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Protein

Glucagon-1

Gene

gcg1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-1
Alternative name(s):
Glucagon I
Cleaved into the following 5 chains:
Glucagon-like peptide 1A
Short name:
GLP-1A
Glucagon-like peptide 1B
Short name:
GLP-1B
Glucagon-like peptide 1C
Short name:
GLP-1C
Glucagon-like peptide 2
Short name:
GLP-2
Gene namesi
Name:gcg1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1000161. gcg.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Propeptidei21 – 5030PRO_0000011390Add
BLAST
Peptidei53 – 8129GlucagonPRO_0000011391Add
BLAST
Propeptidei84 – 9512PRO_0000011392Add
BLAST
Peptidei97 – 13337Glucagon-like peptide 1APRO_0000011393Add
BLAST
Propeptidei136 – 1405PRO_0000011394
Peptidei142 – 17231Glucagon-like peptide 1BPRO_0000011395Add
BLAST
Propeptidei175 – 1784PRO_0000011396
Peptidei180 – 21031Glucagon-like peptide 1CPRO_0000011397Add
BLAST
Propeptidei213 – 22412PRO_0000011398Add
BLAST
Peptidei227 – 25933Glucagon-like peptide 2PRO_0000011399Add
BLAST
Propeptidei261 – 2666PRO_0000011400

Keywords - PTMi

Cleavage on pair of basic residues

Structurei

3D structure databases

ProteinModelPortaliO42143.
SMRiO42143. Positions 53-81, 97-128, 142-171, 180-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG003010.
KOiK05259.

Family and domain databases

InterProiIPR015550. Glucagon.
IPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PANTHERiPTHR11418:SF0. PTHR11418:SF0. 2 hits.
PfamiPF00123. Hormone_2. 5 hits.
[Graphical view]
PRINTSiPR00275. GLUCAGON.
SMARTiSM00070. GLUCA. 5 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O42143-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSTCYMIGI LLMILQNTYQ SPVPETDANS RSVKAARNEA VDDSEQLKEV
60 70 80 90 100
KRHSQGTFTS DYSKYLDSRR AQDFVQWLMN TKRSGELSRR NADYERHAEG
110 120 130 140 150
TFTSDVTQQL DEKAAKEFID WLINGGPSKE IISRRNAEFE RHAEGTYTND
160 170 180 190 200
VTEYLEEKAA KEFIEWLIKG KPKKIRYSRH AEGTFTNDMT NYLEEKAAKE
210 220 230 240 250
FVGWLIKGRP KRNFSEVHSV EEMDRRHADG SFTNDINKVL DIIAAQEFLD
260
WVINTQETER DLLEEQ
Length:266
Mass (Da):30,951
Last modified:January 1, 1998 - v1
Checksum:i544F7BBC20AF872C
GO
Isoform 2 (identifier: O42143-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-261: Missing.

Show »
Length:218
Mass (Da):25,347
Checksum:iD1F7CC5A9655F181
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei214 – 26148Missing in isoform 2. CuratedVSP_001755Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004432 mRNA. Translation: AAB65660.1.
RefSeqiNP_001079142.1. NM_001085673.1. [O42143-1]
UniGeneiXl.193.

Genome annotation databases

GeneIDi373686.
KEGGixla:373686.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004432 mRNA. Translation: AAB65660.1.
RefSeqiNP_001079142.1. NM_001085673.1. [O42143-1]
UniGeneiXl.193.

3D structure databases

ProteinModelPortaliO42143.
SMRiO42143. Positions 53-81, 97-128, 142-171, 180-209.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373686.
KEGGixla:373686.

Organism-specific databases

CTDi2641.
XenbaseiXB-GENE-1000161. gcg.

Phylogenomic databases

HOVERGENiHBG003010.
KOiK05259.

Family and domain databases

InterProiIPR015550. Glucagon.
IPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PANTHERiPTHR11418:SF0. PTHR11418:SF0. 2 hits.
PfamiPF00123. Hormone_2. 5 hits.
[Graphical view]
PRINTSiPR00275. GLUCAGON.
SMARTiSM00070. GLUCA. 5 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLUC1_XENLA
AccessioniPrimary (citable) accession number: O42143
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: January 1, 1998
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.