Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O42145 (C19AA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatase

EC=1.14.14.14
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1a
Estrogen synthase
Gene names
Name:cyp19a1a
Synonyms:cyp19, cyp19a
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens By similarity.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Aromatase
PRO_0000051967

Sites

Metal binding4561Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O42145 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: F04532DEA8FDB628

FASTA50957,354
        10         20         30         40         50         60 
MAGDLLQPCG MKPVRLGEAV VDLLIQRAHN GTERAQDNAC GATATILLLL LCLLLAIRHH 

        70         80         90        100        110        120 
RPHKSHIPGP SFFFGLGPVV SYCRFIWSGI GTASNYYNSK YGDIVRVWIN GEETLILSRS 

       130        140        150        160        170        180 
SAVYHVLRKS LYTSRFGSKL GLQCIGMHEQ GIIFNSNVAL WKKVRAFYAK ALTGPGLQRT 

       190        200        210        220        230        240 
MEICTTSTNS HLDDLSQLTD AQGQLDILNL LRCIVVDVSN RLFLGVPLNE HDLLQKIHKY 

       250        260        270        280        290        300 
FDTWQTVLIK PDVYFRLDWL HRKHKRDAQE LQDAITALIE QKKVQLAHAE KLDHLDFTAE 

       310        320        330        340        350        360 
LIFAQSHGEL SAENVRQCVL EMVIAAPDTL SISLFFMLLL LKQNPDVELK ILQEMDSVLA 

       370        380        390        400        410        420 
GQSLQHSHLS KLQILESFIN ESLRFHPVVD FTMRRALDDD VIEGYNVKKG TNIILNVGRM 

       430        440        450        460        470        480 
HRSEFFSKPN QFSLDNFHKN VPSRFFQPFG SGPRSCVGKH IAMVMMKSIL VALLSRFSVC 

       490        500 
PMKACTVENI PQTNNLSQQP VEEPSSLSV 

« Hide

References

[1]"Isolation and characterization of a zebrafish (Danio rerio) aromatase cDNA."
Bauer M.P., Goetz F.W.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF004521 mRNA. Translation: AAB65788.1.
RefSeqNP_571229.2. NM_131154.2.
UniGeneDr.75765.

3D structure databases

ProteinModelPortalO42145.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID30390.
KEGGdre:30390.

Organism-specific databases

CTD30390.
ZFINZDB-GENE-990415-43. cyp19a1a.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000111912.
HOVERGENHBG050750.
InParanoidO42145.
KOK07434.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806802.
PROO42145.

Entry information

Entry nameC19AA_DANRE
AccessionPrimary (citable) accession number: O42145
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: January 22, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families