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Protein

Receptor protein serine/threonine kinase

Gene

BRK-3

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • chondrocyte development Source: AgBase
  • endochondral bone morphogenesis Source: AgBase
  • negative regulation of chondrocyte proliferation Source: AgBase
  • negative regulation of DNA biosynthetic process Source: BHF-UCL
  • positive regulation of cartilage development Source: AgBase
  • proteoglycan biosynthetic process Source: AgBase

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-201451. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:BRK-3Imported
Synonyms:BMPR2Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei144 – 165HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 497Protein kinaseInterPro annotationAdd BLAST302

Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000043088.
HOVERGENiHBG050705.
KOiK04671.
TreeFamiTF314724.

Family and domain databases

InterProiView protein in InterPro
IPR000472. Activin_recp.
IPR015770. BMPR2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000333. TGFB_receptor.
PANTHERiPTHR23255. PTHR23255. 1 hit.
PTHR23255:SF82. PTHR23255:SF82. 1 hit.
PfamiView protein in Pfam
PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

O42124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVTKNIFH SLSKAAQSEE RLCAFKDPYQ QDHGISESRI SQENGTILCM
60 70 80 90 100
KGSTCYGLWE KTREGDIHLV KQGCWSHIGD PQECHFEECI VTTTPSLIQN
110 120 130 140 150
GTYRFCCCST DLCNVNFTEN FPPPDPTDTT PYNSSHSFHR DETIVIVLAS
160 170 180 190 200
VSVLAVLIAA LFFGYRMLAG DRKQGLHSMN MMEAAASEPS LDLDNLKLLE
210 220 230 240 250
LIGRGRYGAV YKGSLDERPV AVKVFSFANR QNFVNERNIY RIPLMEHDNI
260 270 280 290 300
ARFIVGDERF TADGRMEYLL VMEYYPNGSL CKYLSLHTSD WVSSCRLAHS
310 320 330 340 350
ITRGLAYLHT ELPRGDHYKP AISHRDLNSR NVLVKNDGTC VISDFGLSMK
360 370 380 390 400
LTGNRLVRPG EEDNAAISEV GTIRYMAPEV LEGAVNLRDC ESALKQVDMY
410 420 430 440 450
ALGLIYWEIF MRCTDLFPGE SVPEYQMAFQ TEVGNHPTFE DMQVLVSREK
460 470 480 490 500
QRPKFPEAWK ENSLAVRSLK ETIEDCWDQD AEARLTAQCA EERMAELMMI
510 520 530 540 550
WERNKSVSPT VNPMSTAMQN ERNLSHHRRV SKIRPYPDYS SSSYIEDSIH
560 570 580 590 600
HTDSIVKNIS SEHSMSTTPL TSGEKNRNSI NYERQQAQAR IPSPETSVTS
610 620 630 640 650
LSTNTTTTNT TGLTPSTGMT TISEIPYSDE TNLHTTNVMQ PGGPTPVCLQ
660 670 680 690 700
LTEEDLETNK LDPKEVDKNL KESSDENLME HSLKQFSGPD PLSSTSSSLL
710 720 730 740 750
YPLIKLAVEV TGQQDFTQAS NGQACLIPDV PSAQVYPLPK QQNLPKRPTS
760 770 780 790 800
LPLNTKNSTK EPRLKFGGKH KSNLKQVETG VAKMNTINAA EPHVVTVTMN
810 820 830 840 850
GVAGRTHSIN SHAGTTQYAN GAVPSGQTAS SVAQRAQEML QNQFSGEDSR
860 870 880 890 900
LNINSSPDEH EPLLRREQQV GHDEGVLDRL VDRRERQLDN GRTNVNNNNS
910 920 930 940 950
NPCPVQDTAT LSIQNVARNP GQTQTRRAQR PNSLDLSATN SLDSSSMQLG
960 970 980 990 1000
DSSQDGKSGS GEKIKKRVKT PYSLKRWRPS TWVISTEPLH CEVNNNGGDR
1010 1020 1030
AVHSKSSTAV YLAEGGTATT MVSKDAGVNC L
Length:1,031
Mass (Da):114,639
Last modified:January 1, 1998 - v1
Checksum:iEF6F7B53CC2D302E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000048 Genomic DNA. No translation available.
L77660 mRNA. Translation: AAL40035.1.
AB006785 mRNA. Translation: BAA22057.1.
RefSeqiNP_001001465.1. NM_001001465.1.
UniGeneiGga.105.

Genome annotation databases

EnsembliENSGALT00000049675; ENSGALP00000058326; ENSGALG00000008459.
GeneIDi374147.
KEGGigga:374147.

Similar proteinsi

Entry informationi

Entry nameiO42124_CHICK
AccessioniPrimary (citable) accession number: O42124
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported