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O42124

- O42124_CHICK

UniProt

O42124 - O42124_CHICK

Protein
Submitted name:

BMP type II receptor

Gene

BRK-3

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. receptor signaling protein serine/threonine kinase activity Source: InterPro
    3. transforming growth factor beta-activated receptor activity Source: InterPro

    GO - Biological processi

    1. chondrocyte development Source: AgBase
    2. negative regulation of chondrocyte proliferation Source: AgBase

    Keywords - Molecular functioni

    Kinase, ReceptorSAAS annotationImported, Serine/threonine-protein kinaseSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    BMP type II receptorImported
    Submitted name:
    Type II bone morphogenetic protein receptorImported
    Gene namesi
    Name:BRK-3Imported
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000013771.

    Structurei

    3D structure databases

    ProteinModelPortaliO42124.
    SMRiO42124. Positions 22-121.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000043088.
    HOVERGENiHBG050705.
    InParanoidiO42124.
    KOiK04671.
    OMAiDHYKPAI.
    OrthoDBiEOG7JHM5B.
    PhylomeDBiO42124.
    TreeFamiTF314724.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR015770. BMPR2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PTHR23255:SF63. PTHR23255:SF63. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O42124-1 [UniParc]FASTAAdd to Basket

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    MKSVTKNIFH SLSKAAQSEE RLCAFKDPYQ QDHGISESRI SQENGTILCM     50
    KGSTCYGLWE KTREGDIHLV KQGCWSHIGD PQECHFEECI VTTTPSLIQN 100
    GTYRFCCCST DLCNVNFTEN FPPPDPTDTT PYNSSHSFHR DETIVIVLAS 150
    VSVLAVLIAA LFFGYRMLAG DRKQGLHSMN MMEAAASEPS LDLDNLKLLE 200
    LIGRGRYGAV YKGSLDERPV AVKVFSFANR QNFVNERNIY RIPLMEHDNI 250
    ARFIVGDERF TADGRMEYLL VMEYYPNGSL CKYLSLHTSD WVSSCRLAHS 300
    ITRGLAYLHT ELPRGDHYKP AISHRDLNSR NVLVKNDGTC VISDFGLSMK 350
    LTGNRLVRPG EEDNAAISEV GTIRYMAPEV LEGAVNLRDC ESALKQVDMY 400
    ALGLIYWEIF MRCTDLFPGE SVPEYQMAFQ TEVGNHPTFE DMQVLVSREK 450
    QRPKFPEAWK ENSLAVRSLK ETIEDCWDQD AEARLTAQCA EERMAELMMI 500
    WERNKSVSPT VNPMSTAMQN ERNLSHHRRV SKIRPYPDYS SSSYIEDSIH 550
    HTDSIVKNIS SEHSMSTTPL TSGEKNRNSI NYERQQAQAR IPSPETSVTS 600
    LSTNTTTTNT TGLTPSTGMT TISEIPYSDE TNLHTTNVMQ PGGPTPVCLQ 650
    LTEEDLETNK LDPKEVDKNL KESSDENLME HSLKQFSGPD PLSSTSSSLL 700
    YPLIKLAVEV TGQQDFTQAS NGQACLIPDV PSAQVYPLPK QQNLPKRPTS 750
    LPLNTKNSTK EPRLKFGGKH KSNLKQVETG VAKMNTINAA EPHVVTVTMN 800
    GVAGRTHSIN SHAGTTQYAN GAVPSGQTAS SVAQRAQEML QNQFSGEDSR 850
    LNINSSPDEH EPLLRREQQV GHDEGVLDRL VDRRERQLDN GRTNVNNNNS 900
    NPCPVQDTAT LSIQNVARNP GQTQTRRAQR PNSLDLSATN SLDSSSMQLG 950
    DSSQDGKSGS GEKIKKRVKT PYSLKRWRPS TWVISTEPLH CEVNNNGGDR 1000
    AVHSKSSTAV YLAEGGTATT MVSKDAGVNC L 1031
    Length:1,031
    Mass (Da):114,639
    Last modified:January 1, 1998 - v1
    Checksum:iEF6F7B53CC2D302E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77660 mRNA. Translation: AAL40035.1.
    AB006785 mRNA. Translation: BAA22057.1.
    RefSeqiNP_001001465.1. NM_001001465.1.
    UniGeneiGga.105.

    Genome annotation databases

    GeneIDi374147.
    KEGGigga:374147.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77660 mRNA. Translation: AAL40035.1 .
    AB006785 mRNA. Translation: BAA22057.1 .
    RefSeqi NP_001001465.1. NM_001001465.1.
    UniGenei Gga.105.

    3D structure databases

    ProteinModelPortali O42124.
    SMRi O42124. Positions 22-121.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000013771.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 374147.
    KEGGi gga:374147.

    Organism-specific databases

    CTDi 659.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000043088.
    HOVERGENi HBG050705.
    InParanoidi O42124.
    KOi K04671.
    OMAi DHYKPAI.
    OrthoDBi EOG7JHM5B.
    PhylomeDBi O42124.
    TreeFami TF314724.

    Miscellaneous databases

    NextBioi 20813661.
    PROi O42124.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR015770. BMPR2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    PTHR23255:SF63. PTHR23255:SF63. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "BMP signaling during bone pattern determination in the developing limb."
      Kawakami Y., Ishikawa T., Shimabara M., Tanda N., Enomoto-Iwamoto M., Iwamoto M., Kuwana T., Ueki A., Noji S., Nohno T.
      Development 122:3557-3566(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: EmbryoImported.
    2. Nohno T.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: EmbryoImported.

    Entry informationi

    Entry nameiO42124_CHICK
    AccessioniPrimary (citable) accession number: O42124
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 1, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)