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O42124

- O42124_CHICK

UniProt

O42124 - O42124_CHICK

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Protein
Submitted name:

BMP type II receptor

Gene
BRK-3
Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. receptor signaling protein serine/threonine kinase activity Source: InterPro
  3. transforming growth factor beta-activated receptor activity Source: InterPro

GO - Biological processi

  1. chondrocyte development Source: AgBase
  2. negative regulation of chondrocyte proliferation Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotationsImported, Serine/threonine-protein kinaseSAAS annotations, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
BMP type II receptorImported
Submitted name:
Type II bone morphogenetic protein receptorImported
Gene namesi
Name:BRK-3Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013771.

Structurei

3D structure databases

ProteinModelPortaliO42124.
SMRiO42124. Positions 22-121.

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000043088.
HOVERGENiHBG050705.
InParanoidiO42124.
KOiK04671.
OMAiDHYKPAI.
OrthoDBiEOG7JHM5B.
PhylomeDBiO42124.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR015770. BMPR2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PTHR23255:SF63. PTHR23255:SF63. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42124-1 [UniParc]FASTAAdd to Basket

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MKSVTKNIFH SLSKAAQSEE RLCAFKDPYQ QDHGISESRI SQENGTILCM     50
KGSTCYGLWE KTREGDIHLV KQGCWSHIGD PQECHFEECI VTTTPSLIQN 100
GTYRFCCCST DLCNVNFTEN FPPPDPTDTT PYNSSHSFHR DETIVIVLAS 150
VSVLAVLIAA LFFGYRMLAG DRKQGLHSMN MMEAAASEPS LDLDNLKLLE 200
LIGRGRYGAV YKGSLDERPV AVKVFSFANR QNFVNERNIY RIPLMEHDNI 250
ARFIVGDERF TADGRMEYLL VMEYYPNGSL CKYLSLHTSD WVSSCRLAHS 300
ITRGLAYLHT ELPRGDHYKP AISHRDLNSR NVLVKNDGTC VISDFGLSMK 350
LTGNRLVRPG EEDNAAISEV GTIRYMAPEV LEGAVNLRDC ESALKQVDMY 400
ALGLIYWEIF MRCTDLFPGE SVPEYQMAFQ TEVGNHPTFE DMQVLVSREK 450
QRPKFPEAWK ENSLAVRSLK ETIEDCWDQD AEARLTAQCA EERMAELMMI 500
WERNKSVSPT VNPMSTAMQN ERNLSHHRRV SKIRPYPDYS SSSYIEDSIH 550
HTDSIVKNIS SEHSMSTTPL TSGEKNRNSI NYERQQAQAR IPSPETSVTS 600
LSTNTTTTNT TGLTPSTGMT TISEIPYSDE TNLHTTNVMQ PGGPTPVCLQ 650
LTEEDLETNK LDPKEVDKNL KESSDENLME HSLKQFSGPD PLSSTSSSLL 700
YPLIKLAVEV TGQQDFTQAS NGQACLIPDV PSAQVYPLPK QQNLPKRPTS 750
LPLNTKNSTK EPRLKFGGKH KSNLKQVETG VAKMNTINAA EPHVVTVTMN 800
GVAGRTHSIN SHAGTTQYAN GAVPSGQTAS SVAQRAQEML QNQFSGEDSR 850
LNINSSPDEH EPLLRREQQV GHDEGVLDRL VDRRERQLDN GRTNVNNNNS 900
NPCPVQDTAT LSIQNVARNP GQTQTRRAQR PNSLDLSATN SLDSSSMQLG 950
DSSQDGKSGS GEKIKKRVKT PYSLKRWRPS TWVISTEPLH CEVNNNGGDR 1000
AVHSKSSTAV YLAEGGTATT MVSKDAGVNC L 1031
Length:1,031
Mass (Da):114,639
Last modified:January 1, 1998 - v1
Checksum:iEF6F7B53CC2D302E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77660 mRNA. Translation: AAL40035.1.
AB006785 mRNA. Translation: BAA22057.1.
RefSeqiNP_001001465.1. NM_001001465.1.
UniGeneiGga.105.

Genome annotation databases

GeneIDi374147.
KEGGigga:374147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77660 mRNA. Translation: AAL40035.1 .
AB006785 mRNA. Translation: BAA22057.1 .
RefSeqi NP_001001465.1. NM_001001465.1.
UniGenei Gga.105.

3D structure databases

ProteinModelPortali O42124.
SMRi O42124. Positions 22-121.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000013771.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 374147.
KEGGi gga:374147.

Organism-specific databases

CTDi 659.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000043088.
HOVERGENi HBG050705.
InParanoidi O42124.
KOi K04671.
OMAi DHYKPAI.
OrthoDBi EOG7JHM5B.
PhylomeDBi O42124.
TreeFami TF314724.

Miscellaneous databases

NextBioi 20813661.
PROi O42124.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR015770. BMPR2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
PTHR23255:SF63. PTHR23255:SF63. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "BMP signaling during bone pattern determination in the developing limb."
    Kawakami Y., Ishikawa T., Shimabara M., Tanda N., Enomoto-Iwamoto M., Iwamoto M., Kuwana T., Ueki A., Noji S., Nohno T.
    Development 122:3557-3566(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: EmbryoImported.
  2. Nohno T.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: EmbryoImported.

Entry informationi

Entry nameiO42124_CHICK
AccessioniPrimary (citable) accession number: O42124
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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