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O42124

- O42124_CHICK

UniProt

O42124 - O42124_CHICK

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Protein
Submitted name:

BMP type II receptor

Gene

BRK-3

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. receptor signaling protein serine/threonine kinase activity Source: InterPro
  3. transforming growth factor beta-activated receptor activity Source: InterPro

GO - Biological processi

  1. chondrocyte development Source: AgBase
  2. negative regulation of chondrocyte proliferation Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotationImported, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
BMP type II receptorImported
Submitted name:
Type II bone morphogenetic protein receptorImported
Gene namesi
Name:BRK-3Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013771.

Structurei

3D structure databases

ProteinModelPortaliO42124.
SMRiO42124. Positions 22-121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000043088.
HOVERGENiHBG050705.
InParanoidiO42124.
KOiK04671.
OMAiDHYKPAI.
OrthoDBiEOG7JHM5B.
PhylomeDBiO42124.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR015770. BMPR2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PTHR23255:SF63. PTHR23255:SF63. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42124-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSVTKNIFH SLSKAAQSEE RLCAFKDPYQ QDHGISESRI SQENGTILCM
60 70 80 90 100
KGSTCYGLWE KTREGDIHLV KQGCWSHIGD PQECHFEECI VTTTPSLIQN
110 120 130 140 150
GTYRFCCCST DLCNVNFTEN FPPPDPTDTT PYNSSHSFHR DETIVIVLAS
160 170 180 190 200
VSVLAVLIAA LFFGYRMLAG DRKQGLHSMN MMEAAASEPS LDLDNLKLLE
210 220 230 240 250
LIGRGRYGAV YKGSLDERPV AVKVFSFANR QNFVNERNIY RIPLMEHDNI
260 270 280 290 300
ARFIVGDERF TADGRMEYLL VMEYYPNGSL CKYLSLHTSD WVSSCRLAHS
310 320 330 340 350
ITRGLAYLHT ELPRGDHYKP AISHRDLNSR NVLVKNDGTC VISDFGLSMK
360 370 380 390 400
LTGNRLVRPG EEDNAAISEV GTIRYMAPEV LEGAVNLRDC ESALKQVDMY
410 420 430 440 450
ALGLIYWEIF MRCTDLFPGE SVPEYQMAFQ TEVGNHPTFE DMQVLVSREK
460 470 480 490 500
QRPKFPEAWK ENSLAVRSLK ETIEDCWDQD AEARLTAQCA EERMAELMMI
510 520 530 540 550
WERNKSVSPT VNPMSTAMQN ERNLSHHRRV SKIRPYPDYS SSSYIEDSIH
560 570 580 590 600
HTDSIVKNIS SEHSMSTTPL TSGEKNRNSI NYERQQAQAR IPSPETSVTS
610 620 630 640 650
LSTNTTTTNT TGLTPSTGMT TISEIPYSDE TNLHTTNVMQ PGGPTPVCLQ
660 670 680 690 700
LTEEDLETNK LDPKEVDKNL KESSDENLME HSLKQFSGPD PLSSTSSSLL
710 720 730 740 750
YPLIKLAVEV TGQQDFTQAS NGQACLIPDV PSAQVYPLPK QQNLPKRPTS
760 770 780 790 800
LPLNTKNSTK EPRLKFGGKH KSNLKQVETG VAKMNTINAA EPHVVTVTMN
810 820 830 840 850
GVAGRTHSIN SHAGTTQYAN GAVPSGQTAS SVAQRAQEML QNQFSGEDSR
860 870 880 890 900
LNINSSPDEH EPLLRREQQV GHDEGVLDRL VDRRERQLDN GRTNVNNNNS
910 920 930 940 950
NPCPVQDTAT LSIQNVARNP GQTQTRRAQR PNSLDLSATN SLDSSSMQLG
960 970 980 990 1000
DSSQDGKSGS GEKIKKRVKT PYSLKRWRPS TWVISTEPLH CEVNNNGGDR
1010 1020 1030
AVHSKSSTAV YLAEGGTATT MVSKDAGVNC L
Length:1,031
Mass (Da):114,639
Last modified:January 1, 1998 - v1
Checksum:iEF6F7B53CC2D302E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77660 mRNA. Translation: AAL40035.1.
AB006785 mRNA. Translation: BAA22057.1.
RefSeqiNP_001001465.1. NM_001001465.1.
UniGeneiGga.105.

Genome annotation databases

GeneIDi374147.
KEGGigga:374147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77660 mRNA. Translation: AAL40035.1 .
AB006785 mRNA. Translation: BAA22057.1 .
RefSeqi NP_001001465.1. NM_001001465.1.
UniGenei Gga.105.

3D structure databases

ProteinModelPortali O42124.
SMRi O42124. Positions 22-121.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000013771.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 374147.
KEGGi gga:374147.

Organism-specific databases

CTDi 659.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000043088.
HOVERGENi HBG050705.
InParanoidi O42124.
KOi K04671.
OMAi DHYKPAI.
OrthoDBi EOG7JHM5B.
PhylomeDBi O42124.
TreeFami TF314724.

Miscellaneous databases

NextBioi 20813661.
PROi O42124.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR015770. BMPR2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
PTHR23255:SF63. PTHR23255:SF63. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "BMP signaling during bone pattern determination in the developing limb."
    Kawakami Y., Ishikawa T., Shimabara M., Tanda N., Enomoto-Iwamoto M., Iwamoto M., Kuwana T., Ueki A., Noji S., Nohno T.
    Development 122:3557-3566(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: EmbryoImported.
  2. Nohno T.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: EmbryoImported.

Entry informationi

Entry nameiO42124_CHICK
AccessioniPrimary (citable) accession number: O42124
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)