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Protein
Submitted name:

Mu-calpain large subunit

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei115PROSITE-ProRule annotation1
Active sitei272PROSITE-ProRule annotation1
Active sitei296PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi599 – 610PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi629 – 640PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotationSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Protein family/group databases

MEROPSiC02.001.

Names & Taxonomyi

Protein namesi
Submitted name:
Mu-calpain large subunitImported (EC:3.4.22.52Imported)
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliO42133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 354Calpain catalyticInterPro annotationAdd BLAST300
Domaini586 – 611EF-handInterPro annotationAdd BLAST26
Domaini616 – 651EF-handInterPro annotationAdd BLAST36
Domaini681 – 715EF-handInterPro annotationAdd BLAST35

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

HOVERGENiHBG012645.
KOiK01367.
PhylomeDBiO42133.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
cd00051. EFh. 2 hits.
InterProiView protein in InterPro
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029643. CAPN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
PANTHERiPTHR10183:SF343. PTHR10183:SF343. 1 hit.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 3 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.

Sequencei

Sequence statusi: Complete.

O42133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEPVVPVF CTGVSAQVQR QRAKALGLGQ HQNAVRFRGQ DYAALRDDCL
60 70 80 90 100
RSGSLFRDET FPPSASSLGF RELGPGSSKT RGVTWKRPTE LCRHPQFIVD
110 120 130 140 150
GATRTDICQG ALGDCWLLAA IASLTLNETI LHRVVPHGQS FQNGYAGIFH
160 170 180 190 200
FQIWQFGEWQ DVVVDDYLPT KDGKLLFVHS AEGTEFWSAL LEKAYAKVNG
210 220 230 240 250
CYEALSGGST SEGFEDFTGG VTEWYDLRKP PADLYQIILK ALERGSLLGC
260 270 280 290 300
SIDITSAFDM EAVTFKKLVK GHAYSVTGAK QISYRGQSLG LIRMRNPWGE
310 320 330 340 350
VEWTGAWSDN SSEWNAVEPA LRQQLMVRME DGEFWMSFRD FLREFTRLEI
360 370 380 390 400
CNLTPDALQS RKFRKWNTRL YDGSWRRGST AGGCRNYPAT FWINPQFKIC
410 420 430 440 450
LEEVDDDGDD FGGREPGCSF LLALMQKHRR RERRYGKDME TIGFAVYEVP
460 470 480 490 500
PEHVGHSGVH LQRDFFLSNA SRARSEQFIN LREVSTRLRL PPGEYIVVPS
510 520 530 540 550
TFEPNREGDF VLRVFSEKRA DTEEIDDKIE AKLPDEKVLS EGEIDENFKQ
560 570 580 590 600
LFRQLAGPDM EISVTELQTI LNRIIAKHKD LRTKGFSLES CRSMVNLMDK
610 620 630 640 650
DGNGKLGLVE FNVLWNRIRN YLSVFRKFDL DKSGSMSAYE MRMALEASGY
660 670 680 690 700
KLTQKLHQLL ITRYAEPDLA IDFDSFVCCL VRLETMFRFF QAMDGDNDGV
710
VTFGLLQWLQ LTMFA
Length:715
Mass (Da):81,411
Last modified:January 1, 1998 - v1
Checksum:i70679B21C5E0AD6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007775 mRNA. Translation: BAA22659.1.
PIRiS57195.
RefSeqiNP_001038137.1. NM_001044672.1.
UniGeneiGga.9324.

Genome annotation databases

GeneIDi693249.
KEGGigga:693249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007775 mRNA. Translation: BAA22659.1.
PIRiS57195.
RefSeqiNP_001038137.1. NM_001044672.1.
UniGeneiGga.9324.

3D structure databases

ProteinModelPortaliO42133.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC02.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi693249.
KEGGigga:693249.

Organism-specific databases

CTDi823.

Phylogenomic databases

HOVERGENiHBG012645.
KOiK01367.
PhylomeDBiO42133.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
cd00051. EFh. 2 hits.
InterProiView protein in InterPro
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029643. CAPN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
PANTHERiPTHR10183:SF343. PTHR10183:SF343. 1 hit.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 3 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO42133_CHICK
AccessioniPrimary (citable) accession number: O42133
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: June 7, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.