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Reviewed, UniProtKB/Swiss-Prot O42145 (C19AA_DANRE)

Last modified February 9, 2010. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 19A1a
    EC=1.14.14.1
Alternative name(s):
    CYPXIX
    Aromatase
    Estrogen synthase
    Cytochrome P-450AROM
Gene names
Name: cyp19a1a
Synonyms: cyp19, cyp19a
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

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Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens By similarity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords
   Cellular componentMembrane
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextrinsic to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionaromatase activity

Inferred from electronic annotation. Source: EC

electron carrier activity

Inferred from electronic annotation. Source: InterPro

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Cytochrome P450 19A1a
PRO_0000051967

Sites

Metal binding4561Iron (heme axial ligand) By similarity

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Sequences

Sequence LengthMass (Da)Tools
O42145-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: F04532DEA8FDB628

FASTA50957,354
        10         20         30         40         50         60 
MAGDLLQPCG MKPVRLGEAV VDLLIQRAHN GTERAQDNAC GATATILLLL LCLLLAIRHH 

        70         80         90        100        110        120 
RPHKSHIPGP SFFFGLGPVV SYCRFIWSGI GTASNYYNSK YGDIVRVWIN GEETLILSRS 

       130        140        150        160        170        180 
SAVYHVLRKS LYTSRFGSKL GLQCIGMHEQ GIIFNSNVAL WKKVRAFYAK ALTGPGLQRT 

       190        200        210        220        230        240 
MEICTTSTNS HLDDLSQLTD AQGQLDILNL LRCIVVDVSN RLFLGVPLNE HDLLQKIHKY 

       250        260        270        280        290        300 
FDTWQTVLIK PDVYFRLDWL HRKHKRDAQE LQDAITALIE QKKVQLAHAE KLDHLDFTAE 

       310        320        330        340        350        360 
LIFAQSHGEL SAENVRQCVL EMVIAAPDTL SISLFFMLLL LKQNPDVELK ILQEMDSVLA 

       370        380        390        400        410        420 
GQSLQHSHLS KLQILESFIN ESLRFHPVVD FTMRRALDDD VIEGYNVKKG TNIILNVGRM 

       430        440        450        460        470        480 
HRSEFFSKPN QFSLDNFHKN VPSRFFQPFG SGPRSCVGKH IAMVMMKSIL VALLSRFSVC 

       490        500 
PMKACTVENI PQTNNLSQQP VEEPSSLSV

« Hide

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References

[1]"Isolation and characterization of a zebrafish (Danio rerio) aromatase cDNA."
Bauer M.P., Goetz F.W.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF004521 mRNA. Translation: AAB65788.1.
IPIIPI00482226.
RefSeqNP_571229.2.
UniGeneDr.75765

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGO42145.

Genome annotation databases

EnsemblENSDART00000060605; ENSDARP00000060604; ENSDARG00000041348; Danio rerio. [Genome view]
GeneID30390.
KEGGdre:30390.

Organism-specific databases

CTD30390.
ZFINZDB-GENE-990415-43. cyp19a1a.

Phylogenomic databases

eggNOGfiNOG06676.
HOVERGENO42145.
InParanoidO42145.

Enzyme and pathway databases

BRENDA1.14.14.1. 96826.

Gene expression databases

ArrayExpressO42145.
BgeeO42145.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR017973. Cyt_P450_C.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameC19AA_DANRE
AccessionPrimary (citable) accession number: O42145
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: February 9, 2010
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents