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O42145

- C19AA_DANRE

UniProt

O42145 - C19AA_DANRE

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Protein
Aromatase
Gene
cyp19a1a, cyp19, cyp19a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens By similarity.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi456 – 4561Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIX
    Cytochrome P-450AROM
    Cytochrome P450 19A1a
    Estrogen synthase
    Gene namesi
    Name:cyp19a1a
    Synonyms:cyp19, cyp19a
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-990415-43. cyp19a1a.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Aromatase
    PRO_0000051967Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO42145.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000111912.
    HOVERGENiHBG050750.
    InParanoidiO42145.
    KOiK07434.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42145-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGDLLQPCG MKPVRLGEAV VDLLIQRAHN GTERAQDNAC GATATILLLL    50
    LCLLLAIRHH RPHKSHIPGP SFFFGLGPVV SYCRFIWSGI GTASNYYNSK 100
    YGDIVRVWIN GEETLILSRS SAVYHVLRKS LYTSRFGSKL GLQCIGMHEQ 150
    GIIFNSNVAL WKKVRAFYAK ALTGPGLQRT MEICTTSTNS HLDDLSQLTD 200
    AQGQLDILNL LRCIVVDVSN RLFLGVPLNE HDLLQKIHKY FDTWQTVLIK 250
    PDVYFRLDWL HRKHKRDAQE LQDAITALIE QKKVQLAHAE KLDHLDFTAE 300
    LIFAQSHGEL SAENVRQCVL EMVIAAPDTL SISLFFMLLL LKQNPDVELK 350
    ILQEMDSVLA GQSLQHSHLS KLQILESFIN ESLRFHPVVD FTMRRALDDD 400
    VIEGYNVKKG TNIILNVGRM HRSEFFSKPN QFSLDNFHKN VPSRFFQPFG 450
    SGPRSCVGKH IAMVMMKSIL VALLSRFSVC PMKACTVENI PQTNNLSQQP 500
    VEEPSSLSV 509
    Length:509
    Mass (Da):57,354
    Last modified:January 1, 1998 - v1
    Checksum:iF04532DEA8FDB628
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004521 mRNA. Translation: AAB65788.1.
    RefSeqiNP_571229.2. NM_131154.2.
    UniGeneiDr.75765.

    Genome annotation databases

    GeneIDi30390.
    KEGGidre:30390.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004521 mRNA. Translation: AAB65788.1 .
    RefSeqi NP_571229.2. NM_131154.2.
    UniGenei Dr.75765.

    3D structure databases

    ProteinModelPortali O42145.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 30390.
    KEGGi dre:30390.

    Organism-specific databases

    CTDi 30390.
    ZFINi ZDB-GENE-990415-43. cyp19a1a.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000111912.
    HOVERGENi HBG050750.
    InParanoidi O42145.
    KOi K07434.

    Miscellaneous databases

    NextBioi 20806802.
    PROi O42145.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a zebrafish (Danio rerio) aromatase cDNA."
      Bauer M.P., Goetz F.W.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiC19AA_DANRE
    AccessioniPrimary (citable) accession number: O42145
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: January 22, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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