100
LCLLLAIRHH RPHKSHIPGP SFFFGLGPVV SYCRFIWSGI GTASNYYNSK
110 120 130 140 150
YGDIVRVWIN GEETLILSRS SAVYHVLRKS LYTSRFGSKL GLQCIGMHEQ
160 170 180 190 200
GIIFNSNVAL WKKVRAFYAK ALTGPGLQRT MEICTTSTNS HLDDLSQLTD
210 220 230 240 250
AQGQLDILNL LRCIVVDVSN RLFLGVPLNE HDLLQKIHKY FDTWQTVLIK
260 270 280 290 300
PDVYFRLDWL HRKHKRDAQE LQDAITALIE QKKVQLAHAE KLDHLDFTAE
310 320 330 340 350
LIFAQSHGEL SAENVRQCVL EMVIAAPDTL SISLFFMLLL LKQNPDVELK
360 370 380 390 400
ILQEMDSVLA GQSLQHSHLS KLQILESFIN ESLRFHPVVD FTMRRALDDD
410 420 430 440 450
VIEGYNVKKG TNIILNVGRM HRSEFFSKPN QFSLDNFHKN VPSRFFQPFG
460 470 480 490 500
SGPRSCVGKH IAMVMMKSIL VALLSRFSVC PMKACTVENI PQTNNLSQQP

VEEPSSLSV
Length:509
Mass (Da):57,354
Last modified:January 1, 1998 - v1
Checksum:iF04532DEA8FDB628
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004521 mRNA. Translation: AAB65788.1.
RefSeqiNP_571229.2. NM_131154.2.
UniGeneiDr.75765.

Genome annotation databases

GeneIDi30390.
KEGGidre:30390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004521 mRNA. Translation: AAB65788.1 .
RefSeqi NP_571229.2. NM_131154.2.
UniGenei Dr.75765.

3D structure databases

ProteinModelPortali O42145.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 30390.
KEGGi dre:30390.

Organism-specific databases

CTDi 30390.
ZFINi ZDB-GENE-990415-43. cyp19a1a.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000111912.
HOVERGENi HBG050750.
InParanoidi O42145.
KOi K07434.

Miscellaneous databases

NextBioi 20806802.
PROi O42145.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of a zebrafish (Danio rerio) aromatase cDNA."
    Bauer M.P., Goetz F.W.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiC19AA_DANRE
AccessioniPrimary (citable) accession number: O42145
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3