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Protein

Glucagon-2

Gene

gcg2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-2
Alternative name(s):
Glucagon II
Cleaved into the following 4 chains:
Glucagon-like peptide 1A
Short name:
GLP-1A
Glucagon-like peptide 1B
Short name:
GLP-1B
Glucagon-like peptide 1C
Short name:
GLP-1C
Gene namesi
Name:gcg2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020CuratedAdd
BLAST
Propeptidei21 – 5030PRO_0000011401Add
BLAST
Peptidei53 – 8129GlucagonPRO_0000011402Add
BLAST
Propeptidei84 – 9512PRO_0000011403Add
BLAST
Peptidei97 – 13337Glucagon-like peptide 1APRO_0000011404Add
BLAST
Propeptidei136 – 1405PRO_0000011405
Peptidei142 – 17231Glucagon-like peptide 1BPRO_0000011406Add
BLAST
Propeptidei175 – 1784PRO_0000011407
Peptidei180 – 21031Glucagon-like peptide 1CPRO_0000011408Add
BLAST
Propeptidei213 – 2197PRO_0000011409

Keywords - PTMi

Cleavage on pair of basic residues

Structurei

3D structure databases

ProteinModelPortaliO42144.
SMRiO42144. Positions 53-81, 180-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG003010.
KOiK05259.

Family and domain databases

InterProiIPR015550. Glucagon.
IPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PANTHERiPTHR11418:SF0. PTHR11418:SF0. 1 hit.
PfamiPF00123. Hormone_2. 4 hits.
[Graphical view]
PRINTSiPR00275. GLUCAGON.
SMARTiSM00070. GLUCA. 4 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42144-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSTCYMIGI LLLILQNTYQ SPVPEADGSS RSVKAARNEA VDDSEQLKEV
60 70 80 90 100
KRHSQGTFTS DYSKYLDSRR AQDFVQWLMN TKRSGGLSRR NADYERHAEG
110 120 130 140 150
TFTSDVTQHL DEKAAKEFID WLINGGPTKE IISRRNAEIE RHAEGTYTND
160 170 180 190 200
VTEYLEEKAT KAFIEWLIKG KPKKIRYSRH AEGTFTNDMT NYLEEKAAKE
210
FVGWLINGRP KRKDLLEEH
Length:219
Mass (Da):25,271
Last modified:January 1, 1998 - v1
Checksum:iACC699233C362CE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004433 mRNA. Translation: AAB65661.1.
BC054234 mRNA. Translation: AAH54234.1.
RefSeqiNP_001079787.1. NM_001086318.1.
UniGeneiXl.195.

Genome annotation databases

GeneIDi379477.
KEGGixla:379477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004433 mRNA. Translation: AAB65661.1.
BC054234 mRNA. Translation: AAH54234.1.
RefSeqiNP_001079787.1. NM_001086318.1.
UniGeneiXl.195.

3D structure databases

ProteinModelPortaliO42144.
SMRiO42144. Positions 53-81, 180-209.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379477.
KEGGixla:379477.

Organism-specific databases

CTDi100136748.

Phylogenomic databases

HOVERGENiHBG003010.
KOiK05259.

Family and domain databases

InterProiIPR015550. Glucagon.
IPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PANTHERiPTHR11418:SF0. PTHR11418:SF0. 1 hit.
PfamiPF00123. Hormone_2. 4 hits.
[Graphical view]
PRINTSiPR00275. GLUCAGON.
SMARTiSM00070. GLUCA. 4 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Xenopus proglucagon gene encodes novel GLP-1-like peptides with insulinotropic properties."
    Irwin D.M., Satkunarajah M., Wen Y., Brubaker P.L., Pederson R.A., Wheeler M.B.
    Proc. Natl. Acad. Sci. U.S.A. 94:7915-7920(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGLUC2_XENLA
AccessioniPrimary (citable) accession number: O42144
Secondary accession number(s): Q5D082
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: January 1, 1998
Last modified: October 14, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.